The Many Faces of Astrocytes in Alzheimer's Disease

Neurotoxic reactive astrocytes are induced by activated microglia

Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226

2016 Alzheimer's disease facts and figures

Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069

Glutamate uptake

Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227

Neuropathological alterations in Alzheimer disease

Serrano-Pozo, A., Frosch, M. P., Masliah, E., & Hyman, B. T. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006189 · Cited by 3,345

Single-cell transcriptomic analysis of Alzheimer’s disease

Mathys, H., Davila-Velderrain, J., Peng, Z., Gao, F., Mohammadi, S., Young, J. Z., Menon, M., He, L., Abdurrob, F., Jiang, X., et al. (2019) · Nature · doi:10.1038/s41586-019-1195-2 · Cited by 2,568

Reactive astrocyte nomenclature, definitions, and future directions

Escartin, C., Galea, E., Lakatos, A., O’Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00783-4 · Cited by 2,513

2020 Alzheimer's disease facts and figures

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The glymphatic system: a beginner's guide

Jessen, N. A., Munk, A. S. F., Lundgaard, I., & Nedergaard, M. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1581-6 · Cited by 2,075

Role of neuroinflammation in neurodegeneration development

Zhang, W., Xiao, D., Mao, Q., & Xia, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01486-5 · Cited by 1,668

Role of Microglia and Astrocytes in Alzheimer’s Disease: From Neuroinflammation to Ca2+ Homeostasis Dysregulation

Di Benedetto, G., Burgaletto, C., Bellanca, C. M., Munafò, A., Bernardini, R., & Cantarella, G. (2022) · Cells · doi:10.3390/cells11172728 · Cited by 189

Astrocytes as a Therapeutic Target in Alzheimer’s Disease–Comprehensive Review and Recent Developments

Rodríguez-Giraldo, M., González-Reyes, R. E., Ramírez-Guerrero, S., Bonilla-Trilleras, C. E., Guardo-Maya, S., & Nava-Mesa, M. O. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113630 · Cited by 122

Organ‐On‐A‐Chip Models of the Blood–Brain Barrier: Recent Advances and Future Prospects

Kawakita, S., Mandal, K., Mou, L., Mecwan, M. M., Zhu, Y., Li, S., Sharma, S., Hernández, A. L., Nguyen, H. T., Maity, S., et al. (2022) · Small · doi:10.1002/smll.202201401 · Cited by 103

Amyloid-β specific regulatory T cells attenuate Alzheimer’s disease pathobiology in APP/PS1 mice

Yeapuri, P., Machhi, J., Lu, Y., Abdelmoaty, M. M., Kadry, R., Patel, M., Bhattarai, S., Lu, E., Namminga, K. L., Olson, K. E., et al. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00692-7 · Cited by 85

Alzheimer blood biomarkers: practical guidelines for study design, sample collection, processing, biobanking, measurement and result reporting

Zeng, X., Chen, Y., Sehrawat, A., Lee, J., Lafferty, T. K., Kofler, J., Berman, S., Sweet, R. A., Tudorascu, D., Klunk, W. E., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00711-1 · Cited by 79

Single-cell and single-nuclei RNA sequencing as powerful tools to decipher cellular heterogeneity and dysregulation in neurodegenerative diseases

Durán, R. C., González-Orozco, J. C., Velasco, I., & Wu, J. Q. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.884748 · Cited by 64

Targeting gut microbiota to alleviate neuroinflammation in Alzheimer’s disease

Nguyen, V. T. T., & Endres, K. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114418 · Cited by 52

Modulating Neuroinflammation as a Prospective Therapeutic Target in Alzheimer’s Disease

Lee, E., & Chang, Y. (2025) · Cells · doi:10.3390/cells14030168 · Cited by 39

Astrocytes as Neuroimmunocytes in Alzheimer’s Disease: A Biochemical Tool in the Neuron–Glia Crosstalk along the Pathogenetic Pathways

Stanca, S., Rossetti, M., & Bongioanni, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813880 · Cited by 35

