Tumor-associated fibroblasts predominantly come from local and not circulating precursors

Fiji: an open-source platform for biological-image analysis

Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890 · see citing works

The distribution of secondary growths in cancer of the breast.

Paget, S. (1889) · The Lancet · doi:10.1016/s0140-6736(00)49915-0 · Cited by 5,277 · see citing works

Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC)

Stöckl, S., Göttl, C., Grifka, J. K., & Grässel, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350089 · Cited by 4,670 · see citing works

Fibroblasts in cancer

Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538 · see citing works

A perivascular origin for mesenchymal stem cells in multiple human organs

Crisan, M., Yap, S., Casteilla, L., Chen, C.-W., Corselli, M., Park, T. S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.003 · Cited by 3,991 · see citing works

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

Olive, K. P., Jacobetz, M. A., Davidson, C. J., Gopinathan, A., McIntyre, D., Honess, D., Madhu, B., Goldgraben, M. A., Caldwell, M. E., Allard, D., et al. (2009) · Science · doi:10.1126/science.1171362 · Cited by 3,170 · see citing works

Mesenchymal stem cells reside in virtually all post-natal organs and tissues

Meirelles, L. D. S., Chagastelles, P. C., & Nardi, N. B. (2006) · Journal of Cell Science · doi:10.1242/jcs.02932 · Cited by 2,472 · see citing works

Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma

Provenzano, P. P., Cuevas, C., Chang, A. E., Goel, V. K., Von Hoff, D. D., & Hingorani, S. R. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.01.007 · Cited by 2,195 · see citing works

‘The Ideal Mesh?'

Klinge, U., Park, J.-K., & Klosterhalfen, B. (2013) · Pathobiology · doi:10.1159/000348446 · Cited by 1,791 · see citing works

A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

Moser, A. R., Pitot, H. C., & Dove, W. F. (1990) · Science · doi:10.1126/science.2296722 · Cited by 1,591 · see citing works

Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors

De Palma, M., Venneri, M. A., Galli, R., Sergi, L. S., Politi, L. S., Sampaolesi, M., & Naldini, L. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.002 · Cited by 1,311 · see citing works

Circulating Fibrocytes Define a New Leukocyte Subpopulation That Mediates Tissue Repair

Bucala, R., Spiegel, L. A., Chesney, J. A., Hogan, M. M., & Cerami, A. (1994) · Molecular Medicine · doi:10.1007/bf03403533 · Cited by 1,307 · see citing works

Diversity, topographic differentiation, and positional memory in human fibroblasts

Chang, H. Y., Chi, J., Dudoit, S., Bondre, C., van de Rijn, M., Botstein, D., & Brown, P. O. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162488599 · Cited by 1,151 · see citing works

Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein–α

Kraman, M., Bambrough, P. J., Arnold, J. N., Roberts, E. W., Magiera, L., Jones, J. O., Gopinathan, A., Tuveson, D. A., & Fearon, D. T. (2010) · Science · doi:10.1126/science.1195300 · Cited by 1,134 · see citing works

Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis

Phillips, R. J., Burdick, M. D., Hong, K. M., Lutz, M., Murray, L. A., Xue, Y., Belperio, J. A., Keane, M. P., & Strieter, R. M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20997 · Cited by 1,071 · see citing works

Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth

Quante, M., Tu, S. P., Tomita, H., Gonda, T. A., Wang, S. S. W., Takashi, S., Baik, G. H., Shibata, W., DiPrete, B. L., Betz, K. S., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.01.020 · Cited by 1,047 · see citing works

Abnormalities in Pericytes on Blood Vessels and Endothelial Sprouts in Tumors

Morikawa, S., Bałuk, P., Kaidoh, T., Haskell, A., Jain, R. K., & McDonald, D. M. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64920-6 · Cited by 987 · see citing works

Peripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites

Abe, R., Donnelly, S. C., Peng, T., Bucala, R., & Metz, C. N. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7556 · Cited by 967 · see citing works

Physiological Migration of Hematopoietic Stem and Progenitor Cells

Wright, D. E., Wagers, A. J., Gulati, A. P., Johnson, F. L., & Weissman, I. L. (2001) · Science · doi:10.1126/science.1064081 · Cited by 933 · see citing works

Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts

Kojima, Y., Acar, A., Eaton, E. N., Mellody, K. T., Scheel, C., Ben‐Porath, I., Önder, T. T., Wang, Z. C., Richardson, A. L., Weinberg, R. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013805107 · Cited by 851 · see citing works

Mesenchymal Stem Cells: Potential Precursors for Tumor Stroma and Targeted-Delivery Vehicles for Anticancer Agents

Studeny, M., Marini, F. C., Dembinski, J. L., Zompetta, C., Cabreira-Hansen, M. D. G., Bekele, B. N., Champlin, R. E., & Andreeff, M. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh299 · Cited by 841 · see citing works

Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney

Lin, S., Kisseleva, T., Brenner, D. A., & Duffield, J. S. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080433 · Cited by 834 · see citing works

Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow

Morikawa, S., Mabuchi, Y., Kubota, Y., Nagai, Y., Niibe, K., Hiratsu, E., Suzuki, S., Miyauchi-Hara, C., Nagoshi, N., Sunabori, T., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091046 · Cited by 833 · see citing works

Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression

Spaeth, E. L., Dembinski, J. L., Sasser, A. K., Watson, K., Klopp, A., Hall, B., Andreeff, M., & Marini, F. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004992 · Cited by 807 · see citing works

Stromal myofibroblasts are drivers of invasive cancer growth

De Wever, O., Demetter, P., Mareel, M., & Bracke, M. (2008) · International Journal of Cancer · doi:10.1002/ijc.23925 · Cited by 722 · see citing works

All MSCs Are Pericytes?

