Visuomotor Transformations Underlying Hunting Behavior in Zebrafish
Open accessAbstract
Visuomotor circuits filter visual information and determine whether or not to engage downstream motor modules to produce behavioral outputs. However, the circuit mechanisms that mediate and link perception of salient stimuli to execution of an adaptive response are poorly understood. We combined a virtual hunting assay for tethered larval zebrafish with two-photon functional calcium imaging to simultaneously monitor neuronal activity in the optic tectum during naturalistic behavior. Hunting responses showed mixed selectivity for combinations of visual features, specifically stimulus size, speed, and contrast polarity. We identified a subset of tectal neurons with similar highly selective tuning, which show non-linear mixed selectivity for visual features and are likely to mediate the perceptual recognition of prey. By comparing neural dynamics in the optic tectum during response versus non-response trials, we discovered premotor population activity that specifically preceded initiation of hunting behavior and exhibited anatomical localization that correlated with motor variables. In summary, the optic tectum contains non-linear mixed selectivity neurons that are likely to mediate reliable detection of ethologically relevant sensory stimuli. Recruitment of small tectal assemblies appears to link perception to action by providing the premotor commands that release hunting responses. These findings allow us to propose a model circuit for the visuomotor transformations underlying a natural behavior.
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By virtue of its profuse connectivity with sensory and motor centers and its characteristic intrinsic organization, the teleost optic tectum provides the basis for multisensory integration and sensorimotor transformations required for a number of body-centered behaviors.
“By virtue of its profuse connectivity with a variety of sensory and motor centers, and because of its characteristic intrinsic organization, the teleost optic tectum provides the basis for the multisensory integration and sensorimotor transformations required for a number of body-centered behaviors”
From Spatial Cognition in Teleost Fish: Strategies and Mechanisms (2021) · cites this paper as [108]
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Experimental — accuracy not yet measuredNeural circuits involved in egocentric orientation in teleost fish include mainly several stages of the sensory and perceptual systems, some sensorimotor forebrain circuits, the optic tectum, the cerebellum, and various premotor centers and descending pathways in the brainstem and medulla.
“These neural circuits include mainly several stages of the sensory and perceptual systems, some sensorimotor forebrain circuits, the optic tectum, the cerebellum, and various premotor centers and descending pathways in the brainstem and medulla”
From Spatial Cognition in Teleost Fish: Strategies and Mechanisms (2021) · cites this paper as [108]
The Introduction and the Discussion’s model of hunting behavior (page numbers unavailable) describe visual processing in the optic tectum and proposed pathways through the mesencephalic reticular formation and reticulospinal neurons for orienting turns. The paper studies hunting in larval zebrafish, not egocentric orientation across teleost fish; these passages do not establish the claimed roles for sensorimotor forebrain circuits, the cerebellum, or the medulla. (LLM, conf=0.86)
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- Authors
- Bianco, I. H., & Engert, F.
- Affiliations
- Harvard University (US)
- Corresponding author
- Bianco, Isaac H.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 25
- Issue
- 7
- Pages
- 831-846
- ISSN
- 0960-9822 (ISSN-L)
- PMC
- PMC4386024
- OpenAlex
- W2071663937
- Cited by
- 217
- References
- 49
- Citations by year
- 2026: 10 · 2025: 28 · 2024: 25 · 2023: 14 · 2022: 12 · 2021: 20 · 2020: 32 · 2019: 18 · 2018: 19 · 2017: 14 · 2016: 19 · 2015: 5
- FWCI
- 11.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Current Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust (101195/Z/13/Z, 101195)
- National Institutes of Health (5r01da030304-04)
- National Institute on Drug Abuse (1R01DA030304-01, R01-DA030304)
- National Institute of Neurological Disorders and Stroke (U01NS090449, DP1NS082121, R24NS086601)
- National Center for Chronic Disease Prevention and Health Promotion (DP1 NS082121-02)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Keywords
- visuomotor transformation, hunting behavior, zebrafish larvae, optic tectum, mixed selectivity, prey detection, perception-action coupling, two-photon calcium imaging
- MeSH terms
- Animals, Neurons, Pattern Recognition, Visual, Photic Stimulation, Predatory Behavior, Psychomotor Performance, Size Perception, Superior Colliculi, Visual Perception, Zebrafish, Contrast Sensitivity
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