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Membrane Trafficking Pathways in Alzheimer's Disease
Abstract
Membrane proteins are constantly being trafficked in cells and the relevant proteins in Alzheimer's disease (AD), such as the amyloid precursor protein (APP) and its processing enzymes, are not exempted from that. Molecular cell biologists have been endeavoring to ascertain a roadmap for APP processing and trafficking in various cell types including neurons. This has led to the identification of numerous regulatory sorting mechanisms, protein–protein interactions and lipidic microenvironments that largely define how and where the substrate APP meets its processing enzymes. However, the cell biology of tau, and the formation of neurofibrillary tangles, has long been regarded as a separate field. Nonetheless, recent progress is bringing both worlds together in a new paradigm on how A β toxicity and tau are physiologically connected. Here, we discuss an update of our current appraisal on how membrane trafficking may play an important role in the pathogenesis of the disease and how this could be exploited for effective therapy.
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The γ-secretase complex is formed by a PS1 or PS2 catalytic subunit and three partner proteins, Aph-1, pen-2 and nicastrin.
“The γ-secretase complex is formed by a PS1 or PS2 catalytic subunit and 3 partner proteins, Aph-1, pen-2 and nicastrin (Haass et al., 2012; Rajendran and Annaert, 2012; Masters et al., 2015; Selkoe and Hardy, 2016).”
From Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP (2019) · cites this paper as Rajendran and Annaert, 2012
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Loss of Bin1 Promotes the Propagation of Tau Pathology
Calafate, S., Flavin, W., Verstreken, P., & Moechars, D. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.063 · Cited by 265
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Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A
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Metadata
- Authors
- Rajendran, L., & Annaert, W.
- Affiliations
- Systems and Cell Biology of Neurodegeneration Division of Psychiatry Research University of Zurich August‐Forel Str. 1 Zurich 8008 Switzerland
- Laboratory for Membrane Trafficking Center for Human Genetics (KULeuven) & VIB‐Center for the Biology of Disease Gasthuisberg O&N4, Herestraat 49 Leuven B‐3000 Belgium
- Venue
- Traffic
- Publisher
- Wiley
- Published
- 2012-02-17
- Volume
- 13
- Issue
- 6
- Pages
- 759-770
- ISSN
- 1398-9219
- 1600-0854
- Cited by
- 171
- References
- 18
- Language
- en
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