Caplan, A. I. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.08.008 · Cited by 695 · see citing works

Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

Rinkevich, Y., Walmsley, G. G., Hu, M. S.-M., Maan, Z. N., Newman, A. M., Drukker, M., Januszyk, M., Krampitz, G. W., Gurtner, G. C., Lorenz, H. P., et al. (2015) · Science · doi:10.1126/science.aaa2151 · Cited by 695 · see citing works

Origins of tumor-associated macrophages and neutrophils

Cortez‐Retamozo, V., Etzrodt, M., Newton, A., Rauch, P. J., Chudnovskiy, A., Berger, C., Ryan, R. J. H., Iwamoto, Y., Marinelli, B. S., Gorbatov, R., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113744109 · Cited by 680 · see citing works

Adult bone marrow is a rich source of human mesenchymal ‘stem’ cells but umbilical cord and mobilized adult blood are not

Wexler, S., Donaldson, C., Denning‐Kendall, P. A., Rice, C. M., Bradley, B. A., & Hows, J. (2003) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.04284.x · Cited by 643 · see citing works

Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts

Direkze, N. C., Hodivala-Dilke, K., Jeffery, R., Hunt, T., Poulsom, R., Oukrif, D., Alison, M. R., & Wright, N. A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1708 · Cited by 530 · see citing works

Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth

Purhonen, S., Palm, J., Rossi, D. J., Kaskenpää, N., Rajantie, I., Ylä‐Herttuala, S., Alitalo, K. K., Weissman, I. L., & Salvén, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710516105 · Cited by 399 · see citing works

Stromal Antigen Targeting by a Humanised Monoclonal Antibody: An Early Phase II Trial of Sibrotuzumab in Patients with Metastatic Colorectal Cancer

Hofheinz, R., Al‐Batran, S., Hartmann, F., Hartung, G., Jäger, D., Renner, C., Tanswell, P., Kunz, U., Amelsberg, A., Kuthan, H., et al. (2003) · Oncology Research and Treatment · doi:10.1159/000069863 · Cited by 377 · see citing works

Human circulating CD14+ monocytes as a source of progenitors that exhibit mesenchymal cell differentiation

Kuwana, M., Okazaki, Y., Kodama, H., Izumi, K., Yasuoka, H., Ogawa, Y., Kawakami, Y., & Ikeda, Y. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0403170 · Cited by 301 · see citing works

Concise Review: Multipotent Mesenchymal Stromal Cells in Blood

He, Q., Wan, C., & Li, G. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0335 · Cited by 284 · see citing works

Phase II trial of single agent Val-boroPro (talabostat) inhibiting fibroblast activation protein in patients with metastatic colorectal cancer

Narra, K., Mullins, S., Lee, H.-O., Strzemkowski-Brun, B., Magalong, K., Christiansen, V. J., McKee, P. A., Egleston, B. L., Cohen, S. J., Weiner, L. M., et al. (2007) · Cancer Biology & Therapy · doi:10.4161/cbt.6.11.4874 · Cited by 276 · see citing works

Bystander elimination of antigen loss variants in established tumors

Spiotto, M. T., Rowley, D. A., & Schreiber, H. W. (2004) · Nature Medicine · doi:10.1038/nm999 · Cited by 260 · see citing works

WOUND HEALING AND COLLAGEN FORMATION

Ross, R., EVERETT, N. B., & Tyler, R. (1970) · The Journal of Cell Biology · doi:10.1083/jcb.44.3.645 · Cited by 258 · see citing works

A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations

Magness, S. T., Bataller, R. A., Yang, L., & Brenner, D. A. (2004) · Hepatology · doi:10.1002/hep.20427 · Cited by 246 · see citing works

Effective Immunoconjugate Therapy in Cancer Models Targeting a Serine Protease of Tumor Fibroblasts

Ostermann, E., Garin‐Chesa, P., Heider, K. H., Kalat, M., Lamche, H. R., Puri, C., Kerjaschki, D., Rettig, W. J., & Adolf, G. R. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-5211 · Cited by 246 · see citing works

Carcinoma‐associated fibroblasts: Non‐neoplastic tumour‐promoting mesenchymal cells

Polanska, U. M., & Orimo, A. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24347 · Cited by 208 · see citing works

DNase I-hypersensitive sites enhance α1(I) collagen gene expression in hepatic stellate cells

Yata, Y., Scanga, A. E., Gillan, A., Yang, L., Reif, S. S., Breindl, M., Brenner, D. A., & Rippe, R. A. (2003) · Hepatology · doi:10.1053/jhep.2003.50067 · Cited by 192 · see citing works

Endothelial???stromal interactions in angiogenesis

Hughes, C. C. W. (2008) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3282f97dbc · Cited by 184 · see citing works

Stroma is critical for preventing or permitting immunological destruction of antigenic cancer cells.

Singh, S., Ross, S. R., Acena, M., Rowley, D. A., & Schreiber, H. W. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.1.139 · Cited by 170 · see citing works

IFN-γ– and TNF-dependent bystander eradication of antigen-loss variants in established mouse cancers

Zhang, B., Karrison, T. G., Rowley, D. A., & Schreiber, H. W. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33522 · Cited by 167 · see citing works

IL-22 promotes fibroblast-mediated wound repair in the skin

McGee, H. M., Schmidt, B. A., Booth, C. J., Yancopoulos, G. D., Valenzuela, D. M., Murphy, A. J., Stevens, S., Flavell, R. A., & Horsley, V. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.463 · Cited by 161 · see citing works

The Immunodominant Antigen of an Ultraviolet-induced Regressor Tumor Is Generated by a Somatic Point Mutation in the DEAD Box Helicase p68

Dubey, P., Hendrickson, R. C., Meredith, S. C., Siegel, C., Shabanowitz, J., Skipper, J., Engelhard, V. H., Hunt, D. F., & Schreiber, H. W. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.4.695 · Cited by 146 · see citing works

Extracellular matrix deposition by fibroblasts is necessary to promote capillary‐like tube formation in vitro

Berthod, F., Germain, L., Tremblay, N. M., & Auger, F. A. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20584 · Cited by 145 · see citing works

A new approach to the therapy of cancer based on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2.

