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A Growing Link between Circadian Rhythms, Type 2 Diabetes Mellitus and Alzheimer’s Disease

Peng, X., Fan, R., Xie, L., Shi, X., Dong, K., Zhang, S., Tao, J., Xu, W., Ma, D., Chen, J., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010504 · Cited by 68 · see citing works

Chrononutrition—When We Eat Is of the Essence in Tackling Obesity

Ahluwalia, M. K. (2022) · Nutrients · doi:10.3390/nu14235080 · Cited by 72 · see citing works

Importance of Bmal1 in Alzheimer's disease and associated aging‐related diseases: Mechanisms and interventions

Fan, R., Peng, X., Xie, L., Dong, K., Ma, D., Xu, W., Shi, X., Zhang, S., Chen, J., Yu, X., et al. (2022) · Aging Cell · doi:10.1111/acel.13704 · Cited by 62 · see citing works

Dietary Supplements and Natural Products: An Update on Their Clinical Effectiveness and Molecular Mechanisms of Action During Accelerated Biological Aging

Chen, Y., Hamidu, S., Yang, X., Yan, Y., Wang, Q., Li, L., Oduro, P. K., & Li, Y. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.880421 · Cited by 61 · see citing works

Aging, circadian disruption and neurodegeneration: Interesting interplay

Verma, A. K., Singh, S., & Rizvi, S. I. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2022.112076 · Cited by 55 · see citing works

The clock modulator Nobiletin mitigates astrogliosis‐associated neuroinflammation and disease hallmarks in an Alzheimer’s disease model

Wirianto, M., Wang, C., Kim, E., Koike, N., Gomez‐Gutierrez, R., Nohara, K., Escobedo, G., Choi, J. M., Han, C., Yagita, K., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202101633r · Cited by 45 · see citing works

Nobiletin prevents amyloid β1-40-induced cognitive impairment via inhibition of neuroinflammation and oxidative/nitrosative stress

Ghasemi-Tarie, R., Kiasalari, Z., Fakour, M., Khorasani, M., Keshtkar, S., Baluchnejadmojarad, T., & Roghani, M. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-00949-y · Cited by 42 · see citing works

Circadian rhythm alterations affecting the pathology of neurodegenerative diseases

Canever, J. B., Queiroz, L. Y., Soares, E. S., de Avelar, N. C. P., & Cimarosti, H. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15883 · Cited by 40 · see citing works

A review on recent advances on nobiletin in central and peripheral nervous system diseases

Pang, Y., Xiong, J., Wu, Y., & Ding, W. (2023) · European journal of medical research · doi:10.1186/s40001-023-01450-7 · Cited by 29 · see citing works

Deciphering clock genes as emerging targets against aging

Zhu, Y., Liu, Y., Escames, G., Yang, Z. Z., Zhao, H., Lu, Q., Xue, C., Xu, D., Acuña-Castroviejo, D., & Yang, Y. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101725 · Cited by 31 · see citing works

Modulation of the Circadian Rhythm and Oxidative Stress as Molecular Targets to Improve Vascular Dementia: A Pharmacological Perspective

Trujillo-Rangel, W. Á., Acuña-Vaca, S., Padilla-Ponce, D. J., García-Mercado, F. G., Torres-Mendoza, B. M., Pacheco-Moisés, F. P., Escoto-Delgadillo, M., García‐Benavides, L., & Delgado-Lara, D. L. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084401 · Cited by 27 · see citing works

Natural Compounds for Preventing Age-Related Diseases and Cancers

Ki, M., Youn, S., Kim, D. H., & Pack, S. P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147530 · Cited by 29 · see citing works

Circadian rhythms as modulators of brain health during development and throughout aging

Drunen, R. V., & Eckel‐Mahan, K. L. (2023) · Frontiers in Neural Circuits · doi:10.3389/fncir.2022.1059229 · Cited by 28 · see citing works

Sexual dimorphism in the peripheral metabolic homeostasis and behavior in the TgF344‐AD rat model of Alzheimer's disease