Endocytosis and Alzheimer’s disease

Zadka, Ł., Sochocka, M., Hachiya, N., Chojdak-Łukasiewicz, J., Dzięgiel, P., Piasecki, E., & Leszek, J. (2023) · GeroScience · doi:10.1007/s11357-023-00923-1 · Cited by 33

Challenges and Future Perspectives in Modeling Neurodegenerative Diseases Using Organ‐on‐a‐Chip Technology

Pramotton, F. M., Spitz, S., & Kamm, R. D. (2024) · Advanced Science · doi:10.1002/advs.202403892 · Cited by 33

Preserving cognitive function in patients with Alzheimer's disease: The Alzheimer's disease neuroprotection research initiative (ADNRI)

Liu, J., van Beusekom, H. M. M., Bu, X., Chen, G., Rosado-de-Castro, P. H., Chen, X., Chen, X., Clarkson, A. N., Farr, T. D., Fu, Y., et al. (2023) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.23 · Cited by 32

The Therapeutic and Diagnostic Potential of Amyloid β Oligomers Selective Antibodies to Treat Alzheimer’s Disease

Viola, K. L., Bicca, M. A., Bebenek, A. M., Kranz, D. L., Nandwana, V., Waters, E. A., Haney, C. R., Lee, M. Y., Gupta, A., Brahmbhatt, Z., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.768646 · Cited by 29

Exosomes enriched with miR-124-3p show therapeutic potential in a new microfluidic triculture model that recapitulates neuron–glia crosstalk in Alzheimer’s disease

Évora, A., Garcia, G., Rubi, A., Vitis, E. D., Matos, A. T., Vaz, A. R., Gervaso, F., Gigli, G., Polini, A., & Brites, D. M. T. O. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1474012 · Cited by 31

From attention-deficit hyperactivity disorder to sporadic Alzheimer’s disease—Wnt/mTOR pathways hypothesis

Grünblatt, E., Homolak, J., Perhoč, A. B., Virag, D., Knezović, A., Barilar, J. O., Riederer, P., Walitza, S., Tackenberg, C., & Šalković‐Petrišić, M. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1104985 · Cited by 26

Intermittent theta burst stimulation attenuates oxidative stress and reactive astrogliosis in the streptozotocin-induced model of Alzheimer’s disease-like pathology

Stanojevic, J., Zeljković, M., Dragić, M., Stojanović, I. R., Ilic, T. V., Stevanović, I. D., & Ninković, M. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1161678 · Cited by 27

Iron chelators as a therapeutic option for Alzheimer’s disease—A mini-review

Schreiner, O. D., & Schreiner, T. G. (2023) · Frontiers in Aging · doi:10.3389/fragi.2023.1234958 · Cited by 25

Ancestry‐related differences in chromatin accessibility and gene expression of APOE ε4 are associated with Alzheimer's disease risk

Celis, K., Moreno, M. D. M. M., Rajabli, F., Whitehead, P. L., Hamilton‐Nelson, K. L., Dykxhoorn, D. M., Nuytemans, K., Wang, L., Flanagan, M. E., Weıntraub, S., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13075 · Cited by 23

Neuroinflammation and Alzheimer's disease: Unravelling the molecular mechanisms

Kakkar, A., Singh, H., Singh, B. K., Kumar, A., Mishra, A. K., & Chopra, H. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251374353 · Cited by 26

Emerging Roles of Cells and Molecules of Innate Immunity in Alzheimer’s Disease

Tamburini, B., Badami, G. D., Manna, M. P. L., Azgomi, M. S., Caccamo, N., & Dieli, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241511922 · Cited by 22

Molecular mechanisms of Alzheimer’s disease: From therapeutic targets to promising drugs

Alan, E., Kerry, Z., & Sevin, G. (2023) · Fundamental & Clinical Pharmacology · doi:10.1111/fcp.12861 · Cited by 17

Astrocytic EphA4 signaling is important for the elimination of excitatory synapses in Alzheimer’s disease

Yang, X., Wang, Y., Qiao, Y., Lin, J., Lau, J. K. Y., Fu, W., Fu, A. K. Y., & Ip, N. Y. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2420324122 · Cited by 19

