Functional Connectivity of Brain Structures Correlates with Treatment Outcome in Major Depressive Disorder
Open accessAbstract
Identifying biosignatures to assess the probability of response to an antidepressant for patients with major depressive disorder (MDD) is critically needed. Functional connectivity MRI (fcMRI) offers the promise to provide such a measure. Previous work with fcMRI demonstrated that the correlation in signal from one region to another is a measure of functional connectivity. In this pilot work, a baseline non-task fcMRI was acquired in 14 adults with MDD who were free of all medications. Participants were then treated for 8 weeks with an antidepressant and then clinically re-evaluated. Probabilistic anatomic regions of interest (ROI) were defined for 16 brain regions (eight for each hemisphere) previously identified as being important in mood disorders. These ROIs were used to determine mean time courses for each individual's baseline non-task fcMRI. The correlations in time courses between 16 brain regions were calculated. These calculated correlations were considered to signify measures of functional connectivity. The degree of connectivity for each participant was correlated with treatment outcome. Among 13 participants with 8 weeks follow-up data, connectivity measures in several regions, especially the subcallosal cortex, were highly correlated with treatment outcome. These connectivity measures could provide a means to evaluate how likely a patient is to respond to an antidepressant treatment. Further work using larger samples is required to confirm these findings and to assess if measures of functional connectivity can be used to predict differential outcomes between antidepressant treatments.
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sgACC connectivity with limbic, thalamic, and striatal regions has been associated with the degree of response to treatment.
“and associated with the degree of response to treatment (Anand et al, 2005, 2009; Diaconescu et al, 2011; Kozel et al, 2011).”
From Resting-state cortico-thalamic-striatal connectivity predicts response to dorsomedial prefrontal rTMS in major depressive disorder (2014) · cites this paper as Kozel et al, 2011
The subgenual cingulate has been consistently linked with outcome prediction.
“The subgenual cingulate has been consistently linked with outcome prediction (Davidson et al, 2003; Kennedy et al, 2001; Kozel et al, 2011; Mayberg et al, 1997; Ritchey et al, 2011; Siegle et al, 2006)”
From Resting-state cortico-thalamic-striatal connectivity predicts response to dorsomedial prefrontal rTMS in major depressive disorder (2014) · cites this paper as Kozel et al, 2011
Connectivity between ventral and dorsal regions of the anterior cingulate cortex predicts response to antidepressant medication.
“recent findings suggest that connectivity between ventral and dorsal regions of the anterior cingulate cortex predicts response to antidepressant medication (Kozel et al, 2011).”
From Resting-state cortico-thalamic-striatal connectivity predicts response to dorsomedial prefrontal rTMS in major depressive disorder (2014) · cites this paper as Kozel et al, 2011
Connectivity between similar regions has been implicated with response to antidepressant medication.
“and response to antidepressant medication (Kozel et al, 2011).”
From Resting-state cortico-thalamic-striatal connectivity predicts response to dorsomedial prefrontal rTMS in major depressive disorder (2014) · cites this paper as Kozel et al, 2011
Kozel et al found that baseline connectivity of similar cingulate regions was associated with response to antidepressant medication, but that the association was in the opposite direction to that observed here.
“In line with such an interpretation, it is noteworthy that Kozel et al (Kozel et al, 2011) found that baseline connectivity of similar cingulate regions was associated with response to antidepressant medication, but that the association was in the opposite direction to that observed here.”
