Effects of bioactive compounds on senescence and components of senescence associated secretory phenotypes in vitro
Abstract
Senescence is a permanent cell cycle arrest that is accompanied by changes in cell morphology and physiology occurring in vitro and in vivo .
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Carotenoids participate in the regulation of OS-induced senescence.
“There is evidence that carotenoids participate in the regulation of OS-induced senescence [151,152]”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [151]
Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508 · see citing works
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · see citing works
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750 · see citing works
Reynolds, B. A., & Weiss, S. (1992) · Science · doi:10.1126/science.1553558 · Cited by 5,413 · see citing works
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,178 · see citing works
Rheinwatd, J. G., & Green, H. (1975) · Cell · doi:10.1016/s0092-8674(75)80001-8 · Cited by 4,528 · see citing works
Cellular senescence: when bad things happen to good cells
Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441 · see citing works
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · see citing works
Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration
Beltrami, A. P., Barlucchi, L., Torella, D., Baker, M., Limana, F., Chimenti, S., Kasahara, H., Rota, M., Musso, E., Urbanek, K., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00687-1 · Cited by 3,528 · see citing works
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., A. Saltness, R., Jeganathan, K. B., Verzosa, G. C., Pezeshki, A., et al. (2016) · Nature · doi:10.1038/nature16932 · Cited by 2,891 · see citing works
A DNA damage checkpoint response in telomere-initiated senescence
Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature02118 · Cited by 2,855 · see citing works
Cellular senescence: from physiology to pathology
Muñoz-Espín, D., & Serrano, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3823 · Cited by 2,818 · see citing works
The role of senescent cells in ageing
van Deursen, J. M. (2014) · Nature · doi:10.1038/nature13193 · Cited by 2,623 · see citing works
Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601 · see citing works
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell · doi:10.1111/acel.12344 · Cited by 2,562 · see citing works
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
Narita, M., Nuñez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., & Lowe, S. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00401-x · Cited by 2,278 · see citing works
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
Acosta, J. C., Banito, A., Wuestefeld, T., Georgilis, A., Janich, P., Morton, J. P., Athineos, D., Kang, T.-W., Lasitschka, F., Andrulis, M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2784 · Cited by 2,278 · see citing works
Satellite Cells and the Muscle Stem Cell Niche
Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166 · see citing works
D IETARY F LAVONOIDS : Bioavailability, Metabolic Effects, and Safety
Ross, J. A., & Kasum, C. M. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.111401.144957 · Cited by 2,153 · see citing works
Switching and Signaling at the Telomere
Blackburn, E. H. (2001) · Cell · doi:10.1016/s0092-8674(01)00492-5 · Cited by 2,097 · see citing works
Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell · doi:10.1016/j.cell.2008.03.039 · Cited by 2,086 · see citing works
Nuclear Receptors and Lipid Physiology: Opening the X-Files
Chawla, A., Repa, J. J., Evans, R. M., & Mangelsdorf, D. J. (2001) · Science · doi:10.1126/science.294.5548.1866 · Cited by 2,085 · see citing works
The essence of senescence: Figure 1.
Kuilman, T., Michaloglou, C., Mooi, W. J., & Peeper, D. S. (2010) · Genes & Development · doi:10.1101/gad.1971610 · Cited by 2,038 · see citing works
Senescence of activated stellate cells limits liver fibrosis
Krizhanovsky, V., Yon, M., Dickins, R. A., Hearn, S., Simon, J., Miething, C., Yee, H., Zender, L., & Lowe, S. W. (2008) · Cell · doi:10.1016/j.cell.2008.06.049 · Cited by 2,029 · see citing works
Senescence of Activated Stellate Cells Limits Liver Fibrosis
Krizhanovsky, V., Yon, M., Dickins, R. A., Hearn, S., Simon, J., Miething, C., Yee, H., Zender, L., & Lowe, S. W. (2008) · Cell · doi:10.1016/j.cell.2008.09.015 · Cited by 2,027
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004) · Nature · doi:10.1038/nature02789 · Cited by 1,868 · see citing works
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
Kang, T.-W., Yevsa, T., Woller, N., Hoenicke, L., Wuestefeld, T., Dauch, D., Hohmeyer, A., Gereke, M., Rudalska, R., Potapova, A., et al. (2011) · Nature · doi:10.1038/nature10599 · Cited by 1,621 · see citing works
Herbig, U., Jobling, W. A., Chen, B. P. C., Chen, D. J., & Sedivy, J. M. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00256-4 · Cited by 1,344 · see citing works
Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., Goossens, G. H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, S., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.10.002 · Cited by 1,320 · see citing works
Di Leonardo, A., Linke, S. P., Clarkin, K., & Wahl, G. M. (1994) · Genes & Development · doi:10.1101/gad.8.21.2540 · Cited by 1,215 · see citing works
Senescence is a developmental mechanism that contributes to embryonic growth and patterning
Storer, M., Mas, A., Robert-Moreno, A., Pecoraro, M., Ortells, M. C., Di Giacomo, V., Yosef, R., Pilpel, N., Krizhanovsky, V., Sharpe, J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.041 · Cited by 1,186 · see citing works
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T. (2006) · Nature · doi:10.1038/nature05159 · Cited by 1,106 · see citing works
Cellular Senescence in Aging Primates
Herbig, U., Ferreira, M., Condel, L., Carey, D., & Sedivy, J. M. (2006) · Science · doi:10.1126/science.1122446 · Cited by 1,101 · see citing works
Retinoic Acid Synthesis and Signaling during Early Organogenesis
Duester, G. (2008) · Cell · doi:10.1016/j.cell.2008.09.002 · Cited by 1,098 · see citing works
Endothelial Cell Senescence in Human Atherosclerosis: Role of Telomere in Endothelial Dysfunction
Minamino, T., Miyauchi, H., Yoshida, T., Ishida, Y., Yoshida, H., & Komuro, I. (2002) · Circulation · doi:10.1161/01.cir.0000013836.85741.17 · Cited by 1,061 · see citing works
Lamin B1 loss is a senescence-associated biomarker
Freund, A., Laberge, R.-M., Demaria, M., & Campisi, J. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-10-0884 · Cited by 1,046 · see citing works
Feedback between p21 and reactive oxygen production is necessary for cell senescence
Passos, J. F., Nelson, G., Wang, C., Richter, T., Simillion, C., Proctor, C. J., Miwa, S., Olijslagers, S., Hallinan, J., Wipat, A., et al. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.5 · Cited by 1,019 · see citing works
Geriatric muscle stem cells switch reversible quiescence into senescence
Sousa-Victor, P., Gutarra, S., García-Prat, L., Rodriguez-Ubreva, J., Ortet, L., Ruiz-Bonilla, V., Jardí, M., Ballestar, E., González, S., Serrano, A. L., et al. (2014) · Nature · doi:10.1038/nature13013 · Cited by 1,010 · see citing works
Jun, J.-I., & Lau, L. F. (2010) · Nature Cell Biology · doi:10.1038/ncb2070 · Cited by 998 · see citing works
A crucial role for adipose tissue p53 in the regulation of insulin resistance
Minamino, T., Orimo, M., Shimizu, I., Kunieda, T., Yokoyama, M., Ito, T., Nojima, A., Nabetani, A., Oike, Y., Matsubara, H., et al. (2009) · Nature Medicine · doi:10.1038/nm.2014 · Cited by 891 · see citing works
Does vitamin C act as a pro‐oxidant under physiological conditions?
