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Cited by 189Cell Adhesion Molecules ResearchDevelopmental Biology and Gene RegulationNeuroscience and Neuropharmacology Research

Protocadherins at the Crossroad of Signaling Pathways

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Pancho, Anna, Aerts, Tania, Mitsogiannis, Manuela D., Seuntjens, Eve·2020·Frontiers in Molecular Neuroscience
DOI 10.3389/fnmol.2020.00117PMC PMC7339444
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Abstract

Protocadherins (Pcdhs) are cell adhesion molecules that belong to the cadherin superfamily, and are subdivided into clustered (cPcdhs) and non-clustered Pcdhs (ncPcdhs) in vertebrates. In this review, we summarize their discovery, expression mechanisms, and roles in neuronal development and cancer, thereby highlighting the context-dependent nature of their actions. We furthermore provide an extensive overview of current structural knowledge, and its implications concerning extracellular interactions between cPcdhs, ncPcdhs, and classical cadherins. Next, we survey the known molecular action mechanisms of Pcdhs, emphasizing the regulatory functions of proteolytic processing and domain shedding. In addition, we outline the importance of Pcdh intracellular domains in the regulation of downstream signaling cascades, and we describe putative Pcdh interactions with intracellular molecules including components of the WAVE complex, the Wnt pathway, and apoptotic cascades. Our overview combines molecular interaction data from different contexts, such as neural development and cancer. This comprehensive approach reveals potential common Pcdh signaling hubs, and points out future directions for research. Functional studies of such key factors within the context of neural development might yield innovative insights into the molecular etiology of Pcdh-related neurodevelopmental disorders.

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200 of 292 shown

Cited by

Sorted by citations

Authors
Pancho, A., Aerts, T., Mitsogiannis, M. D., & Seuntjens, E.
Affiliations
KU Leuven (BE)
Corresponding author
Seuntjens, Eve
ORCID
Venue
Frontiers in Molecular Neuroscience
Publisher
Frontiers Media SA
Published
2020-06-30
Volume
13
Pages
117-117
ISSN
1662-5099 (ISSN-L)
DOI
10.3389/fnmol.2020.00117
PMC
PMC7339444
OpenAlex
W3038589694
Cited by
189
References
6
Citations by year
2026: 24 · 2025: 23 · 2024: 42 · 2023: 28 · 2022: 56 · 2021: 14 · 2020: 2
FWCI
3.43
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Molecular Neuroscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Lirias (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Fonds Wetenschappelijk Onderzoek (G0B5916N)
  • KU Leuven
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
protocadherins, clustered protocadherins, adhesion molecules, cadherin superfamily, neuronal development, cancer, proteolytic processing, cytoplasmic domain, WAVE complex, Wnt signaling, apoptosis, neurodevelopmental disorders, signaling pathways

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