Cited by 289Nanoparticle-Based Drug DeliverySurfactants and Colloidal SystemsNanoplatforms for cancer theranostics

The DOI matches its Crossref record; 111 of the 112 references it cites were found in a registry or an index.

Micelles Structure Development as a Strategy to Improve Smart Cancer Therapy

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Abstract

Micelles as colloidal suspension have attracted considerable attention due to their potential use for both cancer diagnosis and therapy. These structures have proven their ability to deliver poorly water-soluble anticancer drugs, improve drug stability, and have good penetration and site-specificity, leading to enhance therapeutic efficacy. Micelles are composed of hydrophobic and hydrophilic components assembled into nanosized spherical, ellipsoid, cylindrical, or unilamellar structures. For their simple formation, they are widely studied, either by using opposite polymers attachment consisting of two or more block copolymers, or by using fatty acid molecules that can modify themselves in a rounded shape. Recently, hybrid and responsive stimuli nanomicelles are formed either by integration with metal nanoparticles such as silver, gold, iron oxide nanoparticles inside micelles or by a combination of lipids and polymers into single composite. Herein, through this special issue, an updated overview of micelles development and their application for cancer therapy will be discussed.

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  1. Alexandridis, P., and Lindman, B. (2000). Micelles of amphilphilic block copolymers as vehicles for drug delivery. Amphiphilic Block Copolymers: Self-Assembly and Applications, Elsevier.
  2. Duncan, 1983, Kopeček, Polymers containing enzymatically degradable bonds, 7. Design of oligopeptide side-chains in poly[n-(2-hydroxypropyl)methacrylamide] copolymers to promote efficient degradation by lysosomal-enzymes, Macromol. Chem. Macromol. Chem. Phys., 184, 1997

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Metadata

Authors
Hanafy, N., El-Kemary, M., & Leporatti, S.
Affiliations
  • Kafrelsheikh University (EG)
  • Istituto di Nanotecnologia (IT)
Corresponding author
Leporatti, Stefano
Venue
Cancers
Publisher
MDPI AG
Published
2018-07-20
Volume
10
Issue
7
Pages
238
ISSN
2072-6694 (ISSN-L)
OpenAlex
W2884808176
Cited by
287
References
112
Citations by year
2026: 15 · 2025: 31 · 2024: 60 · 2023: 37 · 2022: 52 · 2021: 45 · 2020: 32 · 2019: 12 · 2018: 3
FWCI
1.54
Type
journal article
Language
en
Open access
Locations
  • Cancers (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Research Executive Agency (PITN-GA-2012-316549 (IT LIVER))
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords
micelles, cancer therapy, drug delivery, block copolymers, self-assembly, metal nanoparticles, drug stability, local drug delivery

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