Cited by 3,001Gut microbiota and healthInfant Nutrition and HealthOral microbiology and periodontitis research

The DOI matches its Crossref record; 163 of the 163 references it cites were found in a registry or an index.

Role of the normal gut microbiota

Open access

Jandhyala, Sai Manasa·2015·World Journal of Gastroenterology

DOI 10.3748/wjg.v21.i29.8787PMC PMC4528021

Open this paper in CoChat — free account Open PDF

Abstract

Relation between the gut microbiota and human health is being increasingly recognised. It is now well established that a healthy gut flora is largely responsible for overall health of the host. The normal human gut microbiota comprises of two major phyla, namely Bacteroidetes and Firmicutes. Though the gut microbiota in an infant appears haphazard, it starts resembling the adult flora by the age of 3 years. Nevertheless, there exist temporal and spatial variations in the microbial distribution from esophagus to the rectum all along the individual's life span. Developments in genome sequencing technologies and bioinformatics have now enabled scientists to study these microorganisms and their function and microbe-host interactions in an elaborate manner both in health and disease. The normal gut microbiota imparts specific function in host nutrient metabolism, xenobiotic and drug metabolism, maintenance of structural integrity of the gut mucosal barrier, immunomodulation, and protection against pathogens. Several factors play a role in shaping the normal gut microbiota. They include (1) the mode of delivery (vaginal or caesarean); (2) diet during infancy (breast milk or formula feeds) and adulthood (vegan based or meat based); and (3) use of antibiotics or antibiotic like molecules that are derived from the environment or the gut commensal community. A major concern of antibiotic use is the long-term alteration of the normal healthy gut microbiota and horizontal transfer of resistance genes that could result in reservoir of organisms with a multidrug resistant gene pool.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3748/wjg.v21.i29.8787

Cites

163 of 163 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100
Pattern Recognition Receptors and Inflammation
Takeuchi, O., & Akira, S. (2010) · Cell · doi:10.1016/j.cell.2010.01.022 · Cited by 8,895
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820
Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549

Show all 163 references

Research works printed but not linked: 2

Bourriaud C, Akoka S, Goupry S, Robins R, Cherbut C, Michel C. Butyrate production from lactate by human colonic microflora. Reprod Nutr Dev 2002;42:S55.
10.1016/j.immuni.2012 · DOI

