Natural deep eutectic solvents: Properties, applications, and perspectives
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As functional liquid media, natural deep eutectic solvent (NADES) species can dissolve natural or synthetic chemicals of low water solubility. Moreover, the special properties of NADES, such as biodegradability and biocompatibility, suggest that they are alternative candidates for concepts and applications involving some organic solvents and ionic liquids. Owing to the growing comprehension of the eutectic mechanisms and the advancing interest in the natural eutectic phenomenon, many NADES applications have been developed in the past several years. However, unlike organic solvents, the basic structural unit of NADES media primarily depends on the intermolecular interactions among their components. This makes NADES matrices readily influenced by various factors, such as water content, temperature, and component ratio and, thus, extends the metabolomic challenge of natural products (NPs). To enhance the understanding of the importance of NADES in biological systems, this review focuses on NADES properties and applications in NP research. The present thorough chronological and statistical analysis of existing report adds to the recognition of the distinctiveness of (NA)DES, involves a discussion of NADES-related observations in NP research, and reportes applications of these eutectic mixtures. The work identifies potential areas for future studies of (NA)DES by evaluating relevant applications, including their use as extraction and chromatographic media as well as their biomedical relevance. The chemical diversity of natural metabolites that generate or participate in NADES formation highlights the growing insight that biosynthetically primordial metabolites (PRIMs) are as essential to the biological function and bioactivity of unrefined natural products as the biosynthetically more highly evolutionary metabolites (HEVOs) that can be isolated from crude mixtures.
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These properties depend on the chemical nature of the components and on their intermolecular interactions.
“They are dependent on the chemical nature of its components and on their intermolecular interactions (Liu et al. 2018).”
From The perspectives of natural deep eutectic solvents in agri-food sector (2020) · cites this paper as Liu et al. 2018
By knowing the parameters that can affect extraction with DES, one can exploit their high tunability.
“Consequently, by knowing the parameters that can affect the extraction with the usage of DES, one can exploit their high tunability [40].”
From Applications of Deep Eutectic Solvents in Sample Preparation and Extraction of Organic Molecules (2022) · cites this paper as [40]
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- Authors
- Liu, Y., Friesen, J. B., McAlpine, J. B., Lankin, D. C., Chen, S.-N., & Pauli, G. F.
- Affiliations
- National Institutes of Health (US)
- Dominican University (US)
- University of Illinois Chicago (US)
- Corresponding author
- Pauli, Guido F.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-03-07
- Volume
- 81
- Issue
- 3
- Pages
- 679-690
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- PMC
- PMC5913660
- OpenAlex
- W2789815678
- Cited by
- 1,304
- References
- 79
- Citations by year
- 2026: 157 · 2025: 239 · 2024: 210 · 2023: 186 · 2022: 172 · 2021: 144 · 2020: 101 · 2019: 80 · 2018: 15
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Natural Products (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Center for Complementary and Integrative Health (U41AT008706, P50AT000155)
- United States Pharmacopeia
- Topics
- Physical Sciences › Chemical Engineering › Catalysis › Ionic liquids properties and applications
- Physical Sciences › Chemical Engineering › Filtration and Separation › Chemical and Physical Properties in Aqueous Solutions
- Physical Sciences › Engineering › Biomedical Engineering › Phase Equilibria and Thermodynamics
- Keywords
- natural deep eutectic solvents, eutectic mixtures, natural products, biodegradability, biocompatibility, extraction media, chromatographic media, intermolecular interactions, water content effects
- MeSH terms
- Animals, Biological Products, Humans, Plant Extracts, Solubility, Solvents, Temperature, Water
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