Srivastava, H. K., Lasher, A. T., Nagarajan, A., & Sun, L. Y. (2023) · Aging Cell · doi:10.1111/acel.13854 · Cited by 28 · see citing works

Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer’s disease model mice

Lü, Y., Girardi, C. S., Fitz, N. F., McGuire, M. R., Ostach, M. A., Mamun-Or-Rashid, A. N. M., Lefterov, I. M., & Koldamova, R. P. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112785 · Cited by 25 · see citing works

Circadian stabilization loop: the regulatory hub and therapeutic target promoting circadian resilience and physiological health

Kim, E., Yoo, S. H., & Chen, Z. (2022) · F1000Research · doi:10.12688/f1000research.126364.1 · Cited by 21 · see citing works

Involvement of Bile Acid Metabolism and Gut Microbiota in the Amelioration of Experimental Metabolism-Associated Fatty Liver Disease by Nobiletin

Xu, H., Yuan, M., Niu, K., Yang, W. J., Jiang, M., Zhang, L., & Zhou, J. (2024) · Molecules · doi:10.3390/molecules29050976 · Cited by 20 · see citing works

The Circadian Nobiletin-ROR Axis Suppresses Adipogenic Differentiation and IκBα/NF-κB Signaling in Adipocytes

Kim, E., Mawatari, K., Yoo, S. H., & Chen, Z. (2023) · Nutrients · doi:10.3390/nu15183919 · Cited by 20 · see citing works

Chinese formula Guben-Jiannao Ye alleviates the dysfunction of circadian and sleep rhythms in APP/PS1 mice implicated in activation of the PI3K/AKT/mTOR signaling pathway

Mao, J.-Q., Cheng, L., Zhang, Y.-D., Xie, G., & Wang, P. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118696 · Cited by 19 · see citing works

Effect of the Citrus Flavone Nobiletin on Circadian Rhythms and Metabolic Syndrome

Ambe, G. N. N. N., Breda, C., Bhambra, A. S., & Arroo, R. (2022) · Molecules · doi:10.3390/molecules27227727 · Cited by 18 · see citing works

Effects of Qi-Fu-Yin on aging of APP/PS1 transgenic mice by regulating the intestinal microbiome

Xiao, Q., Ye, T., Wang, X., Qi, D., & Cheng, X. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1048513 · Cited by 16 · see citing works

Circadian neurogenetics and its implications in neurophysiology, behavior, and chronomedicine

Naveed, M., Chao, O. Y.-H., Hill, J. W., Yang, Y., Huston, J. P., & Cao, R. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105523 · Cited by 15 · see citing works

Influence of sleep disruption on protein accumulation in neurodegenerative diseases

Wang, X., Wang, R., & Li, J. (2022) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2021.10 · Cited by 12 · see citing works

Nobiletin and Eriodictyol Suppress Release of IL-1β, CXCL8, IL-6, and MMP-9 from LPS, SARS-CoV-2 Spike Protein, and Ochratoxin A-Stimulated Human Microglia

Tsilioni, I., Kempuraj, D., & Theoharides, T. C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020636 · Cited by 9 · see citing works

Nobiletin Stimulates Adrenal Hormones and Modulates the Circadian Clock in Mice

Ryan, C., Tahara, Y., Haraguchi, A., Lu, Y., & Shibata, S. (2024) · Nutrients · doi:10.3390/nu16101491 · Cited by 8 · see citing works

The Clock and the Brain: Circadian Rhythm and Alzheimer’s Disease

Shirkouhi, S. G., Karimi, A., Khatami, S. S., Gashtrodkhani, A. A., Kamari, F., Blaabjerg, M., & Andalib, S. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47070547 · Cited by 7 · see citing works

Advances of therapeutic strategies for Alzheimer’s disease

Guo, X., Yue, R.-Z., Cui, Z., Wang, S., Jia, T., Li, W., Zhang, W., Shan, L., & Li, C. (2025) · Journal of Neurology · doi:10.1007/s00415-025-13456-8 · Cited by 8 · see citing works

Neuroprotective role of nobiletin against amyloid-β (Aβ) aggregation in Parkinson and Alzheimer disease as neurodegenerative diseases of brain

