Infectious burden and cognitive function: The Northern Manhattan Study
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OBJECTIVE: We hypothesized that infectious burden (IB), a composite serologic measure of exposure to common pathogens (i.e., Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus, and herpes simplex virus 1 and 2) associated with vascular risk in the prospective Northern Manhattan Study (NOMAS), would also be associated with cognition. METHODS: Cognition was assessed using the Mini-Mental State Examination (MMSE) at enrollment and the modified Telephone Interview for Cognitive Status (TICS-m) at annual follow-up visits. Adjusted linear and logistic regressions were used to measure the association between IB index and MMSE. Generalized estimating equation models were used to evaluate associations with TICS-m and its change over time. RESULTS: Serologies and cognitive assessments were available in 1,625 participants of the NOMAS cohort. In unadjusted analyses, higher IB index was associated with worse cognition (change per standard deviation [SD] of IB for MMSE was -0.77, p < 0.0001, and for first measurements of TICS-m was -1.89, p < 0.0001). These effects were attenuated after adjusting for risk factors (for MMSE adjusted change per SD of IB = -0.17, p = 0.06, for TICS-m adjusted change per SD IB = -0.68, p < 0.0001). IB was associated with MMSE ≤24 (compared to MMSE >24, adjusted odds ratio 1.26 per SD of IB, 95% confidence interval 1.06-1.51). IB was not associated with cognitive decline over time. The results were similar when IB was limited to viral serologies only. CONCLUSION: A measure of IB associated with stroke risk and atherosclerosis was independently associated with cognitive performance in this multiethnic cohort. Past infections may contribute to cognitive impairment.
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In a large multi-ethnic cohort, an elevated infectious burden, defined as a composite serologic measure of exposure to five specific common pathogens, was associated with cognitive impairment as assessed by the mini-mental state examination.
“In a large multi-ethnic cohort, an elevated infectious burden, defined as a composite serologic measure of exposure to five specific common pathogens (e.g. cytomegalovirus, Helicobacter pylori and herpes simplex virus), was associated with cognitive impairment as assessed by the mini-mental state examination (461, 462).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [461]
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Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Global prevalence of dementia: a Delphi consensus study
Ferri, C. P., Prince, M. J., Brayne, C., Brodaty, H., Fratiglioni, L., Ganguli, M., Hall, K. S., Hasegawa, K., Hendrie, H. C., Huang, Y., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67889-0 · Cited by 5,336 · see citing works
Silent Brain Infarcts and the Risk of Dementia and Cognitive Decline
Vermeer, S. E., Prins, N. D., den Heijer, T., Hofman, A., Koudstaal, P. J., & Breteler, M. M. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022066 · Cited by 2,313 · see citing works
Hachinski, V., Iadecola, C., Petersen, R. C., Breteler, M. M., Nyenhuis, D. L., Black, S. E., Powers, W. J., DeCarli, C., Merino, J. G., Kalaria, R. N., et al. (2006) · Stroke · doi:10.1161/01.str.0000237236.88823.47 · Cited by 1,722 · see citing works
Snowdon, D. A. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03540340047031 · Cited by 1,590 · see citing works
Telephone Interview for Cognitive Status
Brandt, J., Spencer, M., & Folstein, M. F. (1988) · PsycTESTS Dataset · doi:10.1037/t28542-000 · Cited by 1,504 · see citing works
Seroprevalence of Cytomegalovirus Infection in the United States, 1988-1994
Staras, S. A. S., Dollard, S. C., Radford, K. W., Flanders, W. D., Pass, R. F., & Cannon, M. J. (2006) · Clinical Infectious Diseases · doi:10.1086/508173 · Cited by 1,008 · see citing works
Brain infarction and the clinical expression of Alzheimer disease. The Nun Study.
