Cited by 228MicroRNA in disease regulationNeurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

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An updated role of microRNA-124 in central nervous system disorders: a review

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Sun, Yang, Luo, Zhu-Min, Guo, Xiu-Ming, Su, Ding-Feng, Liu, Xia·2015·Frontiers in Cellular Neuroscience

DOI 10.3389/fncel.2015.00193PMC PMC4438253

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Abstract

MicroRNA-124 (miR-124) is the most abundant miRNA in the brain. Biogenesis of miR-124 displays specific temporal and spatial profiles in various cell and tissue types and affects a broad spectrum of biological functions in the central nervous system (CNS). Recently, the link between dysregulation of miR-124 and CNS disorders, such as neurodegeneration, CNS stress, neuroimmune disorders, stroke, and brain tumors, has become evident. Here, we provide an overview of the specific molecular function of miR-124 in the CNS and a revealing insight for the therapeutic potential of miR-124 in the treatment of human CNS diseases.

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The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
Lim, L. P., Lau, N. C., Garrett-Engele, P., Grimson, A., Schelter, J. M., Castle, J., Bartel, D. P., Linsley, P. S., & Johnson, J. M. (2005) · Nature · doi:10.1038/nature03315 · Cited by 4,755
Mechanisms underlying inflammation in neurodegeneration
Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580
Non-coding RNAs and cancer: microRNAs and beyond
Raia, R. M., & Călin, G. A. (2011) · Journal of Nucleic Acids Investigation · doi:10.4081/jnai.2011.e5 · Cited by 3,394
Identification of tissue-specific microRNAs from mouse
Lagos-Quintana, M., Rauhut, R., Yalcin, A., Meyer, J., Lendeckel, W., & Tuschl, T. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00809-6 · Cited by 3,355
The MicroRNA miR-124 Promotes Neuronal Differentiation by Triggering Brain-Specific Alternative Pre-mRNA Splicing
Makeyev, E. V., Zhang, J., Carrasco, M. A., & Maniatis, T. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.015 · Cited by 1,395
Physiological and pathological roles for microRNAs in the immune system
O'Connell, R. M., Rao, D. S., Chaudhuri, A. A., & Baltimore, D. (2010) · Nature Reviews Immunology · doi:10.1038/nri2708 · Cited by 1,378
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Kim, J., Inoue, K., Ishii, J., Vanti, W. B., Voronov, S. V., Murchison, E., Hannon, G., & Abeliovich, A. (2007) · Science · doi:10.1126/science.1140481 · Cited by 1,187

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The National School Lunch Program: Background, Trends, and Issues. Economic Research Report Number 61.
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Authors: Sun, Y., Luo, Z.-M., Guo, X.-M., Su, D.-F., & Liu, X.
Affiliations: Second Military Medical University (CN)
Corresponding author: Liu, Xia
ORCID: Su, Ding-Feng
Liu, Xia
Venue: Frontiers in Cellular Neuroscience
Publisher: Frontiers Media SA
Published: 2015-05-20
Volume: 9
Pages: 193-193
ISSN: 1662-5102 (ISSN-L)
DOI: 10.3389/fncel.2015.00193
PMC: PMC4438253
OpenAlex: W1601508141
Cited by: 223
References: 85
Citations by year: 2026: 8 · 2025: 21 · 2024: 11 · 2023: 18 · 2022: 20 · 2021: 29 · 2020: 32 · 2019: 20 · 2018: 25 · 2017: 15 · 2016: 19 · 2015: 4
FWCI: 2.05
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (81230083, 81473259, 81273606)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: miR-124, central nervous system disorders, neurodegeneration, neuroimmunological diseases, stroke, brain tumors, microRNA biogenesis, therapeutic target

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An updated role of microRNA-124 in central nervous system disorders: a review

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