Sorted by citations

Items 801–900 of 1,002

Prebiotic role of softwood hemicellulose in healthy mice model
Deloule, V., Boisset, C., Hannani, D., Suau, A., Gouëllec, A. L., Chroboczek, J., Botté, C. Y., Yamaryo‐Botté, Y., Chirat, C., & Toussaint, B. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103688 · Cited by 32
In Vitro Evaluation of Prebiotic Properties of a Commercial Artichoke Inflorescence Extract Revealed Bifidogenic Effects
den Abbeele, P. V., Ghyselinck, J., Marzorati, M., Villar, A., Zangara, A., Smidt, C. R., & Risco, E. (2020) · Nutrients · doi:10.3390/nu12061552 · Cited by 31
Gut microbiota as a target to limit toxic effects of traditional Chinese medicine: Implications for therapy
Feng, W., Liu, J., Huang, L., Tan, Y., & Peng, C. Y. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111047 · Cited by 34
The role of microbiota in neonatal hyperbilirubinemia.
Chen, K., & Yuan, T. (2020) · PubMed Central · Cited by 32
Alteration of the fecal microbiota in Chinese patients with Schistosoma japonicum infection
Jiang, Y., Yuan, Z., Shen, Y., Rosa, B. A., Martin, J. C., Cao, S., Zhou, Y., Mitreva, M., & Cao, J. (2021) · Parasite · doi:10.1051/parasite/2020074 · Cited by 31
Metagenomic analysis of the gut microbiome composition associated with vitamin D supplementation in Taiwanese infants
Lei, W., Huang, K., Jhong, J.-H., Chen, C., & Weng, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-82584-8 · Cited by 32
Eosinophilic Esophagitis and Microbiota: State of the Art
Mennini, M., Tambucci, R., Riccardi, C., Rea, F., Angelis, P. D., Fiocchi, A. G., & Assa’ad, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.595762 · Cited by 31
In vitro interactions of Alternaria mycotoxins, an emerging class of food contaminants, with the gut microbiota: a bidirectional relationship
Crudo, F., Aichinger, G., Mihajlovic, J., Varga, E., Dellafiora, L., Warth, B., Dall’Asta, C., Berry, D., & Marko, D. (2021) · Archives of Toxicology · doi:10.1007/s00204-021-03043-x · Cited by 36
Multifaceted Impacts of Periodontal Pathogens in Disorders of the Intestinal Barrier
Liu, Y., Huang, W., Wang, J., Ma, J., Zhang, M., Lü, X., Liu, J., & Kou, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.693479 · Cited by 34
The Gut Microbiota-Derived Immune Response in Chronic Liver Disease
Won, S., Park, E., Jeong, J., Ganesan, R., Gupta, H., Gebru, Y. A., Sharma, S., Kim, D. J., & Suk, K. T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158309 · Cited by 31
Intestinal microbiota changes induced by TNF-inhibitors in IBD-related spondyloarthritis
Ditto, M. C., Parisi, S., Landolfi, G., Borrelli, R., Realmuto, C., Finucci, A., Caviglia, G. P., Ribaldone, D. G., Astegiano, M., Zanetti, A., et al. (2021) · RMD Open · doi:10.1136/rmdopen-2021-001755 · Cited by 31
Oral iron supplementation after antibiotic exposure induces a deleterious recovery of the gut microbiota
Cuisiniere, T., Calvé, A., Fragoso, G., Oliero, M., Hajjar, R., González, E., & Santos, M. M. (2021) · BMC Microbiology · doi:10.1186/s12866-021-02320-0 · Cited by 31
Exercise alleviated intestinal damage and microbial disturbances in mice exposed to fluoride
Fu, R., Niu, R., Zhao, F., Wang, J., Cao, Q., Yu, Y., Liu, C., Zhang, D., & Sun, Z. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2021.132658 · Cited by 31
Gut Microbiome Distinguishes Patients With Epilepsy From Healthy Individuals
Cui, G., Liu, S., Liu, Z., Chen, Y., Wu, T., Lou, J., Wang, H., Zou, Y., Sun, Y., Rao, B., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.696632 · Cited by 33
Beneficial effects of eugenol supplementation on gut microbiota and hepatic steatosis in high-fat-fed mice
Rodrigues, M., Silva, C. B., Joaquim, A. G., Machado, C. D., Ramalho, L. N. Z., Carlos, D., Fassini, P. G., & Suen, V. M. M. (2022) · Food & Function · doi:10.1039/d1fo03619j · Cited by 29
Cardioprotective Effect of Gossypin Against Myocardial Ischemic/Reperfusion in Rats via Alteration of Oxidative Stress, Inflammation and Gut Microbiota
Cheng, G., Zhang, J., Jia, S., Feng, P., Chang, F., Yan, L., Gupta, P., & Wu, H. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s348883 · Cited by 31
The Oncobiome in Gastroenteric and Genitourinary Cancers
