Asiaticoside Induces Human Collagen I Synthesis through TGFβ Receptor I Kinase (TβRI Kinase)-Independent Smad Signaling
Abstract
Skin aging appears to be principally related to a decrease in the levels of type I collagen, the primary component of the skin dermis. Asiaticoside, a saponin component isolated from Centella asiatica, has been shown to induce type I collagen synthesis in human dermal fibroblast cells. However, the mechanism underlying asiaticoside-induced type I collagen synthesis, especially at a molecular level, remains only partially understood. In this study, we have attempted to characterize the action mechanism of asiaticoside in type I collagen synthesis. Asiaticoside was determined to induce the phosphorylation of both Smad 2 and Smad 3. In addition, we detected the asiaticoside-induced binding of Smad 3 and Smad 4. In a consistent result, the nuclear translocation of the Smad 3 and Smad 4 complex was induced via treatment with asiaticoside, pointing to the involvement of asiaticoside in Smad signaling. In addition, SB431542, an inhibitor of the TGFbeta receptor I (TbetaRI) kinase, which is known to be an activator of the Smad pathway, was not found to inhibit both Smad 2 phosphorylation and Type 1 collagen synthesis induced by asiaticoside. Therefore, our results show that asiaticoside can induce type I collagen synthesis via the activation of the TbetaRI kinase-independent Smad pathway.
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Asiaticoside induces type I collagen synthesis via activation of TGF-β receptor I kinase-independent Smad signalling.
“Asiaticoside can induce type I collagen synthesis via the activation of the TGF‐β receptor I kinase‐independent Smad signalling.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [98]
Asiaticoside and madecassoside induce collagen production and thereby prevent skin-ageing caused by low Type 1 collagen secretion in dermis.
“Instead, asiaticoside and madecassoside prove cosmetically useful by inducing the production of collagen and thus preventing skin‐ageing, which is caused as a result of low Type 1 collagen secretion in the dermis.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [98]
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Diniz, L. R. L., Calado, L. L., Duarte, A. B. S., & de Sousa, D. P. (2023) · Metabolites · doi:10.3390/metabo13020276 · Cited by 160 · see citing works
Yao, C.-H., Yeh, J.-Y., Chen, Y.-S., Li, M.-H., & Huang, C.-H. (2017) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1992 · Cited by 151 · see citing works
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Zheng, C. (2007) · Journal of Chinese Integrative Medicine · doi:10.3736/jcim20070324 · Cited by 146 · see citing works
Namviriyachote, N., Lipipun, V., Akkhawattanangkul, Y., Charoonrut, P., & Ritthidej, G. C. (2018) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2018.09.001 · Cited by 115 · see citing works
Ratz-lyko, A., Arct, J., & Pytkowska, K. (2016) · Indian Journal of Pharmaceutical Sciences · doi:10.4103/0250-474x.180247 · Cited by 121 · see citing works
Randriamampionona, D., Diallo, B., Rakotoniriana, E. F., Rabemanantsoa, C., Cheuk, K., Corbisier, A.-M., Mahillon, J., Ratsimamanga, S., & Jaziri, M. E. (2007) · Fitoterapia · doi:10.1016/j.fitote.2007.03.016 · Cited by 112 · see citing works
Wu, F., Bian, D., Xia, Y., Gong, Z., Tan, Q., Chen, J., & Dai, Y. (2012) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2012/848093 · Cited by 105 · see citing works
Haftek, M., Mac‐Mary, S., Bitoux, M. L., Creidi, P., Seité, S., Rougier, A., & Humbert, P. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00732.x · Cited by 95 · see citing works
