Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior
Open accessAbstract
Physical or mental stress leads to neuroplasticity in the brain and increases the risk of depression and anxiety. Stress exposure causes the dysfunction of peripheral T lymphocytes. However, the pathological role and underlying regulatory mechanism of peripheral T lymphocytes in mood disorders have not been well established. Here, we show that the lack of CD4+ T cells protects mice from stress-induced anxiety-like behavior. Physical stress-induced leukotriene B4 triggers severe mitochondrial fission in CD4+ T cells, which further leads to a variety of behavioral abnormalities including anxiety, depression, and social disorders. Metabolomic profiles and single-cell transcriptome reveal that CD4+ T cell-derived xanthine acts on oligodendrocytes in the left amygdala via adenosine receptor A1. Mitochondrial fission promotes the de novo synthesis of purine via interferon regulatory factor 1 accumulation in CD4+ T cells. Our study implicates a critical link between a purine metabolic disorder in CD4+ T cells and stress-driven anxiety-like behavior.
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Peripheral CD4+ T cells are major contributors to the occurrence of mental disorders.
“Moreover, peripheral CD4+ T cells have been reported as the major contributors to the occurrence of mental disorders [15, 16].”
From Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain (2022) · cites this paper as [15]
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- Authors
- Fan, K.-Q., Li, Y.-Y., Wang, H.-L., Mao, X.-T., Guo, J.-X., Wang, F., Huang, L.-J., Li, Y.-N., Ma, X.-Y., Gao, Z.-J., Chen, W., Qian, D.-D., Xue, W.-J., Cao, Q., Zhang, L., Shen, L., Zhang, L., Tong, C., Zhong, J.-Y., Lu, W., Lu, L., Ren, K.-M., Zhong, G., Wang, Y., Tang, M., Feng, X.-H., Chai, R.-J., & Jin, J.
- Affiliations
- Zhejiang University (CN)
- Sir Run Run Shaw Hospital (CN)
- East China Normal University (CN)
- Southeast University (CN)
- ShanghaiTech University (CN)
- Corresponding author
- Jin, Jin
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 179
- Issue
- 4
- Pages
- 864-879.e19
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2983084556
- Cited by
- 312
- References
- 62
- Citations by year
- 2026: 30 · 2025: 43 · 2024: 57 · 2023: 45 · 2022: 54 · 2021: 41 · 2020: 39 · 2019: 3
- FWCI
- 11.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key R&D Program of China (2018YFA0800503, 2018YFD0500100)
- Excellent Young Scientist Fund of NSFC (31822017)
- Zhejiang Provincial Natural Science Foundation of China (LR19C080001)
- Strategic Priority Research Program of the Chinese Academy of Science (XDA16010302)
- National Natural Science Foundation of China (81572651, 81771675, 81622013, 81700913)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Keywords
- stress-induced anxiety, CD4+ T cells, leukotriene B4, mitochondrial fission, purine metabolism, xanthine, adenosine A1 receptor, oligodendrocytes, amygdala, IRF1, depression, social behavior disorders, mood disorders, T cell dysfunction
- MeSH terms
- Amygdala, Animals, Anxiety, Behavior, Animal, Brain Diseases, Metabolic, Disease Models, Animal, Humans, Oligodendroglia, Stress, Psychological, CD4-Positive T-Lymphocytes, Xanthine, Mice, Single-Cell Analysis, Transcriptome, Mitochondrial Dynamics
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