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An updated role of microRNA-124 in central nervous system disorders: a review
Open accessAbstract
MicroRNA-124 (miR-124) is the most abundant miRNA in the brain. Biogenesis of miR-124 displays specific temporal and spatial profiles in various cell and tissue types and affects a broad spectrum of biological functions in the central nervous system (CNS). Recently, the link between dysregulation of miR-124 and CNS disorders, such as neurodegeneration, CNS stress, neuroimmune disorders, stroke, and brain tumors, has become evident. Here, we provide an overview of the specific molecular function of miR-124 in the CNS and a revealing insight for the therapeutic potential of miR-124 in the treatment of human CNS diseases.
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“miR-124, one of the most abundant miRNAs in the CNS, has been implicated in various pathologies within this system [165].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [165]
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“MiR-124 is a brain-enriched miRNA that plays key roles in neurogenesis, synaptic strength and transmission, and glia-neuronal interactions essential for the maintenance of brain homeostasis (Sun et al., 2015; Han et al., 2019).”
From Engineered Extracellular Vesicles Loaded With miR-124 Attenuate Cocaine-Mediated Activation of Microglia (2020) · cites this paper as Sun et al., 2015
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“MiR-124 is produced in neurons, which influences neuronal survival and differentiation, reduces inflammatory microglial activation, and establishes a connection between microglia and neurons (Sun et al. 2015).”
From MiR-124 and MiR-155 as Therapeutic Targets in Microglia-Mediated Inflammation in Multiple Sclerosis (2025) · cites this paper as Sun et al. 2015
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“MiR-124 is the most abundant in the brain and its dysregulation has been related with neurodegeneration, neuroimmune disorders and CNS stress among others (for review, see Sun et al., 2015).”
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Metadata
- Authors
- Sun, Y., Luo, Z.-M., Guo, X.-M., Su, D.-F., & Liu, X.
- Affiliations
- Second Military Medical University (CN)
- Corresponding author
- Liu, Xia
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2015-05-20
- Volume
- 9
- Pages
- 193-193
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC4438253
- OpenAlex
- W1601508141
- Cited by
- 223
- References
- 85
- Citations by year
- 2026: 8 · 2025: 21 · 2024: 11 · 2023: 18 · 2022: 20 · 2021: 29 · 2020: 32 · 2019: 20 · 2018: 25 · 2017: 15 · 2016: 19 · 2015: 4
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81230083, 81473259, 81273606)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- miR-124, central nervous system disorders, neurodegeneration, neuroimmunological diseases, stroke, brain tumors, microRNA biogenesis, therapeutic target
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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