Carr, A. C., & Frei, B. B. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.9.1007 · Cited by 883 · see citing works
Docosahexaenoic acid: Membrane properties of a unique fatty acid
Stillwell, W., & Wassall, S. R. (2003) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(03)00101-4 · Cited by 872 · see citing works
Stein, G. H., Drullinger, L. F., Soulard, A., & Dulić, V. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.2109 · Cited by 868 · see citing works
Roland, L., Grau, M., Matena, J., Teske, M., Gieseke, M., Kampmann, A., Beyerbach, M., Escobar, H. M., Haferkamp, H., Gellrich, N., et al. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms17010001 · Cited by 862 · see citing works
Human Endothelial Cells: Use of Heparin in Cloning and Long-Term Serial Cultivation
Thornton, S. C., Mueller, S. N., & Levine, E. M. (1983) · Science · doi:10.1126/science.6635659 · Cited by 800 · see citing works
Stem cell aging: mechanisms, regulators and therapeutic opportunities
Oh, J., Lee, Y. D., & Wagers, A. J. (2014) · Nature Medicine · doi:10.1038/nm.3651 · Cited by 796 · see citing works
Microarray analysis of replicative senescence
Shelton, D. N., Chang, E., Whittier, P. S., Choi, D., & Funk, W. D. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80420-5 · Cited by 764 · see citing works
Tocotrienols: Vitamin E beyond tocopherols
Sen, C. K., Khanna, S., & Roy, S. (2006) · Life Sciences · doi:10.1016/j.lfs.2005.12.001 · Cited by 730 · see citing works
Toussaint, O., Medrano, E. E., & von Zglinicki, T. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00180-7 · Cited by 713 · see citing works
DNA damage response and cellular senescence in tissues of aging mice
Wang, C., Jurk, D., Maddick, M., Nelson, G., Martin‐Ruiz, C., & Von Zglinicki, T. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00481.x · Cited by 696 · see citing works
The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders
Działo, M., Mierziak, J., Korzun, U., Preisner, M., Szopa, J., & Kulma, A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020160 · Cited by 686 · see citing works
Bagga, D., Wang, L., Farias‐Eisner, R., Glaspy, J. A., & Reddy, S. T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0334211100 · Cited by 639 · see citing works
Senescent cells as a source of inflammatory factors for tumor progression
Davalos, A. R., Coppe, J.-P., Campisi, J., & Desprez, P.-Y. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9220-9 · Cited by 636 · see citing works
Parrinello, S., Coppe, J.-P., Krtolica, A., & Campisi, J. (2005) · Journal of Cell Science · doi:10.1242/jcs.01635 · Cited by 631 · see citing works
Matthews, C., Gorenne, I., Scott, S., Figg, N., Kirkpatrick, P., Ritchie, A., Goddard, M., & Bennett, M. (2006) · Circulation Research · doi:10.1161/01.res.0000233315.38086.bc · Cited by 615 · see citing works
Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence
Coppé, J.-P., Kauser, K., Campisi, J., & Beauséjour, C. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603307200 · Cited by 604 · see citing works
Jurk, D., Wang, C., Miwa, S., Maddick, M., Korolchuk, V., Tsolou, A., Gonos, E. S., Thrasivoulou, C., Jill Saffrey, M., Cameron, K., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00870.x · Cited by 598 · see citing works
Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes
Narita, M., Young, A. R. J., Arakawa, S., Samarajiwa, S. A., Nakashima, T., Yoshida, S., Hong, S., Berry, L. S., Reichelt, S., Ferreira, M., et al. (2011) · Science · doi:10.1126/science.1205407 · Cited by 594 · see citing works
Astrocyte Senescence as a Component of Alzheimer’s Disease
Bhat, R., Crowe, E. P., Bitto, A., Moh, M., Katsetos, C. D., Garcia, F. U., Johnson, F. B., Trojanowski, J. Q., Sell, C., & Torres, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045069 · Cited by 586 · see citing works
Shah, P. P., Donahue, G., Otte, G. L., Capell, B. C., Nelson, D. M., Cao, K., Aggarwala, V., Cruickshanks, H. A., Rai, T. S., McBryan, T., et al. (2013) · Genes & Development · doi:10.1101/gad.223834.113 · Cited by 550 · see citing works
Lysosome-mediated processing of chromatin in senescence
Ivanov, A., Pawlikowski, J., Manoharan, I., van Tuyn, J., Nelson, D. M., Rai, T. S., Shah, P. P., Hewitt, G., Korolchuk, V. I., Passos, J. F., et al. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201212110 · Cited by 539 · see citing works
Nutrients and phytochemicals: from bioavailability to bioefficacy beyond antioxidants
Holst, B., & Williamson, G. (2008) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2008.03.003 · Cited by 536 · see citing works
Fisetin: A Dietary Antioxidant for Health Promotion
Khan, N., Syed, D. N., Ahmad, N., & Mukhtar, H. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4901 · Cited by 512 · see citing works
Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?
Akbar, A. N., & Henson, S. M. (2011) · Nature Reviews Immunology · doi:10.1038/nri2959 · Cited by 474 · see citing works
Bavik, C., Coleman, I., Dean, J. P., Knudsen, B., Plymate, S., & Nelson, P. S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1716 · Cited by 453 · see citing works
Chen, Q. M., Bartholomew, J. C., Campisi, J., Acosta, M., REAGAN, J. D., & Ames, B. N. (1998) · Biochemical Journal · doi:10.1042/bj3320043 · Cited by 442 · see citing works
In vitro antioxidant properties of crude extracts and compounds from brown algae
Balboa, E. M., Conde, E., Moure, A., Falqué, E., & Domínguez, H. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2012.11.026 · Cited by 436 · see citing works
SOAP3-dp: Fast, Accurate and Sensitive GPU-Based Short Read Aligner
Luo, R., Wong, T. K. F., Zhu, J.-Q., Liu, C.-M., Zhu, X., Wu, E., Lee, L., Lin, H., Zhu, W., Cheung, D. W.-L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065632 · Cited by 424 · see citing works
The role of chondrocyte senescence in osteoarthritis
Price, J. S., Waters, J. G., Darrah, C., Pennington, C., Edwards, D. R., Donell, S. T., & Clark, I. M. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00008.x · Cited by 386 · see citing works
Yoshino, J., Conte, C., Fontana, L., Mittendorfer, B., Imai, S., Schechtman, K. B., Gu, C. C., Kunz, I., Fanelli, F. R., Patterson, B. W., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.09.015 · Cited by 381 · see citing works
Non-Antioxidant Activities of Vitamin E
Zingg, J.-M. A., & Azzi, A. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043365332 · Cited by 377 · see citing works
Suzuki, Y., Tsuchiya, M., Wassall, S. R., Choo, Y. M., Govil, G., Kagan, V. E., & Packer, L. (1993) · Biochemistry · doi:10.1021/bi00091a020 · Cited by 374 · see citing works
Carotenoids Functionality, Sources, and Processing by Supercritical Technology: A Review
Mezzomo, N., & Ferreira, S. R. S. (2016) · Journal of Chemistry · doi:10.1155/2016/3164312 · Cited by 374 · see citing works
Is β-Galactosidase Staining a Marker of Senescence in Vitro and in Vivo?