Snowdon, D. A., Greiner, L. H., Mortimer, J. A., et al. (1997) · PubMed · Cited by 846 · see citing works
Epstein, S. E., Zhou, Y., & Zhu, J. (1999) · Circulation · doi:10.1161/01.cir.100.4.e20 · Cited by 512 · see citing works
Identification and localization of Chlamydia pneumoniae in the Alzheimer's brain
Balin, B. J., Gérard, H. C., Arking, E. J., Appelt, D. M., Branigan, P. J., Abrams, J. T., Whittum-Hudson, J. A., & Hudson, A. P. (1998) · Medical Microbiology and Immunology · doi:10.1007/s004300050071 · Cited by 506 · see citing works
Childhood socioeconomic position and cognitive function in adulthood
Kaplan, G. A., Turrell, G., Lynch, J. W., Everson‐Rose, S. A., Helkala, E., & Salonen, J. T. (2001) · International Journal of Epidemiology · doi:10.1093/ije/30.2.256 · Cited by 347 · see citing works
Inflammatory factors are elevated in brain microvessels in Alzheimer's disease
Grammas, P. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00276-7 · Cited by 292 · see citing works
Ngandu, T., Strauss, E. I. V., Helkala, E.-L., Winblad, B. G., Nissinen, A. M., Tuomilehto, J. O., Soininen, H. S., & Kivipelto, M. (2007) · Neurology · doi:10.1212/01.wnl.0000277456.29440.16 · Cited by 290 · see citing works
Letenneur, L., Pérès, K., Fleury, H., Garrigue, I., Barberger-Gateau, P., Helmer, C., Orgogozo, J.-M., Gauthier, S., & Dartigues, J.-F. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003637 · Cited by 252 · see citing works
Cardiovascular risk factors and Alzheimer’s disease
Luchsinger, J. A., & Mayeux, R. P. (2004) · Current Atherosclerosis Reports · doi:10.1007/s11883-004-0056-z · Cited by 238 · see citing works
Relationship between Helicobacter pylori infection and Alzheimer disease
Kountouras, J., Tsolaki, M., Gavalas, E., Boziki, M. K., Zavos, C., Karatzoglou, P., Chatzopoulos, D., & Venizelos, I. (2006) · Neurology · doi:10.1212/01.wnl.0000203644.68059.5f · Cited by 221 · see citing works
Stewart, L. K., Flynn, M. G., Campbell, W. W., Craig, B. A., Robinson, J. P., McFarlin, B. K., Timmerman, K. L., Coen, P. M., Felker, J., & Talbert, E. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.04.003 · Cited by 213 · see citing works
The Influence of Latent Viral Infection on Rate of Cognitive Decline over 4 Years
Aiello, A. E., Haan, M. N., Blythe, L., Moore, K., Gonzalez, J. M., & Jagust, W. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00796.x · Cited by 210 · see citing works
Honjo, K., van Reekum, R., & Verhoeff, N. P. L. G. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2008.12.001 · Cited by 204 · see citing works
Infectious Burden and Risk of Stroke
Elkind, M. S. V. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.271 · Cited by 177 · see citing works
Self-citationChlamydia pneumoniae and the Risk of First Ischemic Stroke
Elkind, M. S. V., Lin, I., Grayston, J. T., & Sacco, R. L. (2000) · Stroke · doi:10.1161/01.str.31.7.1521 · Cited by 165 · see citing works
Self-citationSocial Status and Susceptibility to Respiratory Infections
Cohen, S. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08119.x · Cited by 165 · see citing works
Black, S. A., Espino, D. V., Mahurin, R. K., Lichtenstein, M. J., Hazuda, H. P., Fabrizio, D., Ray, L. A., & Markides, K. S. (1999) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(99)00100-6 · Cited by 151 · see citing works
Smieja, M., Gnarpe, J. A., Lonn, E., Gnarpe, H., Olsson, G. O., Yi, Q., Džavík, V., McQueen, M., & Yusuf, S. (2003) · Circulation · doi:10.1161/01.cir.0000044940.65226.1f · Cited by 149 · see citing works
Heuschmann, P. U., Neureiter, D., Geßlein, M., Craiovan, B. S., Maass, M., Faller, G., Beck, G., Neundoerfer, B., & Kolominsky‐Rabas, P. L. (2001) · Stroke · doi:10.1161/hs1001.097096 · Cited by 136 · see citing works
Strandberg, T. E., Pitkälä, K. H., Linnavuori, K. H., & Tilvis, R. S. (2003) · Stroke · doi:10.1161/01.str.0000086754.32238.da · Cited by 134 · see citing works