Rosenberg, S. A., Lotze, M. T., Muul, L. M., Leitman, S. F., Chang, A. E., Vetto, J. T., Seipp, C. A., & Simpson, C. (1986) · PubMed · Cited by 102 · see citing works

Bone Marrow–Derived Cells Do Not Contribute Significantly to Collagen I Synthesis in a Murine Model of Renal Fibrosis

Roufosse, C. A., Bou–Gharios, G., Prodromidi, E. I., Alexakis, C., Jeffery, R. E., Khan, S., Otto, W. R., Alter, J., Poulsom, R., & Cook, H. T. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005080795 · Cited by 94 · see citing works

Extracellular matrix metalloproteinase inducer/CD147 promotes myofibroblast differentiation by inducing α‐smooth muscle actin expression and collagen gel contraction: implications in tissue remodeling

Huet, E., Vallée, B., Szul, D., Verrecchia, F., Mourah, S., Jester, J. V., Hoang-Xuan, T., Ménashi, S., & GaMson, E. E. (2007) · The FASEB Journal · doi:10.1096/fj.07-8748com · Cited by 93 · see citing works

Phase II Trial of Talabostat and Docetaxel in Advanced Non-small Cell Lung Cancer

Eager, R., Cunningham, C. C., Senzer, N. N., Richards, D., Raju, R. N., Jones, B. N., Uprichard, M. J., & Nemunaitis, J. J. (2009) · Clinical Oncology · doi:10.1016/j.clon.2009.04.007 · Cited by 90 · see citing works

Hematopoietic origins of fibroblasts: I. In vivo studies of fibroblasts associated with solid tumors

LaRue, A. C., Masuya, M., Ebihara, Y., Fleming, P. A., Visconti, R. P., Minamiguchi, H., Ogawa, M., & Drake, C. J. (2006) · Experimental Hematology · doi:10.1016/j.exphem.2005.10.009 · Cited by 73 · see citing works

Evaluation of the tumor targeting of a FAPα-based doxorubicin prodrug

Huang, S., Fang, R. M., Xu, J., Qiu, S., Zhang, H., Du, J., & Cai, S. (2011) · Journal of drug targeting · doi:10.3109/1061186x.2010.511225 · Cited by 67 · see citing works

Fibroblasts/myofibroblasts that participate in cutaneous wound healing are not derived from circulating progenitor cells

Barisic‐Dujmovic, T., Boban, I., & Clark, S. H. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21997 · Cited by 65 · see citing works

The role played by the microenvironment in site-specific metastasis

Klein-Goldberg, A., Maman, S., & Witz, I. P. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.08.029 · Cited by 64 · see citing works

Mesenchymal Stem Cells Remain Host-Derived Independent of the Source of the Stem-Cell Graft and Conditioning Regimen Used

Bartsch, K., Al‐Ali, H. K., Reinhardt, A., Franke, C., Hudecek, M., Kamprad, M., Tschiedel, S., Cross, M. A., Niederwieser, D. W., & Gentilini, C. (2009) · Transplantation · doi:10.1097/tp.0b013e3181938998 · Cited by 58 · see citing works

Longitudinal confocal microscopy imaging of solid tumor destruction following adoptive T cell transfer

Schietinger, A., Arina, A., Liu, R. B., Wells, S., Huang, J., Engels, B., Bindokas, V. P., Bartkowiak, T., Lee, D. D., Herrmann, A., et al. (2013) · OncoImmunology · doi:10.4161/onci.26677 · Cited by 54 · see citing works

Mesenchymal stem cells obtained after bone marrow transplantation or peripheral blood stem cell transplantation originate from host tissue

Dickhut, A., Schwerdtfeger, R., Kuklick, L., Ritter, M., Thiede, C., Neubauer, A., & Brendel, C. A. (2005) · Annals of Hematology · doi:10.1007/s00277-005-1067-8 · Cited by 49 · see citing works

Bone Marrow Subsets Differentiate into Endothelial Cells and Pericytes Contributing to Ewing's Tumor Vessels

Reddy, K., Zhou, Z., Schadler, K., Jia, S.-F., & Kleinerman, E. S. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-2189 · Cited by 48 · see citing works

Gastrointestinal Fibroblasts Have Specialized, Diverse Transcriptional Phenotypes: A Comprehensive Gene Expression Analysis of Human Fibroblasts

Higuchi, Y., Kojima, M., Ishii, G., Aoyagi, K., Sasaki, H., & Ochiai, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129241 · Cited by 47 · see citing works

Tumor Rejection by Modulation of Tumor Stromal Fibroblasts

Schüler, T., Körnig, S., & Blankenstein, T. J. F. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030849 · Cited by 39 · see citing works

Stromal-Hematopoietic Interrelationships: Maximov’s Ideas and Modern Models

Friedenstein, A. J. (1989) · Hämatologie und Bluttransfusion · doi:10.1007/978-3-642-74621-5_27 · Cited by 37 · see citing works

Positional Identity of Murine Mesenchymal Stem Cells Resident in Different Organs Is Determined in the Postsegmentation Mesoderm

Sági, B., Maraghechi, P., Urbán, V. S., Hegyi, B., Szigeti, A., Fajka‐Boja, R., Kudlik, G., Német, K., Monostori, É., Gócza, E., et al. (2011) · Stem Cells and Development · doi:10.1089/scd.2011.0551 · Cited by 36 · see citing works

Differential Responses to Steroid Hormones in Fibroblasts From the Vocal Fold, Trachea, and Esophagus

Mukudai, S., Matsuda, K., Nishio, T., Sugiyama, Y., Bando, H., Hirota, R., Sakaguchi, H., Hisa, Y., & Kawata, M. (2014) · Endocrinology · doi:10.1210/en.2014-1605 · Cited by 36 · see citing works

The architecture of fibroblast monolayers of different origin differentially influences tumor cell growth

