Laminar circuit organization and response modulation in mouse visual cortex
Open accessAbstract
The mouse has become an increasingly important animal model for visual system studies, but few studies have investigated local functional circuit organization of mouse visual cortex. Here we used our newly developed mapping technique combining laser scanning photostimulation (LSPS) with fast voltage-sensitive dye (VSD) imaging to examine the spatial organization and temporal dynamics of laminar circuit responses in living slice preparations of mouse primary visual cortex (V1). During experiments, LSPS using caged glutamate provided spatially restricted neuronal activation in a specific cortical layer, and evoked responses from the stimulated layer to its functionally connected regions were detected by VSD imaging. In this study, we first provided a detailed analysis of spatiotemporal activation patterns at specific V1 laminar locations and measured local circuit connectivity. Then we examined the role of cortical inhibition in the propagation of evoked cortical responses by comparing circuit activity patterns in control and in the presence of GABAa receptor antagonists. We found that GABAergic inhibition was critical in restricting layer-specific excitatory activity spread and maintaining topographical projections. In addition, we investigated how AMPA and NMDA receptors influenced cortical responses and found that blocking AMPA receptors abolished interlaminar functional projections, and the NMDA receptor activity was important in controlling visual cortical circuit excitability and modulating activity propagation. The NMDA receptor antagonist reduced neuronal population activity in time-dependent and laminar-specific manners. Finally, we used the quantitative information derived from the mapping experiments and presented computational modeling analysis of V1 circuit organization. Taken together, the present study has provided important new information about mouse V1 circuit organization and response modulation.
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The enhancement of GABA transmission dynamics within the PV cell network in P15 MeCP2-null V1 likely contributes to the earlier spatial restriction in activity propagation.
“The enhancement of GABA transmission dynamics (39), within PV cell network in particular, in P15 MeCP2 -/y V1 likely contributes to the earlier spatial restriction in activity propagation.”
From MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex (2015) · cites this paper as [39]
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- Authors
- Olivas, N. D., Quintanar-Zilinskas, V., Nenadic, Z., & Xu, X.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Xu, Xiangmin
- Venue
- Frontiers in Neural Circuits
- Publisher
- Frontiers Media SA
- Published
- 2012
- Volume
- 6
- Pages
- 70-70
- ISSN
- 1662-5110 (ISSN-L)
- PMC
- PMC3464489
- OpenAlex
- W1975993768
- Cited by
- 17
- References
- 58
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2021: 1 · 2020: 1 · 2018: 1 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 2
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neural Circuits (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (R00DA023700, K99DA023700)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD060555)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- primary visual cortex, mouse visual cortex, cortical inhibition, GABAergic inhibition, GABA-A receptor antagonists, AMPA receptors, NMDA receptor, activity propagation
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