The Many Faces of Astrocytes in Alzheimer's Disease

Neurotoxic reactive astrocytes are induced by activated microglia

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Neuroinflammation in Alzheimer's disease

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2016 Alzheimer's disease facts and figures

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Glutamate uptake

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Neuropathological alterations in Alzheimer disease

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Single-cell transcriptomic analysis of Alzheimer’s disease

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Reactive astrocyte nomenclature, definitions, and future directions

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2020 Alzheimer's disease facts and figures

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The glymphatic system: a beginner's guide

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Amyloid Precursor Protein Processing and Alzheimer's Disease

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RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

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Alzheimer Mechanisms and Therapeutic Strategies

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The glymphatic pathway in neurological disorders.

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Reactive Gliosis and the Multicellular Response to CNS Damage and Disease

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Understanding RAGE, the receptor for advanced glycation end products

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Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

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Disease-associated astrocytes in Alzheimer’s disease and aging

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A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

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Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

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Astrocytes and Brain Injury

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The genetic landscape of Alzheimer disease: clinical implications and perspectives

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Astrocytes: a central element in neurological diseases

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GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

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Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence

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Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity

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Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease

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Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease

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Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

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Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective

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Identification of diverse astrocyte populations and their malignant analogs

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The Emerging Nature of Astrocyte Diversity

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Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis

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YKL-40: A Novel Prognostic Fluid Biomarker for Preclinical Alzheimer's Disease

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Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map

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Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease

Lau, S.-F., Cao, H., Fu, A. K. Y., & Ip, N. Y. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008762117 · Cited by 476

Astrocytes in Alzheimer's Disease

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Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

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The role of astrocytes in amyloid production and Alzheimer's disease

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Evidence for Astrocytosis in Prodromal Alzheimer Disease Provided by 11 C-Deuterium-L-Deprenyl: A Multitracer PET Paradigm Combining 11 C-Pittsburgh Compound B and 18 F-FDG

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Environmental risk factors for dementia: a systematic review

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Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation

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Astrocytes, neurons, synapses: a tripartite view on cortical circuit development

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Altered Insulin Signaling in Alzheimer’s Disease Brain – Special Emphasis on PI3K-Akt Pathway

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Reactive astrocytes in neurodegenerative diseases

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Fibrous and protoplasmic astrocytes are biochemically and developmentally distinct

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Isolation of glia from Alzheimer’s mice reveals inflammation and dysfunction

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Tumor Necrosis Factor-α, Interleukin-1β, and Interferon-γ Stimulate γ-Secretase-mediated Cleavage of Amyloid Precursor Protein through a JNK-dependent MAPK Pathway

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The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

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Receptor for AGEs (RAGE) as Mediator of NF-kB Pathway Activation in Neuroinflammation and Oxidative Stress

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Astrocyte Biomarkers in Alzheimer’s Disease

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Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model

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Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses

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The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer’s and Huntington’s diseases

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Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer’s disease mouse model

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Connexin 30 sets synaptic strength by controlling astroglial synapse invasion

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Cognitive Decline in Alzheimer's Disease Is Associated with Selective Changes in Calcineurin/NFAT Signaling

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Alterations in Expression of Glutamatergic Transporters and Receptors in Sporadic Alzheimer's Disease

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Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease

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Protein phosphatase 2A dysfunction in Alzheimer’s disease

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The Transforming Growth Factor‐βs

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Role of RAGE in Alzheimer’s Disease

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Deciphering the astrocyte reaction in Alzheimer's disease

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Cellular Functions of the Amyloid Precursor Protein from Development to Dementia

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Epidemiological and Economic Burden of Alzheimer's Disease: A Systematic Literature Review of Data across Europe and the United States of America

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Tau Proteins and Tauopathies in Alzheimer’s Disease

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Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease

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Immunohistochemical distribution of the receptor for advanced glycation end products in neurons and astrocytes in Alzheimer’s disease

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Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades

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Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease

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Structural Remodeling of Astrocytes in the Injured CNS

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Astroglial Glutamate Signaling and Uptake in the Hippocampus

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Microglia and Astrocytes in Disease: Dynamic Duo or Partners in Crime?

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Regulation of neural process growth, elaboration and structural plasticity by NF-κB

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Alterations in cholesterol metabolism as a risk factor for developing Alzheimer’s disease: Potential novel targets for treatment

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Diverse subtypes of astrocytes and their development during corticogenesis

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Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease

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Towards a Better Understanding of GABAergic Remodeling in Alzheimer’s Disease

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Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells

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Activated MAO-B in the brain of Alzheimer patients, demonstrated by [11C]-l-deprenyl using whole hemisphere autoradiography

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Transcriptomic profiling of microglia and astrocytes throughout aging

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Early-onset Alzheimer's Disease: Nonamnestic Subtypes and Type 2 AD

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Astrocyte Senescence and Alzheimer’s Disease: A Review

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Alzheimer's disease β‐secretase BACE1 is not a neuron‐specific enzyme

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TGF-β1 mRNA Increases in Macrophage/Microglial Cells of the Hippocampus in Response to Deafferentation and Kainic Acid-Induced Neurodegeneration

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GLT-1 Loss Accelerates Cognitive Deficit Onset in an Alzheimer's Disease Animal Model

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Astrocytic metabolic and inflammatory changes as a function of age

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TGF‐β1 is an organizer of responses to neurodgeneration

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Region-Specific Transcriptional Control of Astrocyte Function Oversees Local Circuit Activities

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Modifiable Risk Factors for Prevention of Dementia in Midlife, Late Life and the Oldest-Old: Validation of the LIBRA Index

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GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild‐type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease

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Early astrocytosis in autosomal dominant Alzheimer’s disease measured in vivo by multi-tracer positron emission tomography

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