D’Antonio, D. L., Marchetti, S., Pignatelli, P., Piattelli, A., & Curia, M. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179664 · Cited by 33
Potential role of gut microbiota and its metabolites in radiation-induced intestinal damage
Xin, J., Wang, J., Ding, Q., Chen, W., Xu, X., Wei, X., Lv, Y.-H., Wei, Y., Feng, Y., & Zu, X. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114341 · Cited by 32
Gut Microbiota as a Missing Link Between Nutrients and Traits of Human
Chung, H., Nguyễn, T. T. B., Kim, H., & Hong, S. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01510 · Cited by 31
Transplant associated infections—The role of the gastrointestinal microbiota and potential therapeutic options
Chan, S., Hawley, C. M., Campbell, K. L., Morrison, M., Campbell, S. B., Isbel, N. M., Francis, R. S., Playford, E. G., & Johnson, D. W. (2019) · Nephrology · doi:10.1111/nep.13670 · Cited by 30
Molecular Pathogenesis of Colitis-associated Colorectal Cancer: Immunity, Genetics, and Intestinal Microecology
Yin, Y., Wan, J., Yu, J., & Wu, K. (2023) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izad081 · Cited by 35
From Microcosm to Macrocosm: The -Omics, Multiomics, and Sportomics Approaches in Exercise and Sports
Muniz‐Santos, R., Magno-França, A., Jurišica, I., & Cameron, L. C. (2023) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2023.0169 · Cited by 35
MASLD-Related HCC: A Comprehensive Review of the Trends, Pathophysiology, Tumor Microenvironment, Surveillance, and Treatment Options
Shi, Y., Taherifard, E., Saeed, A., & Saeed, A. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46060356 · Cited by 33
Acupuncture influences multiple diseases by regulating gut microbiota
Xu, H., Luo, Y., Li, Q., & Zhu, H. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1371543 · Cited by 33
Exposure to polyethylene microplastics exacerbate inflammatory bowel disease tightly associated with intestinal gut microflora
Ghosal, S., Bag, S., Rao, S. R., & Bhowmik, S. (2024) · RSC Advances · doi:10.1039/d4ra04544k · Cited by 37
From microbes to mind: germ-free models in neuropsychiatric research
Delgado‐Ocaña, S., & Cuesta, S. (2024) · mBio · doi:10.1128/mbio.02075-24 · Cited by 38
Gut microbiota interact with breast cancer therapeutics to modulate efficacy
Arnone, A. A., Ansley, K. C., Heeke, A. L., Howard-McNatt, M. M., & Cook, K. L. (2025) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00185-0 · Cited by 37
The role of probiotics, prebiotics, and synbiotics in the treatment of inflammatory bowel diseases: an overview of recent clinical trials
Yassine, F., Najm, A., & Bilen, M. (2025) · Frontiers in Systems Biology · doi:10.3389/fsysb.2025.1561047 · Cited by 39
The Androbactome and the Gut Microbiota–Testis Axis: A Narrative Review of Emerging Insights into Male Fertility
Kaltsas, A., Giannakodimos, I., Markou, E., Stavropoulos, M., Deligiannis, D., Kratiras, Z., & Chrisofos, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136211 · Cited by 34
Emerging Concepts on the Gut Microbiome and Multiple Sclerosis
Glenn, J. D., & Mowry, E. M. (2016) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2015.0177 · Cited by 30
Utilization of Different Omic Approaches to Unravel Stress Response Mechanisms in the Parasite Entamoeba histolytica
Nagaraja, S., & Ankri, S. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00019 · Cited by 30
Role of Low FODMAP Diet and Probiotics on Gut Microbiome in Irritable Bowel Syndrome (IBS)
Selvaraj, S. M., Wong, S. H., Ser, H., & Lee, L. (2020) · Progress In Microbes & Molecular Biology · doi:10.36877/pmmb.a0000069 · Cited by 31
Diet, adiposity, and the gut microbiota from infancy to adolescence: A systematic review
Wyst, K. B. V., Ortega‐Santos, C. P., Toffoli, S., Lahti, C. E., & Whisner, C. M. (2021) · Obesity Reviews · doi:10.1111/obr.13175 · Cited by 34
Comparative analysis of oral-gut microbiota between captive and wild long-tailed macaque in Thailand
Sawaswong, V., Praianantathavorn, K., Chanchaem, P., Khamwut, A., Kemthong, T., Hamada, Y., Malaivijitnond, S., & Payungporn, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-93779-4 · Cited by 33
Effects of Microbial Transfer during Food-Gut-Feces Circulation on the Health of Bombyx mori
