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Cited by 85Neonatal and fetal brain pathologyInfant Development and Preterm CareNeurogenesis and neuroplasticity mechanisms

Interneuron Development Is Disrupted in Preterm Brains With Diffuse White Matter Injury: Observations in Mouse and Human

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Stolp, Helen B., Fleiss, Bobbi, Arai, Yoko, Supramaniam, Veena, Vontell, Regina, Birtles, Sebastian, Yates, Abi G., Baburamani, Ana A. +4 more·2019·Frontiers in Physiology
DOI 10.3389/fphys.2019.00955PMC PMC6683859
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Abstract

Preterm brain injury, occurring in approximately 30% of infants born <32 weeks gestational age, is associated with an increased risk of neurodevelopmental disorders, such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). The mechanism of grey matter injury in preterm born children is unclear and likely to be multifactorial, however inflammation, a high predictor of poor outcome in preterm infants, has been associated with disrupted interneuron maturation in a number of animal models. Interneurons are important for regulating normal brain development, and disruption in interneuron development, and the downstream effects of this, has been implicated in the aetiology of neurodevelopmental disorders. Here we utilise post-mortem tissue from human preterm cases with) or without diffuse white matter injury (WMI; PMA range: 23+2 to 28+1 for non-WMI group, 26+6 to 30+0 for WMI group, p=0.002), and a model of inflammation-induced preterm diffuse white matter injury (i.p. IL-1β, b.d., 10µg/kg/injection in male CD1 mice from P1-5). Data from human preterm infants show deficits in interneuron numbers in the cortex and delayed development of neuronal arbours at this early stage of development. In the mouse, significant reduction in the number of parvalbumin positive interneurons was observed from postnatal day (P) 10. This decrease in parvalbumin neuron number was largely rectified by P40, though there was a significantly smaller number of parvalbumin positive cells associated with perineuronal nets in the upper cortical layers. Together, these data suggest that inflammation in the preterm brain may be a contributor to injury of specific interneuron in the cortical grey matter. This may represent a potential target for postnatal therapy to reduce the incidence and/or severity of neurodevelopmental disorders in preterm infants.

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  • PNN has an indirect role over principal neurons via regulating synaptic plasticity and dendritic arborization of the interneuron.

    “PNN has an indirect role over principal neurons via regulating synaptic plasticity (Sigal et al., 2019) and dendritic arborization (Stolp et al., 2019) of the interneuron.”

    From Disrupted structural connectivity in ArcAβ mouse model of Aβ amyloidosis (2020) · cites this paper as Stolp et al., 2019

    The Discussion suggests that changes involving perineuronal nets and parvalbumin interneurons may affect pyramidal-neuron function indirectly. But Stolp et al. do not show that perineuronal nets regulate interneuron dendritic arborization; the Results report no significant difference in the dendritic arborization of the cortical neurons examined at P40. The Stolp citation is attached specifically to the arborization part of the citing sentence. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Stolp, H. B., Fleiss, B., Arai, Y., Supramaniam, V., Vontell, R., Birtles, S., Yates, A. G., Baburamani, A. A., Thornton, C., Rutherford, M., Edwards, A. D., & Gressens, P.
Affiliations
  • Royal Veterinary College (GB)
  • Inserm (FR)
  • King's College London (GB)
  • University of Miami (US)
Corresponding author
Stolp, Helen B.
ORCID
Venue
Frontiers in Physiology
Publisher
Frontiers Media SA
Published
2019-07-30
Volume
10
Pages
955-955
ISSN
1664-042X (ISSN-L)
DOI
10.3389/fphys.2019.00955
PMC
PMC6683859
OpenAlex
W2956435356
Cited by
85
References
12
Citations by year
2026: 13 · 2025: 9 · 2024: 12 · 2023: 11 · 2022: 10 · 2021: 16 · 2020: 12 · 2019: 2
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10.40
Type
journal article
Language
en
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  • Frontiers in Physiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RVC Research Online (Royal Veterinary College) (submittedVersion, cc-by)
  • RMIT Research Repository (RMIT University Library) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • Research Portal (King's College London) (submittedVersion, cc-by)
Funders
  • Medical Research Council (MR/K006355/1)
  • Fondation Roger de Spoelberch
  • National Institute for Health Research (NIHR)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
preterm brain injury, interneuron development, parvalbumin interneurons, neuroinflammation, IL-1β, cortical gray matter, perineuronal nets, neurodevelopmental disorders, autism spectrum disorder, attention deficit hyperactivity disorder

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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