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Role of the gut microbiota in inflammatory bowel disease pathogenesis: What have we learnt in the past 10 years?
Open accessAbstract
Our understanding of the microbial involvement in inflammatory bowel disease (IBD) pathogenesis has increased exponentially over the past decade. The development of newer molecular tools for the global assessment of the gut microbiome and the identification of nucleotide-binding oligomerization domain-containing protein 2 in 2001 and other susceptibility genes for Crohn's disease in particular has led to better understanding of the aetiopathogenesis of IBD. The microbial studies have elaborated the normal composition of the gut microbiome and its perturbations in the setting of IBD. This altered microbiome or "dysbiosis" is a key player in the protracted course of inflammation in IBD. Numerous genome-wide association studies have identified further genes involved in gastrointestinal innate immunity (including polymorphisms in genes involved in autophagy: ATG16L1 and IGRM), which have helped elucidate the relationship of the local innate immunity with the adjacent luminal bacteria. These developments have also spurred the search for specific pathogens which may have a role in the metamorphosis of the gut microbiome from a symbiotic entity to a putative pathogenic one. Here we review advances in our understanding of microbial involvement in IBD pathogenesis over the past 10 years and offer insight into how this will shape our therapeutic management of the disease in the coming years.
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“In addition, alteration of the intestinal microbiota has been demonstrated to be a key player in the protracted course of inflammation in inflammatory bowel diseases (IBD) [22].”
From Intestinal Microbiota Is Influenced by Gender and Body Mass Index (2016) · cites this paper as [22]
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“A definitive change of the normal gut microbiota with a breakdown of host-microbial mutualism is probably the defining event in IBD development.59”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [59]
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Cites
Two new Later Stone Age sites from the Final Pleistocene in the Falémé Valley, eastern Senegal
Ndiaye, M., Lespez, L., Tribolo, C., Rassé, M., Hadjas, I., Davidoux, S., Huysecom, É., & Douze, K. (2024) · Monash University Research Portal (Monash University) · doi:10.3929/ethz-b-000667478 · Cited by 24,214
Home visits: a strategy to improve newborn survival - Authors' reply
(2008) · Americanae (AECID Library) · doi:10.1016/s0140 · Cited by 22,524
Correspondence - Tranexamic acid for traumatic brain injury
(2005) · London School of Economics and Political Science Theses Online (London School of Economics and Political Science) · doi:10.1016/s0140-6736 · Cited by 11,894
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030
Molodecky, N. A., Soon, I. S., Rabi, D. M., Ghali, W. A., Ferris, M., Chernoff, G., Benchimol, E. I., Panaccione, R., Ghosh, S., Barkema, H. W., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.10.001 · Cited by 4,833
Research works printed but not linked: 2
- Istivan TS, Smith SC, Fry BN, Coloe PJ. Characterization of Campylobacter concisus hemolysins. FEMS Immunol Med Microbiol 2008; 54: 224-235 [PMID: 18754784 DOI: 10.1111/ j.1574-695X.2008.00467.x] 151 · DOI
- Simpson KW, Dogan B, Rishniw M, Goldstein RE, Klaes- sig S, McDonough PL, German AJ, Yates RM, Russell DG, Johnson SE, Berg DE, Harel J, Bruant G, McDonough SP, Schukken YH. Adherent and invasive Escherichia coli is associated with granulomatous colitis in boxer dogs. Infect Immun 2006; 74: 4778-4792 [PMID: 16861666 DOI: 10.1128/ IAI.00067-06] 153 · DOI