National Seroprevalence and Trends in Herpes Simplex Virus Type 1 in the United States, 1976–1994
Schillinger, J. A., Xu, F., Sternberg, M., Armstrong, G. L., Lee, F. K., Nahmias, A. J., McQuillan, G. M., Louis, M. E. S., & Markowitz, L. E. (2004) · Sexually Transmitted Diseases · doi:10.1097/01.olq.0000145852.43262.c3 · Cited by 130 · see citing works
The Multiple Mechanisms by Which Infection May Contribute to Atherosclerosis Development and Course
Epstein, S. E. (2002) · Circulation Research · doi:10.1161/res.90.1.2 · Cited by 116 · see citing works
Bilbo, S. D. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.04.001 · Cited by 108 · see citing works
Persistent Infection, Inflammation, and Functional Impairment in Older Latinos
Aiello, A. E., Haan, M. N., Pierce, C. M., Simanek, A. M., & Liang, J. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.6.610 · Cited by 96 · see citing works
Socioeconomic and Race/Ethnic Patterns in Persistent Infection Burden Among U.S. Adults
Zajacova, A., Dowd, J. B., & Aiello, A. E. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln012 · Cited by 94 · see citing works
Infectious Burden and Carotid Plaque Thickness
Elkind, M. S. V., Luna, J. M., Moon, Y. P., Boden-Albala, B. M., Liu, K. M., Spitalnik, S. L., Rundek, T., Sacco, R. L., & Paik, M. C. (2010) · Stroke · doi:10.1161/strokeaha.109.571299 · Cited by 89 · see citing works
Self-citationAssociation between Helicobacter pylori infection and mild cognitive impairment
Kountouras, J., Tsolaki, M., Boziki, M. K., Gavalas, E., Zavos, C., Stergiopoulos, C., Kapetanakis, N., Chatzopoulos, D., & Venizelos, I. (2007) · European Journal of Neurology · doi:10.1111/j.1468-1331.2007.01827.x · Cited by 80 · see citing works
Cytomegalovirus Is Present in a Very High Proportion of Brains from Vascular Dementia Patients
Lin, W., Wozniak, M. A., Wilcock, G. K., & Itzhaki, R. F. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0465 · Cited by 72 · see citing works
Seropositivity to Chlamydia pneumoniae Is Associated With Risk of First Ischemic Stroke
Elkind, M. S. V., Tondella, M. L., Feikin, D. R., Fields, B. S., Homma, S., & Tullio, M. R. D. (2006) · Stroke · doi:10.1161/01.str.0000202624.89869.e9 · Cited by 71 · see citing works
Self-citationRingheim, G. E., & Conant, K. E. (2003) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2003.10.013 · Cited by 68 · see citing works
Li, H., Gang, Z., He, Y., Luokun, X., Jie, X., Lei, H. C., Li, W., Chunsong, H., Junyan, L., Mingshen, J., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.6.3644 · Cited by 65 · see citing works
Richards, S. S., Emsley, C. L., Roberts, J., Murray, M. D., Hall, K. S., Gao, S., & Hendrie, H. C. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb04777.x · Cited by 59 · see citing works
Elkind, M. S. V., Luna, J. M., Coffey, C. S., McClure, L. A., Liu, K. M., Spitalnik, S. L., Paik, M. C., Roldan, A., White, C. L., Hart, R. G., et al. (2010) · International Journal of Stroke · doi:10.1111/j.1747-4949.2010.00420.x · Cited by 52 · see citing works
Self-citationCognitive impairment and infectious burden in the elderly
STRANDBERG, T. E., PITKALA, K. H., LINNAVUORI, K., & TILVIS, R. S. (2004) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2004.04.053 · Cited by 43 · see citing works
The Role of Viruses and of APOE in Dementia
Itzhaki, R., Dobson, C., Shipley, S. J., & Wozniak, M. A. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.003 · Cited by 38 · see citing works
EDUCATION AND DEMENTIA: WHAT LIES BEHIND THE ASSOCIATION?
Strandberg, T. E., Pitkälä, K. H., Tienari, P., & Tilvis, R. S. (2008) · Neurology · doi:10.1212/01.wnl.0000338463.74549.c2 · Cited by 32 · see citing works
Exercise Does Not Protect the Female Heart: An Unconvincing Conclusion?
