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An updated role of microRNA-124 in central nervous system disorders: a review
Open accessAbstract
MicroRNA-124 (miR-124) is the most abundant miRNA in the brain. Biogenesis of miR-124 displays specific temporal and spatial profiles in various cell and tissue types and affects a broad spectrum of biological functions in the central nervous system (CNS). Recently, the link between dysregulation of miR-124 and CNS disorders, such as neurodegeneration, CNS stress, neuroimmune disorders, stroke, and brain tumors, has become evident. Here, we provide an overview of the specific molecular function of miR-124 in the CNS and a revealing insight for the therapeutic potential of miR-124 in the treatment of human CNS diseases.
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“miR-124, one of the most abundant miRNAs in the CNS, has been implicated in various pathologies within this system [165].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [165]
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“MiR-124 is a brain-enriched miRNA that plays key roles in neurogenesis, synaptic strength and transmission, and glia-neuronal interactions essential for the maintenance of brain homeostasis (Sun et al., 2015; Han et al., 2019).”
From Engineered Extracellular Vesicles Loaded With miR-124 Attenuate Cocaine-Mediated Activation of Microglia (2020) · cites this paper as Sun et al., 2015
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“MiR-124 is produced in neurons, which influences neuronal survival and differentiation, reduces inflammatory microglial activation, and establishes a connection between microglia and neurons (Sun et al. 2015).”
From MiR-124 and MiR-155 as Therapeutic Targets in Microglia-Mediated Inflammation in Multiple Sclerosis (2025) · cites this paper as Sun et al. 2015
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Metadata
- Authors
- Sun, Y., Luo, Z.-M., Guo, X.-M., Su, D.-F., & Liu, X.
- Affiliations
- Second Military Medical University (CN)
- Corresponding author
- Liu, Xia
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2015-05-20
- Volume
- 9
- Pages
- 193-193
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC4438253
- OpenAlex
- W1601508141
- Cited by
- 223
- References
- 85
- Citations by year
- 2026: 8 · 2025: 21 · 2024: 11 · 2023: 18 · 2022: 20 · 2021: 29 · 2020: 32 · 2019: 20 · 2018: 25 · 2017: 15 · 2016: 19 · 2015: 4
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81230083, 81473259, 81273606)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- miR-124, central nervous system disorders, neurodegeneration, neuroimmunological diseases, stroke, brain tumors, microRNA biogenesis, therapeutic target
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