Flaberg, E., Guvén, H., Savchenko, A., Pavlova, T. V., Kashuba, V. I., Székely, L., & Klein, G. (2012) · International Journal of Cancer · doi:10.1002/ijc.27521 · Cited by 35 · see citing works

Evolutionary aspects of cancer resistance

Klein, G. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2014.01.001 · Cited by 32 · see citing works

Leçons sur la pathologie comparée de l'inflammation : faites à l'Institut Pasteur en Avril et Mai 1891

Mechnikov, I. I. (1892) · G. Masson eBooks · Cited by 31 · see citing works

Cystic fibrosis: production of high levels of uromodulin-like protein by HLA-DR blood monocytes differentiating towards a fibroblastic phenotype

Labat, M. L., Bringuier, A. F., Séébold-Choqueux, C., Moricard, Y., Rault, G., Jehanne, M., Ferrec, C., & MILHAUD, G. (1991) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(91)90003-c · Cited by 13 · see citing works

The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth

de Visser, K. E., & Joyce, J. A. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.016 · Cited by 4,059 · see citing works

A framework for advancing our understanding of cancer-associated fibroblasts

Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., et al. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0238-1 · Cited by 3,863 · see citing works

Crosstalk between cancer‐associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

Mao, X., Xu, J., Wang, W., Liang, C., Hua, J., Liu, J., Zhang, B., Meng, Q., Yu, X., & Shi, S. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01428-1 · Cited by 2,290 · see citing works

Diversity and biology of cancer-associated fibroblasts

Biffi, G., & Tuveson, D. A. (2021) · Physiological Reviews · doi:10.1152/physrev.00048.2019 · Cited by 1,265 · see citing works

Clinical and therapeutic relevance of cancer-associated fibroblasts

Chen, Y., McAndrews, K. M., & Kalluri, R. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00546-5 · Cited by 1,230 · see citing works

Targeting the tumour stroma to improve cancer therapy

Valkenburg, K. C., de Groot, A. E., & Pienta, K. J. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0007-1 · Cited by 1,084 · see citing works

The matrix in cancer

Cox, T. R. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-020-00329-7 · Cited by 989 · see citing works

Cancer-associated fibroblasts in gastrointestinal cancer

Kobayashi, H., Enomoto, A., Woods, S. L., Burt, A. D., Takahashi, M., & Worthley, D. L. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0115-0 · Cited by 596 · see citing works

Cancer-associated fibroblasts: from basic science to anticancer therapy

Yang, D., Liu, J., Qian, H., & Zhuang, Q. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01013-0 · Cited by 572 · see citing works

Fibroblast-macrophage reciprocal interactions in health, fibrosis, and cancer

Buechler, M. B., Fu, W., & Turley, S. J. (2021) · Immunity · doi:10.1016/j.immuni.2021.04.021 · Cited by 494 · see citing works

Fibroblasts in cancer: Unity in heterogeneity

Chhabra, Y., & Weeraratna, A. T. (2023) · Cell · doi:10.1016/j.cell.2023.03.016 · Cited by 488 · see citing works

Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials

Zhang, H., Yue, X., Chen, Z., Liu, C., Wu, W., Zhang, N., Liu, Z., Yang, L., Jiang, Q., Cheng, Q., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01860-5 · Cited by 435 · see citing works

CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer

Pereira, B., Vennin, C., Papanicolaou, M., Chambers, C. R., Herrmann, D., Morton, J. P., Cox, T. R., & Timpson, P. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.09.010 · Cited by 309 · see citing works

Signaling pathways in cancer‐associated fibroblasts: recent advances and future perspectives

Fang, Z., Meng, Q., Xu, J., Wang, W., Zhang, B., Liu, J., Liang, C., Hua, J., Zhao, Y., Yu, X., et al. (2022) · 癌症：英文版 · doi:10.1002/cac2.12392 · Cited by 292 · see citing works

Bone marrow–derived fibroblasts are a functionally distinct stromal cell population in breast cancer

Raz, Y., Cohen, N., Shani, O., Bell, R. E., Novitskiy, S. V., Abramovitz, L., Levy, C., Milyavsky, M., Leider–Trejo, L., Moses, H. L., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20180818 · Cited by 270 · see citing works

Host tissue determinants of tumour immunity

Salmon, H., Remark, R., Gnjatic, S., & Mérad, M. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0125-9 · Cited by 258 · see citing works

The Role of Cancer-Associated Fibroblasts in Cancer Invasion and Metastasis

Asif, P. J., Longobardi, C., Hahne, M., & Medema, J. P. (2021) · Cancers · doi:10.3390/cancers13184720 · Cited by 245 · see citing works

Radiotherapy and Immunotherapy for Cancer: From “Systemic” to “Multisite”

Arina, A., Gutiontov, S. I., & Weichselbaum, R. R. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-2034 · Cited by 234 · see citing works

Tumor-reprogrammed resident T cells resist radiation to control tumors

Arina, A., Beckett, M. A., Fernandez, C., Zheng, W., Pitroda, S. P., Chmura, S. J., Luke, J. J., Forde, M., Hou, Y., Burnette, B., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11906-2 · Cited by 231 · see citing works

Epithelial‐to‐mesenchymal transition in oral squamous cell carcinoma: Challenges and opportunities

Ling, Z., Cheng, B., & Tao, X. (2020) · International Journal of Cancer · doi:10.1002/ijc.33352 · Cited by 228 · see citing works

The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis

Kobayashi, H., Gieniec, K. A., Lannagan, T. R. M., Wang, T., Asai, N., Mizutani, Y., Iida, T., Ando, R., Thomas, E. M., Sakai, A., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.11.037 · Cited by 214 · see citing works

FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors

Cremasco, V., Astarita, J. L., Grauel, A. L., Keerthivasan, S., MacIsaac, K. D., Woodruff, M. C., Wu, M. P., Spel, L., Santoro, S. P., Amoozgar, Z., et al. (2018) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0098 · Cited by 208 · see citing works