Severino, J., Allen, R. G., Balin, S., Balin, A., & Cristofalo, V. J. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4875 · Cited by 370 · see citing works
Nag, S. A. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00025 · Cited by 355 · see citing works
Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging
Ziegler, D. V., Wiley, C. D., & Velarde, M. C. (2014) · Aging Cell · doi:10.1111/acel.12287 · Cited by 353 · see citing works
Flavonoids and Related Compounds as Anti-Allergic Substances
Kawai, M., Hirano, T., Higa, S., Arimitsu, J., 丸田, み., Kuwahara, Y., Ohkawara, T., Hagihara, K., Yamadori, T., Shima, Y., et al. (2007) · Allergology International · doi:10.2332/allergolint.r-06-135 · Cited by 348 · see citing works
Hensley, K., Benaksas, E. J., Bolli, R., Comp, P. C., Grammas, P., Hamdheydari, L., Mou, S., Pye, Q. N., Stoddard, M. F., Wallis, G., et al. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.10.009 · Cited by 311 · see citing works
Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · see citing works
Links between Vitamin D Deficiency and Cardiovascular Diseases
Mozos, I. M., & Mărginean, O. (2015) · BioMed Research International · doi:10.1155/2015/109275 · Cited by 291 · see citing works
Senescence of T Lymphocytes: Implications for Enhancing Human Immunity
Akbar, A. N., Henson, S. M., & Lanna, A. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.09.002 · Cited by 285 · see citing works
Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases
Naylor, R. M., Baker, D. J., & van Deursen, J. M. (2012) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2012.193 · Cited by 280 · see citing works
Cell fusion induced by ERVWE1 or measles virus causes cellular senescence
Chuprin, A., Gal, H., Biron-Shental, T., Biran, A., Amiel, A., Rozenblatt, S., & Krizhanovsky, V. (2013) · Genes & Development · doi:10.1101/gad.227512.113 · Cited by 262 · see citing works
Offord, E. A., Gautier, J.-C., Avanti, O., Scaletta, C., Runge, F., Krämer, K., & Applegate, L. A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00831-6 · Cited by 254 · see citing works
Santis, S. D., Galleggiante, V., Scandiffio, L., Liso, M., Sommella, E., Sobolewski, A., Spilotro, V., Pinto, A., Campiglia, P., Serino, G., et al. (2017) · Nutrients · doi:10.3390/nu9070706 · Cited by 252 · see citing works
Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence
Zwerschke, W., Mazurek, S., Stöckl, P., Hütter, E., EIGENBRODT, E., & Jansen‐Dürr, P. (2003) · Biochemical Journal · doi:10.1042/bj20030816 · Cited by 248 · see citing works
Kao, C.-L., Chen, L., Chang, Y.-L., Yung, M.-C., Hsu, C.-C., Chen, Y., Lo, W., Chen, S., Ku, H., & Hwang, S.-J. (2010) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.4333 · Cited by 241 · see citing works
Saponin adjuvant enhancement of antigen-specific immune responses to an experimental HIV-1 vaccine
Wu, J., Gardner, B. H., Murphy, C. I., Seals, J. R., Kensil, C. R., Recchia, J., Beltz, G. A., Newman, G. W., & Newman, M. J. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.5.1519 · Cited by 241 · see citing works
Furumoto, K., Inoue, E., Nagao, N., Hiyama, E., & Miwa, N. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00351-8 · Cited by 240 · see citing works
The epigenetic role of vitamin C in health and disease
Camarena, V., & Wang, G. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2145-x · Cited by 223 · see citing works
Anti-ageing and rejuvenating effects of quercetin
Chondrogianni, N., Kapeta, S., Chinou, İ., Vassilatou, K., Papassideri, I. S., & Gonos, E. S. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.07.001 · Cited by 220 · see citing works
Majid, S., Kikuno, N., Nelles, J. L., Noonan, E. J., Tanaka, Y., Kawamoto, K., Hirata, H., Li, L. C., Zhao, H., Okino, S. T., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2290 · Cited by 209 · see citing works
Immunosurveillance of senescent cells: the bright side of the senescence program
Sagiv, A., & Krizhanovsky, V. (2013) · Biogerontology · doi:10.1007/s10522-013-9473-0 · Cited by 208 · see citing works
Li, F., Igarashi, M., Leung, J., Sugrue, M. M., Lee, S. W., & Aaronson, S. A. (1999) · Oncogene · doi:10.1038/sj.onc.1202615 · Cited by 207 · see citing works
Lim, H., Park, H., & Kim, H. P. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.06.013 · Cited by 205 · see citing works
Takahashi, A., Imai, Y., Yamakoshi, K., Kuninaka, S., Ohtani, N., Yoshimoto, S., Hori, S., Tachibana, M., Anderton, E., Takeuchi, T., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2011.10.018 · Cited by 205 · see citing works
Senescent Cardiac Fibroblast Is Critical for Cardiac Fibrosis after Myocardial Infarction
Zhu, F., Li, Y., Zhang, J., Piao, C., Liu, T., Li, H.-H., & Du, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074535 · Cited by 201 · see citing works
Bell, J. G., McEvoy, J. W., Tocher, D. R., & SARGENT, J. R. (2000) · Journal of Nutrition · doi:10.1093/jn/130.7.1800 · Cited by 193 · see citing works
Levonen, A., Inkala, M., Heikura, T., Jauhiainen, S., Jyrkkänen, H.-K., Kansanen, E., Määttä, K. M., Romppanen, E., Turunen, P., Rutanen, J., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000258868.80079.4d · Cited by 189 · see citing works
The Role of Vitamin D in the Aging Adult
Meehan, M., & Penckofer, S. (2014) · Journal of Aging and Gerontology · doi:10.12974/2309-6128.2014.02.02.1 · Cited by 189 · see citing works
Furukawa, A., Tada-Oikawa, S., Kawanishi, S., & Oikawa, S. (2007) · Cellular Physiology and Biochemistry · doi:10.1159/000104152 · Cited by 184 · see citing works
Queen, B., & Tollefsbol, T. O. (2010) · Current Aging Science · doi:10.2174/1874609811003010034 · Cited by 178 · see citing works
Resveratrol Induces Premature Senescence in Lung Cancer Cells via ROS-Mediated DNA Damage
Luo, H., Yang, A., Schulte, B. A., Wargovich, M. J., & Wang, G. Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060065 · Cited by 176 · see citing works
Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment
Columbaro, M., Capanni, C., Mattioli, E., Novelli, G., Parnaik, V. K., Squarzoni, S., Maraldi, N. M., & Lattanzi, G. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5318-6 · Cited by 160 · see citing works
