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Mechanisms of Resistance to Macrolide Antibiotics among Staphylococcus aureus

Miklasińska-Majdanik, Maria·2021·Antibiotics
DOI 10.3390/antibiotics10111406
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Abstract

Methicillin resistant Staphylococcus aureus strains pose a serious treatment problem because of their multi-drug resistance (MDR). In staphylococcal strains, resistance to macrolides, lincosamides, and streptogramin B (MLSB) correlates with resistance to methicillin. The rapid transmission of erm genes responsible for MLSB resistance has strongly limited the clinical application of traditional macrolides such as erythromycin. On the other hand, in the age of increasing insensitivity to antibiotics the idea of implementing a therapy based on older generation drugs brings hope that the spread of antibiotic resistance will be limited. A thorough understanding of the resistance mechanisms contributes to design of antibiotics that avoid bacterial insensitivity. This review highlights the mechanisms of action of macrolides and mechanism of resistance to these antibiotics among Staphylococcus aureus.

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Metadata

Authors
Miklasińska-Majdanik, M.
Venue
Antibiotics
Publisher
MDPI AG
Published
2021-11-17
Volume
10
Issue
11
Pages
1406
ISSN
2079-6382
DOI
10.3390/antibiotics10111406
Cited by
122
References
2
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
Medical University of Silesia (PCN-1-058/N/0/I)

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