Alivirdiloo, V., Hajiabbasi, M., Gargari, M. K., Gargari, H. K., Ghazi, F., Mohammadi, M., Rahimi, F., Mobed, A., & Mehra, A. (2024) · Medicinal Chemistry Research · doi:10.1007/s00044-024-03237-9 · Cited by 7 · see citing works

Possible Mitigating Effect of Nobiletin on Rotenone–Induced Parkinsonism in Male Albino Rat Model: Targeting Bmal1/Nrf2 Mediated Ferroptosis and Restoring Mitochondrial Mitophagy

El‐Khalik, S. R. A., AbuoHashish, N. A., Nasif, E., Arakeep, H. M., El‐Anwar, N., Yousef, D. M., & Ayad, N. H. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04438-3 · Cited by 6 · see citing works

The intersection of circadian rhythms and the blood-brain barrier with drug efficacy and delivery in neurological disorders

Schindler, K. A., Torices, S., Schurhoff, N. A., Gallo, D. I., & Toborek, M. J. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115645 · Cited by 7 · see citing works

Sarm1 Regulates Circadian Rhythm Disorder in Alzheimer’s Disease in Mice

Wang, Z., Zeng, S., Jing, Y., Mao, W., & Li, H. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221027 · Cited by 6 · see citing works

Altered Clock Gene Expression in Female APP/PS1 Mice and Aquaporin-Dependent Amyloid Accumulation in the Retina

Carrero, L., Antequera, D., Alcalde, I., Megı́as, D., Ordóñez‐Gutiérrez, L., Gutiérrez, C., Merayo-Llovés, J., Wandosell, F. G., Municio, C., & Carro, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115679 · Cited by 5 · see citing works

CO 2 scrubbing, zero gases, Keeling plots, and a mathematical approach to ameliorate the deleterious effects of ambient CO 2 during 13 C breath testing in humans and animals

McCue, M. D. (2023) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.9639 · Cited by 4 · see citing works

Identification and Therapeutic Potential of Polymethoxylated Flavones in Citri Reticulatae Pericarpium for Alzheimer’s Disease: Targeting Neuroinflammation

Wang, X., Yi, Z., Zhang, Y., Zhang, J., Li, X., Qi, D., Wang, Q., Chai, X., Liu, H., Wang, G., et al. (2025) · Molecules · doi:10.3390/molecules30040771 · Cited by 5 · see citing works

Diurnal Characteristics of the Orexin System Genes and Its Effects on Pathology at Early Stage in 3xTg-AD Mice

Yin, J., Tuo, C.-M., Yu, K.-Y., Hu, X.-H., Fan, Y., & Wu, M. (2023) · NeuroMolecular Medicine · doi:10.1007/s12017-023-08767-w · Cited by 2 · see citing works

A circadian clock regulates the blood-brain barrier across phylogeny

Avila, A., & Zhang, S. (2024) · Vitamins and hormones · doi:10.1016/bs.vh.2024.04.004 · Cited by 2 · see citing works

Potential role of nobiletin in Alzheimer’s disease

Fang, H., Zhang, L., & Zhao, H. (2023) · Journal of Food Bioactives · doi:10.31665/jfb.2023.18361 · Cited by 2 · see citing works

Circadian Disruption Through Light–Dark Cycle Alteration Induced Alzheimer’s Disease-like Pathology in Mice

Zhao, G., Cui, B., Lu, Y., Ma, K., Gao, X., She, X., Zhu, Y., Ji, X., Yang, H. M., & Yang, H. (2026) · Biomolecules · doi:10.3390/biom16020200 · Cited by 1 · see citing works

Disease Conditions

Cornélissen, G., Gubin, D. G., & Otsuka, K. (2024) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781839167553-00455

Effects of deep-sea water on training efficiency, locomotor function and respiratory metabolism in young and aged mice

Fukui, K., Takeuchi, R., Kato, Y., Takeuchi, N., Takenaka, H., & Kohno, M. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e39296