Qin, L., Qi, J., Shen, G., Qin, D., Wu, J., Song, Y., Cao, Y., Zhao, P., & Xia, Q. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.02357-22 · Cited by 30
Hypoxia-tolerant apical-out intestinal organoids to model host-microbiome interactions
Kakni, P., Jutten, B., Carvalho, D. J., Penders, J., Truckenmüller, R. K., Habibović, P., & Giselbrecht, S. (2023) · Journal of Tissue Engineering · doi:10.1177/20417314221149208 · Cited by 34
Gastroparesis: The Complex Interplay with Microbiota and the Role of Exogenous Infections in the Pathogenesis of the Disease
Mandarino, F. V., Sinagra, E., Barchi, A., Verga, M. C., Brinch, D., Raimondo, D., & Danese, S. (2023) · Microorganisms · doi:10.3390/microorganisms11051122 · Cited by 29
Risk factors for ileocolic anastomosis dehiscence; a cohort study
Golda, T., Lazzara, C., Zerpa, C., Sobrino, L., Fico, V., Kreisler, E., & Biondo, S. (2019) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2019.11.020 · Cited by 30
Causal associations between human gut microbiota and cholelithiasis: a mendelian randomization study
Li, W., Ren, A., Qin, Q., Zhao, L., Peng, Q., Ma, R., & Luo, S. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1169119 · Cited by 30
Bifidobacterium affects antitumor efficacy of oncolytic adenovirus in a mouse model of melanoma
Tripodi, L., Feola, S., Granata, I., Whalley, T., Passariello, M., Capasso, C., Coluccino, L., Vitale, M., Scalia, G., Gentile, L., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107668 · Cited by 29
Gut dysbiosis-related thrombosis in inflammatory bowel disease: Potential disease mechanisms and emerging therapeutic strategies
Papa, A., Santini, P., Lucia, S. S. D., Maresca, R., Porfidia, A., Pignatelli, P., Gasbarrini, A., Violi, F., & Pola, R. (2023) · Thrombosis Research · doi:10.1016/j.thromres.2023.11.005 · Cited by 29
Compound probiotics can improve intestinal health by affecting the gut microbiota of broilers
Liu, X., Ma, Z., Wang, Y., Li, L., Jia, H., & Zhang, L. (2023) · Journal of Animal Science · doi:10.1093/jas/skad388 · Cited by 29
Effects of different thickening agents on infant gut microbiota
González‐Bermúdez, C. A., López‐Nicolás, R., Peso‐Echarri, P., Frontela‐Saseta, C., & Martínez‐Graciá, C. (2018) · Food & Function · doi:10.1039/c7fo01992k · Cited by 29
Conjunctival dysbiosis in mucosa-associated lymphoid tissue lymphoma
Asao, K., Hashida, N., Ando, S., Motooka, D., Kurakami, H., Nakamura, S., Yamashita, D., Maruyama, K., Kawasaki, S., Yamada, T., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-44861-5 · Cited by 29
Essential oils and microbiota: Implications for diet and weight control
Ünüsan, N. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.07.014 · Cited by 36
Association between postoperative changes in the gut microbiota and pseudopsia after cardiac surgery: prospective observational study
Maekawa, M., Yoshitani, K., Yahagi, M., Asahara, T., Shishido, Y., Fukushima, S., Tadokoro, N., Fujita, T., & Ohnishi, Y. (2020) · BMC Surgery · doi:10.1186/s12893-020-00907-4 · Cited by 30
Functional Anatomical Changes in Ulcerative Colitis Patients Determine Their Gut Microbiota Composition and Consequently the Possible Treatment Outcome
Bálint, A., Farkas, K., Méhi, O., Kintses, B., Vásárhelyi, B. M., Ari, E. E., Pál, C., Madácsy, T., Maléth, J., Szántó, K. J., et al. (2020) · Pharmaceuticals · doi:10.3390/ph13110346 · Cited by 29
Microbiota‐Host Immunity Communication in Neurodegenerative Disorders: Bioengineering Challenges for In Vitro Modeling
Boeri, L., Perottoni, S., Izzo, L., Giordano, C., & Albani, D. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002043 · Cited by 28
Heat-inactivated Lacticaseibacillus paracasei N1115 alleviates the damage due to brain function caused by long-term antibiotic cocktail exposure in mice
Zhang, Y., Liang, H., Wang, Y., Cheng, R., Pu, F., Yang, Y., Li, J., Wu, S., Shen, X. P., & He, F. (2022) · BMC Neuroscience · doi:10.1186/s12868-022-00724-w · Cited by 29
Toll-like receptor 4 deficiency alleviates lipopolysaccharide-induced intestinal barrier dysfunction
Zhan, L., Zheng, J., Meng, J., Fu, D., Pang, L., & Ji, C. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113778 · Cited by 34
