Cited by 198Tryptophan and brain disordersSuicide and Self-Harm StudiesNeuroinflammation and Neurodegeneration Mechanisms

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Suicide and Microglia: Recent Findings and Future Perspectives Based on Human Studies

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Suzuki, Hisaomi, Ohgidani, Masahiro, Kuwano, Nobuki, Chrétien, Fabrice, Lorin de la Grandmaison, Geoffroy, Onaya, Mitsumoto, Tominaga, Itaru, Setoyama, Daiki, Kang, Dongchon, Mimura, Masaru, Kanba, Shigenobu, Kato, Takahiro A.·2019·Frontiers in Cellular Neuroscience

DOI 10.3389/fncel.2019.00031PMC PMC6381042

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Abstract

Suicide is one of the most disastrous outcomes for psychiatric disorders. Recent advances in biological psychiatry have suggested a positive relationship between some specific brain abnormalities and specific symptoms in psychiatric disorders whose organic bases were previously completely unknown. Microglia, immune cells in the brain, are regarded to play crucial roles in brain inflammation by releasing inflammatory mediators and are suggested to contribute to various psychiatric disorders such as depression and schizophrenia. Recently, activated microglia have been suggested to be one of the possible contributing cells to suicide and suicidal behaviors via various mechanisms especially including the tryptophan-kynurenine pathway. Animal model research focusing on psychiatric disorders has a long history, however, there are only limited animal models that can properly express psychiatric symptoms. In particular, to our knowledge, animal models of human suicidal behaviors have not been established. Suicide is believed to be limited to humans, therefore human subjects should be the targets of research despite various ethical and technical limitations. From this perspective, we introduce human biological studies focusing on suicide and microglia. We first present neuropathological studies using the human postmortem brain of suicide victims. Second, we show recent findings based on positron emission tomography (PET) imaging and peripheral blood biomarker analysis on living subjects with suicidal ideation and/or suicide-related behaviors especially focusing on the tryptophan-kynurenine pathway. Finally, we propose future perspectives and tasks to clarify the role of microglia in suicide using multi-dimensional analytical methods focusing on human subjects with suicidal ideation, suicide-related behaviors and suicide victims.

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Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547
Suicide Prevention Strategies: A Systematic Review
Mann, J. J., Apter, A., Bertolote, J., Beautrais, A., Currier, D., Haas, A., Hegerl, U., Lonnqvist, J., Malone, K., Marusic, A., et al. (2005) · JAMA · doi:10.1001/jama.294.16.2064 · Cited by 2,852
Risks of all-cause and suicide mortality in mental disorders: a meta-review
Chesney, E., Goodwin, G. M., & Fazel, S. (2014) · World Psychiatry · doi:10.1002/wps.20128 · Cited by 2,115
The neuropathology of schizophrenia
Harrison, P. J. (1999) · Brain · doi:10.1093/brain/122.4.593 · Cited by 1,677
Suicide
Hawton, K., & van Heeringen, K. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60372-x · Cited by 1,671
Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism
Block, M. L., & Hong, J.-S. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.004 · Cited by 1,557
Dendritic spine pathology in neuropsychiatric disorders
Penzes, P., Cahill, M. E., Jones, K. A., VanLeeuwen, J.-E., & Woolfrey, K. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2741 · Cited by 1,523
White matter in learning, cognition, and psychiatric disorders
Fields, R. D. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.04.001 · Cited by 1,337
Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes
Setiawan, E., Wilson, A. A., Mizrahi, R., Rusjan, P. M., Miler, L., Rajkowska, G., Suridjan, I., Kennedy, J. L., Rekkas, P. V., Houle, S., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2427 · Cited by 939
Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders
Rupprecht, R., Papadopoulos, V., Rammes, G., Baghai, T. C., Fan, J., Akula, N., Groyer, G., Adams, D., & Schumacher, M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3295 · Cited by 930
Regionally Localized Thinning of the Cerebral Cortex in Schizophrenia
Kuperberg, G. R., Broome, M. R., McGuire, P. K., David, A. S., Eddy, M., Ozawa, F., Goff, D., West, W. C., Williams, S. C. R., van der Kouwe, A. J. W., et al. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.9.878 · Cited by 843
Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide
Steiner, J., Bielau, H., Brisch, R., Danos, P., Ullrich, O., Mawrin, C., Bernstein, H.-G., & Bogerts, B. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.10.013 · Cited by 791
Regionally localized thinning of the cerebral cortex in schizophrenia
Kuperberg, G. R., Broome, M. R., McGuire, P. K., David, A. S., Eddy, M., Ozawa, F., GOFF, D. C., West, W. C., Williams, S., van der Kouwe, A. J. W., et al. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)81127-1 · Cited by 759
