Systematic review with meta-analysis: non-invasive assessment of non-alcoholic fatty liver disease--the role of transient elastography and plasma cytokeratin-18 fragments
Open accessAbstract
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) affects 15-40% of the general population. Some patients have non-alcoholic steatohepatitis (NASH) and progressive fibrosis, and would be candidates for monitoring and treatment. AIM: To review current literature on the use of non-invasive tests to assess the severity of NAFLD. METHODS: Systematic literature searching identified studies evaluating non-invasive tests of NASH and fibrosis using liver biopsy as the reference standard. Meta-analysis was performed for areas with adequate number of publications. RESULTS: Serum tests and physical measurements like transient elastography (TE) have high negative predictive value (NPV) in excluding advanced fibrosis in NAFLD patients. The NAFLD fibrosis score comprises of six routine clinical parameters and has been endorsed by current American guidelines as a screening test to exclude low-risk individuals. The pooled sensitivities and specificities for TE to diagnose F ≥ 2, F ≥ 3 and F4 disease were 79% and 75%, 85% and 85%, and 92% and 92% respectively. Liver stiffness measurement often fails in obese patients, but the success rate can be improved with the use of the XL probe. A number of biomarkers have been developed for the diagnosis of NASH, but few were independently validated. Serum/plasma cytokeratin-18 fragments have been most extensively evaluated and have a pooled sensitivity of 66% and specificity of 82% in diagnosing NASH. CONCLUSIONS: Current non-invasive tests are accurate in excluding advanced fibrosis in NAFLD patients, and may be used for initial assessment. Further development and evaluation of NASH biomarkers are needed.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Adults with class 2 obesity cannot be reliably examined with many ultrasound techniques.
“Unfortunately, adults with class 2 obesity cannot be reliably examined with many of these ultrasound techniques.”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [156]
The Discussion on TE (page unavailable) says obesity is the main reason liver-stiffness measurements fail, supporting a reliability concern for one ultrasound-based technique. It does not single out adults with class 2 obesity or establish that many ultrasound techniques cannot examine them reliably; it also says an XL probe largely overcomes the measurement problem. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Design and validation of a histological scoring system for nonalcoholic fatty liver disease†
Kleiner, D. E., Brunt, E. M., Van Natta, M., Behling, C., Contos, M. J., Cummings, O. W., Ferrell, L. D., Liu, Y., Torbenson, M. S., Unalp‐Arida, A., et al. (2005) · Hepatology · doi:10.1002/hep.20701 · Cited by 10,791 · see citing works
Sterling, R. K., Lissen, E., Clumeck, N., Sola, R., Correa, M. C., Montaner, J., S. Sulkowski, M., Torriani, F. J., Dieterich, D. T., Thomas, D. L., et al. (2006) · Hepatology · doi:10.1002/hep.21178 · Cited by 5,021 · see citing works
Wai, C.-T., Greenson, J. K., Fontana, R. J., Kalbfleisch, J. D., Marrero, J. A., Conjeevaram, H. S., & Lok, A. S.-F. (2003) · Hepatology · doi:10.1053/jhep.2003.50346 · Cited by 4,406 · see citing works
Nonalcoholic Steatohepatitis: A Proposal for Grading and Staging The Histological Lesions
Brunt, E. M., Janney, C. G., Di Bisceglie, A. M., Neuschwander-Tetri, B. A., & Bacon, B. R. (1999) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01377.x · Cited by 3,907 · see citing works