From Resting-state cortico-thalamic-striatal connectivity predicts response to dorsomedial prefrontal rTMS in major depressive disorder (2014) · cites this paper as Kozel et al, 2011
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Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630 · see citing works
Jenkinson, M., Bannister, P., Brady, M., & Smith, S. (2002) · NeuroImage · doi:10.1006/nimg.2002.1132 · Cited by 11,888 · see citing works
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455 · see citing works
Fast robust automated brain extraction
Smith, S. M. (2002) · Human Brain Mapping · doi:10.1002/hbm.10062 · Cited by 10,496 · see citing works
Functional connectivity in the motor cortex of resting human brain using echo‐planar mri
Biswal, B., Zerrin Yetkin, F., Haughton, V. M., & Hyde, J. S. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910340409 · Cited by 9,812 · see citing works
Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0135058100 · Cited by 6,358 · see citing works
Trivedi, M. H., Rush, A. J., Wisniewski, S. R., Nierenberg, A. A., Warden, D., Ritz, L., Norquist, G., Howland, R. H., Lebowitz, B., McGrath, P. J., et al. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.28 · Cited by 3,879 · see citing works
Self-citationRush, A. J., Trivedi, M. H., Ibrahim, H. M., Carmody, T. J., Arnow, B., Klein, D. N., Markowitz, J. C., Ninan, P. T., Kornstein, S., Manber, R., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01866-8 · Cited by 3,829 · see citing works
Self-citationInvestigations into resting-state connectivity using independent component analysis
Beckmann, C. F., DeLuca, M., Devlin, J. T., & Smith, S. M. (2005) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2005.1634 · Cited by 3,398 · see citing works
Structured clinical interview for DSM-IV axis I disorders : SCID-I : clinical version : scoresheet
First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (1997) · American Psychiatric Press eBooks · Cited by 3,101 · see citing works
A CLASSIFICATION OF HAND PREFERENCE BY ASSOCIATION ANALYSIS
Annett, M. (1970) · British Journal of Psychology · doi:10.1111/j.2044-8295.1970.tb01248.x · Cited by 2,305 · see citing works
Greicius, M. D., Flores, B. H., Menon, V., Glover, G. H., Solvason, H. B., Kenna, H., Reiss, A. L., & Schatzberg, A. F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.020 · Cited by 2,214 · see citing works
The Inventory of Depressive Symptomatology (IDS): Psychometric properties
Rush, A. J., Gullion, C. M., Basco, M. R., Jarrett, R. B., & Trivedi, M. H. (1996) · Psychological Medicine · doi:10.1017/s0033291700035558 · Cited by 2,177 · see citing works
Self-citationNeurobiology of emotion perception II: implications for major psychiatric disorders
Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00171-9 · Cited by 1,736 · see citing works
Ostwald, P. F. (1960) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.1960.14.4.817 · Cited by 1,422 · see citing works
Functional connectivity in single and multislice echoplanar imaging using resting-state fluctuations
Lowe, M. J., Mock, B. J., & Sorenson, J. A. (1998) · NeuroImage · doi:10.1006/nimg.1997.0315 · Cited by 1,394 · see citing works
Clinical applications of resting state functional connectivity
Fox, M. (2010) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2010.00019 · Cited by 1,164 · see citing works
Bupropion-SR, Sertraline, or Venlafaxine-XR after Failure of SSRIs for Depression
Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Stewart, J. W., Nierenberg, A. A., Thase, M. E., Ritz, L., Biggs, M. M., Warden, D., Luther, J. F., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052963 · Cited by 1,033 · see citing works
Self-citationCingulate function in depression: a potential predictor of treatment response
Mayberg, H. S., Brannan, S. K., Mahurin, R. K., Jerabek, P. A., Brickman, J. S., Tekell, J. L., Silva, J. A., McGinnis, S., Glass, T. G., Martin, C. C., et al. (1997) · NeuroReport · doi:10.1097/00001756-199703030-00048 · Cited by 1,029 · see citing works
Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic
Ressler, K. J., & Mayberg, H. S. (2007) · Nature Neuroscience · doi:10.1038/nn1944 · Cited by 1,007 · see citing works
Medication Augmentation after the Failure of SSRIs for Depression
Trivedi, M. H., Fava, M., Wisniewski, S. R., Thase, M. E., Quitkin, F., Warden, D., Ritz, L., Nierenberg, A. A., Lebowitz, B. D., Biggs, M. M., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052964 · Cited by 1,002 · see citing works
Self-citationTRIVEDI, M. H., RUSH, A. J., IBRAHIM, H. M., CARMODY, T. J., BIGGS, M. M., SUPPES, T., CRISMON, M. L., SHORES-WILSON, K., TOPRAC, M. G., DENNEHY, E. B., et al. (2004) · Psychological Medicine · doi:10.1017/s0033291703001107 · Cited by 968 · cited 4× · see citing works
“…certified clinical rater completed the HRSD-17 (Hamilton, 1960), the clinician-rated Inventory of Depressive Symptomatology (IDS-C; Rush et al., 1996; Trivedi et al., 2004), the Hamilton Anxiety Rating Scale (HARS; Hamilton, 1959), and the Mini Mental State Evaluation (MMSE; Folstein et al., 1975).”
BackgroundMethodInfluentialSelf-citationMapping functionally related regions of brain with functional connectivity MR imaging.