Mosieniak, G., Adamowicz, M., Alster, O., Jaskowiak, H., Szczepankiewicz, A. A., Wilczynski, G. M., Ciechomska, I. A., & Sikora, E. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.05.004 · Cited by 157 · see citing works
Oncogene-induced senescence results in marked metabolic and bioenergetic alterations
Quijano, C., Cao, L., Fergusson, M. M., Romero, H., Liu, J., Gutkind, S., Rovira, I. I., Mohney, R. P., Karoly, E. D., & Finkel, T. (2012) · Cell Cycle · doi:10.4161/cc.19800 · Cited by 155 · see citing works
Santiago‐Mora, R., Casado‐Díaz, A., de Castro, M. D. L., & Quesada‐Gómez, J. M. (2010) · Osteoporosis International · doi:10.1007/s00198-010-1270-x · Cited by 154 · see citing works
Functional dysregulation of stem cells during aging: a focus on skeletal muscle stem cells
García‐Prat, L., Sousa‐Victor, P., & Muñoz‐Cánoves, P. (2013) · The FEBS Journal · doi:10.1111/febs.12221 · Cited by 152 · see citing works
Effects of Tocotrienols on Life Span and Protein Carbonylation in Caenorhabditis elegans
Adachi, H., & Ishii, N. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.6.b280 · Cited by 146 · see citing works
Meeting the Vitamin A Requirement: The Efficacy and Importance ofβ-Carotene in Animal Species
Green, A. S., & Fascetti, A. J. (2016) · The Scientific World JOURNAL · doi:10.1155/2016/7393620 · Cited by 144 · see citing works
Jin, H., Lian, N., Zhang, F., Chen, L., Chen, Q., Lu, C., Bian, M., Shao, J., Wu, L., & Zheng, S. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.92 · Cited by 143 · see citing works
Munro, J., Barr, N. I., Ireland, H., Morrison, V., & Parkinson, E. K. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.01.017 · Cited by 141 · see citing works
Pluemsamran, T., Onkoksoong, T., & Panich, U. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2012.01118.x · Cited by 140 · see citing works
Pearce, B. C., Parker, R. A., Deason, M. E., Dischino, D. D., Gillespie, E., Qureshi, A. A., Wright, J. R., & Volk, K. (1994) · Journal of Medicinal Chemistry · doi:10.1021/jm00030a012 · Cited by 140 · see citing works
Kumar, S., Millis, A. J. T., & Baglioni, C. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4683 · Cited by 137 · see citing works
Czerwińska, M. E., Kiss, A. K., & Naruszewicz, M. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.09.082 · Cited by 130 · see citing works
Poulsen, R. C., Watts, A. C., Murphy, R., Snelling, S. J. B., Carr, A. J., & Hulley, P. A. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-203146 · Cited by 124 · see citing works
Eicosapentaenoic acid inhibits UV-induced MMP-1 expression in human dermal fibroblasts
Kim, H. H., Shin, C. M., Park, C., Kim, K. H., Cho, K. H., Eun, H. C., & Chung, J. H. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500105-jlr200 · Cited by 119 · see citing works
The emerging role of senescent cells in tissue homeostasis and pathophysiology
Tominaga, K. (2015) · Pathobiology of Aging & Age-related Diseases · doi:10.3402/pba.v5.27743 · Cited by 112 · see citing works
Immunoaging induced by hematopoietic stem cell aging
Wang, J., Geiger, H., & Rudolph, K. L. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.05.004 · Cited by 107 · see citing works
Besancenot, R., Chaligné, R., Tonetti, C., Pasquier, F., Marty, C., Lécluse, Y., Vainchenker, W., Constantinescu, S. N., & Giraudier, S. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000476 · Cited by 107 · see citing works
Rosa, A., Deiana, M., Atzeri, A., Corona, G., Incani, A., Melis, M. P., Appendino, G., & Dessì, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2006.11.006 · Cited by 100 · see citing works
Genetic Variations Associated with Vitamin A Status and Vitamin A Bioavailability
Borel, P., & Desmarchelier, C. (2017) · Nutrients · doi:10.3390/nu9030246 · Cited by 100 · see citing works
Parzonko, A., Czerwińska, M. E., Kiss, A. K., & Naruszewicz, M. (2013) · Phytomedicine · doi:10.1016/j.phymed.2013.05.002 · Cited by 95 · see citing works
Moreno‐Ulloa, A., Nogueira, L., Rodríguez, A., Barboza, J., Hogan, M. C., Ceballos, G. M., Villarreal, F. J., & Ramírez‐Sánchez, I. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu131 · Cited by 94 · see citing works
Sen, A., Marsche, G., Freudenberger, P., Schallert, M., Toeglhofer, A. M., Nagl, C., Schmidt, R., Launer, L. J., & Schmidt, H. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12644 · Cited by 92 · see citing works
Hagl, S., Kocher, A., Schiborr, C., Kolesova, N., Frank, J., & Eckert, G. P. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.07.026 · Cited by 91 · see citing works
Kashino, G., Kodama, S., Nakayama, Y., Suzuki, K., Fukase, K., Goto, M., & Watanabe, M. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00326-5 · Cited by 85 · see citing works
Wang, Y. N., Wu, W., Chen, H. C., & Fang, H. (2010) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2010.02.002 · Cited by 82 · see citing works
Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo
Choi, S.-J., Youn, J., Kim, K., Joo, D. H., Shin, S., Lee, J.-J., Lee, H. K., An, I., Kwon, S., Youn, H. J., et al. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2626 · Cited by 81 · see citing works
All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype
Pellegrini, C., Columbaro, M., Capanni, C., D’Apice, M. R., Cavallo, C., Murdocca, M., Lattanzi, G., & Squarzoni, S. (2015) · Oncotarget · doi:10.18632/oncotarget.4939 · Cited by 80 · see citing works
Sun, Y., Hu, X., Hu, G., Xu, C., & Jiang, H. (2015) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b15-00012 · Cited by 79 · see citing works
Pierpaoli, E., Viola, V., Pilolli, F., Piroddi, M., Galli, F., & Provinciali, M. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.02.018 · Cited by 77 · see citing works
Ginsenoside Rb1 Prevents H2O2-Induced HUVEC Senescence by Stimulating Sirtuin-1 Pathway
Song, Z., Liu, Y., Hao, B., Yu, S., Zhang, H., Liu, D., Zhou, B., Wu, L., Wang, M., Xiong, Z., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112699 · Cited by 76 · see citing works
T cell cultures and the Hayflick limit
Effros, R. B., & Walford, R. L. (1984) · Human Immunology · doi:10.1016/0198-8859(84)90006-5 · Cited by 72 · see citing works
