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Cited by 53Dementia and Cognitive Impairment ResearchSleep and Wakefulness ResearchAlzheimer's disease research and treatments

The DOI matches its Crossref record; 84 of the 85 references it cites were found in a registry or an index.

In Search of Sleep Biomarkers of Alzheimer’s Disease: K-Complexes Do Not Discriminate between Patients with Mild Cognitive Impairment and Healthy Controls

Open access
Reda, Flaminia, Gorgoni, Maurizio, Lauri, Giulia, Truglia, Ilaria, Cordone, Susanna, Scarpelli, Serena, Mangiaruga, Anastasia, D'Atri, Aurora, Ferrara, Michele, Lacidogna, Giordano, Marra, Camillo, Rossini, Paolo Maria, De Gennaro, Luigi·2017·Brain Sciences
DOI 10.3390/brainsci7050051PMC PMC5447933
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Abstract

The K-complex (KC) is one of the hallmarks of Non-Rapid Eye Movement (NREM) sleep. Recent observations point to a drastic decrease of spontaneous KCs in Alzheimer's disease (AD). However, no study has investigated when, in the development of AD, this phenomenon starts. The assessment of KC density in mild cognitive impairment (MCI), a clinical condition considered a possible transitional stage between normal cognitive function and probable AD, is still lacking. The aim of the present study was to compare KC density in AD/MCI patients and healthy controls (HCs), also assessing the relationship between KC density and cognitive decline. Twenty amnesic MCI patients underwent a polysomnographic recording of a nocturnal sleep. Their data were compared to those of previously recorded 20 HCs and 20 AD patients. KCs during stage 2 NREM sleep were visually identified and KC densities of the three groups were compared. AD patients showed a significant KC density decrease compared with MCI patients and HCs, while no differences were observed between MCI patients and HCs. KC density was positively correlated with Mini-Mental State Examination (MMSE) scores. Our results point to the existence of an alteration of KC density only in a full-blown phase of AD, which was not observable in the early stage of the pathology (MCI), but linked with cognitive deterioration.

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  • These graphoelements have been addressed as markers for early cognitive deterioration conditions, such as Alzheimer's disease, where memory deterioration is one of the main complaints.

    “These graphoelements have been addressed as markers for early cognitive deterioration conditions, such as Alzheimer’s disease,127–129 where memory deterioration is one of the main complaints.”

    From Spotlight on dream recall: the ages of dreams (2018) · cites this paper as [128]

  • Age-related microstructural changes of sleep have been linked to cognitive deterioration.

    “age-related microstructural changes of sleep have been linked to cognitive deterioration.123,127–129”

    From Spotlight on dream recall: the ages of dreams (2018) · cites this paper as [128]

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1 of the 85 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. Kubicki, 1989, The effect of age on sleep spindle and K complex density, EEG EMG Z Elektroenzephalogr. Elektromyogr. Verwandte Geb., 20, 59
  2. Spielberger, C.D. (1989). State-Trait Anxiety Inventory: Bibliography, Consulting Psychologists Press. [2nd ed.].
  3. Steriade, M. (2003). Neuronal Substrates of Sleep and Epilepsy, Cambridge UP.

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Metadata

Authors
Reda, F., Gorgoni, M., Lauri, G., Truglia, I., Cordone, S., Scarpelli, S., Mangiaruga, A., D'Atri, A., Ferrara, M., Lacidogna, G., Marra, C., Rossini, P. M., & De Gennaro, L.
Affiliations
  • Sapienza University of Rome (IT)
  • Department of Psychology, Sapienza University of Rome, Rome 00185, Italy
  • Department of Biotechnological and Applied Clinical Science, University of L’Aquila, L’Aquila 67100, Italy
  • Università Cattolica del Sacro Cuore (IT)
ORCID
Venue
Brain Sciences
Publisher
MDPI AG
Published
2017-04-29
Volume
7
Issue
5
Pages
51
ISSN
2076-3425 (ISSN-L)
DOI
10.3390/brainsci7050051
PMC
PMC5447933
OpenAlex
W2611962435
Cited by
52
References
85
Citations by year
2026: 2 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 12 · 2020: 6 · 2019: 9 · 2018: 3 · 2017: 2
FWCI
4.49
Type
journal article
Language
en
Open access
Licence
Locations
  • Brain Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, cc-by)
  • PubliCatt (Università Cattolica del Sacro Cuore) (submittedVersion, cc-by)
  • Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion, cc-by-nc-nd)
Funders
  • MIUR (2010SH7H3F_005)
  • Sapienza Università di Roma (C26A158K25)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords
K-complexes, Alzheimer's disease, mild cognitive impairment, sleep biomarkers, NREM sleep, stage 2 sleep, polysomnography, cognitive decline, Mini-Mental State Examination, amnestic MCI

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