NK cells and solid tumors: therapeutic potential and persisting obstacles

Tong, L., Jiménez‐Cortegana, C., Tay, A. H. M., Wickström, S. L., Galluzzi, L., & Lundqvist, A. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01672-z · Cited by 193 · see citing works

Tumor Abnormality-Oriented Nanomedicine Design

Zhou, Q., Xiang, J., Qiu, N., Wang, Y., Piao, Y., Shao, S., Tang, J., Zhou, Z., & Shen, Y. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00062 · Cited by 194 · see citing works

A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression

Verginadis, I., Avgousti, H., Monslow, J., Skoufos, G., Chinga, F., Kim, K., Leli, N., Karagounis, I. V., Bell, B., Velalopoulou, A., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00918-8 · Cited by 167 · see citing works

The Role of Cancer-Associated Fibroblasts in Prostate Cancer Tumorigenesis

Bonollo, F., Thalmann, G. N., Julio, M. K., & Karkampouna, S. (2020) · Cancers · doi:10.3390/cancers12071887 · Cited by 169 · see citing works

Targeting Cancer Associated Fibroblasts in Liver Fibrosis and Liver Cancer Using Nanocarriers

Kaps, L., & Schuppan, D. (2020) · Cells · doi:10.3390/cells9092027 · Cited by 156 · see citing works

Cancer-Associated Fibroblasts and Tumor-Associated Macrophages in Cancer and Cancer Immunotherapy

Raskov, H., Orhan, A., Gaggar, S., & Gögenur, I. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.668731 · Cited by 150 · see citing works

Epidemiology and biology of relapse after stem cell transplantation

Horowitz, M. M., Schreiber, H. W., Elder, A., Heidenreich, O. T., Vormoor, J. H., Toffalori, C., Vago, L., & Kröger, N. M. (2018) · Bone Marrow Transplantation · doi:10.1038/s41409-018-0171-z · Cited by 150 · see citing works

Cancer-associated fibroblasts: how do they contribute to metastasis?

Kwa, M. Q., Herum, K. M., & Brakebusch, C. (2019) · Clinical & Experimental Metastasis · doi:10.1007/s10585-019-09959-0 · Cited by 144 · see citing works

Localization, tissue biology and T cell state — implications for cancer immunotherapy

Schenkel, J. M., & Pauken, K. E. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00884-8 · Cited by 139 · see citing works

The heterogeneity of cancer‐associated fibroblast subpopulations: Their origins, biomarkers, and roles in the tumor microenvironment

Yamamoto, Y., Kasashima, H., Fukui, Y., Tsujio, G., Yashiro, M., & Maeda, K. (2022) · Cancer Science · doi:10.1111/cas.15609 · Cited by 138 · see citing works

Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth

Yao, M., Ventura, P. B., Jiang, Y., Rodriguez, F. J., Wang, L., Perry, J. S. A., Yang, Y., Wahl, K., Crittenden, R. B., Bennett, M. L., et al. (2020) · Cell · doi:10.1016/j.cell.2019.12.024 · Cited by 132 · see citing works

Roles of the CXCL8-CXCR1/2 Axis in the Tumor Microenvironment and Immunotherapy

Han, Z., Li, Y.-B., Yang, L., Cheng, H., Liu, X., & Chen, H. (2021) · Molecules · doi:10.3390/molecules27010137 · Cited by 138 · see citing works

CAFs orchestrates tumor immune microenvironment—A new target in cancer therapy?

Zhang, C., Fei, Y., Wang, H., Hu, S., Liu, C., Hu, R., & Du, Q. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1113378 · Cited by 129 · see citing works

Cancer-Associated Fibroblasts: Versatile Players in the Tumor Microenvironment

Ganguly, D., Chandra, R., Karalis, J. D., Teke, M. E., Aguilera, T. A., Maddipati, R., Wachsmann, M., Ghersi, D., Siravegna, G., Zeh, H. J., et al. (2020) · Cancers · doi:10.3390/cancers12092652 · Cited by 122 · see citing works

A short field guide to fibroblast function in immunity

Buechler, M. B., & Turley, S. J. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2017.11.001 · Cited by 121 · see citing works

Cancer-associated fibroblasts: Vital suppressors of the immune response in the tumor microenvironment

Xiang, X., Niu, Y., Wang, Z.-H., Ye, L., Peng, W., & Zhou, Q. (2022) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2022.07.006 · Cited by 120 · see citing works

TGFβ pathway inhibition in the treatment of non-small cell lung cancer

Eser, P. Ö., & Janne, P. A. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.11.004 · Cited by 116 · see citing works

Epithelial and stromal co-evolution and complicity in pancreatic cancer

Hingorani, S. R. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-022-00530-w · Cited by 108 · see citing works

Cancer‐associated fibroblasts: Secretions, interactions, and therapy

Farhood, B., Najafi, M., & Mortezaee, K. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27703 · Cited by 109 · see citing works

Altered p53 functionality in cancer-associated fibroblasts contributes to their cancer-supporting features

Arandkar, S., Furth, N., Elisha, Y., Nataraj, N. B., van der Kuip, H., Yarden, Y., Aulitzky, W. E., Ulitsky, I., Geiger, B., & Oren, M. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1719076115 · Cited by 111 · see citing works

Ovarian cancer cell-derived lysophosphatidic acid induces glycolytic shift and cancer-associated fibroblast-phenotype in normal and peritumoral fibroblasts

Radhakrishnan, R., Ha, J. H., Jayaraman, M., Liu, J., Moxley, K. M., Isidoro, C., Sood, A. K., Song, Y. S., & Dhanasekaran, D. N. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.11.023 · Cited by 108 · see citing works

The dynamic roles of the bladder tumour microenvironment

Lee, Y., Lam, H., Rosser, C. J., Theodorescu, D., Parks, W. C., & Chan, K. S. (2022) · Nature Reviews Urology · doi:10.1038/s41585-022-00608-y · Cited by 108 · see citing works

