Dysregulation of miR-15a-5p, miR-497a-5p and miR-511-5p Is Associated with Modulation of BDNF and FKBP5 in Brain Areas of PTSD-Related Susceptible and Resilient Mice
Open accessAbstract
Post-traumatic stress disorder (PTSD) is a neuropsychiatric disorder occurring in susceptible individuals following a traumatic event. Understanding the mechanisms subserving trauma susceptibility/resilience is essential to develop new effective treatments. Increasing evidence suggests that non-coding RNAs, such as microRNAs (miRNAs), may play a prominent role in mediating trauma susceptibility/resilience. In this study, we evaluated the transcriptional expression of two key PTSD-related genes (FKBP5 and BDNF) and the relative targeting miRNAs (miR-15a-5p, miR-497a-5p, miR-511-5p, let-7d-5p) in brain areas of PTSD-related susceptible and resilient mice identified through our recently developed mouse model of PTSD (arousal-based individual screening (AIS) model). We observed lower transcript levels of miR-15a-5p, miR-497a-5p, and miR-511a-5p in the hippocampus and hypothalamus of susceptible mice compared to resilient mice, suggesting that the expression of these miRNAs could discriminate the two different phenotypes of stress-exposed mice. These miRNA variations could contribute, individually or synergically, to the inversely correlated transcript levels of FKBP5 and BDNF. Conversely, in the medial prefrontal cortex, downregulation of miR-15a-5p, miR-511-5p, and let-7d-5p was observed both in susceptible and resilient mice, and not accompanied by changes in their mRNA targets. Furthermore, miRNA expression in the different brain areas correlated to stress-induced behavioral scores (arousal score, avoidance-like score, social memory score and PTSD-like score), suggesting a linear connection between miRNA-based epigenetic modulation and stress-induced phenotypes. Pathway analysis of a miRNA network showed a statistically significant enrichment of molecular processes related to PTSD and stress. In conclusion, our results indicate that PTSD susceptibility/resilience might be shaped by brain-area-dependent modulation of miRNAs targeting FKBP5, BDNF, and other stress-related genes.
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MicroRNAs such as miR-15 and miR-511 have been proposed to regulate FKBP5 expression, linking it to pathways of inflammation and stress response.
“microRNAs such as miR-15 and miR-511 have been proposed to regulate FKBP5 expression, linking it to pathways of inflammation and stress response”
From The clinical use of epigenetics in psychiatry: a narrative review of epigenetic mechanisms, key candidate genes, and precision psychiatry (2025) · cites this paper as [88]
Results §2.1 identifies miR-15a-5p and miR-511-5p as potential FKBP5-targeting miRNAs, and the Introduction links FKBP5 to stress responses. Results §2.2.7 finds cytokine signaling and corticosteroid-response pathways in the broader network of genes targeted by the investigated miRNAs. It does not specifically show that regulation of FKBP5 by these miRNAs links FKBP5 to inflammatory pathways. (LLM, conf=0.83)
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Self-citation
- Authors
- Maurel, O. M., Torrisi, S. A., Barbagallo, C., Purrello, M., Salomone, S., Drago, F., Ragusa, M., & Leggio, G. M.
- Affiliations
- University of Catania (IT)
- Corresponding author
- Ragusa, Marco
- Leggio, Gian Marco
- ORCID
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2021-05-13
- Volume
- 22
- Issue
- 10
- Pages
- 5157
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC8153003
- OpenAlex
- W3160197519
- Cited by
- 44
- References
- 99
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 5 · 2023: 14 · 2022: 9 · 2021: 3
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministero della Salute
- Università di Catania (PIA.CE.RI. 2020-2022, 2020-2022)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- post-traumatic stress disorder, microRNA, miR-15a-5p, let-7d-5p, brain-derived neurotrophic factor, FKBP5, hippocampus, hypothalamus, medial prefrontal cortex, stress response, epigenetic regulation, miRNA network, social memory, avoidance behavior
- MeSH terms
- Tacrolimus Binding Protein 5, Animals, Gene Expression Regulation, Male, Mice, Inbred C57BL, Stress Disorders, Post-Traumatic, Brain-Derived Neurotrophic Factor, Tacrolimus Binding Proteins, MicroRNAs, Mice, Resilience, Psychological
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