Peripheral whole blood microRNA alterations in major depression and bipolar disorder
Open accessAbstract
Major depression (MD) and bipolar disorder (BD) are severe and potentially life-threating mood disorders whose etiology is to date not completely understood. MicroRNAs (miRNAs) are small non-coding RNAs that regulate protein synthesis post-transcriptionally by base-pairing to target gene mRNAs. Growing evidence indicated that miRNAs might play a key role in the pathogenesis of neuropsychiatric disorders and in the action of psychotropic drugs. On these bases, in this study we evaluated the expression levels of 1733 mature miRNAs annotated in miRBase v.17, through a microarray technique, in the blood of 20 MD and 20 BD patients and 20 healthy controls, in order to identify putative miRNA signatures associated with mood disorders. We found that 5 miRNAs (hsa-let-7a-5p, hsa-let-7d-5p, hsa-let-7f-5p, hsa-miR-24-3p and hsa-miR-425-3p) were specifically altered in MD patients and 5 (hsa-miR-140-3p, hsa-miR-30d-5p, hsa-miR-330-5p, hsa-miR-378a-5p and hsa-miR-21-3p) in BD patients, whereas 2 miRNAs (hsa-miR-330-3p and hsa-miR-345-5p) were dysregulated in both the diseases. The bioinformatic prediction of the genes targeted by the altered miRNAs revealed the possible involvement of neural pathways relevant for psychiatric disorders. In conclusion, the observed results indicate a dysregulation of miRNA blood expression in mood disorders and could indicate new avenues for a better understanding of their pathogenetic mechanisms. The identified alterations may represent potential peripheral biomarkers to be complemented with other clinical and biological features for the improvement of diagnostic accuracy.
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In peripheral blood of depressed patients, multiple miRNAs such as miR-330-3p, miR-345-3p, miR-425-3p, and miR-24-3p were reportedly altered.
“In peripheral blood of depressed patients, multiple miRNAs, such as miR-330-3p, miR-345-3p, miR-425-3p, and miR-24-3p, were reportedly altered.243”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [243]
Section 3.2 reports altered peripheral-blood levels of miR-330-3p, miR-425-3p, and miR-24-3p in patients with major depression. It reports miR-345-5p, not the claimed miR-345-3p. Page numbers are not provided in our copy. (LLM, conf=0.92)
Experimental — accuracy not yet measuredmiRNA and lncRNA levels in blood distinguish depressed patients from healthy controls.
“Because miRNA and lncRNA levels in blood distinguish depressed patients from healthy controls,243,310,387”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [243]
Section 3.2 reports blood miRNA levels that differed between major-depression patients and healthy controls. The paper does not report lncRNA levels, and its Discussion describes the miRNAs as potential biomarkers rather than established diagnostic tests. Page numbers were not available in our copy. (LLM, conf=0.90)
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“385,386 Because miRNA and lncRNA levels in blood distinguish depressed patients from healthy controls, 243,310,387 for a diagnostic tool, it is not essential if blood and brain exhibit signi fi cant similarities.”
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- Authors
- Maffioletti, E., Cattaneo, A., Rosso, G., Maina, G., Maj, C., Gennarelli, M., Tardito, D., & Bocchio-Chiavetto, L.
- Affiliations
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- King's College London (GB)
- Ospedale San Luigi Gonzaga (IT)
- University of Milan (IT)
- ORCID
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 200
- Pages
- 250-258
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2340620158
- Cited by
- 181
- References
- 51
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 21 · 2023: 17 · 2022: 17 · 2021: 24 · 2020: 21 · 2019: 18 · 2018: 15 · 2017: 17 · 2016: 3
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- Research Portal (King's College London) (submittedVersion, cc-by-nc-nd)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- IRIS eCampus Telematic University (Università degli Studi eCampus) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- major depressive disorder, bipolar disorder, microRNA expression, peripheral blood, mood disorders, microRNA signature, biomarkers, let-7 microRNA, miR-24, miR-330, miR-21, post-transcriptional regulation, pathogenesis
- MeSH terms
- Adult, Bipolar Disorder, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Biomarkers, MicroRNAs
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