Bandyopadhyay, D., Timchenko, N. A., Suwa, T., Hornsby, P. J., Campisi, J., & Medrano, E. E. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00098-5 · Cited by 72 · see citing works
Lifespan Extension by the Antioxidant Curcumin in Drosophila Melanogaster
Suckow, M. A., & Suckow, B. K. (2006) · International Journal of Biomedical Science · doi:10.59566/ijbs.2006.2401 · Cited by 72 · see citing works
Tomoeones A–H, cytotoxic phloroglucinol derivatives from Hypericum ascyron
Hashida, W., Tanaka, N., Kashiwada, Y., Sekiya, M., Ikeshiro, Y., & Takaishi, Y. (2008) · Phytochemistry · doi:10.1016/j.phytochem.2008.04.026 · Cited by 72 · see citing works
Grabowska, W., Staniak, K., Wnuk, M., Lewińska, A., Suszek, M., Przybylska, D., Mosieniak, G., Sikora, E., & Bielak-Żmijewska, A. (2015) · AGE · doi:10.1007/s11357-014-9744-y · Cited by 70 · see citing works
Genistein-induced LKB1–AMPK activation inhibits senescence of VSMC through autophagy induction
Lee, K. Y., Kim, J., & Choi, H. C. (2016) · Vascular Pharmacology · doi:10.1016/j.vph.2016.02.007 · Cited by 70 · see citing works
Effect of curcumin on aging retinal pigment epithelial cells
Lu, J., Zhu, W. J., Wu, Y., Meng, Y.-F., Wang, J.-Y., Xu, M., & Tao, J.-J. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s84979 · Cited by 68 · see citing works
Malavolta, M., Pierpaoli, E., Giacconi, R., Costarelli, L., Piacenza, F., Basso, A., Cardelli, M., & Provinciali, M. (2016) · Current Drug Targets · doi:10.2174/1389450116666150907105104 · Cited by 68 · see citing works
Lifespan extension by the antioxidant curcumin in Drosophila melanogaster.
Suckow, B. K., & Suckow, M. A. (2006) · Europe PMC (PubMed Central) · Cited by 63 · see citing works
Makpol, S., Durani, L. W., Chua, K. H., Yusof, Y. A. M., & Ngah, W. Z. W. (2011) · BioMed Research International · doi:10.1155/2011/506171 · Cited by 62 · see citing works
Marampon, F., Gravina, G. L., Festuccia, C., Popov, V. M., Colapietro, E. A., Sanità, P., Musio, D., Felice, F. D., Lenzi, A., Jannini, E. A., et al. (2015) · Journal of Endocrinological Investigation · doi:10.1007/s40618-015-0381-9 · Cited by 61 · see citing works
Chronic treatment with ginsenoside Rg3 induces Akt-dependent senescence in human glioma cells
Seong, S., Kim, S. Y., & Kim, S. S. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1604 · Cited by 61 · see citing works
Grabowska, W., Suszek, M., Wnuk, M., Lewińska, A., Wasiak, E., Sikora, E., & Bielak-Żmijewska, A. (2016) · Oncotarget · doi:10.18632/oncotarget.8450 · Cited by 61 · see citing works
Rusin, M., Zajkowicz, A., & Butkiewicz, D. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.06.005 · Cited by 60 · see citing works
Jovanovski, E., Jenkins, A., Dias, A. G., Peeva, V., Sievenpiper, J. L., Arnason, J. T., Rahelić, D., Josse, R. G., & Vuksan, V. (2010) · American Journal of Hypertension · doi:10.1038/ajh.2010.5 · Cited by 59 · see citing works
Protective effects of myricetin against ultraviolet-B-induced damage in human keratinocytes
Huang, J.-H., Huang, C., Fang, J., Yang, C. Z., Chan, C.-M., Wu, N., Kang, S., & Hung, C. (2009) · Toxicology in Vitro · doi:10.1016/j.tiv.2009.09.015 · Cited by 59 · see citing works
Protective effects of (-)-epigallocatechin gallate on UVA-induced damage in ARPE19 cells.
(2008) · PubMed Central · Cited by 57 · see citing works
Kim, J.-A., Ahn, B., Kong, C., & Kim, S. (2012) · British Journal of Dermatology · doi:10.1111/bjd.12187 · Cited by 56 · see citing works
Polyunsaturated fatty acids ameliorate aging via redox-telomere-antioncogene axis
Chen, J., Wei, Y., Chen, X., Jiao, J., & Zhang, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.14236 · Cited by 52 · see citing works
Lim, H. A., Park, H., & Kim, H. P. (2011) · Journal of Pharmacological Sciences · doi:10.1254/jphs.11014fp · Cited by 52 · see citing works
Wertz, K., Seifert, N., Hunziker, P. B., Riss, G., Wyss, A., Lankin, C., & Goralczyk, R. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.018 · Cited by 52 · see citing works
Han, D., Lee, M. H., Kim, B., Lee, J.-J., Hyon, S.-H., & Park, J. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/850684 · Cited by 51 · see citing works
Vitamin E: More than an antioxidant
Steiner, M. (1993) · Clinical Cardiology · doi:10.1002/clc.4960161306 · Cited by 51 · see citing works
Féart, C., Pallet, V., Boucheron, C., Higueret, D., Alfos, S., Letenneur, L., Dartigues, J. F., & Higueret, P. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01858 · Cited by 50 · see citing works
A systematic review on the role of environmental toxicants in stem cells aging
Hodjat, M., Rezvanfar, M. A., & Abdollahi, M. R. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.11.002 · Cited by 49 · see citing works
Wu, W., Chiang, H., Fang, J., Chen, S.-K., Huang, C., & Hung, C. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.02.028 · Cited by 48 · see citing works
Chae, S., Piao, M. J., Kang, K. A., Zhang, R., Kim, K. C., Youn, U. J., Nam, K., Lee, J. H., & Hyun, J. W. (2011) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.110465 · Cited by 46 · see citing works
Yang, H., Son, J., Jung, B., Zheng, M., & Kim, J.-R. (2010) · Planta Medica · doi:10.1055/s-0030-1250458 · Cited by 44 · see citing works
Nucleolar changes in senescing WI-38 cells
Bemiller, P. M., & Lee, L.-H. (1978) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(78)90041-6 · Cited by 43 · see citing works
Lee, J. H., Lim, H. A., Shehzad, O., Kim, Y. S., & Kim, H. P. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.12.035 · Cited by 42 · see citing works
Chen, X., Zhang, J., Fang, Y., Zhao, C., & Zhu, Y. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.3.253 · Cited by 41 · see citing works
Khor, S. C., Razak, A. M., Ngah, W. Z. W., Yusof, Y. A. M., Karim, N. A., & Makpol, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149265 · Cited by 41 · see citing works
Anti-aging Effects of Cyanidin under a Stress-Induced Premature Senescence Cellular System
Choi, M. J., Kim, B. K., Park, K. Y., Yokozawa, T., Song, Y.-O., & Cho, E. J. (2010) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.33.421 · Cited by 40 · see citing works
Curcumin Protects Trabecular Meshwork Cells From Oxidative Stress