Inflammation-associated depression: From serotonin to kynurenine
Dantzer, R., O’Connor, J. C., Lawson, M. A., & Kelley, K. W. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.09.012 · Cited by 726
The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression
Maes, M., Leonard, B. E., Myint, A. M., Kubera, M., & Verkerk, R. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.12.017 · Cited by 700
Sex differences in microglial colonization of the developing rat brain
Schwarz, J. M., Sholar, P. W., & Bilbo, S. D. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07630.x · Cited by 672
Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis
Kreisel, T., Frank, M. G., Licht, T., Reshef, R., Ben-Menachem-Zidon, O., Baratta, M. V., Maier, S. F., & Yirmiya, R. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.155 · Cited by 663
The peripheral benzodiazepine binding site in the brain in multiple sclerosis
Banati, R. B., Newcombe, J., Gunn, R. N., Cagnin, A., Turkheimer, F., Heppner, F., Price, G., Wegner, F., Giovannoni, G., Miller, D. H., et al. (2000) · Brain · doi:10.1093/brain/123.11.2321 · Cited by 661
Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia
Yuyama, K., Sun, H., Mitsutake, S., & Igarashi, Y. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.324616 · Cited by 612
Caspase signalling controls microglia activation and neurotoxicity
Burguillos, M. A., Deierborg, T., Kavanagh, E., Persson, A., Hajji, N., Garcia-Quintanilla, A., Cano, J., Brundin, P., Englund, E., Venero, J. L., et al. (2011) · Nature · doi:10.1038/nature09788 · Cited by 585
Microglia Activation in Recent-Onset Schizophrenia: A Quantitative (R)-[11C]PK11195 Positron Emission Tomography Study
van Berckel, B. N. M., Bossong, M. G., Boellaard, R., Kloet, R. W., Schuitemaker, A., Caspers, E., Luurtsema, G., Windhorst, A. D., Cahn, W., Lammertsma, A. A., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.025 · Cited by 582
Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?
Steiner, J., Walter, M., Gos, T., Guillemin, G. J., Bernstein, H.-G., Sarnyai, Z., Mawrin, C., Brisch, R., Bielau, H., zu Schwabedissen, L., et al. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-94 · Cited by 568
Neuroinflammation in Schizophrenia-Related Psychosis: A PET Study
Doorduin, J., de Vries, E. F. J., Willemsen, A. T. M., de Groot, J. C., Dierckx, R., & Klein, H. C. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.109.066647 · Cited by 561
Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides
Torres-Platas, S. G., Cruceanu, C., Chen, G. G., Turecki, G., & Mechawar, N. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.05.007 · Cited by 545
Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions
Tynan, R. J., Naicker, S., Hinwood, M., Nalivaiko, E., Buller, K. M., Pow, D. V., Day, T. A., & Walker, F. R. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.02.001 · Cited by 531
Microglial Activation in Young Adults With Autism Spectrum Disorder
Suzuki, K., Sugihara, G., Ouchi, Y., Nakamura, K., Futatsubashi, M., Takebayashi, K., Yoshihara, Y., Omata, K., Matsumoto, K., Tsuchiya, K. J., et al. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.272 · Cited by 523
Cytokines and schizophrenia: microglia hypothesis of schizophrenia
Monji, A., Kato, T., & Kanba, S. (2009) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2009.01945.x · Cited by 508
Self-citation
Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [11C]PBR28 PET Brain Imaging Study
Bloomfield, P. S., Selvaraj, S., Veronese, M., Rizzo, G., Bertoldo, A., Owen, D. R., Bloomfield, M., Bonoldi, I., Kalk, N. J., Turkheimer, F., et al. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.14101358 · Cited by 446
Evidence that Microglia Mediate the Neurobiological Effects of Chronic Psychological Stress on the Medial Prefrontal Cortex
Hinwood, M., Morandini, J., Day, T. A., & Walker, F. R. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr229 · Cited by 420
Cargo proteins of plasma astrocyte‐derived exosomes in Alzheimer's disease
Goetzl, E. J., Mustapic, M., Kapogiannis, D., Eitan, E., Lobach, I. V., Goetzl, L., Schwartz, J. B., & Miller, B. L. (2016) · The FASEB Journal · doi:10.1096/fj.201600756r · Cited by 386
Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims
Pandey, G. N., Rizavi, H. S., Ren, X., Fareed, J., Hoppensteadt, D. A., Roberts, R. C., Conley, R. R., & Dwivedi, Y. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.08.006 · Cited by 378
A cross-national study on gender differences in suicide intent
Freeman, A., Mergl, R., Kohls, E., Székely, A., Gusmão, R. M., Arensman, E., Koburger, N., Hegerl, U., & Rummel‐Kluge, C. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1398-8 · Cited by 363
Elevated translocator protein in anterior cingulate in major depression and a role for inflammation in suicidal thinking: A positron emission tomography study