He, Z., Hu, Y., Niu, Z., Zhong, K., Liu, T., Yang, M., Ji, L., & Hu, W. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115865 · Cited by 93 · see citing works
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Jung, E., Lee, J., Baek, J. H., Jung, K., Lee, J., Huh, S., Kim, S., Koh, J., & Park, D. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.02.012 · Cited by 91 · see citing works
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Lee, J.-S., Jung, E., Lee, J., Huh, S., Kim, J.-E., Park, M., So, J., Ham, Y., Jung, K., Hyun, C., et al. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.06.008 · Cited by 89 · see citing works
Self-citationWan, J., Gong, X., Jiang, R., Zhang, Z., & Zhang, L. (2013) · Phytotherapy Research · doi:10.1002/ptr.4838 · Cited by 75 · see citing works
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Tan, S. C., Bhattamisra, S. K., Chellappan, D. K., & Candasamy, M. (2021) · Applied Sciences · doi:10.3390/app11188475 · Cited by 72 · see citing works
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Namviriyachote, N., Muangman, P., Chinaroonchai, K., Chuntrasakul, C., & Ritthidej, G. C. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.10.166 · Cited by 68 · see citing works
Liu, E., Gao, H., Zhao, Y., Pang, Y., Yao, Y., Yang, Z., Zhang, X., Wang, Y., Yang, S., Ma, X., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.900439 · Cited by 72 · see citing works
Baek, S., Ho, T.-T., Lee, H., Jung, G., Kim, Y., Jeong, C.-S., & Park, S. (2019) · Plant Biotechnology Reports · doi:10.1007/s11816-019-00573-w · Cited by 59 · see citing works
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Long, H. S., Stander, M. A., & Wyk, B.-E. V. (2012) · South African Journal of Botany · doi:10.1016/j.sajb.2012.07.017 · Cited by 54 · see citing works
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Nowwarote, N., Osathanon, T., Jitjaturunt, P., Manopattanasoontorn, S., & Pavasant, P. (2012) · Phytotherapy Research · doi:10.1002/ptr.4742 · Cited by 50 · see citing works
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Abedi, F., Ramezani, M., Dehghan, R., Amiri, M. S., Moghadam, A. T., Shakour, N., Elyasi, S., Sahebkar, A., & Emami, S. A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-64872-5_25 · Cited by 48 · see citing works
Hsu, M.-F., & Chiang, B. (2009) · Process Biochemistry · doi:10.1016/j.procbio.2008.09.021 · Cited by 41 · see citing works
Wang, X.-B., Wang, W., Zhu, X.-C., Ye, W.-J., Cai, H., Wu, P.-L., Huang, X.-Y., & Wang, L.-X. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.07.016 · Cited by 41 · see citing works
Tsuji, K., Ishikura, S., Akagawa, M., & Saeki, H. (2010) · Connective Tissue Research · doi:10.3109/03008200903486188 · Cited by 41 · see citing works
Kuo, C.-W., Chiu, Y.-F., Wu, M., Li, M.-H., Wu, C.-N., Chen, W.-S., & Huang, C.-H. (2021) · Polymers · doi:10.3390/polym13040579 · Cited by 39 · see citing works
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Lim, J., Lee, H., Hong, S., Lee, J., & Kim, Y. (2024) · Antioxidants · doi:10.3390/antiox13040483 · Cited by 37 · see citing works
Self-citationPlengmuankhae, W., & Tantitadapitak, C. (2015) · South African Journal of Botany · doi:10.1016/j.sajb.2015.01.013 · Cited by 37 · see citing works
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Yasurin, P., Sriariyanun, M., & Phusantisampan, T. (2015) · King Mongkut’s University of Technology North Bangkok International Journal of Applied Science and Technology · doi:10.14416/j.ijast.2015.11.001 · Cited by 37 · see citing works
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Angerhofer, C. K., Maes, D. H., & Giacomoni, P. U. (2009) · Elsevier eBooks · doi:10.1016/b978-0-8155-1584-5.50014-4 · Cited by 37 · see citing works
Mechanisms of carvacrol-induced expression of type I collagen gene
Lee, J., Jung, E., Yu, H., Kim, Y., Ha, J., Kim, Y. S., & Park, D. (2008) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2008.06.007 · Cited by 33 · see citing works
Self-citationKim, E. A., Park, J. S., Kim, M. S., Jeong, M. Y., Park, H. J., Choi, J. H., Seo, J. H., Choi, Y. S., & Kang, M. J. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s335039 · Cited by 32 · see citing works
Self-citationZulkipli, N. N., Zakaria, R., Long, I., Abdullah, S. F., Muhammad, E. F., Wahab, H. A., & Sasongko, T. H. (2020) · Molecules · doi:10.3390/molecules25173991 · Cited by 32 · see citing works
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Xu, P., & Yu, B. (2021) · Advances in carbohydrate chemistry and biochemistry · doi:10.1016/bs.accb.2021.11.001 · Cited by 30 · see citing works
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Hernández‐Vázquez, L., Bonfill, M., Moyano, E., Cusido, R. M., Navarro‐Ocaña, A., & Palazón, J. (2009) · Biotechnology Letters · doi:10.1007/s10529-009-0143-x · Cited by 30 · see citing works
Current Updates on Centella asiatica: Phytochemistry, Pharmacology and Traditional Uses
Md, M. S. (2013) · Medicinal Plant Research · doi:10.5376/mpr.2013.03.0004 · Cited by 24 · see citing works
Hossain, M. L., Rahman, M. A., Siddika, A., Adnan, M. H., Rahman, H., Diba, F., Hasan, M. Z., & Asaduzzaman, S. M. (2019) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-019-00122-5 · Cited by 23 · see citing works
Yoo, N. H., Kim, O.-T., Kim, J. B., Kim, S. H., Kim, Y., Bang, K.-H., Hyun, D. Y., Cha, S. W., Kim, M. Y., & Hwang, B. (2011) · Plant Biotechnology Reports · doi:10.1007/s11816-011-0173-4 · Cited by 23 · see citing works
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Ogidi, O. I. (2023) · Sustainable development and biodiversity · doi:10.1007/978-981-19-6974-4_12 · Cited by 22 · see citing works
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Younis, L. T., Hassan, M. I. A., Ali, T. B. T., & Bustami, T. J. (2017) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2017.12.003 · Cited by 20 · see citing works
Hashem, M., Jun, K.-Y., Lee, E., Lim, S., Choo, H. P., & Kwon, Y. (2008) · Molecules and Cells · doi:10.1016/s1016-8478(23)14047-7 · Cited by 20 · see citing works
Pithi Chanvorachote, B., Pongrakhananon, V., Luanpitpong, S., Chanvorachote, B., Wannachaiyasit, S., & Nimmannit, U. (2010) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2010.00577_1.x · Cited by 20 · see citing works
Juengwatanatrakul, T., Sritularak, B., Amornnopparattanakul, P., Tassanawat, P., Putalun, W., Tanaka, H., & Morimoto, S. (2010) · The Analyst · doi:10.1039/c0an00868k · Cited by 19 · see citing works
Hong, W., Hwang‐Bo, J., Jeon, H., Ko, M., Choi, J., Jeong, Y.-J., Park, J.-H., Kim, I., Kim, T., Kim, H., et al. (2021) · Nutrients · doi:10.3390/nu13114090 · Cited by 18 · see citing works
Self-citationLee, J., Jung, E., Lee, H., Seo, Y., Koh, J., & Park, D. (2008) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2008.00440.x · Cited by 18 · see citing works
Self-citationIshikura, S., Saeki, H., & Tsuji, K. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.103 · Cited by 18 · see citing works
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Sahu, R. K., Roy, A., Matlam, M., Deshmukh, V., Dwivedi, J., & Jha, A. K. (2013) · Research Journal of Medicinal Plant · doi:10.3923/rjmp.2013.1.22 · Cited by 15 · see citing works
Bozkaya, O., Ekici, H., Gök, Z. G., Bozkaya, E., Ekici, S., Yiğitoğlu, M., & Vargel, İ. (2022) · Ankara Üniversitesi Veteriner Fakültesi Dergisi · doi:10.33988/auvfd.1014802 · Cited by 14 · see citing works
Kim, M.-H., Yoon, E. J., Kim, J. S., Park, S. J., & Lee, H. (2023) · doi:10.21203/rs.3.rs-2787704/v1 · Cited by 13 · see citing works
