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The Golgi Apparatus: A Key Player in Innate Immunity

Mărunţelu, Ion, Constantinescu, Alexandra-Elena, Covache-Busuioc, Razvan-Adrian, Constantinescu, Ileana·2024·International Journal of Molecular Sciences
DOI 10.3390/ijms25074120PMC PMC11012725
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Abstract

The Golgi apparatus, long recognized for its roles in protein processing and vesicular trafficking, has recently been identified as a crucial contributor to innate immune signaling pathways. This review discusses our expanding understanding of the Golgi apparatus’s involvement in initiating and activating these pathways. It highlights the significance of membrane connections between the Golgi and other organelles, such as the endoplasmic reticulum, mitochondria, endosomes, and autophagosomes. These connections are vital for the efficient transmission of innate immune signals and the activation of effector responses. Furthermore, the article delves into the Golgi apparatus’s roles in key immune pathways, including the inflammasome-mediated activation of caspase-1, the cGAS-STING pathway, and TLR/RLR signaling. Overall, this review aims to provide insights into the multifunctional nature of the Golgi apparatus and its impact on innate immunity.

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Metadata

Authors
Mărunţelu, I., Constantinescu, A.-E., Covache-Busuioc, R.-A., & Constantinescu, I.
Affiliations
  • Immunology and Transplant Immunology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
  • Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2024-04-08
Volume
25
Issue
7
Pages
4120
ISSN
1422-0067
DOI
10.3390/ijms25074120
PMC
PMC11012725
Cited by
20
References
5
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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