Xi, L. (2002) · Circulation Research · doi:10.1161/01.res.0000029423.88400.52 · Cited by 20 · see citing works
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- Mira Katan, Yeseon Park Moon, Myunghee Cho Paik, et al. Infectious burden and cognitive function: The Northern Manhattan Study This information is current as of March 25, 2013 rights reserved. Print ISSN: 0028-3878. Online ISSN: 1526-632X. 1951, it is now a weekly with 48 issues per year. Copyright © 2013 American Academy of Neurology. All ® is the official journal of the American Academy of Neurology. Published continuously since Neurology
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Boehme, A. K., Esenwa, C., & Elkind, M. S. V. (2017) · Circulation Research · doi:10.1161/circresaha.116.308398 · Cited by 1,952 · see citing works
Self-citationImmunoneuropsychiatry — novel perspectives on brain disorders
Pape, K., Tamouza, R., Leboyer, M., & Zipp, F. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0174-4 · Cited by 455 · see citing works
Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works
Alzheimer’s disease and gut microbiota
Hu, X., Wang, T., & Jin, F. (2016) · Science China Life Sciences · doi:10.1007/s11427-016-5083-9 · Cited by 371 · see citing works
Long-term cerebral consequences of sepsis
Widmann, C. N., & Heneka, M. T. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70017-1 · Cited by 361 · see citing works
Jeremic, D., Jiménez-Díaz, L., & Navarro-López, J. D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101496 · Cited by 306 · see citing works
Inflammatory risk factors, biomarkers and associated therapy in ischaemic stroke
Esenwa, C. C., & Elkind, M. S. V. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.125 · Cited by 282 · see citing works
Self-citationHarris, S. A., & Harris, E. A. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142853 · Cited by 279 · see citing works
A study on the association between infectious burden and A lzheimer's disease
Bu, X., Yao, X., Jiao, S. ‐., Zeng, F., Liu, Y. ‐., Xiang, Y., Liang, C. ‐., Wang, Q. ‐., Wang, X., Cao, H., et al. (2014) · European Journal of Neurology · doi:10.1111/ene.12477 · Cited by 273 · see citing works
Zhong, B.-L., Chen, S.-L., Tu, X., & Conwell, Y. (2017) · The Journals of Gerontology Series B: Psychological Sciences and Social Sciences · doi:10.1093/geronb/gbw037 · Cited by 259 · see citing works
Infection as a Stroke Risk Factor and Determinant of Outcome After Stroke
Elkind, M. S. V., Boehme, A. K., Smith, C. J., Meisel, A., & Buckwalter, M. S. (2020) · Stroke · doi:10.1161/strokeaha.120.030429 · Cited by 252 · see citing works
Self-citationRole of neuroinflammation in neurodegeneration: new insights
McManus, R. M., & Heneka, M. T. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0241-2 · Cited by 247 · see citing works
Itzhaki, R. F. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00202 · Cited by 199 · see citing works
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Gareau, M. G. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_16 · Cited by 189 · see citing works
Rizzo, L. B., Costa, L. G., Mansur, R. B., Swardfager, W., Belangero, S. I., Grassi-Oliveira, R., McIntyre, R. S., Bauer, M. E., & Brietzke, E. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.02.004 · Cited by 183 · see citing works
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Clinical effects of Helicobacter pylori outside the stomach
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Molecular Mechanisms for Herpes Simplex Virus Type 1 Pathogenesis in Alzheimer’s Disease
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Review: Impact of Helicobacter pylori on Alzheimer's disease: What do we know so far?
