The temporal and spatial origins of cortical interneurons predict their physiological subtype
Open accessAbstract
Interneurons of the cerebral cortex represent a heterogeneous population of cells with important roles in network function. At present, little is known about how these neurons are specified in the developing telencephalon. To explore whether this diversity is established in the early progenitor populations, we conducted in utero fate-mapping of the mouse medial and caudal ganglionic eminences (MGE and CGE, respectively), from which most cortical interneurons arise. Mature interneuron subtypes were assessed by electrophysiological and immunological analysis, as well as by morphological reconstruction. At E13.5, the MGE gives rise to fast-spiking (FS) interneurons, whereas the CGE generates predominantly regular-spiking interneurons (RSNP). Later at E15.5, the CGE produces RSNP classes distinct from those generated from the E13.5 CGE. Thus, we provide evidence that the spatial and temporal origin of interneuron precursors in the developing telencephalic eminences predicts the intrinsic physiological properties of mature interneurons.
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The CGE produces all VIP+ and CCK+ cortical interneurons along with several less abundant types such as single bouquet cells.
“the CGE produces all VIP+ and CCK+ cortical interneurons along with several other less abundant types of interneurons such as single bouquet cells”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Butt et al., 2005
The Nkx2.1 lineage also gives rise to dendrite targeting somatostatin (SST)-expressing interneurons, and thus use of Nkx2.1-Cre lines in isolation results in recombination within a wide variety of perisomatic and dendrite targeting interneurons.
“However, the Nkx2.1 lineage also gives rise to dendrite targeting somatostatin (SST)-expressing interneurons, and thus use of Nkx2.1-Cre lines in isolation will result in recombination within a wide variety of perisomatic and dendrite targeting interneurons (147, 339, 1138, 1233, 1235).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [147]
PVBCs have origin in the MGE with specification driven by the homeodomain transcription factor Nkx2.1 (21% of MGE-derived interneurons).
“PVBCs have origin in the MGE with specification driven by the homeodomain transcription factor Nkx2.1 (21% of MGE-derived interneurons, see assumptions above) (147, 575, 1138, 1233).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [147]
Temporal dynamics significantly impact mature interneuron fate.
“Complementing the spatial control of interneuron specification within the GEs is a temporal dynamic that has significant impact on mature interneuron fate”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [147]
The CGE is a source of cortical interneurons that assume mature fates distinct from MGE-derived interneurons.
“in vitro culture and in vivo transplant studies implicated the CGE as a source of cortical interneurons that assumed mature fates distinct from MGE-derived interneurons”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [147]
MGE progenitors preferentially express Nkx2.1, which must be downregulated in migrating postmitotic cells for them to avoid the striatum and reach the cortex.
“MGE progenitors preferentially express the transcription factor Nkx2.1 (147, 148, 829, 1233), which must be downregulated in migrating postmitotic cells in order for them to avoid the striatum and reach the cortex”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [147]
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Self-citation
- Authors
- Butt, S. J. B., Fuccillo, M., Nery, S., Noctor, S., Kriegstein, A., Corbin, J. G., & Fishell, G.
- Affiliations
- NYU Langone Health (US)
- Columbia University (US)
- Corresponding author
- Fishell, Gord
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2005-11
- Volume
- 48
- Issue
- 4
- Pages
- 591-604
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2024009242
- Cited by
- 587
- References
- 49
- Citations by year
- 2026: 9 · 2025: 19 · 2024: 23 · 2023: 20 · 2022: 18 · 2021: 22 · 2020: 40 · 2019: 27 · 2018: 31 · 2017: 24 · 2016: 33 · 2015: 24 · 2014: 29 · 2013: 35 · 2012: 33
- FWCI
- 7.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2815 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Human Frontier Science Program
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- cortical interneurons, interneuron subtypes, ganglionic eminence, medial ganglionic eminence, caudal ganglionic eminence, interneuron specification, fast-spiking interneurons, telencephalon development
- MeSH terms
- Action Potentials, Animals, Animals, Newborn, Cell Differentiation, Cell Movement, Cerebral Cortex, Embryo, Mammalian, Immunohistochemistry, Interneurons, Reaction Time, Stem Cells, Telencephalon, Cellular Senescence, Stem Cell Transplantation, Embryonic Development, Mice
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