Nutritional factors influencing microbiota-mediated colonization resistance of the oral cavity: A literature review
Akimbekov, N. S., Digel, I., Yerezhepov, A. Y., Shardarbek, R. S., Wu, X., & Zha, J. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1029324 · Cited by 37
Latent Potential of Multifunctional Selenium Nanoparticles in Neurological Diseases and Altered Gut Microbiota
Ashraf, H., Cossu, D., Ruberto, S., Noli, M., Jasemi, S., Simula, E. R., & Sechi, L. A. (2023) · Materials · doi:10.3390/ma16020699 · Cited by 33
Effects of Aeromonas hydrophila infection on the intestinal microbiota, transcriptome, and metabolomic of common carp (Cyprinus carpio)
Zhang, L., Wang, L., Huang, J., Jin, Z., Guan, J., Yu, H., Zhang, M., Yu, M., Jiang, H., & Qiao, Z. (2023) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2023.108876 · Cited by 29
Supplementation of microencapsulated probiotics modulates gut health and intestinal microbiota
Gyawali, I., Zhou, G., Xu, G., Li, G., Wang, Y., Zeng, Y., Li, J., Zhou, J., Zhu, C., Shu, G., et al. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3414 · Cited by 35
The role of mucoprotectants in the management of gastrointestinal disorders
Eutamène, H., Beaufrand, C., Harkat, C., & Théodorou, V. (2017) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2018.1378573 · Cited by 29
Inflammatory Diseases of the Gut
Rohr, M., Narasimhulu, C. A., Sharma, D., Doomra, M., Riad, A., Naser, S. A., & Parthasarathy, S. (2018) · Journal of Medicinal Food · doi:10.1089/jmf.2017.0138 · Cited by 34
Probiotics- its functions and influence on the ageing process: A comprehensive review
Choudhary, P., Kathuria, D., Suri, S., Bahndral, A., & Naveen, A. K. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.102389 · Cited by 36
An insight into the critical role of gut microbiota in triggering the phthalate-induced toxicity and its mitigation using probiotics
Goyal, S. P., & Chakkaravarthi, S. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.166889 · Cited by 28
Elucidating the causal association between gut microbiota and intrahepatic cholangiocarcinoma through Mendelian randomization analysis
Chen, Z., Shi, W., Chen, K., Lu, C., Li, X., & Li, Q. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1288525 · Cited by 29
Advances in gut–brain organ chips
Zhang, Y., Lu, S., Zhuang, J., & Liang, L. (2024) · Cell Proliferation · doi:10.1111/cpr.13724 · Cited by 31
Unlocking the mind-gut connection: Impact of human microbiome on cognition
Castells‐Nobau, A., Mayneris‐Perxachs, J., & Fernández‐Real, J. M. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.07.019 · Cited by 31
Gut microbiota in irritable bowel syndrome: a narrative review of mechanisms and microbiome-based therapies
Li, X.-M., Yuan, Q., Huang, H., & Wang, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1695321 · Cited by 35
Valeric Acid: A Gut-Derived Metabolite as a Potential Epigenetic Modulator of Neuroinflammation in the Gut–Brain Axis
Paciolla, C., Manganelli, M., Chiano, M. D., Montenegro, F., Gallone, A., Sallustio, F., & Guida, G. (2025) · Cells · doi:10.3390/cells14221823 · Cited by 35
Through the Scope Darkly: The Gut Mycobiome Comes into Focus
Hernández‐Santos, N., & Klein, B. S. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.11.013 · Cited by 28
Reevaluating our understanding of lactulose breath tests by incorporating hydrogen sulfide measurements
Birg, A., Hu, S., & Lin, H. C. (2019) · JGH Open · doi:10.1002/jgh3.12145 · Cited by 28
Effect of heat-killed Streptococcus thermophilus on type 2 diabetes rats
Gao, X., Wang, F., Zhao, P., Zhang, R., & Zeng, Q. (2019) · PeerJ · doi:10.7717/peerj.7117 · Cited by 28
Murine Models for the Investigation of Colonization Resistance and Innate Immune Responses in Campylobacter Jejuni Infections
Mousavi, S., Bereswill, S., & Heimesaat, M. M. (2021) · Current topics in microbiology and immunology · doi:10.1007/978-3-030-65481-8_9 · Cited by 28
Future Directions in Reducing Gastrointestinal Disorders in Children With ASD Using Fecal Microbiota Transplantation
Żebrowska-Różańska, P., Łaczmańska, I., & Łaczmański, Ł. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.630052 · Cited by 32