Doulberis, M., Kotronis, G., Thomann, R., Pοlyzos, S. A., Boziki, M. K., Gialamprinou, D., Deretzi, G., Katsinelos, P., & Kountouras, J. (2017) · Helicobacter · doi:10.1111/hel.12454 · Cited by 127 · see citing works
Influence of Aging and Environment on Presentation of Infection in Older Adults
Chakhtoura, N. G. E., Bonomo, R. A., & Jump, R. (2017) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2017.07.017 · Cited by 126 · see citing works
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Herpes simplex virus type 1 and Alzheimer's disease: possible mechanisms and signposts
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Tarter, K. D., Simanek, A. M., Dowd, J. B., & Aiello, A. E. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit616 · Cited by 78 · see citing works
Infection and Stroke: an Update on Recent Progress
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Self-citationWelcome, M. O. (2019) · NeuroMolecular Medicine · doi:10.1007/s12017-019-08547-5 · Cited by 76 · see citing works
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Lövheim, H., Norman, T., Weidung, B., Olsson, J., Josefsson, M., Adolfsson, R., Nyberg, L. H., & Elgh, F. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-171162 · Cited by 73 · see citing works
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Kristen, H., Santana, S., Sastre, I., Recuero, M., Bullido, M. J., & Aldudo, J. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.06.014 · Cited by 61 · see citing works
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Xu, Y., Wang, Q., Liu, Y., Cui, R., Lu, K., & Zhao, Y. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.01.025 · Cited by 48 · see citing works
A proposed role of human defensins in Helicobacter pylori-related neurodegenerative disorders
Kountouras, J., Deretzi, G., Gavalas, E., Zavos, C., Pοlyzos, S. A., Kazakos, E. I., Giartza‐Taxidou, E., Vardaka, E., Kountouras, C., Katsinelos, P., et al. (2014) · Medical Hypotheses · doi:10.1016/j.mehy.2013.12.025 · Cited by 43 · see citing works
Infectious disease burden and cognitive function in young to middle-aged adults
Gale, S. D., Erickson, L. D., Berrett, A. N., Brown, B. L., & Hedges, D. W. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.10.014 · Cited by 42 · see citing works
Microbial Origins of Chronic Diseases
Gargano, L. M., & Hughes, J. M. (2013) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-032013-182426 · Cited by 40 · see citing works
Shi, H., Li, Y., Dong, C., Si, G., Xu, Y., Peng, M., & Li, Y. (2021) · Helicobacter · doi:10.1111/hel.12865 · Cited by 39 · see citing works
Salani, F., Sterbini, V., Sacchinelli, E., Garramone, M., & Bossù, P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01768 · Cited by 37 · see citing works
Role of B cells and the aging brain in stroke recovery and treatment
Engler-Chiurazzi, E. B., Monaghan, K. L., Wan, E. C. K., & Ren, X. S. (2020) · GeroScience · doi:10.1007/s11357-020-00242-9 · Cited by 37 · see citing works
Implications of Microorganisms in Alzheimer’s Disease
Yadav, P., Lee, Y., Panday, H., Kant, S., Bajwa, N., Parashar, R., Jha, S. K., Jha, N. K., Nand, P., Lee, S., et al. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44100314 · Cited by 36 · see citing works
Mechanistic insights into the role of herpes simplex virus 1 in Alzheimer’s disease
Feng, S., Liu, Y., Zhou, Y., Shu, Z., Cheng, Z., Brenner, C., & Feng, P. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1245904 · Cited by 36 · see citing works
Kobayashi, N., Shinagawa, S., Nagata, T., Shimada, K., Shibata, N., Ohnuma, T., Kasanuki, K., Arai, H., Yamada, H., Nakayama, K., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168816 · Cited by 36 · see citing works
Association between Toxoplasma gondii seropositivity and memory function in nondemented older adults
Wyman, C. E., Gale, S. D., Hedges‐Muncy, A., Erickson, L. D., Wilson, E., & Hedges, D. W. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.01.018 · Cited by 36 · see citing works
Septicemia is associated with increased risk for dementia: a population-based longitudinal study
Chou, C.-H., Lee, J., Lin, C., Sung, Y., Lin, C.-C., Muo, C., Yang, F., Wen, C.-P., Wang, I., Kao, C., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.20899 · Cited by 35 · see citing works
Procalcitonin and Midregional Proatrial Natriuretic Peptide as Markers of Ischemic Stroke
Mira, K., Moon, Y. P., Paik, M. C., Müeller, B., Huber, A., Sacco, R. L., & Elkind, M. S. V. (2016) · Stroke · doi:10.1161/strokeaha.115.011392 · Cited by 34 · see citing works
Self-citationKoyama, T., Kuriyama, N., Ozaki, E., Matsui, D., Watanabe, I., Miyatani, F., Kondo, M., Tamura, A., Kasai, T., Ohshima, Y., et al. (2016) · BMC Neurology · doi:10.1186/s12883-016-0776-z · Cited by 33 · see citing works
Viral Infections, Are They a Trigger and Risk Factor of Alzheimer’s Disease?