Holmes, S. E., Hinz, R., Conen, S., Gregory, C. J., Matthews, J. C., Anton-Rodriguez, J. M., Gerhard, A., & Talbot, P. S. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.08.005 · Cited by 346
Connecting inflammation with glutamate agonism in suicidality
Erhardt, S., Lim, C. K., Linderholm, K. R., Janelidze, S., Lindqvist, D., Samuelsson, M., Lundberg, K., Postolache, T. T., Träskman-Bendz, L., Guillemin, G. J., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.248 · Cited by 345
Morphometric characterization of microglial phenotypes in human cerebral cortex
Torres-Platas, S. G., Comeau, S., Rachalski, A., Bo, G. D., Cruceanu, C., Turecki, G., Giros, B., & Mechawar, N. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-12 · Cited by 329
Neuroinflammation in schizophrenia especially focused on the role of microglia
Monji, A., Kato, T. A., Mizoguchi, Y., Horikawa, H., Seki, Y., Kasai, M., Yamauchi, Y., Yamada, S., & Kanba, S. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.12.002 · Cited by 314
Self-citation
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Bay-Richter, C., Linderholm, K. R., Lim, C. K., Samuelsson, M., Träskman-Bendz, L., Guillemin, G. J., Erhardt, S., & Brundin, L. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.07.012 · Cited by 304
Kynurenine pathway in depression: a systematic review and meta-analysis
Ogyu, K., Kubo, K., Noda, Y., Iwata, Y., Tsugawa, S., Omura, Y., Wada, M., Tarumi, R., Plitman, E., Moriguchi, S., et al. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.023 · Cited by 301
Self-citation
Life events and psychosocial factors in elderly suicides—A case-control study
RUBENOWITZ, E., WAERN, M., WILHELMSON, K., & ALLEBECK, P. (2001) · Psychological Medicine · doi:10.1017/s0033291701004457 · Cited by 277
The “Big‐Bang” for modern glial biology: Translation and comments on Pío del Río‐Hortega 1919 series of papers on microglia
Sierra, A., de Castro, F., del Río‐Hortega, J., Rafael Iglesias‐Rozas, J., Garrosa, M., & Kettenmann, H. (2016) · Glia · doi:10.1002/glia.23046 · Cited by 266
Association of translocator protein total distribution volume with duration of untreated major depressive disorder: a cross-sectional study
Setiawan, E., Attwells, S., Wilson, A. A., Mizrahi, R., Rusjan, P., Miler, L., Xu, C., Sharma, S. K., Kish, S. J., Houle, S., et al. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30048-8 · Cited by 256
Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder
Sublette, M. E., Galfalvy, H. C., Fuchs, D., Lapidus, M., Grunebaum, M. F., Oquendo, M. A., John Mann, J., & Postolache, T. T. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.05.002 · Cited by 250
Distribution of HLA-DR-positive microglia in schizophrenia reflects impaired cerebral lateralization
Steiner, J. H., Mawrin, C., Ziegeler, A., Bielau, H., Ullrich, O., Bernstein, H., & Bogerts, B. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0090-8 · Cited by 232
Kynurenines: from the perspective of major psychiatric disorders
Myint, A.-M. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08551.x · Cited by 230
Biomarkers of Suicide Attempt Behavior: Towards a Biological Model of Risk
Sudol, K., & Mann, J. J. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0781-y · Cited by 225
Stress induced morphological microglial activation in the rodent brain: Involvement of interleukin-18
Sugama, S., Fujita, M., Hashimoto, M., & Conti, B. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.02.043 · Cited by 216
Microglia of Prefrontal White Matter in Suicide
Schnieder, T. P., Trencevska, I., Rosoklija, G., Stankov, A., Mann, J. J., Smiley, J., & Dwork, A. J. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000107 · Cited by 202
Antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide
Hashioka, S., Klegeris, A., Monji, A., Kato, T., Sawada, M., McGeer, P. L., & Kanba, S. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.03.022 · Cited by 198
Self-citation
An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation
Brundin, L., Sellgren, C. M., Lim, C. K., Grit, J., Pålsson, E., Landén, M., Samuelsson, M., Lundgren, K., Brundin, P., Fuchs, D., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.133 · Cited by 195
Frontal white matter anisotropy and symptom severity of late-life depression: a magnetic resonance diffusion tensor imaging study
Nobuhara, K. (2006) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.055129 · Cited by 191
Peripheral benzodiazepine receptors in patients with chronic schizophrenia: a PET study with [11C]DAA1106
Takano, A., Arakawa, R., Ito, H., Tateno, A., Takahashi, H., Matsumoto, R., Okubo, Y., & Suhara, T. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000313 · Cited by 174
Risperidone significantly inhibits interferon-γ-induced microglial activation in vitro
Kato, T. A., Monji, A., Hashioka, S., & Kanba, S. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.01.019 · Cited by 173
Self-citation
Kynurenine pathway metabolites and suicidality
Bryleva, E. Y., & Brundin, L. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.01.034 · Cited by 168
Neuropathology of mood disorders: Do we see the stigmata of inflammation?