Red Wine High-Molecular-Weight Polyphenolic Complex: An Emerging Modulator of Human Metabolic Disease Risk and Gut Microbiota
Suo, H., Shishir, M. R. I., Xiao, J., Wang, M., Chen, F., & Cheng, K. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c03158 · Cited by 28
New perspective on fecal microbiota transplantation in liver diseases
Suk, K. T., & Koh, H. (2021) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15729 · Cited by 28
Probiotic supplementation demonstrates therapeutic potential in treating gut dysbiosis and improving neurocognitive function in age-related dementia
Meng, H. Y. H., Mak, C. C. H., Mak, J. W. Y., Zuo, T., Ko, H., & Chan, F. K. L. (2022) · European Journal of Nutrition · doi:10.1007/s00394-021-02760-4 · Cited by 31
Crosstalk Communications Between Islets Cells and Insulin Target Tissue: The Hidden Face of Iceberg
Langlois, A., Dumond, A., Vion, J., Pinget, M., & Bouzakri, K. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.836344 · Cited by 32
Cancer immunotherapy resistance: The impact of microbiome-derived short-chain fatty acids and other emerging metabolites
Hersi, F., Elgendy, S. M., Shamma, S. A. A., Altell, R. T., Sadiek, O., & Omar, H. A. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120573 · Cited by 29
Aetiology, diagnosis and management of small intestinal bacterial overgrowth
Ahmed, J. F., Padam, P., & Ruban, A. (2023) · Frontline Gastroenterology · doi:10.1136/flgastro-2022-102163 · Cited by 28
Urine metabolomics and microbiome analyses reveal the mechanism of anti-tuberculosis drug-induced liver injury, as assessed for causality using the updated RUCAM: A prospective study
Wang, M.-G., Wu, S., Zhang, M., & He, J.-Q. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1002126 · Cited by 34
Chronic alcohol-induced dysbiosis of the gut microbiota and gut metabolites impairs sperm quality in mice
Li, H. Z., Li, N., Lu, Q., Yang, J., Jiang, Z., Zhu, Q., Yi, S., Fu, W., Luo, T., Tang, J., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1042923 · Cited by 30
Dietary supplementation of bilberry anthocyanin on growth performance, intestinal mucosal barrier and cecal microbes of chickens challenged with Salmonella Typhimurium
Zhang, S., Wang, Y., Ye, J., Fan, Q., Lin, X., Gou, Z., & Jiang, S. (2023) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-022-00799-9 · Cited by 28
Effect of whole-grain consumption on changes in fecal microbiota: a review of human intervention trials
Koecher, K. J., McKeown, N. M., Sawicki, C. M., Menon, R. S., & Slavin, J. L. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuz008 · Cited by 28
Gut Microbiota in Patients with Morbid Obesity Before and After Bariatric Surgery: a Ten-Year Review Study (2009–2019)
Koulas, S. G., Stefanou, C. K., Stefanou, S. K., Tepelenis, K., Zikos, N., Tepetes, K., & Kapsoritakis, A. N. (2020) · Obesity Surgery · doi:10.1007/s11695-020-05074-2 · Cited by 29
Changes in the gut microbiota of Nigerian infants within the first year of life
Oyedemi, O. T., Shaw, S., Martin, J. C., Ayeni, F. A., & Scott, K. P. (2022) · PLoS ONE · doi:10.1371/journal.pone.0265123 · Cited by 29
Gut Microbiota and Neuroinflammation in Acute Liver Failure and Chronic Liver Disease
Giuli, L., Maestri, M., Santopaolo, F., Pompili, M., & Ponziani, F. R. (2023) · Metabolites · doi:10.3390/metabo13060772 · Cited by 30
Superparamagnetic iron oxide nanoparticle regulates microbiota–gut–inner ear axis for hearing protection
Guo, Z., Wu, Y., Chen, B., Kong, M., Xie, P., Li, Y., Liu, D., Chai, R., & Gu, N. (2024) · National Science Review · doi:10.1093/nsr/nwae100 · Cited by 29
Gut–Liver Axis Dysregulation in Portal Hypertension: Emerging Frontiers
Lombardi, M., Troisi, J., Motta, B. M., Torre, P., Masarone, M., & Persico, M. (2024) · Nutrients · doi:10.3390/nu16071025 · Cited by 27
The Role of Gut Microbiota and Its Metabolites in Patients with Heart Failure
Cienkowski, K., Cienkowska, A., Kupczyńska, K., & Bielecka-Dabrowa, A. M. (2024) · Biomedicines · doi:10.3390/biomedicines12040894 · Cited by 27
Biological toxicity of sulfamethoxazole in aquatic ecosystem on adult zebrafish (Danio rerio)