Chalasani, N., Younossi, Z. M., Lavine, J. E., Diehl, A. M., Brunt, E. M., Cusi, K. J., Charlton, M., & Sanyal, A. J. (2012) · Hepatology · doi:10.1002/hep.25762 · Cited by 3,805 · see citing works
Whiting, P., Rutjes, A. W., Reitsma, J. B., Bossuyt, P. M., & Kleijnen, J. (2003) · BMC Medical Research Methodology · doi:10.1186/1471-2288-3-25 · Cited by 3,592 · see citing works
Reitsma, J. B., Glas, A. S., Rutjes, A. W. S., Scholten, R. J. P. M., Bossuyt, P. M., & Zwinderman, A. H. (2005) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2005.02.022 · Cited by 3,369 · cited 1× · see citing works
“Summary estimates of sensitivity and specificity, along with 95% CIs, were obtained by using the bivariate random-effects modelling approach (minimum four studies).(32) Besides accounting for study size and”
MethodAngulo, P., Hui, J. M., Marchesini, G., Bugianesi, E., George, J., Farrell, G. C., Enders, F., Saksena, S., Burt, A. D., Bida, J. P., et al. (2007) · Hepatology · doi:10.1002/hep.21496 · Cited by 3,198 · see citing works
Long-term follow-up of patients with NAFLD and elevated liver enzymes
Ekstedt, M., Franzén, L. E., Mathiesen, U. L., Thorelius, L., Holmqvist, M., Bodemar, G., & Kechagias, S. (2006) · Hepatology · doi:10.1002/hep.21327 · Cited by 2,302 · see citing works
Williams, C. D., Stengel, J. Z., Asike, M., Torres, D. M., Shaw, J. C., Contreras, M., Landt, C. L., & Harrison, S. A. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.09.038 · Cited by 2,146 · see citing works
The utility of radiological imaging in nonalcoholic fatty liver disease
Saadeh, S. N., Younossi, Z. M., Remer, E. M., Gramlich, T., Ong, J. P., Hurley, M. E., Mullen, K. D., Cooper, J. N., & Sheridan, M. J. (2002) · Gastroenterology · doi:10.1053/gast.2002.35354 · Cited by 2,112 · see citing works
Hernaez, R., Lazo, M., Bonekamp, S., Kamel, I., Brancati, F. L., Guallar, E., & Clark, J. M. (2011) · Hepatology · doi:10.1002/hep.24452 · Cited by 1,585 · see citing works
Comparison of Noninvasive Markers of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease
Shah, A. G., Lydecker, A. D., Murray, K. F., Tetri, B., Contos, M. J., & Sanyal, A. J. (2009) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2009.05.033 · Cited by 1,561 · see citing works
A hierarchical regression approach to meta‐analysis of diagnostic test accuracy evaluations
Rutter, C. M., & Gatsonis, C. (2001) · Statistics in Medicine · doi:10.1002/sim.942 · Cited by 1,510 · see citing works
Dixon, J. B., Bhathal, P. S., & O’Brien, P. E. (2001) · Gastroenterology · doi:10.1053/gast.2001.25540 · Cited by 1,365 · see citing works
Wong, V. W.-S., Vergniol, J., Wong, G. L.-H., Foucher, J., Chan, H. L.-Y., Le Bail, B., Choi, P. C.-L., Kowo, M., Chan, A. W.-H., Merrouche, W., et al. (2010) · Hepatology · doi:10.1002/hep.23312 · Cited by 1,322 · see citing works
Ascha, M. S., Hanouneh, I. A., Lopez, R., Tamimi, T. A.-R., Feldstein, A. F., & Zein, N. N. (2010) · Hepatology · doi:10.1002/hep.23527 · Cited by 1,296 · see citing works
Pitfalls of Liver Stiffness Measurement: A 5-Year Prospective Study of 13,369 Examinations
Castéra, L., Foucher, J., Bernard, P., Carvalho, F., Allaix, D., Merrouche, W., Couzigou, P., & de Lédinghen, V. (2009) · Hepatology · doi:10.1002/hep.23425 · Cited by 1,157 · see citing works
Chitturi, S., Abeygunasekera, S., Farrell, G. C., Holmes-Walker, J., Hui, J. M., Fung, C., Karim, R., Lin, R., Samarasinghe, D., Liddle, C., et al. (2002) · Hepatology · doi:10.1053/jhep.2002.30692 · Cited by 1,122 · see citing works