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Marchesi, J. R., Adams, D. H., Fava, F., Hermes, G. D. A., Hirschfield, G. M., Hold, G., Quraishi, M. N., Kinross, J., Smidt, H., Tuohy, K. M., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309990 · Cited by 2,302
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Wang, L., Wang, N., Zhang, W., Cheng, X., Yan, Z., Shao, G., Wang, X., Wang, R., & Fu, C. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00904-4 · Cited by 2,131
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Jia, W., Xie, G., & Jia, W. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.119 · Cited by 1,924
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Gao, J., Xu, K., Liu, H., Liu, G., Bai, M., Peng, C., Li, T., & Yin, Y. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00013 · Cited by 1,357
Khan, I., Ullah, N., Zha, L., Bai, Y., Khan, A., Zhao, T., Che, T., & Zhang, C. (2019) · Pathogens · doi:10.3390/pathogens8030126 · Cited by 771
Human gut microbiota in health and disease: Unveiling the relationship
Afzaal, M., Saeed, F., Shah, Y. A., Hussain, M., Rabail, R., Socol, C. T., Hassoun, A., Pateiro, M., Lorenzo, J. M., Rusu, A. V., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.999001 · Cited by 762
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Haro, C., Rangel-Zúñiga, O. A., Alcalá-Díaz, J. F., Gómez-Delgado, F., Pérez-Martínez, P., Delgado-Lista, J., Quintana-Navarro, G. M., Landa, B. B., Navas-Cortés, J. A., Tena-Sempere, M., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0154090 · Cited by 671
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Simpson, H. L., & Campbell, B. J. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13248 · Cited by 602
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Schirmer, M., Franzosa, E. A., Lloyd‐Price, J., McIver, L. J., Schwager, R., Poon, T. W., Ananthakrishnan, A. N., Andrews, E., Barron, G., Lake, K., et al. (2017) · Nature Microbiology · doi:10.1038/s41564-017-0089-z · Cited by 594
Li, G., Lin, J., Zhang, C., Gao, H., Lu, H., Gao, X., Zhu, R., Li, Z., Li, M., & Liu, Z. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1968257 · Cited by 480
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Engen, P. A. (2015) · Alcohol research · doi:10.35946/arcr.v37.2.07 · Cited by 451
Hou, Q., Ye, L., Liu, H., Huang, L., Yang, Q., Turner, J. R., & Yu, Q. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0070-2 · Cited by 410
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Mills, S., Stanton, C., Lane, J. A., Smith, G., & Ross, R. P. (2019) · Nutrients · doi:10.3390/nu11040923 · Cited by 426
The dormant blood microbiome in chronic, inflammatory diseases
Potgieter, M., Bester, J., Kell, D. B., & Pretorius, E. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv013 · Cited by 384
Zhou, X., Li, W., Wang, S., Zhang, P., Wang, Q., Xiao, J., Zhang, C., Zheng, X. M., Xu, X., Xue, S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.028 · Cited by 376
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Baldelli, V., Scaldaferri, F., Putignani, L., & CHIERICO, F. D. (2021) · Microorganisms · doi:10.3390/microorganisms9040697 · Cited by 389
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Zhao, Z., & Liu, W. C. (2020) · Technology in Cancer Research & Treatment · doi:10.1177/1533033820962117 · Cited by 377
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Fan, F., Sang, L.-X., & Jiang, M. (2017) · Molecules · doi:10.3390/molecules22030484 · Cited by 338
Ganji‐Arjenaki, M., & Rafieian‐Kopaei, M. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.25911 · Cited by 314
Ata, B., Yıldız, Ş., Türkgeldi, E., Pérez‐Brocal, V., Dinleyici, E. Ç., Moyá, A., & Urman, B. (2019) · Scientific Reports · doi:10.1038/s41598-019-39700-6 · Cited by 294
Role of microbial communities in the pathogenesis of periodontal diseases and caries
Mira, Á., Simón‐Soro, Á., & Curtis, M. A. (2017) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12671 · Cited by 296