Transcriptional regulation by PHGDH drives amyloid pathology in Alzheimer’s disease

Chen, J., Hadi, F., Wen, X., Zhao, W., Xu, M., Xue, S., Lin, P., Calandrelli, R., Richard, J. L. C., Song, Z., et al. (2025) · Cell · doi:10.1016/j.cell.2025.03.045 · Cited by 19

The role of ADAM10 in astrocytes: Implications for Alzheimer’s disease

Elsworthy, R. J., Hill, E. J., Dunleavy, C., & Aldred, S. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1056507 · Cited by 17

Alzheimer’s Disease, Obesity, and Type 2 Diabetes: Focus on Common Neuroglial Dysfunctions (Critical Review and New Data on Human Brain and Models)

Tolédano, A., Rodríguez‐Casado, A., Álvarez, M., & Toledano‐Díaz, A. (2024) · Brain Sciences · doi:10.3390/brainsci14111101 · Cited by 19

Emerging Role of Oligodendrocytes Malfunction in the Progression of Alzheimer's Disease

Tylek, K., & Basta‐Kaim, A. (2025) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-025-10236-z · Cited by 19

Human stem cell transplantation models of Alzheimer’s disease

Ifediora, N., Canoll, P., & Hargus, G. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1354164 · Cited by 18

Decoding neuroinflammation in Alzheimer’s disease: a multi-omics and AI-driven perspective for precision medicine

Lin, S., Zhan, Y., Wang, R., & Pei, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1616899 · Cited by 21

Experimental colitis in young Tg2576 mice accelerates the onset of an Alzheimer’s-like clinical phenotype

Lorenzini, L., Zanella, L., Sannia, M., Baldassarro, V. A., Moretti, M., Cescatti, M., Quadalti, C., Baldi, S., Bartolucci, G., Gloria, L. D., et al. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01471-2 · Cited by 15

Supplementation of Seaweed Extracts to the Diet Reduces Symptoms of Alzheimer’s Disease in the APPswePS1ΔE9 Mouse Model

Martens, N., Zhan, N., Yam, S. C., Leijten, F. P. J., Palumbo, M., Caspers, M. P. M., Tiane, A., Friedrichs, S., Li, Y., der Zee, L. V. V., et al. (2024) · Nutrients · doi:10.3390/nu16111614 · Cited by 15

Activation of Gq-Coupled Receptors in Astrocytes Restores Cognitive Function in Alzheimer’s Disease Mice Model

Gerasimov, E., Борисович, Б. И., & Власова, О. Л. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129969 · Cited by 14

Amyloid pathology disrupts gliotransmitter release in astrocytes

Pillai, A. G., & Nadkarni, S. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1010334 · Cited by 15

Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

Das, D., Sonthalia, S., Stein-O.’Brien, G., Wahbeh, M., Feuer, K. L., Goff, L. A., Colantuoni, C., Mahairaki, V., & Avramopoulos, D. (2024) · BMC Biology · doi:10.1186/s12915-024-01867-4 · Cited by 14

Connectome-based biophysics models of Alzheimer’s disease diagnosis and prognosis

Torok, J., Anand, C., Verma, P., & Raj, A. (2022) · Translational research · doi:10.1016/j.trsl.2022.08.008 · Cited by 11

The relationships between neuroglial alterations and neuronal changes in Alzheimer’s disease, and the related controversies I: Gliopathogenesis and glioprotection

Toledano‐Díaz, A., Álvarez, M., & Tolédano, A. (2022) · Journal of Central Nervous System Disease · doi:10.1177/11795735221128703 · Cited by 11

Aβ1-42 Accumulation Accompanies Changed Expression of Ly6/uPAR Proteins, Dysregulation of the Cholinergic System, and Degeneration of Astrocytes in the Cerebellum of Mouse Model of Early Alzheimer Disease

Bychkov, M. L., Isaev, A. B., Andreev-Andrievskiy, A. A., Petrov, K. A., Paramonov, A. S., Kirpichnikov, M. P., & Lyukmanova, E. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914852 · Cited by 12