Zhou, J., Yun, X., Wang, J., Li, Q., Wang, Y., Zhang, W., & Fan, Z. (2024) · Scientific Reports · doi:10.1038/s41598-024-59971-y · Cited by 28
The correlation between intestinal colonization and infection of carbapenem-resistant Klebsiella pneumoniae: A systematic review
Cai, S., Wang, Z., Han, X., Hu, H., Quan, J., Jiang, Y., Du, X., Zhou, Z., & Yu, Y. (2024) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2024.04.013 · Cited by 27
Therapeutic targeting of the host-microbiota-immune axis: implications for precision health
Nazir, A., Hussain, F. H. N., Hussain, T. H. N., Dweik, R. A., & Raza, A. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1570233 · Cited by 31
The intriguing role of Rifaximin in gut barrier chronic inflammation and in the treatment of Crohn’s disease
Lopetuso, L. R., Napoli, M., Rizzatti, G., & Gasbarrini, A. (2018) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2018.1483333 · Cited by 27
Minireview on the Relations between Gut Microflora and Parkinson’s Disease: Further Biochemical (Oxidative Stress), Inflammatory, and Neurological Particularities
Ilie, O., Ciobica, A. S., McKenna, J., Doroftei, B., & Mavroudis, I. A. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/4518023 · Cited by 29
Human Microbiome: age-related changes and functions
Kaybysheva, V. O., Zharova, M. E., Filimendikova, K. Y., & Nikonov, E. L. (2020) · Russian Journal of Evidence-Based Gastroenterology · doi:10.17116/dokgastro2020902142 · Cited by 31
Metagenomics approach to the intestinal microbiome structure and function in high fat diet-induced obesity in mice fed with conjugated linoleic acid (CLA)
Liu, L., He, Y., Wang, K., Miao, J., & Zheng, Z. (2020) · Food & Function · doi:10.1039/d0fo02112a · Cited by 27
Characteristics of the vaginal microbiomes in prepubertal girls with and without vulvovaginitis
Wu, X., Liu, J., Yuchen, P., Liu, H., Zhang, M., & Jing, S. (2021) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-021-04152-2 · Cited by 29
Microbiota composition and intestinal integrity remain unaltered after the inclusion of hydrolysed Nannochloropsis gaditana in Sparus aurata diet
Cerezo, I. M., Zeo-Sánchez, D. E. D., García‐Márquez, J., Ruíz-Jarabo, I., Sáez-Casado, M. I., Balebona, M. C., Moríñigo, M. Á., & Tapia-Paniagua, S. T. (2021) · Scientific Reports · doi:10.1038/s41598-021-98087-5 · Cited by 27
The Possible Role of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 on Locomotor Activity and Oxidative Stress in a Rotenone‐Induced Zebrafish Model of Parkinson’s Disease
Ilie, O., Paduraru, E., Robea, M. A., Balmuș, I.-M., Jijie, R., Nicoară, M., Ciobica, A. S., Nita, I.-B., Dobrin, R., & Doroftei, B. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9629102 · Cited by 27
Gut microbiome and metabolome in a non-human primate model of chronic excessive alcohol drinking
Piacentino, D., Grant-Beurmann, S., Vizioli, C., Li, X., Moore, C. F., Ruiz‐Rodado, V., Lee, M. R., Joseph, P. V., Fraser, C. M., Weerts, E. M., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01728-6 · Cited by 29
Effects of Probiotic Supplementation on Exercise with Predominance of Aerobic Metabolism in Trained Population: A Systematic Review, Meta-Analysis and Meta-Regression
Santibañez-Gutierrez, A., Fernández-Landa, J., Calleja-González, J., Delextrat, A. A., & Mielgo‐Ayuso, J. (2022) · Nutrients · doi:10.3390/nu14030622 · Cited by 29
Heat Stress Affects Faecal Microbial and Metabolic Alterations of Rabbits
Bai, X., Shi, Y., Tang, L., Chen, L., Fan, H., Wang, H., Wang, J., Jia, X., Chen, S., & Lai, S. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.817615 · Cited by 27
The increasing importance of the gut microbiome in acne vulgaris
Siddiqui, R., Makhlouf, Z., & Khan, N. A. (2022) · Folia Microbiologica · doi:10.1007/s12223-022-00982-5 · Cited by 32
Understanding and harnessing triple-negative breast cancer-related microbiota in oncology
Devoy, C., Bueso, Y. F., & Tangney, M. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1020121 · Cited by 29
Evaluation of the gut microbiome alterations in healthy rats after dietary exposure to different synthetic ZnO nanoparticles
Zhu, X., Li, H., Zhou, L., Jiang, H., Ji, M., & Chen, J. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121250 · Cited by 27

