Mecamylamine - a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

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Drugs of abuse: anatomy, pharmacology and function of reward pathways

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Mammalian nicotinic acetylcholine receptors: from structure to function

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A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.

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Nicotine activates and desensitizes midbrain dopamine neurons

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Nicotinic acetylcholine receptors and the regulation of neuronal signalling

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Co‐Morbidity of Smoking in Patients with Psychiatric and Substance Use Disorders

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The Effects of Nicotine on Attention, Information Processing, and Short-Term Memory in Patients with Dementia of the Alzheimer Type

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Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in alzheimer's disease

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The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour

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Cholinergic Activity in Autism: Abnormalities in the Cerebral Cortex and Basal Forebrain

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Chronic Exposure to Nicotine Upregulates the Human α4β2 Nicotinic Acetylcholine Receptor Function

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Abnormal Regulation of High Affinity Nicotinic Receptors in Subjects with Schizophrenia

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Effects of Cigarette Smoking on Spatial Working Memory and Attentional Deficits in Schizophrenia

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Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments

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Nicotinic receptor stimulation protects neurons against β‐amyloid toxicity

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Intravenous nicotine in Alzheimer's disease: a pilot study

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Varenicline Reduces Alcohol Self-Administration in Heavy-Drinking Smokers

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Nicotinic acetylcholine receptors as targets for antidepressants

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Four-week nicotine skin patch treatment effects on cognitive performance in Alzheimer's disease

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Analysis of Mecamylamine Stereoisomers on Human Nicotinic Receptor Subtypes

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Neuronal Systems Underlying Behaviors Related to Nicotine Addiction: Neural Circuits and Molecular Genetics

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The neurobiology of tobacco dependence: A preclinical perspective on the role of the dopamine projections to the nucleus

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Mecamylamine combined with nicotine skin patch facilitates smoking cessation beyond nicotine patch treatment alone

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Effects of Smoking Abstinence on Visuospatial Working Memory Function in Schizophrenia

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Nicotinic receptor mechanisms and cognition in normal states and neuropsychiatric disorders

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Ca2+ Permeability of the (α4)3(β2)2 Stoichiometry Greatly Exceeds That of (α4)2(β2)3 Human Acetylcholine Receptors

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Nicotine patches in Alzheimer's disease: Pilot study on learning, memory, and safety

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Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade

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The mesolimbic dopamine-activating properties of ethanol are antagonized by mecamylamine

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Nicotine and Behavioral Markers of Risk for Schizophrenia A Double-Blind, Placebo-Controlled, Cross-Over Study

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Accumbal dopamine overflow after ethanol: Localization of the antagonizing effect of mecamylamine

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Inter‐relationships between conditioned and primary reinforcement in the maintenance of cigarette smoking

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Nicotine-mecamylamine treatment for smoking cessation: The role of pre-cessation therapy.

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Psychostimulant-Induced Behavioral Sensitization Depends on Nicotinic Receptor Activation

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Chronic nicotine differentially alters cocaine-induced locomotor activity in adolescent vs. adult male and female rats

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Acute nicotinic blockade produces cognitive impairment in normal humans

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Epibatidine and ABT 418 reveal selective losses of α4β2 nicotinic receptors in Alzheimer brains

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Nicotine–mecamylamine treatment for smoking cessation: The role of pre-cessation therapy.

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Molecular analysis of nicotinic receptor expression in autism

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Structurally different neuronal nicotinic acetylcholine receptor subtypes purified and characterized using monoclonal antibodies

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Pharmacological Characterization of Nicotine-Induced Seizures in Mice

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Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice

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Age-Related Effects of the Nicotinic Antagonist Mecamylamine on Cognition and Behavior

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The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not β2- or α7-nicotinic acetylcholine receptor subunit knockout mice

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Nicotinic Antagonist Augmentation of Selective Serotonin Reuptake Inhibitor-Refractory Major Depressive Disorder: A Preliminary Study

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An acute dose of nicotine enhances cue-induced cocaine craving

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Properties of neuronal nicotinic acetylcholine receptor mutants from humans suffering from autosomal dominant nocturnal frontal lobe epilepsy

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Neuropharmacology of Cocaine and Ethanol Dependence

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A Nicotine Antagonist, Mecamylamine, Reduces Cue-Induced Cocaine Craving in Cocaine-Dependent Subjects

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High-affinity nicotinic acetylcholine receptors are required for antidepressant effects of amitriptyline on behavior and hippocampal cell proliferation

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The acetylcholine receptor of the neuromuscular junction recognizes mecamylamine as a noncompetitive antagonist.