Reduced levels of NGF shift astrocytes toward a neurotoxic phenotype

Tiberi, A., Carucci, N., Testa, G., Rizzi, C., Pacifico, P., Borgonovo, G., Arisi, I., D'Onofrio, M., Brandi, R., Gan, W.-B., et al. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1165125 · Cited by 10

Optogenetics in Alzheimer’s Disease: Focus on Astrocytes

Mitroshina, Е. V., Kalinina, E. P., & Vedunova, M. V. (2023) · Antioxidants · doi:10.3390/antiox12101856 · Cited by 11

Low-Dose Radiation Therapy Impacts Microglial Inflammatory Response without Modulating Amyloid Load in Female TgF344-AD Rats

Ceyzériat, K., Jaques, E., Gloria, Y., Badina, A. M., Millet, P., Koutsouvelis, N., Dipasquale, G., Frisoni, G. B., Zilli, T., Garibotto, V., et al. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231153 · Cited by 10

Involvement of astrocyte senescence in Alzheimer's disease

Tüzer, F., & Torres, C. A. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102594 · Cited by 10

regionalpcs improve discovery of DNA methylation associations with complex traits

Eulalio, T. Y., Sun, M., Gevaert, O., Greicius, M. D., Montine, T. J., Nachun, D. C., & Montgomery, S. B. (2025) · Nature Communications · doi:10.1038/s41467-024-55698-6 · Cited by 8

Interpretable deep learning framework for understanding molecular changes in human brains with Alzheimer’s disease: implications for microglia activation and sex differences

Trivedi, M. R., Joshi, A. M., Shah, J., Readhead, B. P., Wilson, M. A., Su, Y., Reiman, E. M., Wu, T., & Wang, Q. (2025) · npj Aging · doi:10.1038/s41514-025-00258-5 · Cited by 9

Repurposing Artemisinin-Based Drugs from Antimalarial to Pan-Therapeutic: Pharmacological Promise and Therapeutic Challenges

Wu, D., Zeng, H., Tan, J., Xu, Q., Khan, F. A., Pandupuspitasari, N. S., Yang, S., & Huang, C. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s545163 · Cited by 9

The Adult Neurogenesis Theory of Alzheimer’s Disease

Abbate, C. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221279 · Cited by 11

Transcriptomic Analyses of Neurotoxic Astrocytes Derived from Adult Triple Transgenic Alzheimer’s Disease Mice

Carvalho, D. B., Díaz‐Amarilla, P., Dapueto, R., Santi, M. D., Duarte, P., Savio, E., Engler, H., Abin‐Carriquiry, J. A., & Arredondo, F. (2023) · Journal of Molecular Neuroscience · doi:10.1007/s12031-023-02105-2 · Cited by 7

Human hippocampal astrocytes: Computational dissection of their transcriptome, sexual differences and exosomes across ageing and mild‐cognitive impairment

Guebel, D. V. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.16081 · Cited by 7

Astrocyte response in Alzheimer’s disease: Good or bad?

Ismail, A., Al-Kuraishy, H. M., Al-Gareeb, A. I., Albuhadily, A. K., Yassen, A. S. A., Alexiou, A. T., Papadakis, M., & Batiha, G. E. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149971 · Cited by 6

Searching for the cellular underpinnings of the selective vulnerability to tauopathic insults in Alzheimer’s disease

Torok, J., Maia, P. D., Anand, C., & Raj, A. (2025) · Communications Biology · doi:10.1038/s42003-025-07575-1 · Cited by 8

Prioritizing genes associated with brain disorders by leveraging enhancer-promoter interactions in diverse neural cells and tissues

Zhao, X., Song, L., Yang, A., Zhang, J., Zhang, J., Yang, Y., & Zhao, X. (2023) · Genome Medicine · doi:10.1186/s13073-023-01210-6 · Cited by 5

Photocleavable Mass-Tagged Oligonucleotide Probes for Multiplexed and Multiomic Tissue Imaging of Targeted Transcripts

Bell, J. M., Yagnik, G. B., Dettori, L. G., Carvalho, P., Wan, Z., Rothschild, K. J., & Lim, M. J. (2025) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.5c00057 · Cited by 5