Authors: Jandhyala, S. M.
Venue: World Journal of Gastroenterology
Publisher: Baishideng Publishing Group Inc.
Published: 2015
Volume: 21
Issue: 29
Pages: 8787
ISSN: 1007-9327 (ISSN-L)
DOI: 10.3748/wjg.v21.i29.8787
PMC: PMC4528021
OpenAlex: W1420654867
Cited by: 3,001
References: 163
Citations by year: 2026: 170 · 2025: 382 · 2024: 491 · 2023: 439 · 2022: 391 · 2021: 366 · 2020: 266 · 2019: 205 · 2018: 142 · 2017: 102 · 2016: 36 · 2015: 4
FWCI: 9.18
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: World Journal of Gastroenterology (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: gut microbiota, Bacteroidetes, Firmicutes, infant gut colonization, nutrient metabolism, gut mucosal barrier, immunomodulation, pathogen protection, mode of delivery, breast milk, infant formula, diet, antibiotic use, antibiotic resistance genes, horizontal gene transfer, multidrug resistance
MeSH terms: Bacillota, Gastrointestinal Microbiome, Age Factors, Anti-Bacterial Agents, Bacteriological Techniques, Diet, Health Status, Homeostasis, Humans, Intestines, Computational Biology, Probiotics, Bacteroidetes, Host-Pathogen Interactions, Prebiotics, Synbiotics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Role of the normal gut microbiota

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks