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MT5-MMP Promotes Alzheimer’s Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro
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This could contribute to the inability to detect steady-state C99 levels and thus mask a putative impact of MT5-MMP in C99 metabolism.
“Taken together, this could contribute to the inability to detect steady-state C99 levels and thus mask a putative impact of MT5-MMP in C99 metabolism, as previously shown in adult 5xFAD mice [13, 17].”
C99 did not accumulate in developing neural cells.
“C99 did not accumulate in developing neural cells.”
Stable levels of C83 are found in the frontal cortex of 5xFAD mice lacking MT5-MMP.
“data showing stable levels of C83 in the frontal cortex of 5xFAD mice lacking MT5-MMP [17].”
MT5-MMP can modulate APP/Aβ metabolism.
“Knowing that MT5-MMP can modulate APP/Aβ metabolism [13, 17]”
MT5-MMP deficiency markedly reduces the levels of Aβ and C99 in early stages of Alzheimer's disease pathology.
“MT5-MMP is a new pro-amyloidogenic factor, whose deficiency markedly reduced the levels of Aβ and C99 in early stages of the pathology”
MT5-MMP deficiency prevents deficits in long-term potentiation (LTP), spatial learning and working memory in 5xFAD mice.
“concomitant with prevention of deficits in long-term potentiation (LTP), spatial learning and working memory [13, 17].”
The impact of MT5-MMP in AD may begin at a stage well before the onset of obvious pathological and clinical signs.
“Such regulation highlights that the impact of MT5-MMP in AD, previously described in adult mice [13, 17], may actually begin at a stage well before the onset of obvious pathological and clinical signs.”
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Metadata
- Authors
- Baranger, K., Bonnet, A. E., Girard, S. D., Paumier, J.-M., García-González, L., Elmanaa, W., Bernard, A., Charrat, E., Stephan, D., Bauer, C., Moschke, K., Lichtenthaler, S. F., Roman, F. S., Checler, F., Khrestchatisky, M., & Rivera, S.
- Venue
- Frontiers in Molecular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2017-01-10
- Volume
- 9
- ISSN
- 1662-5099
- PMC
- PMC5223243
- Cited by
- 44
- References
- 9
- Funders
- Agence Nationale de la Recherche (MAD5, PREVENTAD)
- Aix-Marseille Université (A*MIDEX Management de Talents)
- Association France Alzheimer
- Deutsche Forschungsgemeinschaft (FOR2290)
- Fondation pour la Recherche Médicale
- Fondation Plan Alzheimer
- Ministère de l’Enseignement Supérieur et de la Recherche
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