The identification of a Distinct Astrocyte Subtype that Diminishes in Alzheimer’s Disease

Wei, H., Withrow, J. S., Rakshit, J., Amin, F. U., Nahm, J., Mowry, F. E., Mao, Z., Bhattacharjee, M. B., Zhu, J., Yang, Y., et al. (2024) · Aging and Disease · doi:10.14336/ad.2024.0205-1 · Cited by 7

Gene co-expression patterns shared between chemobrain and neurodegenerative disease models in rodents

Zare, M.-S., Abedpoor, N., Hajibabaie, F., & Walker, A. K. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106944 · Cited by 6

Role of astrocytes in Alzheimer's disease pathogenesis and the impact of exercise-induced remodeling

Shao, J., Deng, Q., Feng, S., Wu, C., Liu, X., & Yang, L. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150418 · Cited by 5

The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma

Caniceiro, A. B., Agostinho, S. P., Piochi, L. F., Rosário‐Ferreira, N., & Moreira, I. S. (2026) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.71131 · Cited by 4

Altered metabolic function induced by Aβ‐oligomers and PSEN1 mutations in iPSC ‐derived astrocytes

Elsworthy, R. J., Finelli, M. J., Aqattan, S., Dunleavy, C., King, M. C., Ludlam, A., Tarczyluk, M. A., Allen, S., Prosser, S., Chen, R., et al. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16267 · Cited by 7

Generating PET scan patterns in Alzheimer’s by a mathematical model

Lee, C., & Friedman, A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0299637 · Cited by 4

Transactivation Response DNA-Binding Protein of 43 (TDP-43) and Glial Cell Roles in Neurological Disorders

Hussain, H., Djurin, T., Rodriguez, J., Daneelian, L., Sundi, S., Fadel, A., & Saadoon, Z. F. (2022) · Cureus · doi:10.7759/cureus.30639 · Cited by 4

The relationships between neuroglial and neuronal changes in Alzheimer’s disease, and the related controversies II: gliotherapies and multimodal therapy

Toledano‐Díaz, A., Álvarez, M. I., & Tolédano, A. (2022) · Journal of Central Nervous System Disease · doi:10.1177/11795735221123896 · Cited by 5

SOX9 Expression Is Increased in Alzheimer’s Disease (AD) and Is Associated With Disease Progression and APOE4 Genotype: A Computational Approach

Alamoudi, A. A. (2023) · Cureus · doi:10.7759/cureus.36129 · Cited by 4

Human brain single nucleus cell type enrichments in neurodegenerative diseasesPreprint

Alvarado, C. X., Weller, C. A., Johnson, N., Leonard, H. L., Singleton, A., Reed, X., Blauwendraat, C., & Nalls, M. A. (2023) · medRxiv · doi:10.1101/2023.06.30.23292084 · Cited by 4

Characterization of Isolated Human Astrocytes from Aging Brain

Serrano, G. E., Aslam, S., Walker, J. E., Piras, I. S., Huentelman, M. J., Arce, R. A., Glass, M. J., Intorcia, A. J., Suszczewicz, K. E., Borja, C. I., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073416 · Cited by 3

Senescence as a Central Node in Alzheimer’s Disease: Molecular Triggers, Cellular Effectors, and RNA-Based Interventions

Some, A., Naskar, N., Thomas, D. M., Jeengar, M. K., & Nassar, A. (2026) · Neurochemical Research · doi:10.1007/s11064-026-04737-3 · Cited by 3

AstroGreen transgenic mouse illuminates the trafficking of astrocyte-derived extracellular vesicles

Nieland, L., Haidar, E. A., Rufino‐Ramos, D., Prabhakar, S., Samaha, Y., Breyne, K., Fordjour, F. K., Das, S., Broekman, M. L. D., Gould, S. J., et al. (2025) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2025.104051 · Cited by 2

Therapeutic Potential of HAEEPGP Peptide Against β-Amyloid Induced Neuropathology

