Heterofucan from Sargassum filipendula induces apoptosis in HeLa cells
Open accessAbstract
Fucan is a term used to denominate a family of sulfated polysaccharides rich in sulfated l-fucose. Heterofucan SF-1.5v was extracted from the brown seaweed Sargassum filipendula by proteolytic digestion followed by sequential acetone precipitation. This fucan showed antiproliferative activity on Hela cells and induced apoptosis. However, SF-1.5v was not able to activate caspases. Moreover, SF-1.5v induced glycogen synthase kinase (GSK) activation, but this protein is not involved in the heterofucan SF-1.5v induced apoptosis mechanism. In addition, ERK, p38, p53, pAKT and NFκB were not affected by the presence of SF-1.5v. We determined that SF-1.5v induces apoptosis in HeLa mainly by mitochondrial release of apoptosis-inducing factor (AIF) into cytosol. In addition, SF-1.5v decreases the expression of anti-apoptotic protein Bcl-2 and increased expression of apoptogenic protein Bax. These results are significant in that they provide a mechanistic framework for further exploring the use of SF-1.5v as a novel chemotherapeutics against human cervical cancer.
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Fucoidan from Sargassum filipendula showed antiproliferative activity on HeLa cells and induced apoptosis by mitochondrial release of AIF into cytosol, but did not activate caspases.
“The fucoidan from Sargassum filipendula showed antiproliferative activity on HeLa cells [39] and induced apoptosis by mitochondrial release of apoptosis inducing factor (AIF) into cytosol, but was not able to activate caspases [40].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [40]
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- Authors
- Silva Costa, L., Silva Telles, C. B., Medeiros Oliveira, R., Duarte Barreto Nobre, L. T., Dantas-Santos, N., Barros Gomes Camara, R., Santana Santos Pereira Costa, M., Almeida-Lima, J., Melo-Silveira, R. F., Lopes Albuquerque, I. R., Leite, E. L., & Oliveira Rocha, H. A.
- Affiliations
- Laboratory of Biotechnology of Natural Polymers (BIOPOL), Departament of Biochemistry, Federal University of Rio Grande do Norte (UFRN), Natal-RN, Brazil
- Universidade Federal do Rio Grande do Norte (BR)
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2011-04-14
- Volume
- 9
- Issue
- 4
- Pages
- 603-614
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC3124975
- OpenAlex
- W2033365400
- Semantic Scholar
- 9990eb842ccb69c1b3f103694c3ba03032363460
- Cited by
- 51
- References
- 26
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 9 · 2019: 5 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 7 · 2014: 2 · 2013: 5 · 2012: 5
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Keywords
- Sargassum filipendula, sulfated polysaccharides, apoptosis, HeLa cells, cervical cancer, apoptosis-inducing factor, mitochondrial release, Bcl-2, Bax, antiproliferative activity, caspase-independent apoptosis, glycogen synthase kinase
- MeSH terms
- Uterine Cervical Neoplasms, Cytosol, Female, Fucose, HeLa Cells, Humans, Mitochondria, Polysaccharides, Gene Expression Regulation, Neoplastic, Apoptosis, Sargassum, Cell Proliferation, Apoptosis Inducing Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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