Cordes, D., Haughton, V. M., Arfanakis, K., Wendt, G. J., Turski, P. A., Moritz, C. H., Quigley, M., & Meyerand, M. E. (2000) · PubMed Central · Cited by 908 · see citing works
A meta‐analytic study of changes in brain activation in depression
Fitzgerald, P. B., Laird, A. R., Maller, J., & Daskalakis, Z. J. (2008) · Human Brain Mapping · doi:10.1002/hbm.20426 · Cited by 903 · see citing works
Siegle, G. J., Thompson, W., Carter, C. S., Steinhauer, S. R., & Thase, M. E. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.048 · Cited by 857 · see citing works
Anand, A., Li, Y., Wang, Y., Wu, J., Gao, S., Bukhari, L., Mathews, V. P., Kalnin, A., & Lowe, M. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.02.021 · Cited by 787 · see citing works
Kennedy, S. H., Evans, K. R., Krüger, S., Mayberg, H. S., Meyer, J. H., McCann, S., Arifuzzman, A. I., Houle, S., & Vaccarino, F. J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.6.899 · Cited by 710 · see citing works
Use of fMRI to Predict Recovery From Unipolar Depression With Cognitive Behavior Therapy
Siegle, G. J., Carter, C. S., & Thase, M. E. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.4.735 · Cited by 495 · see citing works
Linking Mind and Brain in the Study of Mental Illnesses: A Project for a Scientific Psychopathology
Andreasen, N. C. (1997) · Science · doi:10.1126/science.275.5306.1586 · Cited by 451 · see citing works
Structured Clinical Interview for DSM-IV (SCID)
Kübler, U. (2013) · Springer eBooks · doi:10.1007/978-1-4419-1005-9_66 · Cited by 445 · see citing works
Kennedy, S. H., Konarski, J. Z., Segal, Z. V., Lau, M. A., Bieling, P. J., McIntyre, R. S., & Mayberg, H. S. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.5.778 · Cited by 420 · see citing works
Rush, A. J., Bernstein, I. H., Trivedi, M. H., Carmody, T. J., Wisniewski, S., Mundt, J. C., Shores-Wilson, K., Biggs, M. M., Woo, A., Nierenberg, A. A., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.022 · Cited by 385 · see citing works
Self-citationAntidepressant Effect on Connectivity of the Mood-Regulating Circuit: An fMRI Study
Anand, A., Li, Y., Wang, Y., Wu, J., Gao, S., Bukhari, L., Mathews, V. P., Kalnin, A., & Lowe, M. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300725 · Cited by 324 · see citing works
Tenebäck, C. C., Nahas, Z. H., Speer, A. M., Molloy, M. A., Stallings, L. E., SPICER, K. M., Risch, S. C., & George, M. S. (1999) · Journal of Neuropsychiatry · doi:10.1176/jnp.11.4.426 · Cited by 249 · see citing works
A meta-analytic study of changes in brain activation in depression
Fitzgerald, P. B., Maller, J. J., Hoy, K. E., Oxley, T. J., Daskalakis, Z. J., & Laird, A. R. (2006) · Acta Neuropsychiatrica · doi:10.1017/s0924270800031173 · Cited by 233 · see citing works
Anand, A., Li, Y., Wang, Y., Gardner, K., & Lowe, M. J. (2007) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/appi.neuropsych.19.3.274 · Cited by 215 · see citing works
Dougherty, D. D., Weiss, A. P., Cosgrove, G. R., Alpert, N. M., Cassem, E. H., Nierenberg, A. A., Price, B. H., Mayberg, H. S., Fischman, A. J., & Rauch, S. L. (2003) · Journal of Neurosurgery · doi:10.3171/jns.2003.99.6.1010 · Cited by 193 · see citing works
Neural correlates of emotion regulation in psychopathology
Taylor, S. F., & Liberzon, I. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.08.006 · Cited by 182 · see citing works
Structured Clinical Interview for DSM-IV (SCID)
Glasofer, D. R., Brown, A. J., & Riegel, M. (2017) · Springer eBooks · doi:10.1007/978-981-287-104-6_80 · Cited by 150 · see citing works
. Comparison of self-report and clinician ratings on two inventories of depressive symptomatology.