Kechko, O. I., Mukhina, K. A., Yanvarev, D. V., Eremina, S. Y., Katkova-Zhukotskaya, O. A., Chaprov, K., Drutskaya, M. S., Kozin, S. A., Makarov, A. А., & Mitkevich, V. A. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05349-8 · Cited by 3

Material considerations for delivering therapeutics across the blood–brain barrier

Zoba, A. N., & Tringides, C. M. (2025) · APL Materials · doi:10.1063/5.0284305 · Cited by 2

Glial cells are involved in day–night protein dysregulation in the hippocampus of a mouse model of Alzheimer’s disease

Badina, A. M., Tahiri, H., Ouarour, A., Ceyzériat, K., Millet, P., Tournier, B. B., & Chakir, I. (2025) · Scientific Reports · doi:10.1038/s41598-025-30965-8 · Cited by 2

An emerging spectrum of therapeutic targets for Alzheimer's disease

Goetzl, E. J. (2023) · The FASEB Journal · doi:10.1096/fj.202301461r · Cited by 2

Altered metabolic function induced by amyloid-beta oligomers and PSEN1-mutations in iPSC-derived astrocytesPreprint

Elsworthy, R. J., Finelli, M. J., Aqattan, S., Dunleavy, C., King, M. C., Ludlam, A., Allen, S. L., Prosser, S., Chen, R. E., Martínez‐Jarquín, S., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.23.554346 · Cited by 2

Neuroprotective effects of sodium molybdate in a beta-amyloid–induced rat model of Alzheimer’s disease: An In Vivo preclinical study

Shahsavari, F., Eidi, A., & Sotoodehnejadnematalahi, F. (2025) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2025.127774 · Cited by 2

Presenilin 1 E280A mutation induces dysfunctional astrocytic phenotype in menstrual stromal-derived astrocyte-like cells

Correa, N. Q., Mendivil‐Perez, M., Velez‐Pardo, C., Jiménez-Del-Río, M., & Quiroz-Correa, Q. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05902-7 · Cited by 1

Dexmedetomidine Exerts Multi-level Effects to Ameliorate Alzheimer’s Disease Pathology in the Adult Zebrafish Brain

Nazli, D., Poyraz, Y. K., Can, K., Ipekgil, D., Cakmak, N., Turhanlar‐Sahin, E., Hacoglu, S., Erdost, H. A., Iyilikci, L., & Ozhan, G. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05906-9 · Cited by 1

Toll like receptor 4 (TLR4) in neuroinflammation: From acute hemorrhagic stroke to chronic neurodegeneration

Choudhary, H. H., Yoshida, J., Islam, R., Wang, Z., & Hanafy, K. A. (2026) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x261468877 · Cited by 1

Astrocytes in Neuroinflammatory and Neurodegenerative Diseases

Bhandarkar, S., Qavi, D., Park, C., & Pitt, D. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95702-1.00048-8 · Cited by 1

Natural products from selected medicinal plants as potential therapeutics in Alzheimer's disease

Nair, P. G., Dixit, A. K., Dixit, D., Rotwar, D. S., & Sharma, M. K. (2024) · Studies in natural products chemistry · doi:10.1016/b978-0-443-15628-1.00008-8 · Cited by 1

The Synergistic Roles of Glial Cells and Non-Coding RNAs in the Pathogenesis of Alzheimer’s Disease and Related Dementias (ADRDs)

Risen, S. J., Wahl, D., LaRocca, T. J., & Moreno, J. A. (2025) · Neuroglia · doi:10.3390/neuroglia6020022 · Cited by 1

Ancestry-related differences in chromatin accessibility and gene expression of APOE4 are associated with Alzheimer disease riskPreprint

Celis, K., Moreno, M. D. M. M., Rajabli, F., Whitehead, P. L., Hamilton‐Nelson, K. L., Dykxhoorn, D. M., Nuytemans, K., Wang, L., Dalgard, C. L., Flanagan, M. E., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.27.514114

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Additional file 7 of Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