Crystal Structures of Circadian Clock Proteins and Their Applications in Structure-Based Drug Design Studies

Gül, Ş. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95502-7.00240-2

Potential circadian rhythm-related pathogenic genes in diabetic nephropathy: a multi-omics Mendelian randomization study

Mao, Y., Zhang, M., Li, X., Zhang, Z., Rong, W., Zhang, X., Feng, L., & Xu, J. X. (2026) · Renal Failure · doi:10.1080/0886022x.2026.2663248

Brain and Muscle ARNT-Like 1 Ameliorates Sepsis-Induced Acute Lung Injury by Orchestrating Endoplasmic Reticulum-Phagy and Mitochondrial Metabolism

Li, J., Liu, S., Xue, Z., Wang, H., Pan, M., Yan, Y., Zhang, R., Yan, Y., Wang, S., Pan, Z., et al. (2026) · Critical Care Medicine · doi:10.1097/ccm.0000000000007182

Mitochondrial Dynamics and SLC25 Transporters in Neurodegeneration: From Mechanisms to Therapeutic Opportunities

Morciano, G., Gorgoglione, R., Porcelli, V., Ahmed, A., Scarcia, P., Vozza, A., Lasorsa, F. M., Fiermonte, G., & Palmieri, L. (2026) · Biomolecules · doi:10.3390/biom16060842

Systemic association between aging and Alzheimer′s disease: From shared mechanisms to multi-target interventions

Jiang, Q., & Yan-Jiang, W. A. N. G. (2026) · Shengming kexue · doi:10.3724/cbls.2026100

Nobiletin as a Geroprotective Flavonoid: Mechanisms of Action, Therapeutic Potential, and Challenges of Bioavailability

Sip, S., Gościniak, A., Hoede, N., Htike, M. H., Khin, H. Y., Lai, W.-W., Naing, H. H., Szopa, A., & Cielecka‐Piontek, J. (2026) · Antioxidants · doi:10.3390/antiox15091129

REV-ERB-Mediated Regulation of Neural Functional Mechanisms by Phytochemicals in the Circadian System

Ming-ying, P., Wang, J.-B., Li, R., Wang, Z., Lu, M., & Huang, J. (2026) · Nutrients · doi:10.3390/nu18183071

NPAS2 attenuates diabetic cardiomyopathy by preserving pyruvate dehydrogenase activity and mitochondrial metabolic homeostasis

Li, W., Han, B., Zhu, D., 栾丽霞, & Dang, X. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1980726

The clock modulator Nobiletin mitigates astrogliosis‐associated neuroinflammation and disease hallmarks in an Alzheimer’s disease model

Wirianto, M., Wang, C., Kim, E., Koike, N., Gomez‐Gutierrez, R., Nohara, K., Escobedo, G., Choi, J. M., Han, C., Yagita, K., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202101633r · Cited by 45 · see citing works

Nobiletin Ameliorates Aβ 1–42 ‐Induced Cognitive Disorder and Mitochondrial Dysfunction via Targeting the Key Circadian Regulator Bmal1

Gao, H., Qu, Q., Wang, N., Gao, X. J., Li, P., Mou, Y., Kong, X., Chen, Y., Li, D., & Tan, X. (2025) · Food Safety and Health · doi:10.1002/fsh3.70040

THE ROLE OF THE CIRCADIAN CLOCK IN DISEASE AND TISSUE FUNCTION

Wirianto, M. (2024) · Digital Commons-TMC (Texas Medical Center)

Effects of aging and genotype on circadian rhythms, sleep, and clock gene expression in APPxPS1 knock-in mice, a model for Alzheimer's disease

Duncan, M. J., Smith, J. T., Franklin, K. M., Beckett, T. L., Murphy, M. P., Clair, D. K. S., Donohue, K. D., Striz, M., & O’Hara, B. F. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.05.011 · Cited by 106 · see citing works

Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer's disease neuropathology

Niu, L., Zhang, F., Xu, X., Yang, Y., Li, S., Liu, H., & Le, W. (2021) · Brain Pathology · doi:10.1111/bpa.13028 · Cited by 149 · see citing works