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Cited by 322Neuroscience and Neuropharmacology ResearchTactile and Sensory InteractionsNeurogenesis and neuroplasticity mechanisms

Circuit analysis of experience-dependent plasticity in the developing rat barrel cortex

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Shepherd, Gordon M.G, Pologruto, Thomas A, Svoboda, Karel·2003·Neuron
DOI 10.1016/s0896-6273(03)00152-1
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Abstract

Sensory deprivation during a critical period reduces spine motility and disrupts receptive field structure of layer 2/3 neurons in rat barrel cortex. To determine the locus of plasticity, we used laser scanning photostimulation, allowing us to rapidly map intracortical synaptic connectivity in brain slices. Layer 2/3 neurons differed in their spatial distributions of presynaptic partners: neurons directly above barrels received, on average, significantly more layer 4 input than those above the septa separating barrels. Complementary connectivity was found in deprived cortex: neurons above septa were now strongly coupled to septal regions, while connectivity between barrel regions and layer 2/3 was reduced. These results reveal competitive interactions between barrel and septal circuits in the establishment of precise intracortical circuits.

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  • The organization of barrel cortex depends on segregation of layer 4 to layer 2/3 excitatory connections into distinct barrel and septal circuits.

    “The organization of the barrel cortex relies on the segregation of layer 4 to layer 2/3 excitatory connections in distinct barrel and septal circuits.”

    From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Shepherd et al., 2003

  • In sensory-deprived mice, layer 2/3 neurons receive stronger inputs from layer 4 neurons in septal regions, suggesting that normal columnar maturation requires competitive interactions among layer 4 neurons.

    “In sensory deprived mice, layer 2/3 neurons receive stronger inputs from layer 4 neurons in septal regions altered, which suggests that the normal maturation of the columnar organization requires competitive interactions among layer 4 neurons (Shepherd et al., 2003).”

    From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Shepherd et al., 2003

  • Layer 2/3 neurons above barrels receive stronger inputs than those above the septa separating barrels.

    “Specifically, layer 2/3 neurons above barrels receive stronger inputs than those immediately above the septa separating the barrels (Shepherd et al., 2003).”

    From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Shepherd et al., 2003

  • Columnar refinement begins at the end of the first postnatal week and requires thalamocortical inputs.

    “Columnar refinement begins at the end of the first postnatal week and requires thalamocortical inputs.”

    From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Shepherd et al., 2003

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Authors
Shepherd, G. M. G., Pologruto, T. A., & Svoboda, K.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
Svoboda, Karel
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2003-04
Volume
38
Issue
2
Pages
277-289
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/s0896-6273(03)00152-1
OpenAlex
W2053358664
Cited by
322
References
62
Citations by year
2026: 3 · 2025: 6 · 2024: 7 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 10 · 2019: 6 · 2018: 13 · 2017: 14 · 2016: 11 · 2015: 14 · 2014: 16 · 2013: 17 · 2012: 21
FWCI
6.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
experience-dependent plasticity, barrel cortex, sensory deprivation, critical period, layer 2/3 neurons, cortical development
MeSH terms
Afferent Pathways, Animals, Brain Mapping, Glutamates, Lasers, Nerve Net, Neuronal Plasticity, Neurons, Photic Stimulation, Sensory Deprivation, Somatosensory Cortex, Ultraviolet Rays, Vibrissae, Rats, Wistar, Patch-Clamp Techniques, Rats, In Vitro Techniques

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