Lin, C., & Wu, X. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-19883 · Cited by 39 · see citing works
Phloroglucinol Attenuates Free Radical-induced Oxidative Stress
So, M. J., & Cho, E. J. (2014) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2014.19.3.129 · Cited by 38 · see citing works
Genetic Variations Involved in Vitamin E Status
Borel, P., & Desmarchelier, C. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122094 · Cited by 37 · see citing works
Yamagata, K., Suzuki, S., & Tagami, M. (2015) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2015.10.006 · Cited by 35 · see citing works
Malavolta, M., Costarelli, L., Giacconi, R., Piacenza, F., Basso, A., Pierpaoli, E., Marchegiani, F., Cardelli, M., Provinciali, M., & Mocchegiani, E. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.02.006 · Cited by 35 · see citing works
Piao, M. J., Zhang, R., Lee, N. H., & Hyun, J. W. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2012.01074.x · Cited by 34 · see citing works
Shi, A.-W., Gu, N., Xm, L., Wang, X., & Peng, Y.-Z. (2011) · Journal of International Medical Research · doi:10.1177/147323001103900418 · Cited by 34 · see citing works
Lt, L., Jb, C., Yl, Z., Sp, Y., & He, L. (2016) · PubMed · Cited by 34 · see citing works
Blomquist, E., Westermark, B., & Pontén, J. (1980) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(80)90093-7 · Cited by 33 · see citing works
Oh, S.-J., Lee, S., Choi, W.-Y., & Lim, C. (2014) · Journal of Biosciences · doi:10.1007/s12038-014-9460-x · Cited by 32 · see citing works
Liu, D., Chen, Y., Liu, Y., Hao, B., Zhou, B., Wu, L., Wang, M., Chen, L., Wu, W.-K., & Qian, X. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.1072 · Cited by 32 · see citing works
Zhang, N., Li, Z., Xu, K., Wang, Y., & Wang, Z. (2016) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b16-00085 · Cited by 32 · see citing works
Mezzomo, N., Tenfen, L., Farias, M. S., Friedrich, M. T., Pedrosa, R. C., & Ferreira, S. R. S. (2014) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2014.09.021 · Cited by 30 · see citing works
SIRT6/NF-κB signaling axis in ginsenoside Rg1-delayed hematopoietic stem/progenitor cell senescence.
Tang, Y., Zhou, Y., Wang, Y., Wang, J., & Ding, J.-C. (2015) · PubMed Central · Cited by 30 · see citing works
Chung, J., Kim, S., Lee, S., Chung, J., Oh, Y., & Shim, S. (2013) · Journal of Food Science · doi:10.1111/1750-3841.12112 · Cited by 29 · see citing works
Chen, J., Lazarenko, O. P., Blackburn, M. L., Badger, T. M., & Ronis, M. J. J. (2014) · Endocrinology · doi:10.1210/en.2014-1427 · Cited by 28 · see citing works
Vitamin E Supplementation Delays Cellular SenescenceIn Vitro
Fata, G. L., Seifert, N., Weber, P., & Mohajeri, M. H. (2015) · BioMed Research International · doi:10.1155/2015/563247 · Cited by 24 · see citing works
Senescence as A Consequence of Ginsenoside Rg1Response on K562 Human Leukemia Cell Line
Liu, J., Cai, S., Zhou, Y., Zhang, X.-P., Liu, D., Jiang, R., & Wang, Y. (2012) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2012.13.12.6191 · Cited by 21 · see citing works
Tsai, R. Y. L. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2152-y · Cited by 20 · see citing works
Lane, D. J. R., Jansson, P. J., & Richardson, D. R. (2016) · Aging · doi:10.18632/aging.100966 · Cited by 18 · see citing works
Gendron, M.-È., Thorin‐Trescases, N., Mamarbachi, A. M., Villeneuve, L. R., Théorêt, J., Mehri, Y., & Thorin, É. (2011) · Dose-Response · doi:10.2203/dose-response.11-014.thorin · Cited by 16 · see citing works
A Natural Model of Mouse Cardiac Myocyte Senescence
Wang, Z., Rong, X., Luo, B., Qin, S., Lu, L., Zhang, X., Sun, Y., Hu, Q., & Zhang, C. (2016) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-016-9711-3 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Role of p53 in the Regulation of Cellular Senescence
Mijit, M., Caracciolo, V., Melillo, A., Amicarelli, F., & Giordano, A. (2020) · Biomolecules · doi:10.3390/biom10030420 · Cited by 639 · see citing works
Senolytics and senostatics as adjuvant tumour therapy
Short, S. C., Fielder, E., Miwa, S., & von Zglinicki, T. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.01.056 · Cited by 201 · see citing works
Anti-senescence compounds: A potential nutraceutical approach to healthy aging
Gurău, F., Baldoni, S., Prattichizzo, F., Espinosa, E., Amenta, F., Procopio, A. D., Albertini, M. C., Bonafè, M., & Olivieri, F. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.05.001 · Cited by 179 · see citing works
Ağagündüz, D., Şahin, T. Ö., Yılmaz, B., Ekenci, K. D., Özer, Ş. D., & Capasso, R. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/1534083 · Cited by 161 · see citing works
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
Anti-senescent drug screening by deep learning-based morphology senescence scoring
Kusumoto, D., Seki, T., Sawada, H., Kunitomi, A., Katsuki, T., Kimura, M., Ito, S., Komuro, J., Hashimoto, H., Fukuda, K., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20213-0 · Cited by 143 · see citing works
Kumar, R., Sharma, A., Kumari, A., Gulati, A., Padwad, Y. S., & Sharma, R. (2018) · Biogerontology · doi:10.1007/s10522-018-9785-1 · Cited by 143 · see citing works
Vitamin E: Regulatory Role on Signal Transduction
Zingg, J.-M. A. (2018) · IUBMB Life · doi:10.1002/iub.1986 · Cited by 136 · see citing works
Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers in Aging Research
Yessenkyzy, A., Saliev, T. M., Zhanaliyeva, M., Masoud, A., Umbayev, B. A., Sergazy, S., Кривых, Е. А., Gulyayev, A., & Nurgozhin, T. S. (2020) · Nutrients · doi:10.3390/nu12051344 · Cited by 115 · see citing works
Radiation-induced senescence: therapeutic opportunities
Kim, J. H., Brown, S. L., & Gordon, M. N. (2023) · Radiation Oncology · doi:10.1186/s13014-022-02184-2 · Cited by 105 · see citing works
Strategies for senolytic drug discovery
Power, H., Valtchev, P., Dehghani, F., & Schindeler, A. (2023) · Aging Cell · doi:10.1111/acel.13948 · Cited by 81 · see citing works
Topical anti-inflammatory activity of palmitoleic acid improves wound healing
