Neuronal connectivity in major depressive disorder: a systematic review
Open accessAbstract
BACKGROUND: The causes of major depressive disorder (MDD), as one of the most common psychiatric disorders, still remain unclear. Neuroimaging has substantially contributed to understanding the putative neuronal mechanisms underlying depressed mood and motivational as well as cognitive impairments in depressed individuals. In particular, analyses addressing changes in interregional connectivity seem to be a promising approach to capture the effects of MDD at a systems level. However, a plethora of different, sometimes contradicting results have been published so far, making general conclusions difficult. Here we provide a systematic overview about connectivity studies published in the field over the last decade considering different methodological as well as clinical issues. METHODS: A systematic review was conducted extracting neuronal connectivity results from studies published between 2002 and 2015. The findings were summarized in tables and were graphically visualized. RESULTS: The review supports and summarizes the notion of an altered frontolimbic mood regulation circuitry in MDD patients, but also stresses the heterogeneity of the findings. The brain regions that are most consistently affected across studies are the orbitomedial prefrontal cortex, anterior cingulate cortex, amygdala, hippocampus, cerebellum and the basal ganglia. CONCLUSION: The results on connectivity in MDD are very heterogeneous, partly due to different methods and study designs, but also due to the temporal dynamics of connectivity. While connectivity research is an important step toward a complex systems approach to brain functioning, future research should focus on the dynamics of functional and effective connectivity.
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Many studies of functional connectivity in depression have involved relatively small numbers of participants and whole-brain regions.
“A number of studies have provided evidence for different functional connectivities that may include the OFC, anterior cingulate cortex, amygdala and hippocampus, but many of these studies have involved relatively small numbers of participants, and whole-brain regions (Helm et al., 2018).”
From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as Helm et al., 2018
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Flagged first, then by citations
Research works printed but not linked: 2
- [31]Miller K Biomechanics of the Brain, Biological and Medical Physics, Biomedical Engineering New York Springer 2011
- [109]Kaiser RH Andrews-Hanna JR Wager TD Pizzagalli DA Large-Scale Network Dysfunction in Major Depressive Disorder JAMA Psychiatry 2015 72 6 603 611 25785575 PMC4456260
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The orbitofrontal cortex: reward, emotion and depression
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Pathologically reduced neural flexibility recovers during psychotherapy of OCD patients
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Self-citationCasaglia, E., & Luppi, P. (2022) · Journal of Sleep Research · doi:10.1111/jsr.13633 · Cited by 8 · see citing works
- Authors
- Helm, K., Viol, K., Weiger, T. M., Tass, P. A., Grefkes, C., del Monte, D., & Schiepek, G.
- Affiliations
- University of Salzburg (AT)
- Paracelsus Medical University (AT)
- Stanford Medicine (US)
- Forschungszentrum Jülich (DE)
- Corresponding author
- Schiepek, Günter
- ORCID
- Venue
- Neuropsychiatric Disease and Treatment
- Publisher
- Informa UK Limited
- Published
- 2018-10
- Volume
- Volume 14
- Pages
- 2715-2737
- ISSN
- 1176-6328 (ISSN-L)
- 1178-2021
- PMC
- PMC6200438
- OpenAlex
- W2896970273
- Cited by
- 164
- References
- 115
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 26 · 2023: 19 · 2022: 18 · 2021: 37 · 2020: 21 · 2019: 9
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Neuropsychiatric Disease and Treatment (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- ePLUS (submittedVersion)
- Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion, cc-by-nc)
- JuSER (Forschungszentrum Jülich) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- major depressive disorder, neuronal connectivity, interregional connectivity, mood regulation, anterior cingulate cortex, amygdala, hippocampus, cerebellum, basal ganglia, functional connectivity, effective connectivity
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