Strategies to address key challenges of metallacycle/metallacage-based supramolecular coordination complexes in biomedical applications

Xu, D., Li, Y., Yin, S., & Huang, F. (2024) · Chemical Society Reviews · doi:10.1039/d3cs00926b · Cited by 108 · see citing works

Stroma Involvement in Pancreatic Ductal Adenocarcinoma: An Overview Focusing on Extracellular Matrix Proteins

Liot, S., Balas, J., Aubert, A., Prigent, L., Mercier‐Gouy, P., Verrier, B., Bertolino, P., Hennino, A., Valcourt, U., & Lambert, E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.612271 · Cited by 106 · see citing works

Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma therapy: Challenges and opportunities

Qin, Q., Yu, R., Eriksson, J., Tsai, H., & Zhu, H. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216859 · Cited by 97 · see citing works

Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma: An Update on Heterogeneity and Therapeutic Targeting

Vaish, U., Jain, T., Are, A. C., & Dudeja, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413408 · Cited by 94 · see citing works

Impaired function of dendritic cells within the tumor microenvironment

Xiao, Z., Wang, R., Wang, X., Yang, H., Dong, J.-M., He, X., Yang, Y., Guo, J., Cui, J., & Zhou, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1213629 · Cited by 101 · see citing works

Epigenetic Control of the Tumor Microenvironment

Marks, D. L., Olson, R. L., & Fernández-Zapico, M. E. (2016) · Epigenomics · doi:10.2217/epi-2016-0110 · Cited by 91 · see citing works

Photoacoustic imaging as a tool to probe the tumour microenvironment

Brown, E. L., Brunker, J., & Bohndiek, S. E. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.039636 · Cited by 88 · see citing works

Functional diversity of cancer‐associated fibroblasts in modulating drug resistance

Bu, L., Baba, H., Yasuda, T., Uchihara, T., & Ishimoto, T. (2020) · Cancer Science · doi:10.1111/cas.14578 · Cited by 85 · see citing works

Dangerous Liaisons: Circulating Tumor Cells (CTCs) and Cancer-Associated Fibroblasts (CAFs)

Hurtado, P., Martínez-Peña, I., & Piñeiro, R. (2020) · Cancers · doi:10.3390/cancers12102861 · Cited by 75 · see citing works

Modeling pancreatic cancer in mice for experimental therapeutics

Mallya, K. B., Gautam, S. K., Aithal, A., Batra, S. K., & Jain, M. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188554 · Cited by 83 · see citing works

Inhibition of Nox4‐dependent ROS signaling attenuates prostate fibroblast activation and abrogates stromal‐mediated protumorigenic interactions

Sampson, N., Brunner, E., Weber, A., Puhr, M., Schäfer, G., Szyndralewiez, C., & Klocker, H. (2018) · International Journal of Cancer · doi:10.1002/ijc.31316 · Cited by 81 · see citing works

A 3D View of Colorectal Cancer Models in Predicting Therapeutic Responses and Resistance

Reidy, E., Leonard, N. A., Treacy, O., & Ryan, A. E. (2021) · Cancers · doi:10.3390/cancers13020227 · Cited by 81 · see citing works

Cancer-Associated Fibroblast Heterogeneity: A Factor That Cannot Be Ignored in Immune Microenvironment Remodeling

Chen, P., Wei, W.-F., Wu, H.-Z., Fan, L., & Wang, W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.671595 · Cited by 78 · see citing works

The Extracellular Matrix: A Key Accomplice of Cancer Stem Cell Migration, Metastasis Formation, and Drug Resistance in PDAC

Wang, D., Li, Y., Ge, H., Ghadban, T., Reeh, M., & Güngör, C. (2022) · Cancers · doi:10.3390/cancers14163998 · Cited by 77 · see citing works

Cancer-associated fibroblasts and its derived exosomes: a new perspective for reshaping the tumor microenvironment

Peng, Z., Tong, Z., Ren, Z., Ye, M.-P., & Hu, K.-W. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00665-y · Cited by 74 · see citing works

Cancer‐associated fibroblasts in nonsmall cell lung cancer: From molecular mechanisms to clinical implications

Wong, K.-Y., Cheung, A., Chen, B.-N., Chan, W.-N., Yu, J., Lo, K.-W., Kang, W., & To, K.-F. (2022) · International Journal of Cancer · doi:10.1002/ijc.34127 · Cited by 70 · see citing works

Cancer immune exclusion: breaking the barricade for a successful immunotherapy

Bruni, S., Mercogliano, M. F., Mauro, F. L., Russo, R. I. C., & Schillaci, R. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1135456 · Cited by 66 · see citing works

The role of cancer-associated fibroblasts in renal cell carcinoma. An example of tumor modulation through tumor/non-tumor cell interactions

Errarte, P., Larrinaga, G., & Lopez, J. I. (2019) · Journal of Advanced Research · doi:10.1016/j.jare.2019.09.004 · Cited by 60 · see citing works

Role of the tumor microenvironment in cancer hallmarks and targeted therapy (Review)

Naser, R., Fakhoury, I., El‑Fouani, A., Abi‑Habib, R., & El‑Sibai, M. (2022) · International Journal of Oncology · doi:10.3892/ijo.2022.5471 · Cited by 61 · see citing works

Fibrocytes and fibroblasts—Where are we now

Chong, S. G., Sato, S., Kolb, M. R. J., & Gauldie, J. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.105595 · Cited by 61 · see citing works

Targeting Vascular Endothelial-Cadherin in Tumor-Associated Blood Vessels Promotes T-cell–Mediated Immunotherapy

Zhao, Y., Ting, K. K., Li, J., Cogger, V. C., Chen, J., Johansson, A., Ngiow, S. F., Holst, J., Grau, G. E., Goel, S., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3129 · Cited by 61 · see citing works

Heterogeneity, crosstalk, and targeting of cancer-associated fibroblasts in cholangiocarcinoma

Vilà, P. C., Ravichandra, A., Lizaso, A. A., Perugorria, M. J., & Affò, S. (2023) · Hepatology · doi:10.1097/hep.0000000000000206 · Cited by 59 · see citing works

Chemotherapy-induced metastasis: molecular mechanisms and clinical therapies

Su, J., Li, S.-J., Zhou, X., Zhang, Z.-J., Yan, Y., Liu, S.-L., & Qi, Q. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01093-8 · Cited by 52 · see citing works

Fight the Cancer, Hit the CAF!