Mechawar, N., & Savitz, J. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.212 · Cited by 165
Interleukin-34 Selectively Enhances the Neuroprotective Effects of Microglia to Attenuate Oligomeric Amyloid-β Neurotoxicity
Mizuno, T., Doi, Y., Mizoguchi, H., Jin, S., Noda, M., Sonobe, Y., Takeuchi, H., & Suzumura, A. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.06.011 · Cited by 159
The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-γ
Bian, Q., Kato, T. A., Monji, A., Hashioka, S., Mizoguchi, Y., Horikawa, H., & Kanba, S. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.06.031 · Cited by 155
Self-citation
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Ohgidani, M., Kato, T. A., Setoyama, D., Sagata, N., Hashimoto, R., Shigenobu, K., Yoshida, T., Hayakawa, K., Shimokawa, N., Miura, D., et al. (2014) · Scientific Reports · doi:10.1038/srep04957 · Cited by 150
Self-citation
Neuroinflammation in suicide: Toward a comprehensive model
Courtet, P., Giner, L., Seneque, M., Guillaume, S., Olie, E., & Ducasse, D. (2016) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2015.1054879 · Cited by 146
Plasma Metabolites Predict Severity of Depression and Suicidal Ideation in Psychiatric Patients-A Multicenter Pilot Analysis
Setoyama, D., Kato, T. A., Hashimoto, R., Kunugi, H., Hattori, K., Hayakawa, K., Sato‐Kasai, M., Shimokawa, N., Kaneko, S., Yoshida, S., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165267 · Cited by 130
Self-citation
Inhibitory effects of aripiprazole on interferon‐γ‐induced microglial activation via intracellular Ca2+ regulation in vitro
Kato, T. A., Mizoguchi, Y., Monji, A., Horikawa, H., Suzuki, S. O., Seki, Y., Iwaki, T., Hashioka, S., & Kanba, S. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05435.x · Cited by 123
Self-citation
Anti-Inflammatory Properties of Antipsychotics Via Microglia Modulations: Are Antipsychotics a ‘Fire Extinguisher’ in the Brain of Schizophrenia?
Kato, T. A., Monji, A., Mizoguchi, Y., Hashioka, S., Horikawa, H., Seki, Y., Kasai, M., Utsumi, H., & Kanba, S. (2011) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955711795906941 · Cited by 123
Self-citation
Inhibitory effects of SSRIs on IFN-γ induced microglial activation through the regulation of intracellular calcium
Horikawa, H., Kato, T. A., Mizoguchi, Y., Monji, A., Seki, Y., Ohkuri, T., Gotoh, L., Yonaha, M., Ueda, T., Hashioka, S., et al. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.07.015 · Cited by 118
Self-citation
The role of the kynurenine pathway in suicidality in adolescent major depressive disorder
Bradley, K. A. L., Case, J. A. C., Khan, O., Ricart, T., Hanna, A., Alonso, C. M., & Gabbay, V. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.03.031 · Cited by 115
Abnormal protein and mRNA expression of inflammatory cytokines in the prefrontal cortex of depressed individuals who died by suicide
Pandey, G. N., Rizavi, H. S., Zhang, H., Bhaumik, R., & Ren, X. (2018) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.170192 · Cited by 113
The course and outcome of depression in different cultures: 10-year follow-up of the WHO Collaborative Study on the Assessment of Depressive Disorders
Thornicroft, G., & Sartorius, N. (1993) · Psychological Medicine · doi:10.1017/s0033291700026489 · Cited by 109
The role of the kynurenine metabolism in major depression
Myint, A.-M., Schwarz, M., & Müller, N. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-011-0741-3 · Cited by 107
Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals
Clark, S. M., Pocivavsek, A., Nicholson, J. D., Notarangelo, F. M., LANGENBERG, P. W., McMahon, R. P., Kleinman, J. E., Hyde, T. M., Stiller, J. W., Postolache, T. T., et al. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.150226 · Cited by 94
Anxiety Disorders: Sex Differences in Serotonin and Tryptophan Metabolism.
