Comparison of the Effects of Intermittent Energy Restriction and Continuous Energy Restriction among Adults with Overweight or Obesity: An Overview of Systematic Reviews and Meta-Analyses
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There is considerable heterogeneity across the evidence regarding the effects of intermittent energy restriction and continuous energy restriction among adults with overweight or obesity which presents difficulties for healthcare decision-makers and individuals. This overview of systematic reviews aimed to evaluate and synthesize the existing evidence regarding the comparison of the two interventions. We conducted a search strategy in eight databases from the databases' inception to December 2021. The quality of 12 systematic reviews was assessed with A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR 2) and the Grading of Recommendations Assessment, Development and Evaluation (GRADE). One review was rated as high quality, 1 as moderate, 4 as low, and 6 as critically low. A meta-analysis of the original studies was conducted for comparison of primary intermittent energy restriction protocols with continuous energy restriction. Intermittent energy restriction did not seem to be more effective in weight loss compared with continuous energy restriction. The advantages of intermittent energy restriction in reducing BMI and waist circumference and improvement of body composition were not determined due to insufficient evidence. The evidence quality of systematic reviews and original trials remains to be improved in future studies.
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Existing systematic reviews and meta-analyses have conducted pairwise comparisons but have not yielded conclusive evidence regarding the optimal caloric restriction regimen.
“To date, existing systematic reviews and meta-analyses have conducted pairwise comparisons, such as STF versus CER [22], IER versus CER [23], and STF versus CER [24, 25]. However, these studies have not yielded conclusive evidence regarding the optimal regimen.”
From Comparing caloric restriction regimens for effective weight management in adults: a systematic review and network meta-analysis (2024) · cites this paper as [23]
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“In Figure 6 and Table 3, four quantitative reviews [19,24,26,39] and three qualitative reviews [25,36,37] showed that IER was not distinguishable from CER in effect on FM, consistent with our meta-analysis (MD −0.”
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Huang, J., Li, Y., Chen, M., Cai, Z., Cai, Z., & Jiang, Z. (2024) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-024-01657-9 · Cited by 25 · see citing works
“To date, existing systematic reviews and meta-analyses have conducted pairwise comparisons, such as STF versus CER [22], IER versus CER [23], and STF versus CER [24, 25].”
BackgroundKarimi, M., Akhgarjand, C., Houjaghani, H., Nejad, M. M., Sohrabpour, A. A., Poustchi, H., Mohammadi, H., Chamari, M., & Imani, H. (2025) · Clinical Therapeutics · doi:10.1016/j.clinthera.2025.01.007 · Cited by 12 · see citing works
- Authors
- Wang, J., Wang, F., Chen, H., Liu, L., Zhang, S., Luo, W., Wang, G., & Hu, X.
- Affiliations
- Sichuan University (CN)
- Corresponding author
- Wang, Guan
- Hu, Xiuying
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2022-05-31
- Volume
- 14
- Issue
- 11
- Pages
- 2315
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC9183159
- OpenAlex
- W4281638490
- Cited by
- 17
- References
- 9
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 5 · 2023: 3
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- the National Natural Science Foundation of China (22177083, 81803755, HXHL20015, HXHL21011, 2020JDS0128, 2021YJ0016, 2020SCU12062)
- West China Nursing Discipline Development Special Fund Project, Sichuan University (22177083, 81803755, HXHL20015, HXHL21011, 2020JDS0128, 2021YJ0016, 2020SCU12062)
- Sichuan Science and Technology Program (22177083, 81803755, HXHL20015, HXHL21011, 2020JDS0128, 2021YJ0016, 2020SCU12062)
- Sichuan University Postdoctoral Research and Development Foundation (22177083, 81803755, HXHL20015, HXHL21011, 2020JDS0128, 2021YJ0016, 2020SCU12062)
- Topics
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- intermittent energy restriction, continuous energy restriction, obesity, overweight, weight loss, body mass index, waist circumference, body composition, dietary intervention, quality of evidence
- MeSH terms
- Systematic Reviews as Topic, Adult, Humans, Obesity, Weight Loss, Overweight, Waist Circumference
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