Assessment of Hepatic Fibrosis With Magnetic Resonance Elastography
Yin, M., Talwalkar, J. A., Glaser, K. J., Manduca, A., Grimm, R. C., Rossman, P. J., Fidler, J. L., & Ehman, R. L. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.06.012 · Cited by 951 · see citing works
McPherson, S., Stewart, S. F., Henderson, E., Burt, A. D., & Day, C. P. (2010) · Gut · doi:10.1136/gut.2010.216077 · Cited by 946 · see citing works
Harrison, S. A., Oliver, D., Arnold, H. L., Gogia, S., & Neuschwander‐Tetri, B. A. (2008) · Gut · doi:10.1136/gut.2007.146019 · Cited by 869 · see citing works
Wigg, A. J., Roberts-Thomson, I. C., Dymock, R. B., McCarthy, P. J., Grose, R. H., & Cummins, A. G. (2001) · Gut · doi:10.1136/gut.48.2.206 · Cited by 836 · see citing works
Kim, D., Kim, R. W., Kim, H. J., & Therneau, T. M. (2013) · Hepatology · doi:10.1002/hep.26156 · Cited by 772 · see citing works
Schwenzer, N. F., Springer, F., Schraml, C., Stefan, N., Machann, J., & Schick, F. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.05.023 · Cited by 751 · see citing works
Guha, I. N., Parkes, J., Roderick, P. J., Chattopadhyay, D., Cross, R., Harris, S., Kaye, P., Burt, A. D., Ryder, S. D., Aithal, G. P., et al. (2007) · Hepatology · doi:10.1002/hep.21984 · Cited by 744 · see citing works
Magnetic Resonance Elastography for the Noninvasive Staging of Liver Fibrosis
Huwart, L., Sempoux, C. L., Vicaut, É., Salameh, N., Annet, L., Danse, É., Peeters, F., ter Beek, L. C., Rahier, J., Sinkus, R., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.076 · Cited by 726 · see citing works
Cytokeratin-18 Fragment Levels as Noninvasive Biomarkers for Nonalcoholic Steatohepatitis
Feldstein, A. E., Wieckowska, A., López, R., Liu, Y., Zein, N. N., & McCullough, A. J. (2009) · Hepatology · doi:10.1002/hep.23050 · Cited by 711 · see citing works
Wieckowska, A., Zein, N. N., Yerian, L. M., López, R., McCullough, A. J., & Feldstein, A. E. (2006) · Hepatology · doi:10.1002/hep.21223 · Cited by 668 · see citing works
Wong, V. W.-S., Wong, G. L., Choi, P. C. L., Chan, A. W. H., Li, M. K.-P., Chan, H.-Y., Chim, A. M.-L., Yu, J. Q., Sung, J. J. �., & Chan, H. L. (2010) · Gut · doi:10.1136/gut.2009.205088 · Cited by 648 · see citing works
Younossi, Z. M., Stepanova, M., Rafiq, N., Makhlouf, H. R., Younoszai, Z., Agrawal, R., & Goodman, Z. D. (2011) · Hepatology · doi:10.1002/hep.24268 · Cited by 636 · see citing works
Haukeland, J. W., Damås, J. K., Konopski, Z., Løberg, E. M., Haaland, T., Goverud, I. L., Torjesen, P. A., Birkeland, K. I., Bjøro, K., & Aukrust, P. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.02.011 · Cited by 605 · see citing works
Increased Hepatic and Circulating Interleukin-6 Levels in Human Nonalcoholic Steatohepatitis
Wieckowska, A., Papouchado, B. G., Li, Z., Lopez, R., Zein, N. N., & Feldstein, A. E. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01774.x · Cited by 597 · see citing works
AST/ALT Ratio Predicts Cirrhosis in Patients With Chronic Hepatitis C Virus Infection
Sheth, S. G., Flamm, S. L., Gordon, F. D., & Chopra, S. (1998) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1998.044_c.x · Cited by 583 · see citing works
Paradis, V., Zalinski, S., Chelbi, E., Guedj, N., Degos, F., Vilgrain, V., Bédossa, P., & Belghiti, J. (2008) · Hepatology · doi:10.1002/hep.22734 · Cited by 567 · see citing works
Prevalence of obesity and diabetes in patients with cryptogenic cirrhosis: A case-control study
Poonawala, A., Nair, S. P., & Thuluvath, P. J. (2000) · Hepatology · doi:10.1053/jhep.2000.17894 · Cited by 566 · see citing works
