Field Evaluation of Preventive Efficacy of Monthly Multimodal Prophylactic Treatment (Milbactor® and Vectra® 3D) against Dirofilaria spp. in Dogs
Open accessAbstract
Dirofilaria immitis and Dirofilaria repens are mosquito-borne pathogens responsible for dirofilariasis in humans and animals. Their transmission and spread depend on the activity of vectors and the frequency of hosts in a given area. Here, we investigated the efficacy of a monthly multimodal prophylactic (MMP) strategy against canine dirofilariasis on Corsica Island (France). The study was conducted as evidence of an efficacy trial in which eighty dogs were divided into two groups: (i) one test group consisted of 25 dogs under the MMP [per-os administration of 1.5 tablets of milbemycin-oxime-praziquantel (Milbactor®) and a topical line-on application of a 3.6 mL solution of dinotefuran-permethrin-pyriproxyfen (Vectra® 3D)] and (ii) a control group under different real-life prophylactic treatments (RLP) based on the use of ectoparasiticides (different formulations: deltamethrin, fluralaner, fipronil) and/or macrocyclic lactone-based products (milbemycin-oxime/praziquantel, milbemycin-oxime, moxidectin) during the period from June to October 2017. All animals were followed up for one year, with blood collected at day 0, with follow-up at 6 and 12 months. Samples were tested for Dirofilaria spp. by species-specific qPCR. At the end of the study, no new case of Dirofilaria spp. infection was detected in the test group. However, the cumulative incidence of Dirofilaria spp. infection was 16.4% (n = 9; p = 0.027) in the control group. The data illustrate that, in contrast to RLP treatment, which failed to protect at least 16.4% of dogs, the MMP based on the simultaneous administration of milbemycin oxime-praziquantel and dinotefuran-permethrin-pyriproxyfen efficiently protects dogs in a high-risk area from Dirofilaria spp. infection.
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Both Dirofilaria spp. were detected in Oc. caspius from Solaro, an area endemic for dirofilariasis.
“Both Dirofilaria spp. were detected in Oc. caspius from Solaro, an area endemic for dirofilariasis [6, 31].”
From Dirofilaria immitis and Dirofilaria repens in mosquitoes from Corsica Island, France (2021) · cites this paper as [31]
Previous epidemiological studies confirmed the circulation of Dirofilaria spp. in human, dog and mosquito (Ae. albopictus) populations from Corsica.
“Previous epidemiological studies confirmed the circulation of Dirofilaria spp. in human, dog and mosquito (i.e., Ae. albopictus) populations from the island [6, 30, 31].”
From Dirofilaria immitis and Dirofilaria repens in mosquitoes from Corsica Island, France (2021) · cites this paper as [31]
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Cites
Human and animal dirofilariasis: The emergence of a zoonotic mosaic
Simón, F., Siles-Lucas, M., Morchón, R., González-Miguel, J., Mellado, I., Carretón, E., & Montoya-Alonso, J. A. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.00012-12 · Cited by 834 · see citing works
Chapter 4 Heartworm Disease in Animals and Humans
McCall, J. W., Genchi, C., Kramer, L. H., Guerrero, J., & Venco, L. (2008) · Advances in Parasitology · doi:10.1016/s0065-308x(08)00204-2 · Cited by 609 · see citing works
Vector-borne helminths of dogs and humans in Europe
Otranto, D., Dantas-Torres, F., Brianti, E., Traversa, D., Petrić, D., Genchi, C., & Capelli, G. (2013) · Parasites & Vectors · doi:10.1186/1756-3305-6-16 · Cited by 336 · see citing works
Choice and Interpretation of Statistical Tests Used When Competing Risks Are Present
Dignam, J. J., & Kocherginsky, M. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.12.9866 · Cited by 268 · see citing works
Prichard, R. K., & Geary, T. G. (2019) · International Journal for Parasitology Drugs and Drug Resistance · doi:10.1016/j.ijpddr.2019.06.002 · Cited by 144 · see citing works
Blocking transmission of vector-borne diseases
Schorderet-Weber, S., Noack, S., Selzer, P. M., & Kaminsky, R. (2017) · International Journal for Parasitology Drugs and Drug Resistance · doi:10.1016/j.ijpddr.2017.01.004 · Cited by 86 · see citing works
The Complexity of Zoonotic Filariasis Episystem and Its Consequences: A Multidisciplinary View
Simón, F., González-Miguel, J., Diosdado, A., Gómez, P. J., Morchón, R., & Kartashev, V. (2017) · BioMed Research International · doi:10.1155/2017/6436130 · Cited by 76 · see citing works