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Usuda, H., Okamoto, T., & Wada, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147613 · Cited by 277
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Pinto, R. D., Pietropaoli, D., Chandar, A. K., Ferri, C., & Cominelli, F. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000546 · Cited by 249
Fecal and Mucosal Microbiota Profiling in Irritable Bowel Syndrome and Inflammatory Bowel Disease
Presti, A. L., Zorzi, F., CHIERICO, F. D., Altomare, A., Cocca, S., Avola, A., Biasio, F. D., Russo, A., Cella, E., Reddel, S., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01655 · Cited by 228
Toll-Like Receptors: Regulators of the Immune Response in the Human Gut
Hug, H., Mohajeri, M., & La Fata, G. (2018) · Nutrients · doi:10.3390/nu10020203 · Cited by 217
Bishehsari, F., Engen, P. A., Preite, N. Z., Tunçil, Y. E., Naqib, A. D., Shaikh, M. W., Rossi, M., Wilber, S., Green, S. J., Hamaker, B. R., et al. (2018) · Genes · doi:10.3390/genes9020102 · Cited by 227
Prosberg, M. V., Bendtsen, F., Vind, I., Petersen, A. M., & Gluud, L. L. (2016) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2016.1216587 · Cited by 210
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Keku, T. O., Dulal, S., Deveaux, A. E., Jovov, B., & Han, X. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00360.2012 · Cited by 207
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Lu, Q., Yang, M.-F., Liang, Y.-J., Xu, J., Xu, H.-M., Nie, Y.-Q., Wang, L.-S., Yao, J., & Li, D.-F. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s353038 · Cited by 222
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Mudd, J. C., & Brenchley, J. M. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw258 · Cited by 195
Wang, Y., Zhang, N., Kan, J., Zhang, X., Wu, X., Sun, R., Tang, S., Liu, J., Qian, C., & Jin, C. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.02.090 · Cited by 189
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Becker, C., Neurath, M. F., & Wirtz, S. (2015) · ILAR Journal · doi:10.1093/ilar/ilv030 · Cited by 185
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Fusobacterium nucleatum and colorectal cancer: A mechanistic overview
Goradel, N. H., Heidarzadeh, S., Jahangiri, S., Farhood, B., Mortezaee, K., Khanlarkhani, N., & Negahdari, B. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27250 · Cited by 179
Tavakoli, P., Vollmer-Conna, U. S., Hadzi-Pavlovic, D., & Grimm, M. (2021) · Public health reviews · doi:10.3389/phrs.2021.1603990 · Cited by 173
How to: establish and run a stool bank
Terveer, E. M., van Beurden, Y. H., Goorhuis, A., Seegers, J. F. M. L., Bauer, M. P., van Nood, E., Dijkgraaf, M. G. W., Mulder, C. J. J., Vandenbroucke-Grauls, C. M. J. E., Verspaget, H. W., et al. (2017) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2017.05.015 · Cited by 168
Fiebiger, U., Bereswill, S., & Heimesaat, M. M. (2016) · European Journal of Microbiology and Immunology · doi:10.1556/1886.2016.00036 · Cited by 165
Lavoie, S., Conway, K. L., Lassen, K. G., Jijon, H. B., Pan, H., Chun, E., Michaud, M., Lang, J. K., Gallini, C. A., Dreyfuss, J. M., et al. (2019) · eLife · doi:10.7554/elife.39982 · Cited by 164
Roberts, F. A., & Darveau, R. P. (2015) · Periodontology 2000 · doi:10.1111/prd.12087 · Cited by 151
Giardia Alters Commensal Microbial Diversity throughout the Murine Gut
Barash, N. R., Maloney, J. G., Singer, S. M., & Dawson, S. C. (2017) · Infection and Immunity · doi:10.1128/iai.00948-16 · Cited by 155
Shmuel-Galia, L., Humphries, F., Lei, X., Ceglia, S., Wilson, R., Jiang, Z., Ketelut-Carneiro, N., Foley, S. E., Pechhold, S. B., Houghton, J., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.05.008 · Cited by 149
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Atreya, R. N., & Siegmund, B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00424-6 · Cited by 150