Papait, A., Romoli, J., Stefani, F. R., Chiodelli, P., Montresor, M. C., Agoni, L., Silini, A. R., & Parolini, O. (2022) · Cancers · doi:10.3390/cancers14153570 · Cited by 55 · see citing works

Cancer-associated fibroblasts: tumor defenders in radiation therapy

Zhang, Y., Lv, N., Li, M., Liu, M., & Wu, C. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06060-z · Cited by 52 · see citing works

Origin of cancer-associated fibroblasts and tumor-associated macrophages in humans after sex-mismatched bone marrow transplantation

Kurashige, M., Kohara, M., Ohshima, K., Tahara, S., Hori, Y., Nojima, S., Wada, N., Ikeda, J., Miyamura, K., Ito, M., et al. (2018) · Communications Biology · doi:10.1038/s42003-018-0137-0 · Cited by 51 · see citing works

The Multifaceted Roles of MSCs in the Tumor Microenvironment: Interactions With Immune Cells and Exploitation for Therapy

Papait, A., Stefani, F. R., Cargnoni, A., Magatti, M., Parolini, O., & Silini, A. R. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00447 · Cited by 52 · see citing works

Inflammatory Role of Cancer-Associated Fibroblasts in Invasive Breast Tumors Revealed Using a Fibrous Polymer Scaffold

Balachander, G. M., Talukdar, P. M., Debnath, M., Rangarajan, A., & Chatterjee, K. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b07609 · Cited by 49 · see citing works

PARP inhibitors promote stromal fibroblast activation by enhancing CCL5 autocrine signaling in ovarian cancer

Li, X., Fang, T., Xu, S., Jin, P., Zhou, D., Wang, Z., Li, H., Yang, Z., Chen, G., Xu, Z., et al. (2021) · npj Precision Oncology · doi:10.1038/s41698-021-00189-w · Cited by 46 · see citing works

The Heterogeneity of the Tumor Microenvironment as Essential Determinant of Development, Progression and Therapy Response of Pancreatic Cancer

Group Young Researchers in Inflammatory Carcinogenesis, Wandmacher, A. M., Mehdorn, A., & Sebens, S. (2021) · Cancers · doi:10.3390/cancers13194932 · Cited by 44 · see citing works

Fibroblast diversity and plasticity in the tumor microenvironment: roles in immunity and relevant therapies

Xu, Y., Li, W., Lin, S., Liu, B., Wu, P., & Li, L. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01204-2 · Cited by 45 · see citing works

Single-cell and bulk RNA-sequence identified fibroblasts signature and CD8 + T-cell - fibroblast subtype predicting prognosis and immune therapeutic response of bladder cancer, based on machine learning: bioinformatics multi-omics study

Li, J., Kong, Z., Qi, Y., Wang, W., Su, Q., Huang, W., Zhang, Z., Li, S., & Du, E. (2024) · International Journal of Surgery · doi:10.1097/js9.0000000000001516 · Cited by 45 · see citing works

A glitch in the matrix: organ-specific matrisomes in metastatic niches

Deasy, S. K., & Erez, N. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.08.001 · Cited by 44 · see citing works

Lorazepam Stimulates IL6 Production and Is Associated with Poor Survival Outcomes in Pancreatic Cancer

Cornwell, A. C., Tisdale, A. A., Venkat, S., Maraszek, K. E., Alahmari, A. A., George, A. M., Attwood, K. M., George, M., Rempinski, D., Franco‐Barraza, J., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-0547 · Cited by 42 · see citing works

Metastasis-associated fibroblasts in peritoneal surface malignancies

Ramos, C., Gerakopoulos, V., & Oehler, R. (2024) · British Journal of Cancer · doi:10.1038/s41416-024-02717-4 · Cited by 42 · see citing works

Tumor Microenvironment of Esophageal Cancer

Schiffmann, L. M., Plum, P. S., Fuchs, H. F., Babic, B., Bruns, C. J., & Schmidt, T. (2021) · Cancers · doi:10.3390/cancers13184678 · Cited by 42 · see citing works

Important Cells and Factors from Tumor Microenvironment Participated in Perineural Invasion

Chen, Z.-R., Fang, Y., & Jiang, W.-H. (2023) · Cancers · doi:10.3390/cancers15051360 · Cited by 42 · see citing works

Targeting the devil: Strategies against cancer-associated fibroblasts in colorectal cancer

Chen, Y., Liang, Z., & Lai, M. (2024) · Translational research · doi:10.1016/j.trsl.2024.04.003 · Cited by 41 · see citing works

A Quick Guide to CAF Subtypes in Pancreatic Cancer

Brichkina, A. I., Polo, P., Sharma, S. D., Visestamkul, N., & Lauth, M. (2023) · Cancers · doi:10.3390/cancers15092614 · Cited by 40 · see citing works

The role of cancer-associated fibroblasts in breast cancer metastasis

Li, Y., Wang, C., Huang, T. H., Yu, X., & Tian, B. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1194835 · Cited by 40 · see citing works

Fibroblast heterogeneity in prostate carcinogenesis

ChallaSivaKanaka, S., Vickman, R. E., Kakarla, M., Hayward, S. W., & Franco, O. E. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.10.028 · Cited by 39 · see citing works

Mucin 5AC–Mediated CD44/ITGB1 Clustering Mobilizes Adipose-Derived Mesenchymal Stem Cells to Modulate Pancreatic Cancer Stromal Heterogeneity

