The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development
Open accessAbstract
Natural products from plants were extracted and widely studied for their activities against many disease conditions. The selection of the extracting solvent is crucial to develop selective and effective methods for the extraction and isolation of target compounds in the plant matrices. Pharmacological properties of plant extracts and their bioactive principles are related to their excellent solubility, stability, and bioavailability when administered by different routes. This review aims to critically analyze natural deep eutectic solvents (NADES) as green solvents in their application to improve the extraction performance of plant metabolites in terms of their extractability besides the stability, bioactivity, solubility, and bioavailability. Herein, the opportunities for NADES to be used in pharmaceutical formulations development including plant metabolites-based nutraceuticals are discussed.
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Cites
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Natural deep eutectic solvents: Properties, applications, and perspectives
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“The viscosity of NADES is affected by hydrogen bonding and van der Walls interactions [18].”
BackgroundMethodInfluential
Cited by
Major phytochemicals: Recent advances in health benefits and extraction method
Kumar, A., P, N., Kumar, M., Jose, A., Tomer, V., Oz, E., Proestos, C., Zeng, M., Elobeid, T., K, S., et al. (2023) · Molecules · doi:10.3390/molecules28020887 · Cited by 784
Natural Deep Eutectic Solvents (NaDES): Green Solvents for Pharmaceutical Applications and Beyond
Chevé-Kools, E., Choi, Y. H., Roullier, C., Ruprich-Robert, G., Grougnet, R., Chapeland-Leclerc, F., & Hollmann, F. (2025) · Green Chemistry · doi:10.1039/d4gc06386d · Cited by 156
Siddiqui, S. A., Ali Redha, A., Salauddin, M., Harahap, I. A., & Rupasinghe, H. P. V. (2025) · Critical Reviews in Analytical Chemistry · doi:10.1080/10408347.2023.2266846 · Cited by 110
Plaza, M., & Marina, M. L. (2025) · Microchemical Journal · doi:10.1016/j.microc.2025.113366 · Cited by 23
Ruesgas Ramon, M., Durand, E., Garcia-Sosa, K., & Peña-Rodríguez, L. M. (2023) · PeerJ Analytical Chemistry · doi:10.7717/peerj-achem.28 · Cited by 21
Metadata
- Authors
- Hikmawanti, N. P. E., Ramadon, D., Jantan, I., & Mun’im, A.
- Venue
- Plants
- Publisher
- MDPI AG
- Published
- 2021-10-01
- Volume
- 10
- Issue
- 10
- Pages
- 2091
- ISSN
- 2223-7747 (ISSN-L)
- OpenAlex
- W3202155886
- Cited by
- 361
- References
- 63
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development. https://app.cochat.ai/papers/10.3390/plants10102091
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- Hikmawanti, N. P. E., Ramadon, D., Jantan, I., & Mun’im, A. (2021). Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development. Plants. https://doi.org/10.3390/plants10102091
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