Rippee‐Brooks, M. D., Wu, W., Dong, J., Pappolla, M. A., Fang, X., & Bao, X. (2024) · Pathogens · doi:10.3390/pathogens13030240 · Cited by 31 · see citing works
Beydoun, M. A., Beydoun, H. A., Hedges, D. W., Erickson, L. D., Gale, S. D., Weiss, J., El‐Hajj, Z. W., Evans, M. K., & Zonderman, A. B. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14141 · Cited by 31 · see citing works
Rossor, M. N., & Knapp, M. R. J. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60248-3 · Cited by 32 · see citing works
Stebbins, R. C., Noppert, G. A., Yang, Y. C., Dowd, J. B., Simanek, A. M., & Aiello, A. E. (2020) · American Journal of Epidemiology · doi:10.1093/aje/kwaa238 · Cited by 32 · see citing works
Association between toxocariasis and cognitive function in young to middle-aged adults
Erickson, L. D., Gale, S. D., Berrett, A., Brown, B. L., & Hedges, D. W. (2015) · Folia Parasitologica · doi:10.14411/fp.2015.048 · Cited by 31 · see citing works
APOE ϵ 4 modifies the relationship between infectious burden and poor cognition
Zhao, C., Strobino, K., Moon, Y. P., Cheung, Y. K., Sacco, R. L., Stern, Y., & Elkind, M. S. V. (2020) · Neurology Genetics · doi:10.1212/nxg.0000000000000462 · Cited by 31 · see citing works
Self-citationBiobehavioral Aspects of the COVID-19 Pandemic: A Review
Hall, P. A., Sheeran, P., Fong, G. T., Cheah, C. S. L., Oremus, M., Liu-Ambrose, T. Y. L., Sakib, M. N., Butt, Z. A., Ayaz, H., Jandu, N., et al. (2021) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000932 · Cited by 31 · see citing works
Neuroimmune Mechanisms and Sex/Gender-Dependent Effects in the Pathophysiology of Mental Disorders
Kokkosis, A. G., & Tsirka, S. E. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.266163 · Cited by 28 · see citing works
The Role of Incarceration as a Risk Factor for Cognitive Impairment
Cox, R. J. A., & Wallace, R. B. (2022) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbac138 · Cited by 28 · see citing works
Berrett, A. N., Gale, S. D., Erickson, L. D., Brown, B. L., & Dawson, W. O. (2016) · Helicobacter · doi:10.1111/hel.12303 · Cited by 27 · see citing works
Association of midlife antibiotic use with subsequent cognitive function in women
Mehta, R. S., Lochhead, P., Wang, Y., Ma, W., Nguyen, L. H., Kochar, B., Huttenhower, C., Grodstein, F., & Chan, A. T. (2022) · PLoS ONE · doi:10.1371/journal.pone.0264649 · Cited by 26 · see citing works
Engler-Chiurazzi, E. B., Russell, A. E., Povroznik, J. M., McDonald, K., Porter, K., Wang, D. S., Hammock, J., Billig, B. K., Felton, C. C., Yilmaz, A., et al. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.12.013 · Cited by 28 · see citing works
Gale, S. D., Erickson, L. D., Brown, B. L., & Hedges, D. W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116874 · Cited by 24 · see citing works
Smith, C. J., & Ashford, J. W. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221218 · Cited by 22 · see citing works
Nemergut, M., Batkova, T., Vigašová, D., Bartoš, M., Hlozankova, M., Schenkmayerová, A., Lišková, B., Sheardová, K., Vyhnálek, M., Hort, J., et al. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.157114 · Cited by 22 · see citing works
Zhao, H., & Chen, N. (2022) · Journal of Asian Economics · doi:10.1016/j.asieco.2022.101507 · Cited by 21 · see citing works
Perspectives on the Tertiary Prevention Strategy for Alzheimer's Disease
Bu, X., Jiao, S., Lian, Y., & Wang, Y. (2015) · Current Alzheimer Research · doi:10.2174/1567205013666151215110114 · Cited by 20 · see citing works
Jones, R. (2014) · Journal of Advances in Medicine and Medical Research · doi:10.9734/bjmmr/2015/13302 · Cited by 20 · see citing works
The Role of the Gut Microbiota and Microbial Metabolites in the Pathogenesis of Alzheimer’s Disease
Wang, Y. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220417005115 · Cited by 21 · see citing works
Vadakkan, K. I. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.06.042 · Cited by 20 · see citing works
Elkind, M. S. V., Moon, M. P., Rundek, T., Wright, C. B., Cheung, K., Sacco, R. L., & Hornig, M. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.07.011 · Cited by 19 · see citing works
Self-citationKawasaki, M., Arai, Y., Takayama, M., Hirata, T., Takayama, M., Abe, Y., Niimura, H., Mimura, M., Takebayashi, T., & Hirose, N. (2016) · AGE · doi:10.1007/s11357-016-9890-5 · Cited by 18 · see citing works
Simultaneous Detection of Herpes Simplex Virus Type 1 Latent and Lytic Transcripts in Brain Tissue
Zhang, S., Zeng, J., Zhou, Y., Gao, R., Rice, S., Guo, X., Liu, Y., Feng, P., & Zhao, Z. (2022) · ASN NEURO · doi:10.1177/17590914211053505 · Cited by 17 · see citing works
Harrison, M. A. A., Morris, S. L., Rudman, G. A., Rittenhouse, D. J., Monk, C. H., Sakamuri, S. S. V. P., Jones, M., Hasan, M. M., Khatun, M. S., Wang, H., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.12.033 · Cited by 19 · see citing works
Simanek, A. M., Dowd, J. B., Zajacova, A., & Aiello, A. E. (2014) · Epidemiology and Infection · doi:10.1017/s0950268814003215 · Cited by 15 · see citing works
Shi, R., Yu, S., Larbi, A., Ng, T. P., & Lu, Y. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.07.026 · Cited by 14 · see citing works
Cerebral Response to Peripheral Challenge with a Viral Mimetic
Konat, G. W. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1746-3 · Cited by 14 · see citing works
Mira, K., Moon, Y. P., von Eckardstein, A., Spanaus, K. S., DeRosa, J. T., Gutierrez, J., DeCarli, C. S., Wright, C. B., Sacco, R. L., & Elkind, M. S. V. (2017) · Stroke · doi:10.1161/strokeaha.116.014945 · Cited by 14 · see citing works
Self-citationA link between microbial infection and cognition?
Swardfager, W., & Black, S. E. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.93 · Cited by 14 · see citing works
Roberts, J. A., Elkind, M. S. V., Liu, M., Wright, C. B., Rundek, T., & Gutierrez, J. (2023) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2023.120856 · Cited by 13 · see citing works
Self-citationAlzheimer's disease and herpes viruses: Current events and perspectives
Pinchera, B., Filippo, I. D., Cuccurullo, F., Salvatore, E., & Gentile, I. (2024) · Reviews in Medical Virology · doi:10.1002/rmv.2550 · Cited by 13 · see citing works
Russell, D., Dowding, D., Trifilio, M., McDonald, M. V., Song, J., Adams, V., Ojo, M., Perry, E. K., & Shang, J. (2021) · Health & Social Care in the Community · doi:10.1111/hsc.13321 · Cited by 13 · see citing works
Katsinelos, P., Doulberis, M., Pοlyzos, S. A., Papaefthymiou, A., Katsinelos, P., & Kountouras, J. (2019) · Current Molecular Medicine · doi:10.2174/1566524019666190917125917 · Cited by 13 · see citing works
Expanded taxonomies of human memory
Finley, J. R. (2025) · Frontiers in Cognition · doi:10.3389/fcogn.2024.1505549 · Cited by 14 · see citing works
Zhang, L.-N., Li, M., Shang, Y., Zhao, F., Huang, H., & Lao, F. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200607 · Cited by 10 · see citing works
White, K. A., Hutton, S. R., Weimer, J. M., & Sheridan, P. A. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.06.007 · Cited by 12 · see citing works
Noppert, G. A., Aiello, A. E., O'Rand, A. M., & Cohen, H. J. (2018) · Epidemiology and Infection · doi:10.1017/s095026881800153x · Cited by 11 · see citing works
Periodontal Disease and Risk of Dementia in Medicare Patients with Hepatitis C Virus
Malone, J., Jung, J., Tran, L., & Zhao, C. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210666 · Cited by 11 · see citing works
Serum anti-NMDA-receptor antibodies and cognitive function after ischemic stroke (PROSCIS-B)
Sperber, P. S., Gebert, P., Broersen, L. H. A., Huo, S., Piper, S. K., Teegen, B., Heuschmann, P. U., Prüß, H., Endres, M., Liman, T., et al. (2022) · Journal of Neurology · doi:10.1007/s00415-022-11203-x · Cited by 10 · see citing works
Back to the Future: The Role of Infections in Psychopathology. Focus on OCD.