Dey, P., Sasaki, G. Y., Wei, P. Y., Li, J., Wang, L., Zhu, J., McTigue, D. M., Yu, Z., & Bruno, R. S. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.01.017 · Cited by 145
Correlation between early-life regulation of the immune system by microbiota and allergy development
Gensollen, T., & Blumberg, R. S. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.02.011 · Cited by 147
Meroni, M., Longo, M., & Dongiovanni, P. (2019) · Nutrients · doi:10.3390/nu11112642 · Cited by 152
Frykman, P. K., Nordenskjöld, A., Kawaguchi, A. L., Hui, T., Granström, A. L., Cheng, Z., Tang, J., Underhill, D. M., Iliev, I. D., Funari, V., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124172 · Cited by 135
Xie, X., He, Y., Li, H., Dong, Y. J., Na, L., Sun, T., Zhang, D., Shi, X., Xia, Y., Jiang, T., et al. (2018) · Nutrition · doi:10.1016/j.nut.2018.10.038 · Cited by 138
Importance of gut microbiota in obesity
Cornejo-Pareja, I. M., Muñoz‐Garach, A., Clemente‐Postigo, M., & Tinahones, F. J. (2018) · European Journal of Clinical Nutrition · doi:10.1038/s41430-018-0306-8 · Cited by 147
SIGNR3‐dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis
Lightfoot, Y. L., Selle, K., Yang, T., Goh, Y. J., Sahay, B., Zadeh, M., Owen, J. L., Colliou, N., Li, E., Johannssen, T., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201490296 · Cited by 141
van Praagh, J. B., de Goffau, M. C., Bakker, I. S., van Goor, H., Harmsen, H. J. M., Olinga, P., & Havenga, K. (2018) · Annals of Surgery · doi:10.1097/sla.0000000000002651 · Cited by 132
Saponins regulate intestinal inflammation in colon cancer and IBD
Dong, J., Liang, W., Wang, T., Sui, J., Wang, J., Deng, Z., & Chen, D. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.04.010 · Cited by 127
Mukherjee, S., Joardar, N., Sengupta, S., & Babu, S. P. S. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.07.010 · Cited by 129
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Ma, N., Chen, X., Johnston, L. J., & Ma, X. (2022) · iMeta · doi:10.1002/imt2.54 · Cited by 124
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Shi, Y., Dong, Y., Huang, W., Zhu, D., Mao, H., & Su, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157259 · Cited by 121
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Raza, M. H., Gul, K., Arshad, A., Riaz, N., Waheed, U., Rauf, A., Aldakheel, F. M., Alduraywish, S. A., Rehman, M. U., Abdullah, M., et al. (2018) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-018-2816-0 · Cited by 122
Diet, microbiota, and dysbiosis: a ‘recipe’ for colorectal cancer
Vipperla, K., & O’Keefe, S. J. (2016) · Food & Function · doi:10.1039/c5fo01276g · Cited by 117
Weber, D., Oefner, P. J., Dettmer, K., Hiergeist, A., Koestler, J., Gessner, A., Weber, M., Stämmler, F., Hahn, J. R., Wolff, D., et al. (2016) · Bone Marrow Transplantation · doi:10.1038/bmt.2016.66 · Cited by 112
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Bell, J. S., Spencer, J. I., Yates, R. L., Yee, S. A., Jacobs, B. M., & DeLuca, G. C. (2018) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12520 · Cited by 111
Association of dietary fibre intake and gut microbiota in adults
Lin, D., Peters, B. A., Friedlander, C., Freiman, H. J., Goedert, J. J., Sinha, R., Miller, G., Bernstein, M. A., Hayes, R. B., & Ahn, J. (2018) · British Journal of Nutrition · doi:10.1017/s0007114518002465 · Cited by 109
Yang, L., Wu, G., Wu, Q., Peng, L., & Yuan, L. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-00849-1 · Cited by 110
Deleu, S., Arnauts, K., Deprez, L., Machiels, K., Ferrante, M., Huys, G. R. B., Thevelein, J. M., Raes, J., & Vermeire, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24010768 · Cited by 110
Chiu, C.-M., Huang, W.-C., Weng, S.-L., Tseng, H., Liang, C., Wang, W.-C., Yang, T., Yang, T.-L., Weng, C.-T., Chang, T., et al. (2014) · BioMed Research International · doi:10.1155/2014/906168 · Cited by 110
