The DOI matches its Crossref record; 169 of the 173 references it cites were found in a registry or an index.
Dopamine: A Modulator of Circadian Rhythms in the Central Nervous System
Open accessAbstract
Circadian rhythms are daily rhythms that regulate many biological processes - from gene transcription to behavior - and a disruption of these rhythms can lead to a myriad of health risks. Circadian rhythms are entrained by light, and their 24-h oscillation is maintained by a core molecular feedback loop composed of canonical circadian ("clock") genes and proteins. Different modulators help to maintain the proper rhythmicity of these genes and proteins, and one emerging modulator is dopamine. Dopamine has been shown to have circadian-like activities in the retina, olfactory bulb, striatum, midbrain, and hypothalamus, where it regulates, and is regulated by, clock genes in some of these areas. Thus, it is likely that dopamine is essential to mechanisms that maintain proper rhythmicity of these five brain areas. This review discusses studies that showcase different dopaminergic mechanisms that may be involved with the regulation of these brain areas' circadian rhythms. Mechanisms include how dopamine and dopamine receptor activity directly and indirectly influence clock genes and proteins, how dopamine's interactions with gap junctions influence daily neuronal excitability, and how dopamine's release and effects are gated by low- and high-pass filters. Because the dopamine neurons described in this review also release the inhibitory neurotransmitter GABA which influences clock protein expression in the retina, we discuss articles that explore how GABA may contribute to the actions of dopamine neurons on circadian rhythms. Finally, to understand how the loss of function of dopamine neurons could influence circadian rhythms, we review studies linking the neurodegenerative disease Parkinson's Disease to disruptions of circadian rhythms in these five brain areas. The purpose of this review is to summarize growing evidence that dopamine is involved in regulating circadian rhythms, either directly or indirectly, in the brain areas discussed here. An appreciation of the growing evidence of dopamine's influence on circadian rhythms may lead to new treatments including pharmacological agents directed at alleviating the various symptoms of circadian rhythm disruption.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“SCN neuronal firing is also reduced in these mice from young adulthood and progressively worsens with age, suggesting a weakened circadian pacemaker276 and a potential loss of dopaminergic modulation of circadian rhythms via midbrain, striatal and SCN circuits277,278.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [278]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The physiology, signaling, and pharmacology of dopamine receptors
Beaulieu, J.-M., & Gainetdinov, R. R. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.002642 · Cited by 2,763
Prolactin: structure, function, and regulation of secretion
Freeman, M. E., Kanyicska, B., Lerant, A., & Nagy, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1523 · Cited by 2,457
Central and Peripheral Circadian Clocks in Mammals
Mohawk, J. A., Green, C. B., & Takahashi, J. S. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153128 · Cited by 2,265
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870
Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment
Chaudhuri, К. R., & Schapira, A. H. V. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70068-7 · Cited by 1,818
Smell identification ability: changes with age.
Doty, R. L., Shaman, P., Applebaum, S. L., Giberson, R. S., Siksorski, L., & Rosenberg, L. (1984) · Science · doi:10.1126/science.6505700 · Cited by 1,357
Central projections of melanopsin‐expressing retinal ganglion cells in the mouse
Hattar, S., Kumar, M., Park, A., Tong, P., Tung, J., Yau, K., & Berson, D. M. (2006) · Journal of Comparative Neurology · doi:10.1002/cne.20970 · Cited by 996
Genetic Animal Models of Parkinson's Disease
Dawson, T. M., Ko, H. S., & Dawson, V. L. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.034 · Cited by 866
Doty, R. L., Deems, D. A., & Stellar, S. (1988) · Neurology · doi:10.1212/wnl.38.8.1237 · Cited by 838
Witkovsky, P. (2004) · Documenta Ophthalmologica · doi:10.1023/b:doop.0000019487.88486.0a · Cited by 811
Flagged first, then by citations
4 of the 173 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Dominguez-Rodriguez, 2009, Disruption of normal circadian rhythms and cardiovascular events., Heart Metab., 44, 11
- Golgi, 1875, Sulla fina struttura dei bulbi olfactorii., Riv. Sper. Freniatr. Med. Leg., 1, 405
- Nolte, 2009, The Human Brain: An Introduction to its Functional Anatomy
- Rivkees, 1997, Functional D1 and D5 dopamine receptors are expressed in the suprachiasmatic, supraoptic, and paraventricular nuclei of primates., Synapse, 26, 1, 10.1002/(SICI)1098-2396(199705)26:11::AID-SYN13.0.CO;2-D · DOI
Cited by
Sorted by citations
Rhythms of life: circadian disruption and brain disorders across the lifespan
Logan, R. W., & McClung, C. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0088-y · Cited by 713
Circadian rhythms in neurodegenerative disorders
Nassan, M. M., & Videnović, A. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00577-7 · Cited by 266
Circadian rhythms, refractive development, and myopia
Chakraborty, R., Ostrin, L. A., Nickla, D. L., Iuvone, P. M., Pardue, M. T., & Stone, R. A. (2018) · Ophthalmic and Physiological Optics · doi:10.1111/opo.12453 · Cited by 235
A method for single-neuron chronic recording from the retina in awake mice
Hong, G., Tian-ming Fu, B., Qiao, M., Viveros, R. D., Yang, X., Zhou, T., Lee, J. M., Park, H., Sanes, J. R., & Lieber, C. M. (2018) · Science · doi:10.1126/science.aas9160 · Cited by 171
Printing Flexible and Hybrid Electronics for Human Skin and Eye‐Interfaced Health Monitoring Systems
Kim, K., Kim, B., & Lee, C. H. (2019) · Advanced Materials · doi:10.1002/adma.201902051 · Cited by 148
Metadata
- Authors
- Korshunov, K. S., Blakemore, L. J., & Trombley, P. Q.
- Affiliations
- Florida State University (US)
- Corresponding author
- Trombley, Paul Q.
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2017-04-03
- Volume
- 11
- Pages
- 91-91
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC5376559
- OpenAlex
- W2598018500
- Cited by
- 173
- References
- 173
- Citations by year
- 2026: 14 · 2025: 27 · 2024: 19 · 2023: 24 · 2022: 18 · 2021: 23 · 2020: 12 · 2019: 11 · 2018: 18 · 2017: 7
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (T32 DC000044)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- dopamine, circadian rhythm, clock genes, clock proteins, dopamine receptors, gap junctions, neuronal excitability, GABA, dopaminergic neurons, retina, olfactory bulb, striatum, midbrain, hypothalamus, Parkinson's disease, circadian rhythm disruption, light entrainment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