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Precessation treatment with nicotine skin patch facilitates smoking cessation

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GANGLIONIC BLOCKING PROPERTIES OF 3-METHYLAMINOISOCAMPHANE HYDROCHLORIDE (MECAMYLAMINE): A SECONDARY AMINE

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Nicotine for the treatment of Tourette's syndrome

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Nicotine and Nicotinic Receptor Involvement in Neuropsychiatric Disorders

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Multicenter, Double-Blind, Placebo-Controlled Study of Mecamylamine Monotherapy for Tourette's Disorder

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Evidence for a complex influence of nicotinic acetylcholine receptors on hippocampal serotonin release

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Mecamylamine: new therapeutic uses and toxicity/risk profile

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What is the nature of mecamylamine's antagonism of the central effects of nicotine?

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Mechanisms Underlying the Comorbidity of Tobacco Use in Mental Health and Addictive Disorders

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Varenicline Augmentation in Depressed Smokers: An 8-Week, Open-Label Study

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TC‐5214 (S‐(+)‐Mecamylamine): A Neuronal Nicotinic Receptor Modulator with Antidepressant Activity

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Mecamylamine Modifies the Pharmacokinetics and Reinforcing Effects of Alcohol

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Antidepressant-like effects of nicotine and mecamylamine in the mouse forced swim and tail suspension tests: role of strain, test and sex

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Neuronal nicotinic receptor inhibition for treating mood disorders preliminary controlled evidence with mecamylamine

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Mecamylamine (Inversine®): an old antihypertensive with new research directions

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Nicotine and nicotinic receptor antagonists potentiate the antidepressant‐like effects of imipramine and citalopram

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Neuronal nicotinic acetylcholine receptor subunits in autism: an immunohistochemical investigation in the thalamus

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Dopamine responsiveness to drugs of abuse: A shell‐core investigation in the nucleus accumbens of the mouse

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The status of pharmacotherapy for autism spectrum disorders

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Enhancement of cocaine-seeking behavior by repeated nicotine exposure in rats

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Mecamylamine does not precipitate withdrawal in cigarette smokers

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Mecamylamine in Tourette's Syndrome: A Two-Year Retrospective Case Study

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Effects of Nicotine and Mecamylamine Microinjections into the Nucleus Accumbens on Ethanol and Sucrose Self-Administration

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Effects of nicotinic agonists and antagonists on N‐methyl‐D‐aspartate‐induced 3H‐norepinephrine release and 3H‐(1‐[1‐(2‐thienyl)cyclohexyl]‐piperidine) binding in rat hippocampus

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The nicotinic acetylcholine receptor antagonist mecamylamine prevents escalation of cocaine self-administration in rats with extended daily access

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Effects of acute abstinence, reinstatement, and mecamylamine on biochemical and behavioral measures of cigarette smoking in schizophrenia

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Pharmacological evaluation of the antagonism of nicotine's central effects by mecamylamine and pempidine.

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Rapid Relief of Block by Mecamylamine of Neuronal Nicotinic Acetylcholine Receptors of Rat Chromaffin Cells In Vitro: An Electrophysiological and Modeling Study

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Nicotinic cholinergic antagonists: A novel approach for the treatment of autism

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Comorbid bipolar disorder in Tourette’s syndrome responds to the nicotinic receptor antagonist mecamylamine (Inversine)

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Nicotine promotes the intracellular growth of Mycobacterium tuberculosis in epithelial cells

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Co‐administration of morphine and levamisole increases death risk, produces neutropenia and modifies antinociception in mice

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A tailed mirtron promotes longevity in Drosophila

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