Vecchia, A. D., & Marazziti, D. (2022) · PubMed Central · doi:10.36131/cnfioritieditore20220407 · Cited by 10 · see citing works
When Is Critical Illness Not Like an Asteroid Strike?
Iwashyna, T. J., & Prescott, H. C. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201306-1092ed · Cited by 9 · see citing works
Sickness and sleep health predict frustration and affective responses to a frustrating trigger
Balter, L., Sundelin, T., & Axelsson, J. (2021) · Scientific Reports · doi:10.1038/s41598-020-80461-4 · Cited by 6 · see citing works
Cuervo-Zanatta, D., Pérez-Grijalva, B., González-Magaña, E., Hernández-Acosta, J., Murugesan, S., Garcı́a-Mena, J., & Perez‐Cruz, C. (2021) · Studies in natural products chemistry · doi:10.1016/b978-0-12-819489-8.00019-3 · Cited by 7 · see citing works
Roberts, J. A., Elkind, M. S. V., Liu, M., Assuras, S., Levin, B. E., Guzmán, V., Rundek, T., & Gutierrez, J. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70457 · Cited by 6 · see citing works
Self-citationInfectious Burden and its Role in Cerebrovascular Disease and Cognitive Impairment
Mira, K., & Elkind, M. S. V. (2013) · Future Virology · doi:10.2217/fvl.13.74 · Cited by 6 · see citing works
Self-citationJones, R. (2016) · Journal of Neuroinfectious Diseases · doi:10.4172/2314-7326.1000213 · Cited by 6 · see citing works
- Authors
- Katan, M., Moon, Y. P., Paik, M. C., Sacco, R. L., Wright, C. B., & Elkind, M. S. V.
- Affiliations
- From the Department of Neurology (M.K., Y.P.M., M.S.V.E.) and Department of Epidemiology and Gertrude Sergievsky Center (M.S.V.E.), Columbia University College of Physicians and Surgeons, New York; Department of Biostatistics (M.C.P.), Mailman School of Public Health, Columbia University, New York, NY; and Departments of Neurology, Epidemiology & Public Health, and Neuroscience (R.L.S., C.B.W.), and Department of Genetics (R.L.S.), Miller School of Medicine, University of Miami, Miami, FL.
- University of Miami (US)
- Venue
- Neurology
- Published
- 2013-03-26
- Volume
- 80
- Issue
- 13
- Pages
- 1209-1215
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC3691781
- OpenAlex
- W2017987395
- Cited by
- 141
- References
- 44
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 10 · 2023: 6 · 2022: 14 · 2021: 16 · 2020: 10 · 2019: 11 · 2018: 4 · 2017: 8 · 2016: 14 · 2015: 15 · 2014: 11 · 2013: 10
- FWCI
- 11.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Science Foundation
- American Heart Association
- Bristol-Myers Squibb
- GlaxoSmithKline
- Sanofi
- McKnight Foundation
- Fondation Leducq
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (29993, 130982)
- National Institutes of Health (R37 NS29993)
- National Heart, Lung, and Blood Institute (R01HL108623)
- National Institute of Neurological Disorders and Stroke (R01NS048134, R37NS029993, R01NS48134, R37 NS 29993., K02NS059729)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- infectious burden, cognitive function, cognitive impairment, Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus, herpes simplex virus, vascular risk, cognitive decline, stroke risk, atherosclerosis, Northern Manhattan Study
- MeSH terms
- Aged, Cognition, Cognition Disorders, Female, Humans, Infections, Interviews as Topic, Male, Mental Status Schedule, Middle Aged, Neuropsychological Tests, Prospective Studies, Risk Factors, Cohort Studies, Stroke
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