Dietary resveratrol alters lipid metabolism-related gene expression of mice on an atherogenic diet
Abstract
Background/aims Resveratrol, a polyphenolic activator of the silent information regulation 2 homolog 1 (SIRT1), is known to extend lifespan and improve metabolic disease. The aim of the present study is to test whether resveratrol protects against metabolic steatohepatitis through the modulation of lipid metabolism-related genes.Methods We used a mouse model in which steatohepatitis can be induced by an atherogenic diet (Ath diet) to evaluate the effects of resveratrol on steatotic hepatitis and hepatic gene expression.Results The Ath diet induced excessive weight gain, hepatomegaly, dyslipidemia, and steatohepatitis after 8 weeks. The addition of resveratrol protected against Ath diet-induced changes and also alleviated steatohepatitis. Whole-genome expression analysis revealed that an Ath diet altered the hepatic expression of genes involved in lipid metabolism, and the addition of resveratrol to the diet reversed that effect. Real-time PCR and Western blot analysis confirmed the Ath diet up-regulated the levels of genes related to lipogenesis and down-regulated genes involved in lipolysis. Resveratrol clearly suppressed the Ath diet-induced alterations of the expression of genes related to lipid metabolism.Conclusions Resveratrol ameliorated dyslipidemia and steatohepatitis induced by the Ath diet, and its beneficial effects were associated with the altered expression of hepatic genes involved in lipid metabolism.
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Resveratrol reduces hepatic lipid synthesis in rats.
“Consistent with data in rats, where resveratrol has been shown to reduce hepatic lipid synthesis (Ahn et al., 2008; Arichi et al., 1982), we observed reduced IHL content.”
From Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans (2011) · cites this paper as Ahn et al., 2008
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- Authors
- Ahn, J., Cho, I., Kim, S., Kwon, D., & Ha, T.
- Affiliations
- Korea Food Research Institute (KR)
- ORCID
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 49
- Issue
- 6
- Pages
- 1019-1028
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W1988128873
- Cited by
- 173
- References
- 43
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 11 · 2021: 7 · 2020: 10 · 2019: 7 · 2018: 12 · 2017: 15 · 2016: 10 · 2015: 15 · 2014: 14 · 2013: 16 · 2012: 17
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Rural Development Administration
- Korea Science and Engineering Foundation
- Korea Food Research Institute
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- resveratrol, SIRT1, steatohepatitis, atherogenic diet, lipid metabolism, hepatic gene expression, lipogenesis, lipolysis, dyslipidemia, hepatomegaly, polyphenols, metabolic steatohepatitis
- MeSH terms
- Resveratrol, Animals, Antioxidants, Body Weight, Diet, Atherogenic, Eating, Fatty Liver, Lipids, Liver, Male, Mice, Inbred C57BL, Organ Size, Stilbenes, Gene Expression, Oligonucleotide Array Sequence Analysis, Lipid Metabolism, Mice
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