Self-citationA Convergent Synthesis of the Triterpene Saponin Asiaticoside
Shao, W., Cao, X., Shen, L., Zhang, F., & Yu, B. (2017) · Asian Journal of Organic Chemistry · doi:10.1002/ajoc.201700153 · Cited by 13 · see citing works
Munar‐Bestard, M., Llopis-Grimalt, M. A., Ramis, J. M., & Monjo, M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13091502 · Cited by 12 · see citing works
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Srivastava, S. K., Tiwari, S., Srivastava, N., Verma, S., & Rawat, A. K. S. (2018) · Proceedings of the National Academy of Sciences India Section B Biological Sciences · doi:10.1007/s40011-018-1021-x · Cited by 11 · see citing works
Hartog, A., Smit, H. F., van der Kraan, P. M., Hoijer, M. A., & Garssen, J. (2009) · Experimental Biology and Medicine · doi:10.3181/0810-rm-298 · Cited by 11 · see citing works
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Jin, L., Qin, Y., Zhao, Y., Zhou, X., & Zeng, Y. (2025) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2025.112579 · Cited by 10 · see citing works
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Ferreira, Â. C., Hochman, B., Furtado, F., Bonatti, S., & Ferreira, L. M. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00300.x · Cited by 9 · see citing works
., A. I. C. D., Peter, G., Jude, S., Arundhathy, C. A., Jacob, J., Amalraj, A., Pius, A., & Gopi, S. (2017) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826076.2017.1280681 · Cited by 10 · see citing works
Venesia, N. F., Fachrial, E., & Lister, I. N. E. (2020) · American Scientific Research Journal for Engineering, Technology, and Sciences · Cited by 10 · see citing works
Khalili Hassanabad, M., Mirjalili, M. H., & Mohajeri, M. (2025) · Industrial Crops and Products · doi:10.1016/j.indcrop.2025.120796 · Cited by 9 · see citing works
Review of Malaysian medicinal plants with potential wound healing activity
Wiart, C., Tan, P. L., Rajagopal, M. S., Chew, Y.-L., Leong, M. Y., Tan, L. F., & Yap, V. L. (2024) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-024-04548-5 · Cited by 9 · see citing works
Khotimah, H., Ismail, D. D. L., Widasmara, D., Riawan, W., Retnaningtyas, E., Nugraheni, R. W., Puspita, O. E., Adianingsih, O. R., Mardiyah, M., & Setiawan, A. (2022) · F1000Research · doi:10.12688/f1000research.109318.1 · Cited by 9 · see citing works
RetractedKim, D. M., Baek, S., Park, J. M., Kim, D., Lee, S., Lee, J., Park, C. G., & Han, D. K. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15092220 · Cited by 8 · see citing works
Self-citationIn silico studies of natural compounds of Centella Asiatica as anti-aging and wound healing agents
Khotimah, H., Setiawan, A., Rita, C. I., Mardiyah, M., Ali, A. M., Sukatman, M. P., Retnaningtyas, E., Ismail, D. D. S. L., Widasmara, D., Nurseta, T., et al. (2021) · AIP conference proceedings · doi:10.1063/5.0053016 · Cited by 12 · see citing works
Ahuja, M., Patel, M., Majrashi, M., Mulabagal, V., & Dhanasekaran, M. (2017) · Medicinal and aromatic plants of the world · doi:10.1007/978-981-10-5978-0_1 · Cited by 9 · see citing works
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Fernenda, L., Ramadani, A. P., & Syukri, Y. (2023) · Jurnal Sains Farmasi & Klinis · doi:10.25077/jsfk.9.3.237-244.2022 · Cited by 7 · see citing works
Jung, E., Cho, J. Y., Park, D., Kim, M. H., Park, B., Lee, S. Y., & Lee, J. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.10.011 · Cited by 7 · see citing works
Self-citationKatayoshi, T., Kusano, Y., Shibata, T., Uchida, K., & Tsuji, K. (2021) · Bioscience Biotechnology and Biochemistry · doi:10.1093/bbb/zbab155 · Cited by 7 · see citing works