Weimann, E., Silva, M. B. B., Murata, G. M., Bortolon, J. R., Dermargos, A., Curi, R., & Hatanaka, E. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205338 · Cited by 80 · see citing works
Giménez‐Bastida, J. A., Ávila‐Gálvez, M. Á., Espı́n, J. C., & González‐Sarrías, A. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111260 · Cited by 73 · see citing works
Bai, J., Wang, Y., Wang, J., Zhai, J., He, F., & Zhu, G. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00520.2019 · Cited by 72 · see citing works
Zhang, L., Zhang, J., Zhang, Y., Fei, C., Wang, L., Yi, Z.-W., & Zhang, Z. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108756 · Cited by 69 · see citing works
Giménez‐Bastida, J. A., Ávila‐Gálvez, M. Á., Espı́n, J. C., & González‐Sarrías, A. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900629 · Cited by 68 · see citing works
In-vivo biotransformation of citrus functional components and their effects on health
Karn, A., Zhao, C., Yang, F., Cui, J., Gao, Z., Wang, M., Wang, F., Xiao, H., & Zheng, J. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1746234 · Cited by 66 · see citing works
Targeting AMPK signaling by polyphenols: a novel strategy for tackling aging
Xu, W., Luo, Y., Yin, J., Huang, M., & Luo, F. (2022) · Food & Function · doi:10.1039/d2fo02688k · Cited by 69 · see citing works
Melchior, S., Codrich, M., Gorassini, A., Méhn, D., Ponti, J., Verardo, G., Tell, G., Calzolai, L., & Calligaris, S. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.136680 · Cited by 64 · see citing works
Li, Y., Hou, X., Yang, C., Pang, Y., Li, X., Jiang, G., & Liu, Y. (2019) · Scientific Reports · doi:10.1038/s41598-019-39486-7 · Cited by 64 · see citing works
Impact of Metal Ions on Cellular Functions: A Focus on Mesenchymal Stem/Stromal Cell Differentiation
Peters, K., Staehlke, S., Rebl, H., Jonitz‐Heincke, A., & Hahn, O. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251810127 · Cited by 63 · see citing works
Mbara, K. C., Devnarain, N., & Owira, P. M. O. (2022) · Pharmaceutical Medicine · doi:10.1007/s40290-022-00444-w · Cited by 60 · see citing works
Rusu, M. E., Gheldiu, A.-M., Mocan, A., Vlase, L., & Popa, D. (2018) · Food & Function · doi:10.1039/c7fo01967j · Cited by 59 · see citing works
Neuroinflammation in pathogenesis of Alzheimer’s disease: Phytochemicals as potential therapeutics
Vaiserman, A. M., Koliada, A. K., & Lushchak, O. V. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111259 · Cited by 57 · see citing works
Probiotic bacteria as modulators of cellular senescence: emerging concepts and opportunities
Sharma, R., & Padwad, Y. S. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1697148 · Cited by 56 · see citing works
Moreira, P., Sousa, F. J., Matos, P., Brites, G. S., Gonçalves, M. J., Cavaleiro, C., Figueirinha, A., Salgueiro, L., Batista, M. T., Branco, P. C., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030561 · Cited by 54 · see citing works
Benefits of tree nut consumption on aging and age-related diseases: Mechanisms of actions
Rusu, M. E., Simedrea, R., Gheldiu, A.-M., Mocan, A., Vlase, L., Popa, D., & Ferreira, I. C. F. R. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.03.006 · Cited by 53 · see citing works
Wang, X., Zhang, J., Xiu, C., Yang, J., Fang, J., & Lei, Y. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/7151946 · Cited by 51 · see citing works
Oxidative stress and cell senescence as drivers of ageing: Chicken and egg
von Zglinicki, T. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102558 · Cited by 52 · see citing works
Curcumin: A therapeutic potential in ageing-related disorders
Vaiserman, A. M., Koliada, A. K., Zayachkivska, A., & Lushchak, O. V. (2020) · PharmaNutrition · doi:10.1016/j.phanu.2020.100226 · Cited by 46 · see citing works
Proinflammatory Arterial Stiffness Syndrome: A Signature of Large Arterial Aging
Wang, M., Monticone, R. E., & McGraw, K. R. (2018) · Journal of Vascular Research · doi:10.1159/000490244 · Cited by 45 · see citing works
Zheng, L., He, S., Wang, H., Li, J., Liu, Y., & Liu, S. (2024) · Aging and Disease · doi:10.14336/ad.2024.0206 · Cited by 44 · see citing works
Vitkevičienė, A., Baksiene, S., Borutinskaite, V. V., & Navakauskienė, R. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.09.005 · Cited by 40 · see citing works
Identification of SYK inhibitor, R406 as a novel senolytic agent
Cho, H.-J., Yang, E. J., Park, J. T., Kim, J., Kim, E.-C., Jung, K., Park, S. C., & Lee, Y. (2020) · Aging · doi:10.18632/aging.103135 · Cited by 40 · see citing works
Manipulation of molecular pathways and senescence hallmarks by natural compounds in fibroblast cells
Momtaz, S., Baeeri, M., Rahimifard, M., Haghi‐Aminjan, H., Hassani, S., & Abdollahi, M. R. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27909 · Cited by 34 · see citing works
Lü, S., Zhou, J., Yang, C., Zhang, X., Shi, Y., Liu, J., Yan, X., Liang, J., Liu, X., Luo, L., et al. (2022) · Food & Function · doi:10.1039/d2fo01246d · Cited by 30 · see citing works
Uncovering key mechanisms and intervention therapies in aging skin
Zhang, Y., Liu, L., Yue, L., Huang, Y., Wang, B., & Liu, P. (2024) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2024.07.009 · Cited by 30 · see citing works
Drygalski, K., Siewko, K., Chomentowski, A., Odrzygóźdź, C., Zalewska, A., Kretowski, A. J., & Maciejczyk, M. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8872702 · Cited by 29 · see citing works
Dicarbonyls induce senescence of human vascular endothelial cells
Santos, A. N., Jacobs, K., Simm, A., Glaubitz, N., Horstkorte, R., & Hofmann, B. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.07.009 · Cited by 23 · see citing works
3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing
Younis, L. T., Hassan, M. I. A., Ali, T. B. T., & Bustami, T. J. (2017) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2017.12.003 · Cited by 20 · see citing works
Sharma, R. (2021) · PharmaNutrition · doi:10.1016/j.phanu.2021.100281 · Cited by 20 · see citing works
Türer, B. Y., & Şanlıer, N. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae079 · Cited by 21 · see citing works
Sharma, R., & Padwad, Y. S. (2019) · Nutrition · doi:10.1016/j.nut.2019.01.020 · Cited by 20 · see citing works