Songtachalert, T., Roomruangwong, C., Carvalho, A., Bourin, M., & Maes, M. (2018) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026618666181115093136 · Cited by 94
Anti-inflammatory treatment in schizophrenia
Müller, N., Myint, A.-M., Krause, D., Weidinger, E., & Schwarz, M. J. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.11.008 · Cited by 89
Does escitalopram reduce neurotoxicity in major depression?
Halaris, A., Myint, A.-M., Savant, V., Meresh, E., Lim, E., Guillemin, G., Hoppensteadt, D., Fareed, J., & Sinacore, J. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.04.026 · Cited by 86
Animal models to improve our understanding and treatment of suicidal behavior
Gould, T. D., Georgiou, P., Brenner, L. A., Brundin, L., Can, A., Courtet, P., Donaldson, Z. R., Dwivedi, Y., Guillaume, S., Gottesman, I. I., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.50 · Cited by 85
Decreased quinolinic acid in the hippocampus of depressive patients: evidence for local anti-inflammatory and neuroprotective responses?
Busse, M., Busse, S., Myint, A.-M., Gos, T., Dobrowolny, H., Müller, U., Bogerts, B., Bernstein, H., & Steiner, J. H. (2014) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-014-0562-0 · Cited by 83
Fluoxetine and S-citalopram inhibit M1 activation and promote M2 activation of microglia in vitro
Su, F., Yi, H., Xu, L., & Zhang, Z. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.02.028 · Cited by 82
A 20-year review of trends in deliberate self-harm in a British town, 1981–2000
O'loughlin, S., & Sherwood, J. (2005) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-005-0912-3 · Cited by 81
Exosomal biomarkers in Down syndrome and Alzheimer's disease
Hamlett, E. D., Ledreux, A., Potter, H., Chial, H. J., Patterson, D., Espinosa, J. M., Bettcher, B. M., & Granholm, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.08.028 · Cited by 80
TNF-α from hippocampal microglia induces working memory deficits by acute stress in mice
Ohgidani, M., Kato, T. A., Sagata, N., Hayakawa, K., Shimokawa, N., Sato‐Kasai, M., & Kanba, S. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.08.022 · Cited by 79
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Authors: Suzuki, H., Ohgidani, M., Kuwano, N., Chrétien, F., Lorin de la Grandmaison, G., Onaya, M., Tominaga, I., Setoyama, D., Kang, D., Mimura, M., Kanba, S., & Kato, T. A.
Affiliations: National Hospital Organization Shimofusa Psychiatric Medical Center (JP)
Kyushu University (JP)
Institut Pasteur (FR)
Keio University (JP)
Corresponding author: Kato, Takahiro A.
ORCID: Suzuki, Hisaomi
Ohgidani, Masahiro
Chrétien, Fabrice
Onaya, Mitsumoto
Setoyama, Daiki
Kang, Dongchon
Mimura, Masaru
Kato, Takahiro A.
Venue: Frontiers in Cellular Neuroscience
Publisher: Frontiers Media SA
Published: 2019-02-13
Volume: 13
Pages: 31-31
ISSN: 1662-5102 (ISSN-L)
DOI: 10.3389/fncel.2019.00031
PMC: PMC6381042
OpenAlex: W2912835554
Cited by: 198
References: 105
Citations by year: 2026: 2 · 2025: 11 · 2024: 16 · 2023: 6 · 2022: 12 · 2021: 93 · 2020: 46 · 2019: 12
FWCI: 13.36
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Japan Agency for Medical Research and Development (17dk0307047h0003, JP18dk0307075, JP18dm0107095)
SENSHIN Medical Research Foundation
Japan Society for the Promotion of Science (15K15431, 26713039, 18H04042, 17H01550, 16H03741, JP16H06403, JP25117011, 16H06403, 18K07417, 17K19915, 16H02666)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: suicide, microglia, neuroinflammation, kynurenine pathway, suicidal ideation, suicide-related behaviors, positron emission tomography, blood biomarkers, mental illness, depression, schizophrenia

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Suicide and Microglia: Recent Findings and Future Perspectives Based on Human Studies

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