Noppradit, B., Klinnawee, L., Leeratiwong, C., Praparatana, R., & Puttarak, P. (2024) · Phytochemical Analysis · doi:10.1002/pca.3371 · Cited by 6 · see citing works
Wongrattanakamon, P., Nimmanpipug, P., Sirithunyalug, B., Saenjum, C., & Jiranusornkul, S. (2018) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-018-3451-4 · Cited by 5 · see citing works
Tuong, W., Walker, L. M., & Sivamani, R. K. (2015) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2014.0273 · Cited by 5 · see citing works
Zhang, Z., Ma, J.-W., Feng, R., & Wang, Z. (2018) · PubMed Central · Cited by 5 · see citing works
Kim, M., Lee, S., Heo, H., Chung, J.-W., Sung, J., Jeong, H. S., & Lee, J. (2022) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2022.51.7.671 · Cited by 4 · see citing works
Self-citationLiu, X., Song, Y., Chen, X., Huang, M., Zhao, C., Zhou, X., & Zhou, X. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.810244 · Cited by 4 · see citing works
Lin, Y.-K., Liang, C., Lin, Y., Lin, T.-W., Vázquez, J. J., van Campen, A., & Chiang, C. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105955 · Cited by 4 · see citing works
Research advances of traditional Chinese medicine in delaying skin aging
Zhang, L. (2009) · Journal of Chinese Integrative Medicine · doi:10.3736/jcim20090315 · Cited by 4 · see citing works
Esmaeili, S., Rahmati, M., Salehi, M., Yahaya, B. H., & Zamani, S. (2026) · Skin Research and Technology · doi:10.1111/srt.70325 · Cited by 3 · see citing works
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Al-Nahain, R. J. A. (2015) · CRC Press eBooks · doi:10.1201/b19773-5 · Cited by 3 · see citing works
Umar, N. M., Parumasivam, T., & Toh, S. (2021) · Pharmaceutical Sciences · doi:10.34172/ps.2021.16 · Cited by 3 · see citing works
Jayram, J., Kondaveeti, S. S., Johnson, C. G., Sampath, P. J., & Kalachaveedu, M. (2021) · The International Journal of Lower Extremity Wounds · doi:10.1177/15347346211052140 · Cited by 3 · see citing works
Asiaticoside Supports Collagen Production for Firmer Skin
Lee, J., Kim, S., Jung, E., Lee, J., Kim, S. N., Park, D., & Kim, Y. S. (2009) · Elsevier eBooks · doi:10.1016/b978-0-8155-2029-0.50024-7 · Cited by 2 · see citing works
Self-citationCentella asiatica: From Ethnomedicinal Uses to the Possibility of New Drug Discovery
Al‐Nahain, A., Jahan, R., Rahman, T., Nurunnabi, M., & Rahmatullah, M. (2015) · CRC Press eBooks · doi:10.1201/b19773-3 · Cited by 2 · see citing works
- Authors
- Lee, J., Jung, E., Kim, Y., Park, J., Park, J., Hong, S., Kim, J., Hyun, C., Kim, Y. S., & Park, D.
- Affiliations
- Seoul National University (KR)
- ORCID
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 2006-01
- Volume
- 72
- Issue
- 4
- Pages
- 324-328
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W1983420953
- Cited by
- 123
- References
- 0
- Citations by year
- 2026: 9 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 12 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 9 · 2014: 4 · 2013: 8 · 2012: 6
- FWCI
- 2.16
- Type
- journal article
- Language
- de
- Open access
- closed
- Locations
- Planta Medica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Keywords
- asiaticoside, Centella asiatica, type I collagen synthesis, Smad signaling, Smad2 phosphorylation, Smad3 phosphorylation, SMAD4, skin aging, dermal fibroblasts, saponins, nuclear translocation
- MeSH terms
- Receptor, Transforming Growth Factor-beta Type I, Fibroblasts, Humans, Keratolytic Agents, Phytotherapy, Plant Extracts, Triterpenes, Blotting, Western, Signal Transduction, Skin Aging, Protein Serine-Threonine Kinases, Receptors, Transforming Growth Factor beta, Collagen Type I, Centella, Smad3 Protein, Smad4 Protein
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