Ganguly, K., Cox, J. L., Ghersi, D., Grandgenett, P. M., Hollingsworth, M. A., Jain, M., Sushil Kumar, K., & Batra, S. K. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.02.032 · Cited by 39 · see citing works

The Origin, Differentiation, and Functions of Cancer-Associated Fibroblasts in Gastrointestinal Cancer

Huang, J., Tsang, W. Y., Li, Z., & Guan, X. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.07.001 · Cited by 40 · see citing works

Cancer-associated fibroblasts in the tumor microenvironment: heterogeneity, crosstalk mechanisms, and therapeutic implications

Huang, Z., Chen, J., Zhu, T., Li, J., Ng, H. Y., Zhou, Y., Gu, X., Xu, S., & Jia, R. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02533-1 · Cited by 45 · see citing works

Increased PD-L1 expression and IL-6 secretion characterize human lung tumor-derived perivascular-like cells that promote vascular leakage in a perfusable microvasculature model

Bichsel, C. A., Wang, L., Froment, L., Berezowska, S., Müller, S. K., Dorn, P., Marti, T. M., Peng, R., Geiser, T., Schmid, R. A., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-09928-1 · Cited by 38 · see citing works

Targeting INHBA in Ovarian Cancer Cells Suppresses Cancer Xenograft Growth by Attenuating Stromal Fibroblast Activation

Li, X., Yang, Z., Xu, S., Wang, Z., Jin, P., Yang, X., Zhang, Z., Wang, Y., Xiao, W., Fang, T., et al. (2019) · Disease Markers · doi:10.1155/2019/7275289 · Cited by 37 · see citing works

Cancer-Associated Fibroblast Diversity Shapes Tumor Metabolism in Pancreatic Cancer

Peiffer, R., Boumahd, Y., Gullo, C., Crake, R., Letellier, E., Bellahcène, A., & Peulen, O. (2022) · Cancers · doi:10.3390/cancers15010061 · Cited by 37 · see citing works

Cancer-associated fibroblasts in radiotherapy: Bystanders or protagonists?

Martínez-Zubiaurre, I., & Hellevik, T. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01093-5 · Cited by 36 · see citing works

Cross-Talk Between Cancer and Its Cellular Environment—A Role in Cancer Progression

Turlej, E., Domaradzka, A., Radzka, J., Drulis‐Fajdasz, D., Kulbacka, J., & Gizak, A. (2025) · Cells · doi:10.3390/cells14060403 · Cited by 42 · see citing works

Exosomes: a double‐edged sword in cancer immunotherapy

Chen, J., Hu, S., Liu, J., Jiang, H., Wang, S., & Yang, Z. (2025) · MedComm · doi:10.1002/mco2.70095 · Cited by 35 · see citing works

The Tango between Cancer-Associated Fibroblasts (CAFs) and Immune Cells in Affecting Immunotherapy Efficacy in Pancreatic Cancer

Stouten, I., van Montfoort, N., & Hawinkels, L. J. A. C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108707 · Cited by 34 · see citing works

Ovarian stromal cells as a source of cancer-associated fibroblasts in human epithelial ovarian cancer: A histopathological study

Fujisawa, M., Moh-Moh-Aung, A., Zeng, Z., Yoshimura, T., Wani, Y., & Matsukawa, A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205494 · Cited by 32 · see citing works

METTL3 in cancer-associated fibroblasts-derived exosomes promotes the proliferation and metastasis and suppresses ferroptosis in colorectal cancer by eliciting ACSL3 m6A modification

Ren, H., Wang, M., Ma, X., An, L., Guo, Y., & Ma, H. (2024) · Biology Direct · doi:10.1186/s13062-024-00511-z · Cited by 31 · see citing works

Emergence of Cancer-Associated Fibroblasts as an Indispensable Cellular Player in Bone Metastasis Process

Mukaida, N., Zhang, D., & Sasaki, S. (2020) · Cancers · doi:10.3390/cancers12102896 · Cited by 31 · see citing works

Enhancer reprogramming promotes the activation of cancer-associated fibroblasts and breast cancer metastasis

Li, Q., Lv, X., Han, C., Kong, Y., Dai, Z., Huo, D., Li, T., Li, D., Li, W., Wang, X., et al. (2022) · Theranostics · doi:10.7150/thno.75853 · Cited by 30 · see citing works

Expression of EMT-Related Genes in Hybrid E/M Colorectal Cancer Cells Determines Fibroblast Activation and Collagen Remodeling

Николаевна, Д. И., Shirmanova, M. V., Ignatova, N. I., Dudenkova, V. V., Lukina, M. M., Вадимовна, З. Е., Safina, D. R., Kostrov, S. V., Didych, D. A., Kuzmich, A. I., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218119 · Cited by 30 · see citing works

Do Carcinoma-Associated Fibroblasts Adjacent to Breast Cancer Cells Originate from Circulating Mesenchymal Stem Cells?

Haviv, I. (2007) · Defense Technical Information Center (DTIC)

Bone marrow cells as precursors of the tumor stroma

Worthley, D. L., Si, Y., Quante, M., Churchill, M., Mukherjee, S., & Wang, T. C. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.03.006 · Cited by 28 · see citing works

Fibroblasts in the Tumor Microenvironment

Truffi, M., Sorrentino, L., & Corsi, F. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-37184-5_2 · Cited by 134 · see citing works

A cancer stem cell model as the point of origin of cancer-associated fibroblasts in tumor microenvironment

Nair, N., Calle, A. S., Zahra, M. H., Prieto‐Vila, M., Oo, A. K. K., Hurley, L. C., Vaidyanath, A., Seno, A., Masuda, J., Iwasaki, Y., et al. (2017) · PMC · doi:10.60692/mv0pa-gdt34 · Cited by 4 · see citing works

Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts

Direkze, N. C., Hodivala-Dilke, K., Jeffery, R., Hunt, T., Poulsom, R., Oukrif, D., Alison, M. R., & Wright, N. A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1708 · Cited by 530 · see citing works