Cited by 1,081Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietPomegranate: compositions and health benefits

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Dietary Polyphenols and Their Biological Significance

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Han, Xiuzhen, Shen, Tao, Lou, Hongxiang·2007·International Journal of Molecular Sciences

DOI 10.3390/i8090950PMC PMC3871896

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Abstract

Dietary polyphenols represent a wide variety of compounds that occur in fruits,vegetables, wine, tea, extra virgin olive oil, chocolate and other cocoa products. They aremostly derivatives and/or isomers of flavones, isoflavones, flavonols, catechins andphenolic acids, and possess diverse biological properties such as antioxidant, antiapoptosis,anti-aging, anticarcinogen, anti-inflammation, anti-atherosclerosis, cardiovascularprotection, improvement of the endothelial function, as well as inhibition of angiogenesisand cell proliferation activity. Most of these biological actions have been attributed to theirintrinsic reducing capabilities. They may also offer indirect protection by activatingendogenous defense systems and by modulating cellular signaling processes such asnuclear factor-kappa B (NF-кB) activation, activator protein-1(AP-1) DNA binding,glutathione biosynthesis, phosphoinositide 3 (PI3)-kinase/protein kinase B (Akt) pathway,mitogen-activated protein kinase (MAPK) proteins [extracellular signal-regulated proteinkinase (ERK), c-jun N-terminal kinase (JNK) and P38 ] activation, and the translocationinto the nucleus of nuclear factor erythroid 2 related factor 2 (Nrf2). This paper covers themost recent literature on the subject, and describes the biological mechanisms of action andprotective effects of dietary polyphenols.

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Lotito, 2006, Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: Cause, consequence, or epiphenomenon?, Free Radic. Biol. Med, 41, 1727, 10.1016/j.freeradbiomed.2006.04.033 · DOI
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Authors: Han, X., Shen, T., & Lou, H.
Affiliations: Shandong University (CN)
Department of Natural Product Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, P. R. China
ORCID: Han, Xiuzhen
Shen, Tao
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2007-09-12
Volume: 8
Issue: 9
Pages: 950-988
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/i8090950
PMC: PMC3871896
OpenAlex: W2166129369
Cited by: 1,081
References: 200
Citations by year: 2026: 29 · 2025: 44 · 2024: 78 · 2023: 83 · 2022: 81 · 2021: 80 · 2020: 79 · 2019: 78 · 2018: 72 · 2017: 75 · 2016: 60 · 2015: 54 · 2014: 80 · 2013: 52 · 2012: 48
FWCI: 10.97
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
Keywords: dietary polyphenols, flavonoids, catechins, phenolic acids, isoflavones, flavonols, antioxidant activity, anti-inflammatory activity, anticarcinogenic activity, anti-aging, cardioprotection, endothelial function, angiogenesis inhibition, cell proliferation inhibition, NF-κB signaling, MAPK signaling, PI3K/Akt signaling, Nrf2, glutathione synthesis

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Dietary Polyphenols and Their Biological Significance

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