Laidoudi, Y., Davoust, B., Varloud, M., Niang, E. H. A., Fenollar, F., & Mediannikov, O. (2020) · Parasites & Vectors · doi:10.1186/s13071-020-04185-0 · Cited by 74 · see citing works
Self-citationAonuma, H., Yoshimura, A., Perera, N., Shinzawa, N., Bando, H., Oshiro, S., Nelson, B., Fukumoto, S., & Kanuka, H. (2009) · Parasites & Vectors · doi:10.1186/1756-3305-2-15 · Cited by 71 · see citing works
Diagnosis of Imported Canine Filarial Infections in Germany 2008 – 2010
Pantchev, N., Etzold, M., Daugschies, A., & Dyachenko, V. (2011) · Parasitology Research · doi:10.1007/s00436-011-2403-7 · Cited by 69 · see citing works
Roussel, C., Drake, J., & Chacon, J. M. A. (2019) · Parasites & Vectors · doi:10.1186/s13071-019-3712-4 · Cited by 48 · see citing works
Tahir, D., Bittar, F., Barré-Cardi, H., Sow, D., Dahmani, M., Mediannikov, O., Raoult, D., Davoust, B., & Parola, P. (2017) · Veterinary Parasitology · doi:10.1016/j.vetpar.2017.01.002 · Cited by 41 · see citing works
Self-citationMcCall, J. W., Varloud, M., Hodgkins, E., Mansour, A., DiCosty, U., McCall, S. D., Carmichael, J., Carson, B., & Carter, J. (2017) · Parasites & Vectors · doi:10.1186/s13071-017-2438-4 · Cited by 34 · see citing works
Self-citationMcTier, T. L., Kryda, K., Wachowski, M., Mahabir, S. P., Ramsey, D. S., Rugg, D., Mazaleski, M. M., Therrien, C., Adams, E. L., Wolff, T., et al. (2019) · Parasites & Vectors · doi:10.1186/s13071-019-3632-3 · Cited by 34 · see citing works
[Imported parasites in dogs: Dirofilaria repens and Dipetalonema reconditum].
Zahler, M., Glaser, B., & Gothe, R. (1997) · PubMed · Cited by 24 · see citing works
Moraes-da-Silva, M. D. F. C. V., Mendes-de-Almeida, F., Abdalla, L. D. S., Merlo, A., Paiva, J. P., & Labarthe, N. (2016) · Parasites & Vectors · doi:10.1186/s13071-016-1697-9 · Cited by 20 · see citing works
Chemoprophylaxis of Dirofilaria immitis (Leidy 1856) infection at a high challenge environment
Labarthe, N., Willi, L. M. V., Paiva, J. P., de Miranda, M. G. N., Zoreck, K., & Mendes-de-Almeida, F. (2015) · Parasites & Vectors · doi:10.1186/s13071-015-1141-6 · Cited by 17 · see citing works
Cesare, A. D., Braun, G., Giulio, E. D., Paoletti, B., Aquilino, V., Bartolini, R., Torre, F. L., Meloni, S., Drake, J., Pandolfi, F., et al. (2014) · Parasites & Vectors · doi:10.1186/1756-3305-7-347 · Cited by 15 · see citing works
Tahir, D., Davoust, B., Alméras, L., Berenger, J.-M., Varloud, M., & Parola, P. (2017) · Medical and Veterinary Entomology · doi:10.1111/mve.12243 · Cited by 11 · see citing works
Self-citationTahir, D., Davoust, B., Varloud, M., et al. (2016) · Medical and Veterinary Entomology · doi:10.1111/mve.12206 · Cited by 10 · see citing works
Self-citationLaidoudi, Y., Tahir, D., Medkour, H., Varloud, M., Mediannikov, O., & Davoust, B. (2020) · Insects · doi:10.3390/insects11080507 · Cited by 9 · see citing works
Self-citationWysmołek, M. E., Klockiewicz, M., Sobczak-Filipiak, M., Długosz, E., & Wiśniewski, M. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.577466 · Cited by 9 · see citing works
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Dirofilaria immitis and Dirofilaria repens in mosquitoes from Corsica Island, France
Younes, L., Barré-Cardi, H., Bedjaoui, S., Ayhan, N., Varloud, M., Mediannikov, O., Otranto, D., & Davoust, B. (2021) · Parasites & Vectors · doi:10.1186/s13071-021-04931-y · Cited by 23 · see citing works
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- Authors
- Laidoudi, Y., Medkour, H., Tahir, D., Dahmana, H., Marié, J.-L., Varloud, M., Mediannikov, O., & Davoust, B.
- Affiliations
- Aix-Marseille Université (FR)
- Service de Santé des Armées (FR)
- Ceva Santé Animale, 10, Av de la Ballastière, 33500 Libourne, France
- Corresponding author
- Laidoudi, Younes
- Davoust, Bernard
- ORCID
- Venue
- Parasitologia
- Publisher
- MDPI AG
- Published
- 2021-07-30
- Volume
- 1
- Issue
- 3
- Pages
- 130-136
- ISSN
- 2673-6772 (ISSN-L)
- OpenAlex
- W3189028871
- Cited by
- 2
- References
- 22
- Citations by year
- 2026: 1 · 2021: 1
- FWCI
- 0.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Parasitologia (publishedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Keywords
- canine dirofilariasis, Dirofilaria immitis, Dirofilaria repens, ectoparasiticides, macrocyclic lactones, prophylaxis efficacy, mosquito-borne filariasis, dogs
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