Synergistic Protective Effect of Agastache rugosa and Centella asiatica against UVB-Induced Damage in Human Skin Fibroblasts
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Minha Kim, Seungjun Lee, Huijin Heo, Jong-Wook Chung, Jeehye Sung, Heon Sang Jeong, and Junsoo Lee. Journal of the Korean Society of Food Science and Nutrition 2022;51:671-8. https://doi.org/10.3746/jkfn.2022.51.7.671
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The combination of Agastache rugosa and C. asiatica exhibited a synergistic protective effect, reducing UVB-induced cytotoxicity and oxidative stress in human skin fibroblasts.
“The results showed that the combination of Agastache rugosa and C. asiatica exhibited a synergistic protective effect, reducing UVB‐induced cytotoxicity and oxidative stress in the fibroblasts.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [40]
The Abstract reports a synergistic protective effect of the combined extracts in UVB-irradiated human skin fibroblasts, with higher cell viability. The paper discusses antioxidant activity as a possible explanation, but its reported combination results measure cell viability, not a reduction in oxidative stress. (LLM, conf=0.85)
Experimental — accuracy not yet measuredThe Kim et al. 40 study is classified as Level III evidence according to the Oxford Centre for Evidence-Based Medicine.
“According to the Oxford Centre for Evidence‐Based Medicine, this study can be classified as Level III”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [40]
The Methods passage (section labeled 서 론; page not provided) describes experiments in Hs68 human skin fibroblasts, but does not assign the study an evidence level. A search for the Oxford Centre for Evidence-Based Medicine and Level III found no classification in our copy. The classification appears to be the citing authors’ assessment, which this source alone cannot verify. (LLM, conf=0.76)
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Cites
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Cited by
Sorted by citations
Cosmeceuticals in photoaging: A review.
Chan, L. K. W., Lee, K. W. A., Lee, C. H., Lam, K. W. P., Lee, K. F. V., Wu, R., Wan, J., Shivananjappa, S., Sky, W. T. H., Choi, H., et al. (2024) · Skin Research and Technology · doi:10.1111/srt.13730 · Cited by 23 · see citing works
“In the study conducted by Kim et al., 40 the authors aimed to investigate the synergistic protective effect of Agastache rugosa and C. asiat-ica againstUVB-induceddamageinhumanskinfibroblasts.”
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Chemical constituents, health benefits, and applications of Agastache rugosa : A review
Lin, E., Zhang, N., Wang, Y., Liang, J., Li, H., & Chen, L. (2025) · Food Science and Human Wellness · doi:10.26599/fshw.2025.9250857
Capsosiphon fulvescens Calcium Mixture Protects Hs68 Fibroblasts from UVB-Induced Damage
Im, J.-H., Park, S., Lee, M.-K., Jeong, J.-H., & Lee, H.-I. (2026) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2026.55.1.57
- Authors
- Kim, M., Lee, S., Heo, H., Chung, J.-W., Sung, J., Jeong, H. S., & Lee, J.
- Affiliations
- Chungbuk National University (KR)
- Department of Food Science and Biotechnology, Chungbuk National University
- Gyeongkuk National University (KR)
- Corresponding author
- Lee, Junsoo
- Venue
- Journal of the Korean Society of Food Science and Nutrition
- Published
- 2022-07-31
- Volume
- 51
- Issue
- 7
- Pages
- 671-678
- ISSN
- 1226-3311 (ISSN-L)
- 2288-5978
- OpenAlex
- W4288080426
- Cited by
- 4
- References
- 28
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of the Korean Society of Food Science and Nutrition (publishedVersion, cc-by-nc)
- Funders
- Regional Innovation Strategy (1345341783)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- Agastache rugosa, Centella asiatica, human dermal fibroblasts, photoprotection, herbal combination
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