The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Polyphenols and Human Health: The Role of Bioavailability
Open accessAbstract
Polyphenols are a group of phytochemicals with potential health-promoting effects. They are classified as flavonoid (flavonols, flavanols, flavones, flavanones, isoflavones, and anthocyanins) and non-flavonoid molecules (phenolic acids, hydroxycinnamic acids, lignans, stilbenes, and tannins). Although an increasing number of trials have shown a correlation among polyphenol consumption and a reduction in risk factors for chronic diseases, discrepancies in explaining their positive effects have been found in terms of the bioavailability. In fact, polyphenols show a low bioavailability due to several factors: interaction with the food matrix, the metabolic processes mediated by the liver (phase I and II metabolism), intestine and microbiota. On the other hand, the biological activities of phenol compounds may be mediated by their metabolites, which are produced in vivo, and recent studies have confirmed that these molecules may have antioxidant and anti-phlogistic properties. This review discusses the studies performed in vivo, which consider the polyphenol bioavailability and their different food sources. Factors influencing the biological effects of the main classes of polyphenols are also considered.
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Cites
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Cited by
Oxidative Stress: The Role of Antioxidant Phytochemicals in the Prevention and Treatment of Diseases
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RONS and Oxidative Stress: An Overview of Basic Concepts
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Polyphenols and Their Impact on the Prevention of Neurodegenerative Diseases and Development
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Biological and pharmacological aspects of tannins and potential biotechnological applications
Melo, L. F. M. D., Aquino-Martins, V. G. D. Q., Silva, A. P. D., Oliveira Rocha, H. A., & Scortecci, K. C. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.135645 · Cited by 137
Metadata
- Authors
- Di Lorenzo, C., Colombo, F., Biella, S., Stockley, C., & Restani, P.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2021-01-19
- Volume
- 13
- Issue
- 1
- Pages
- 273
- ISSN
- 2072-6643 (ISSN-L)
- OpenAlex
- W3121734311
- Cited by
- 903
- References
- 73
- FWCI
- 55.66
- Type
- journal article
- Language
- en
- Open access
- gold
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