Cellular Senescence: A Bridge Between Diabetes and Microangiopathy
Liu, J., Guo, B., Liu, Q., Zhu, G., Wang, Y., Wang, N., Yang, Y., & Fu, S. (2024) · Biomolecules · doi:10.3390/biom14111361 · Cited by 19 · see citing works
Herb-Derived Products: Natural Tools to Delay and Counteract Stem Cell Senescence
Abruzzo, P. M., Canaider, S., Pizzuti, V., Pampanella, L., Casadei, R., Facchin, F., & Ventura, C. (2020) · Stem Cells International · doi:10.1155/2020/8827038 · Cited by 18 · see citing works
Ricciarelli, R., Azzi, A., & Zingg, J.-M. A. (2020) · BioFactors · doi:10.1002/biof.1636 · Cited by 17 · see citing works
The immunosenescence clock: A new method for evaluating biological age and predicting mortality risk
Li, S., Wang, K., Wu, J., & Zhu, Y. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102653 · Cited by 16 · see citing works
Nutritional Hormesis in a Modern Environment
Ademowo, O. S., Dias, I. H. K., Pararasa, C., & Griffiths, H. R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814253-0.00006-1 · Cited by 15 · see citing works
Piragine, E., Felice, M. D., Germelli, L., Brinkmann, V., Flori, L., Martini, C., Calderone, V., Ventura, N., Pozzo, E. D., & Testai, L. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112495 · Cited by 13 · see citing works
Tan, J., Wei, J., & Lu, H. (2023) · Inflammation · doi:10.1007/s10753-023-01809-2 · Cited by 11 · see citing works
Niu, H., Qian, L., Sun, B., Liu, W., Wang, F., Wang, Q., Ji, X., Luo, Y., Nesa, E. U., Lou, H., et al. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.08.007 · Cited by 11 · see citing works
Mitochondrial Metabolism in X-Irradiated Cells Undergoing Irreversible Cell-Cycle Arrest
Hirose, E., Noguchi, M., Ihara, T., & Yokoya, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031833 · Cited by 10 · see citing works
Yang, H., Lv, D., Li, X., Chen, Y., Xu, H., Wu, H., Wang, Z., Cao, X., Tang, B., Deng, W., et al. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00763-1 · Cited by 9 · see citing works
Russo, M., Moccia, S., Spagnuolo, C., Tedesco, I., & Russo, G. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415959 · Cited by 8 · see citing works
Zhu, S., Xing, C., Zhang, G., Peng, H., & Wang, Z. (2021) · Europe PMC (PubMed Central) · Cited by 8 · see citing works
Drivers of centrosome abnormalities: Senescence progression and tumor immune escape
Jiang, T., Jin, H., Ji, X., Zheng, X., Xu, C., & Zhang, P. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.01.008 · Cited by 8 · see citing works
Structure and biomedical applications of bioactive polyphenols from food and fruits
Chang, Y., He, F., Wang, T., & Aisa, H. A. (2022) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.16789 · Cited by 9 · see citing works
Guo, Y., Wang, S., Dong, Y., & Liu, Y. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.114371 · Cited by 6 · see citing works
Lewińska, A., Sodagam, L., Błoniarz, D., Siems, K., Wnuk, M., & Rattan, S. I. S. (2019) · Molecules · doi:10.3390/molecules25010141 · Cited by 6 · see citing works
Exosomal dynamics: Bridging the gap between cellular senescence and cancer therapy
Aswani, B. S., Sajeev, A., Hegde, M., Mishra, A., Abbas, M., Vayalpurayil, T., Sethi, G., & Kunnumakkara, A. B. (2025) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2025.112045 · Cited by 5 · see citing works
Jumah, H. (2023) · Wasit Journal of Pure sciences · doi:10.31185/wjps.226 · Cited by 4 · see citing works
Vaiserman, A. M., Lushchak, O. V., Zayachkivska, A., & Koliada, A. K. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823679-6.00014-x · Cited by 3 · see citing works
The Anticarcinogenic Properties of Brassica Vegetables
Ross, I. A. (2024) · Springer eBooks · doi:10.1007/978-3-031-63681-3_5 · Cited by 2 · see citing works
Rudolf, H., Walter, M., Fuellen, G., Hartmann, A., Secci, R., Mensch, J., Jäger, K., Steinhagen‐Thiessen, E., Barrantes, I., Palmer, D. H., et al. (2024) · doi:10.59368/agingbio.20240020 · Cited by 2 · see citing works
Mechanisms of cell senescence in aging
von Zglinicki, T. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-815962-0.00003-2 · Cited by 2 · see citing works
Li, R., Tao, M., Yuan, J., Huang, Y., Xu, T., & Xu, X. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.71532 · Cited by 1 · see citing works
Elimination of Senescent Cells by Polyphenols and Flavonoids
Harald, A. K. (2021) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-1247-3_1-1
Cellular senescence during aging
von Zglinicki, T. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823761-8.00017-3
Elimination of Senescent Cells by Polyphenols and Flavonoids
Harald, A. K. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-5422-0_1
Senotherapy as a Novel Therapeutic Method in Cancer Treatment: With a Focus on Head and Neck Cancer
Ziaei, H., & Harada, H. (2023) · Interdisciplinary cancer research · doi:10.1007/16833_2022_118
Ishagh, B., Tbatou, W., Ghouizi, A. E., Elaraj, T., Ouaritini, Z. B., Ousaaid, D., & Lyoussi, B. (2026) · In vitro models · doi:10.1007/s44164-026-00116-y
- Authors
- Mária, J., & Ingrid, Ž.
- Affiliations
- Institute of Medical Chemistry
- ORCID
- Ingrid, Žitňanová
- Venue
- Food & Function
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2017
- Volume
- 8
- Issue
- 7
- Pages
- 2394-2418
- ISSN
- 2042-6496 (ISSN-L)
- 2042-650X
- OpenAlex
- W2727908196
- Cited by
- 71
- References
- 190
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 10 · 2023: 9 · 2022: 10 · 2021: 6 · 2020: 11 · 2019: 9 · 2018: 9 · 2017: 2
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food & Function (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- cellular senescence, senescence-associated secretory phenotype, bioactive compounds, stress-induced senescence, replicative senescence, senolytics, polyphenols, ginsenosides, omega-3 fatty acids, phloridzin, telomere shortening, telomerase activity, reactive oxygen species, lipid peroxidation, antioxidant enzymes, p53, p21, matrix metalloproteinases, UV irradiation, age-related diseases
- MeSH terms
- Aging, Animals, Biological Factors, Humans, Signal Transduction, Telomere, Cellular Senescence, Cell Proliferation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review