Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders.

Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

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How regulatory T cells work

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

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Renal and Extrarenal Effects of Gum Arabic (Acacia Senegal) - What Can be Learned from Animal Experiments?

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Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4

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The inhibitory cytokine IL-35 contributes to regulatory T-cell function

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Secukinumab in plaque psoriasis—results of two phase 3 trials

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Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

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TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

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IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

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Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells

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Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

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Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

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Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn’s disease: unexpected results of a randomised, double-blind placebo-controlled trial

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TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology

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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

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Generation of pathogenic TH17 cells in the absence of TGF-β signalling

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Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)

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Natural versus adaptive regulatory T cells

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The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

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Epigenetic Control of the foxp3 Locus in Regulatory T Cells

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Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy

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Induction and effector functions of TH17 cells

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Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

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Induction and molecular signature of pathogenic TH17 cells

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A Validated Regulatory Network for Th17 Cell Specification

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Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

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Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

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Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis

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FDA-approved small-molecule kinase inhibitors

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Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

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Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation

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Deacetylase inhibition promotes the generation and function of regulatory T cells

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IL-21 and TGF-β are required for differentiation of human TH17 cells

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Increased Expression of Interleukin 23 p19 and p40 in Lesional Skin of Patients with Psoriasis Vulgaris

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TGF-β: A Master of All T Cell Trades

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IL-35-mediated induction of a potent regulatory T cell population

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Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

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Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): a randomised, double-blind, placebo-controlled, phase 3 trial

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Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3

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Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

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Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial

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Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

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Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms

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Evidence for a cross-talk between human neutrophils and Th17 cells

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Secukinumab Inhibition of Interleukin-17A in Patients with Psoriatic Arthritis

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Efficacy and safety of the anti-IL-12/23 p40 monoclonal antibody, ustekinumab, in patients with active psoriatic arthritis despite conventional non-biological and biological anti-tumour necrosis factor therapy: 6-month and 1-year results of the phase 3, multicentre, double-blind, placebo-controlled, randomised PSUMMIT 2 trial

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Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)

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Interleukin-6 and its receptors: a highly regulated and dynamic system

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Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial

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Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial

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CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness

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Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3− and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner

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Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation

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Adalimumab for prevention of uveitic flare in patients with inactive non-infectious uveitis controlled by corticosteroids (VISUAL II): a multicentre, double-masked, randomised, placebo-controlled phase 3 trial

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Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

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Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β and Interleukin-10

Li, M. O., & Flavell, R. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.003 · Cited by 501 · see citing works

Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor

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Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

Segal, B. M., Constantinescu, C. S., Raychaudhuri, A., Kim, L., Fidelus-Gort, R., & Kasper, L. H. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70173-x · Cited by 479 · see citing works

Transcriptional regulation of Th17 cell differentiation

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Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis

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Foxp3 Inhibits RORγt-mediated IL-17A mRNA Transcription through Direct Interaction with RORγt*

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IL ‐22, not simply a Th17 cytokine

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Pathophysiology of psoriasis: Recent advances on IL-23 and Th17 cytokines

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Tofacitinib versus etanercept or placebo in moderate-to-severe chronic plaque psoriasis: a phase 3 randomised non-inferiority trial

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IL-17 in Chronic Inflammation: From Discovery to Targeting

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CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity

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Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes

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