Cited by 289Nanoparticle-Based Drug DeliverySurfactants and Colloidal SystemsNanoplatforms for cancer theranostics

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Micelles Structure Development as a Strategy to Improve Smart Cancer Therapy

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Hanafy, Nemany, El-Kemary, Maged, Leporatti, Stefano·2018·Cancers

DOI 10.3390/cancers10070238PMC PMC6071246

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Abstract

Micelles as colloidal suspension have attracted considerable attention due to their potential use for both cancer diagnosis and therapy. These structures have proven their ability to deliver poorly water-soluble anticancer drugs, improve drug stability, and have good penetration and site-specificity, leading to enhance therapeutic efficacy. Micelles are composed of hydrophobic and hydrophilic components assembled into nanosized spherical, ellipsoid, cylindrical, or unilamellar structures. For their simple formation, they are widely studied, either by using opposite polymers attachment consisting of two or more block copolymers, or by using fatty acid molecules that can modify themselves in a rounded shape. Recently, hybrid and responsive stimuli nanomicelles are formed either by integration with metal nanoparticles such as silver, gold, iron oxide nanoparticles inside micelles or by a combination of lipids and polymers into single composite. Herein, through this special issue, an updated overview of micelles development and their application for cancer therapy will be discussed.

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Authors: Hanafy, N., El-Kemary, M., & Leporatti, S.
Affiliations: Kafrelsheikh University (EG)
Istituto di Nanotecnologia (IT)
Corresponding author: Leporatti, Stefano
ORCID: Hanafy, Nemany
El-Kemary, Maged
Leporatti, Stefano
Venue: Cancers
Publisher: MDPI AG
Published: 2018-07-20
Volume: 10
Issue: 7
Pages: 238
ISSN: 2072-6694 (ISSN-L)
DOI: 10.3390/cancers10070238
PMC: PMC6071246
OpenAlex: W2884808176
Cited by: 287
References: 112
Citations by year: 2026: 15 · 2025: 31 · 2024: 60 · 2023: 37 · 2022: 52 · 2021: 45 · 2020: 32 · 2019: 12 · 2018: 3
FWCI: 1.54
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Cancers (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Research Executive Agency (PITN-GA-2012-316549 (IT LIVER))
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords: micelles, cancer therapy, drug delivery, block copolymers, self-assembly, metal nanoparticles, drug stability, local drug delivery

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Micelles Structure Development as a Strategy to Improve Smart Cancer Therapy

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