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Micelles Structure Development as a Strategy to Improve Smart Cancer Therapy
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Micelles as colloidal suspension have attracted considerable attention due to their potential use for both cancer diagnosis and therapy. These structures have proven their ability to deliver poorly water-soluble anticancer drugs, improve drug stability, and have good penetration and site-specificity, leading to enhance therapeutic efficacy. Micelles are composed of hydrophobic and hydrophilic components assembled into nanosized spherical, ellipsoid, cylindrical, or unilamellar structures. For their simple formation, they are widely studied, either by using opposite polymers attachment consisting of two or more block copolymers, or by using fatty acid molecules that can modify themselves in a rounded shape. Recently, hybrid and responsive stimuli nanomicelles are formed either by integration with metal nanoparticles such as silver, gold, iron oxide nanoparticles inside micelles or by a combination of lipids and polymers into single composite. Herein, through this special issue, an updated overview of micelles development and their application for cancer therapy will be discussed.
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![Scheme 3 Hybrid polymer lipid protein nanocarrier. Step 1: Assembly of chitosan and oleic acid; step 2: Folic acid (FA) conjugation with bovine serum albumin; and step 3: functionalization of chitosan grafted oleic acid surface by using bovine serum albumin (BSA)-FA (Figure adapted with permission from ref. [53]).](/paper-figures/cd35787c0ab74d688c5462e33628d483/micelles-structure-development-as-a-strategy-to-improve-smart-cancer-therapy-figure-3.jpg)
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“SAXS experiments are extensively applied to investigate the structure of polymeric micelles in solution, empty or loaded with drugs, providing detailed description of their size, shape and inner architecture on the 1-100 nm length-scale [191,192].”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [192]
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Metadata
- Authors
- Hanafy, N., El-Kemary, M., & Leporatti, S.
- Affiliations
- Kafrelsheikh University (EG)
- Istituto di Nanotecnologia (IT)
- Corresponding author
- Leporatti, Stefano
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2018-07-20
- Volume
- 10
- Issue
- 7
- Pages
- 238
- ISSN
- 2072-6694 (ISSN-L)
- PMC
- PMC6071246
- OpenAlex
- W2884808176
- Cited by
- 287
- References
- 112
- Citations by year
- 2026: 15 · 2025: 31 · 2024: 60 · 2023: 37 · 2022: 52 · 2021: 45 · 2020: 32 · 2019: 12 · 2018: 3
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Cancers (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Research Executive Agency (PITN-GA-2012-316549 (IT LIVER))
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- micelles, cancer therapy, drug delivery, block copolymers, self-assembly, metal nanoparticles, drug stability, local drug delivery
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