The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.
Cross-Talk between NADPH Oxidase and Mitochondria: Role in ROS Signaling and Angiogenesis
Open accessAbstract
Angiogenesis, a new vessel formation from the pre-existing ones, is essential for embryonic development, wound repair and treatment of ischemic heart and limb diseases. However, dysregulated angiogenesis contributes to various pathologies such as diabetic retinopathy, atherosclerosis and cancer. Reactive oxygen species (ROS) derived from NADPH oxidase (NOX) as well as mitochondria play an important role in promoting the angiogenic switch from quiescent endothelial cells (ECs). However, how highly diffusible ROS produced from different sources and location can communicate with each other to regulate angiogenesis remains unclear. To detect a localized ROS signal in distinct subcellular compartments in real time in situ, compartment-specific genetically encoded redox-sensitive fluorescence biosensors have been developed. Recently, the intercellular communication, “cross-talk”, between ROS derived from NOX and mitochondria, termed “ROS-induced ROS release”, has been proposed as a mechanism for ROS amplification at distinct subcellular compartments, which are essential for activation of redox signaling. This “ROS-induced ROS release” may represent a feed-forward mechanism of localized ROS production to maintain sustained signaling, which can be targeted under pathological conditions with oxidative stress or enhanced to promote therapeutic angiogenesis. In this review, we summarize the recent knowledge regarding the role of the cross-talk between NOX and mitochondria organizing the sustained ROS signaling involved in VEGF signaling, neovascularization and tissue repair.
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Cites
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Cited by
The role of ROS in tumour development and progression
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ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways
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Oxidative Stress: Signaling Pathways, Biological Functions, and Disease
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Mechanistic Pathogenesis of Endothelial Dysfunction in Diabetic Nephropathy and Retinopathy
Yang, J., & Liu, Z. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.816400 · Cited by 281
Zhao, T., Wu, W., Sui, L., Huang, Q., Nan, Y., Liu, J., & Ai, K. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.06.006 · Cited by 267
Metadata
- Authors
- Fukai, T., & Ushio-Fukai, M.
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2020-08-06
- Volume
- 9
- Issue
- 8
- Pages
- 1849
- ISSN
- 2073-4409 (ISSN-L)
- OpenAlex
- W3047601213
- Cited by
- 300
- References
- 128
- FWCI
- 11.82
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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