Das, D., Sonthalia, S., Stein-O.’Brien, G., Wahbeh, M., Feuer, K., Goff, L. A., Colantuoni, C., Mahairaki, V., & Avramopoulos, D. (2024) · Figshare · doi:10.6084/m9.figshare.26700856

Additional file 19 of Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

Das, D., Sonthalia, S., Stein-O.’Brien, G., Wahbeh, M., Feuer, K., Goff, L. A., Colantuoni, C., Mahairaki, V., & Avramopoulos, D. (2024) · Figshare · doi:10.6084/m9.figshare.26700892

Additional file 9 of Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

Das, D., Sonthalia, S., Stein-O.’Brien, G., Wahbeh, M., Feuer, K., Goff, L. A., Colantuoni, C., Mahairaki, V., & Avramopoulos, D. (2024) · Figshare · doi:10.6084/m9.figshare.26700862

Additional file 26 of Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

Das, D., Sonthalia, S., Stein-O.’Brien, G., Wahbeh, M., Feuer, K., Goff, L. A., Colantuoni, C., Mahairaki, V., & Avramopoulos, D. (2024) · Figshare · doi:10.6084/m9.figshare.26700913

Additional file 3 of Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

Das, D., Sonthalia, S., Stein-O.’Brien, G., Wahbeh, M., Feuer, K., Goff, L. A., Colantuoni, C., Mahairaki, V., & Avramopoulos, D. (2024) · Figshare · doi:10.6084/m9.figshare.26700844

Additional file 20 of Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

Das, D., Sonthalia, S., Stein-O.’Brien, G., Wahbeh, M., Feuer, K., Goff, L. A., Colantuoni, C., Mahairaki, V., & Avramopoulos, D. (2024) · Figshare · doi:10.6084/m9.figshare.26700895

Additional file 12 of Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

Das, D., Sonthalia, S., Stein-O.’Brien, G., Wahbeh, M., Feuer, K., Goff, L. A., Colantuoni, C., Mahairaki, V., & Avramopoulos, D. (2024) · Figshare · doi:10.6084/m9.figshare.26700871

Additional file 25 of Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

Das, D., Sonthalia, S., Stein-O.’Brien, G., Wahbeh, M., Feuer, K., Goff, L. A., Colantuoni, C., Mahairaki, V., & Avramopoulos, D. (2024) · Figshare · doi:10.6084/m9.figshare.26700910

Additional file 2 of Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

Das, D., Sonthalia, S., Stein-O.’Brien, G., Wahbeh, M., Feuer, K., Goff, L. A., Colantuoni, C., Mahairaki, V., & Avramopoulos, D. (2024) · Figshare · doi:10.6084/m9.figshare.25530408

Additional file 8 of Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

Das, D., Sonthalia, S., Stein-O.’Brien, G., Wahbeh, M., Feuer, K., Goff, L. A., Colantuoni, C., Mahairaki, V., & Avramopoulos, D. (2024) · Figshare · doi:10.6084/m9.figshare.26700859

Additional file 5 of Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

Das, D., Sonthalia, S., Stein-O.’Brien, G., Wahbeh, M., Feuer, K., Goff, L. A., Colantuoni, C., Mahairaki, V., & Avramopoulos, D. (2024) · Figshare · doi:10.6084/m9.figshare.26700850

Additional file 17 of Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

Das, D., Sonthalia, S., Stein-O.’Brien, G., Wahbeh, M., Feuer, K., Goff, L. A., Colantuoni, C., Mahairaki, V., & Avramopoulos, D. (2024) · Figshare · doi:10.6084/m9.figshare.26700886

Additional file 6 of Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

Das, D., Sonthalia, S., Stein-O.’Brien, G., Wahbeh, M., Feuer, K., Goff, L. A., Colantuoni, C., Mahairaki, V., & Avramopoulos, D. (2024) · Figshare · doi:10.6084/m9.figshare.26700853

Additional file 21 of Insights for disease modeling from single-cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

Das, D., Sonthalia, S., Stein-O.’Brien, G., Wahbeh, M., Feuer, K., Goff, L. A., Colantuoni, C., Mahairaki, V., & Avramopoulos, D. (2024) · Figshare · doi:10.6084/m9.figshare.26700898

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