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Nistal, E., Fernández-Fernández, N., Vivas, S., & Olcoz, J. L. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00220 · Cited by 111
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Sun, R., Xu, C., Feng, B., Gao, X., & Liu, Z. (2021) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848211018098 · Cited by 105
Park, S., Kim, J., Chun, J., Han, K., Soh, H., Kang, E. A., Lee, H. J., Im, J. P., & Kim, J. S. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8081191 · Cited by 99
Oral iron exacerbates colitis and influences the intestinal microbiome
Mahalhal, A., Williams, J. M., Johnson, S., Ellaby, N., Duckworth, C. A., Burkitt, M. D., Liu, X., Hold, G. L., Campbell, B. J., Pritchard, D. M., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202460 · Cited by 98
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Nagpal, R., Kumar, M., Yadav, A. K., Hemalatha, R., Yadav, H., Marotta, F., & Yamashiro, Y. (2016) · Beneficial Microbes · doi:10.3920/bm2015.0062 · Cited by 97
Dubinsky, V., Reshef, L., Bar, N., Keizer, D., Golan, N., Rabinowitz, K. M., Godny, L., Yadgar, K., Zonensain, K., Tulchinsky, H., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.10.001 · Cited by 96
Manandhar, I., Alimadadi, A., Aryal, S., Munroe, P. B., Joe, B., & Cheng, X. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00360.2020 · Cited by 91
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Henson, M. A., & Phalak, P. (2017) · BMC Systems Biology · doi:10.1186/s12918-017-0522-1 · Cited by 90
Sexually dimorphic characteristics of the small intestine and colon of prepubescent C57BL/6 mice
Steegenga, W. T., Mischke, M., Lute, C., Boekschoten, M. V., Pruis, M. G. M., Lendvai, Á., Verkade, H. J., Boekhorst, J., Timmerman, H. M., Plösch, T., et al. (2014) · Biology of Sex Differences · doi:10.1186/s13293-014-0011-9 · Cited by 90
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Borghi, E., Borgo, F., Severgnini, M., Savini, M. N., Casiraghi, M. C., & Vignoli, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020344 · Cited by 90
Olbjørn, C., Småstuen, M. C., Thiis‐Evensen, E., Nakstad, B., Vatn, M. H., Jahnsen, J., Ricanek, P., Vatn, S., Moen, A. E. F., Tannæs, T. M., et al. (2019) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s186235 · Cited by 86
Subramanian, S., Ekbom, A., & Rhodes, J. M. (2016) · Gut · doi:10.1136/gutjnl-2016-312673 · Cited by 88
Jayakumar, S., & Loomba, R. S. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15314 · Cited by 87
Prevalence and Phenotype of Concurrent Psoriasis and Inflammatory Bowel Disease
Eppinga, H., Poortinga, S., Thio, H. B., Nijsten, T. E. C., Nuij, V. J. A. A., van der Woude, C. J., Vodegel, R. M., Fuhler, G. M., & Peppelenbosch, M. P. (2017) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000001169 · Cited by 85
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Metadata
- Authors
- Hold, G. L.
- Affiliations
- University of Aberdeen (GB)
- Corresponding author
- Hold, Georgina L
- ORCID
- Hold, Georgina L
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2014
- Volume
- 20
- Issue
- 5
- Pages
- 1192
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC3921503
- OpenAlex
- W2115524426
- Cited by
- 365
- References
- 235
- Citations by year
- 2026: 12 · 2025: 26 · 2024: 27 · 2023: 25 · 2022: 24 · 2021: 40 · 2020: 27 · 2019: 41 · 2018: 36 · 2017: 31 · 2016: 31 · 2015: 34 · 2014: 11
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
- Keywords
- gut microbiota, inflammatory bowel disease, Crohn's disease, dysbiosis, NOD2, susceptibility genes, innate immunity, autophagy, ATG16L1, pathogen identification
- MeSH terms
- Animals, Bacteria, Colitis, Ulcerative, Crohn Disease, Humans, Immunity, Innate, Intestines, Phenotype, Risk Factors, Immunity, Mucosal, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Microbiota, Dysbiosis
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