Impaired voluntary control in PTSD: probing self-regulation of the ACC with real-time fMRI
Open accessAbstract
Background. Posttraumatic stress disorder (PTSD) is characterized by deficits in the self-regulation of cognitions and emotions. Neural networks of emotion regulation may exhibit reduced control mediated by the anterior cingulate cortex (ACC), contributing to aberrant limbic responses in PTSD. Methods. Real-time fMRI neurofeedback (rt-fMRI NF) assessed self-regulation of the ACC in nine patients with PTSD after single trauma exposure and nine matched healthy controls. All participants were instructed to train ACC upregulation on three training days. Results. Both groups achieved regulation, which was associated with wide-spread brain activation encompassing the ACC. Compared to the controls, regulation amplitude and learning rate was lower in patients, correlating with symptom severity. In addition, a frontopolar activation cluster was associated with self-regulation efforts in patients. Conclusions. For the first time, we tested self-regulation of the ACC in patients with PTSD. The observed impairment supports models of ACC-mediated regulation deficits that may contribute to the psychopathology of PTSD. Controlled trials in a larger sample are needed to confirm our findings and to directly investigate whether training of central regulation mechanisms improves emotion regulation in PTSD.
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Nine patients with PTSD learned voluntary regulation of the anterior cingulate cortex in a social NF paradigm (Zweerings et al., 2018).
“Furthermore, nine patients with PTSD learned voluntary regulation of the anterior cingulate cortex (ACC) in a social NF paradigm (Zweerings et al., 2018).”
From Rt-fMRI neurofeedback-guided cognitive reappraisal training modulates amygdala responsivity in posttraumatic stress disorder (2020) · cites this paper as Zweerings et al., 2018
Rt-fMRI NF trainings have been shown to support perceived control and self-efficacy, thus potentially motivating behavioral change.
“Rt-fMRI NF trainings have been shown to support perceived control (Zweerings et al., 2018) and self-efficacy (Mehler et al., 2018), thus potentially motivating behavioral change (MacDuffie et al., 2018).”
From Rt-fMRI neurofeedback-guided cognitive reappraisal training modulates amygdala responsivity in posttraumatic stress disorder (2020) · cites this paper as Zweerings et al., 2018
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- Authors
- Zweerings, J., Pflieger, E. M., Mathiak, K. A., Zvyagintsev, M., Kacela, A., Flatten, G., & Mathiak, K.
- Affiliations
- RWTH Aachen University (DE)
- EUREGIO (DE)
- Corresponding author
- Zweerings, Jana
- Venue
- Frontiers in Psychiatry
- Publisher
- Frontiers Media SA
- Published
- 2018-05-30
- Volume
- 9
- Pages
- 219-219
- ISSN
- 1664-0640 (ISSN-L)
- PMC
- PMC5989618
- OpenAlex
- W2799426207
- Cited by
- 52
- References
- 56
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 4 · 2023: 7 · 2022: 9 · 2021: 12 · 2020: 5 · 2019: 3
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Psychiatry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- RWTH Publications (RWTH Aachen) (submittedVersion, other-oa)
- Funders
- Deutsche Forschungsgemeinschaft (APIC: 01EE1405B, DFG IRTG 2150, IRTG-2150, MA2631/6-1, 2631/6-1, MA 2631/6)
- Bundesministerium für Bildung und Forschung (01EE1405B, 01EE1405C, APIC: 01EE1405B)
- RWTH Aachen University
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Keywords
- post-traumatic stress disorder, anterior cingulate cortex, emotion regulation, self-regulation, real-time fMRI neurofeedback, volitional control, frontopolar cortex, symptom severity
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