Rush, A. J., Carmody, T. J., Ibrahim, H. M., Trivedi, M. H., Biggs, M. M., Shores-Wilson, K., Crismon, M. L., Toprac, M. G., & Kashner, T. M. (2006) · Psychiatric Services · doi:10.1176/ps.2006.57.6.829 · Cited by 128 · see citing works
Self-citationIrwin, W., Anderle, M. J., Abercrombie, H. C., Schaefer, S. M., Kalin, N. H., & Davidson, R. J. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.09.057 · Cited by 87 · see citing works
Detecting low‐frequency functional connectivity in fMRI using a self‐organizing map (SOM) algorithm
Peltier, S. J., Polk, T. A., & Noll, D. C. (2003) · Human Brain Mapping · doi:10.1002/hbm.10144 · Cited by 87 · see citing works
Kennedy, S. H. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.987.899 · Cited by 41 · see citing works
A meta‐analytic study of changes in brain activation in depression
Fitzgerald, P. B., Laird, A. R., Maller, J. J., & Daskalakis, Z. J. (2008) · Human Brain Mapping · doi:10.1002/hbm.20613 · Cited by 36 · see citing works
Brain Correlates of Antidepressant Treatment Outcome from Neuroimaging Studies in Depression
Dougherty, D. D., & Rauch, S. L. (2007) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2006.12.007 · Cited by 31 · see citing works
Developing a Neuropsychiatric Functional Brain Imaging Test
Kozel, F. A., & Trivedi, M. H. (2008) · Neurocase · doi:10.1080/13554790701881731 · Cited by 18 · see citing works
Self-citationIdentifying Phronotypes in Psychiatry
Kozel, F. A. (2010) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2010.00141 · Cited by 5 · see citing works
Self-citationDeveloping a Neuropsychiatric Functional Brain Imaging Test
Kozel, F. A., & Trivedi, M. H. (2020) · Neurocase · doi:10.4324/9781003059752-6 · Cited by 3 · see citing works
Self-citationBiswal (1997) · doi:10.1002/(sici)1099-1492(199706/08)10:4/5
Xiong (1999) · doi:10.1002/(sici)1097-0193(1999)8:2/3
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Mulders, P. C., van Eijndhoven, P. F., Schene, A. H., Beckmann, C. F., & Tendolkar, I. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.07.014 · Cited by 884 · see citing works
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Liston, C., Chen, A. C., Zebley, B. D., Drysdale, A. T., Gordon, R., Leuchter, B., Voss, H. U., Casey, B. J., Etkin, A., & Dubin, M. J. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.01.023 · Cited by 763 · see citing works
Dichter, G. S., Gibbs, D., & Smoski, M. J. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.09.028 · Cited by 375 · see citing works
Salomons, T. V., Dunlop, K., Kennedy, S. H., Flint, A., Geraci, J., Giacobbe, P., & Downar, J. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.222 · Cited by 299 · see citing works
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Helm, K., Viol, K., Weiger, T. M., Tass, P. A., Grefkes, C., del Monte, D., & Schiepek, G. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s170989 · Cited by 164 · see citing works
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Dunlop, K., Talishinsky, A., & Liston, C. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1072-6 · Cited by 80 · see citing works
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- Authors
- Kozel, F. A., Rao, U., Lu, H., Nakonezny, P. A., Grannemann, B., McGregor, T., Croarkin, P. E., Mapes, K. S., Tamminga, C. A., & Trivedi, M. H.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Meharry Medical College (US)
- Corresponding author
- Kozel, F. Andrew
- ORCID
- Venue
- Frontiers in Psychiatry
- Publisher
- Frontiers Media SA
- Published
- 2011
- Volume
- 2
- Pages
- 7-7
- ISSN
- 1664-0640 (ISSN-L)
- PMC
- PMC3089997
- OpenAlex
- W2153012113
- Cited by
- 61
- References
- 52
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 7 · 2013: 5 · 2012: 4
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Stanley Medical Research Institute
- National Institutes of Health (MH084021)
- National Institute of Mental Health (R01MH062464, R01MH068391, MH084021, K23MH070897, R01MH084021)
- National Institute on Drug Abuse (R01DA015131, R01DA017804, R01DA014037, R01DA017805)
- National Institute of Neurological Disorders and Stroke (R01NS067015)
- National Center for Research Resources (G12RR003032, U54RR026140, UL1RR024982)
- National Institute on Minority Health and Health Disparities (U54MD007593)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- major depressive disorder, functional connectivity, antidepressant response, treatment outcome prediction, biosignatures, subcallosal cortex, mood disorders
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