Park, S. H., Kim, P. N., Kim, K. W., Lee, S., Yoon, S. E., Park, S. W., Ha, H. K., Lee, M.-G., Hwang, S. H., Lee, S., et al. (2006) · Radiology · doi:10.1148/radiol.2391050361 · Cited by 538 · see citing works
Pais, R., Charlotte, F., Fedchuk, L., Bédossa, P., Lebray, P., Poynard, T., & Ratziu, V. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.04.027 · Cited by 520 · see citing works
Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2
Miura, K., Yang, L., van Rooijen, N., Ohnishi, H., & Seki, E. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00365.2011 · Cited by 503 · see citing works
Angulo, P., Bugianesi, E., Bjornsson, E. S., Charatcharoenwitthaya, P., Mills, P. R., Barrera, F., Haflidadottir, S., Day, C. P., & George, J. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.06.057 · Cited by 502 · see citing works
Myers, R. P., Pomier–Layrargues, G., Kirsch, R., Pollett, A. F., Duarte‐Rojo, A., Wong, D., Beaton, M. D., Levstik, M. A., Crotty, P., & Elkashab, M. (2011) · Hepatology · doi:10.1002/hep.24624 · Cited by 502 · see citing works
Ratziu, V., Massard, J., Charlotte, F., Messous, D., Imbert‐Bismut, F., Bonyhay, L., Tahiri, M., Munteanu, M., Thabut, D., Cadranel, J. F. D., et al. (2006) · BMC Gastroenterology · doi:10.1186/1471-230x-6-6 · Cited by 491 · see citing works
Wong, V. W., Chu, C. W., Wong, G. L., Chan, R., Chim, A. M., Ong, A., Yeung, D. K., Yiu, K. K., Chu, S. H.-T., Woo, J., et al. (2011) · Gut · doi:10.1136/gutjnl-2011-300342 · Cited by 491 · see citing works
Friedrich-Rust, M., Nierhoff, J., Lupșor‐Platon, M., Sporea, I., Fierbinteanu-Braticevici, C. G., Strobel, D. D., Takahashi, K., Yoneda, M., Suda, T., Zeuzem, S., et al. (2011) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2011.01537.x · Cited by 476 · see citing works
Bhala, N. B., Angulo, P., van der Poorten, D., Lee, E., Hui, J. M., Saracco, G. M., Adams, L. A., Charatcharoenwitthaya, P., Topping, J. H., Bugianesi, E., et al. (2011) · Hepatology · doi:10.1002/hep.24491 · Cited by 450 · see citing works
Roskams, T., Yang, S. Q., Koteish, A., Durnez, A., DeVos, R., Huang, X., Achten, R., Verslype, C., & Diehl, A. M. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63489-x · Cited by 447 · see citing works
Chen, J., Talwalkar, J. A., Yin, M., Glaser, K. J., Sanderson, S. O., & Ehman, R. L. (2011) · Radiology · doi:10.1148/radiol.11101942 · Cited by 434 · see citing works
Adipokines and cytokines in non‐alcoholic fatty liver disease
Jarrar, M. H., Baranova, A. V., Collantes, R. S., Ranard, B. L., Stepanova, M., Bennett, C., Fang, Y. H., Elariny, H. A., Goodman, Z. D., Chandhoke, V., et al. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03586.x · Cited by 430 · see citing works
Yoneda, M., Yoneda, M., Mawatari, H., Fujita, K., Endo, H., Iida, H., Nozaki, Y., Yonemitsu, K., Higurashi, T., Takahashi, H., et al. (2007) · Digestive and Liver Disease · doi:10.1016/j.dld.2007.10.019 · Cited by 423 · see citing works
Characteristics of Patients With Nonalcoholic Steatohepatitis Who Develop Hepatocellular Carcinoma
Yasui, K., Hashimoto, E., Komorizono, Y., Koike, K., Arii, S., Imai, Y., Shima, T., Kanbara, Y., Saibara, T., Mori, T., et al. (2011) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.01.023 · Cited by 420 · see citing works
Non-invasive diagnosis of non-alcoholic fatty liver disease. A critical appraisal
Machado, M. V., & Cortez‐Pinto, H. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.11.021 · Cited by 411 · see citing works
Nonalcoholic Fatty Liver Disease: US-based Acoustic Radiation Force Impulse Elastography
Yoneda, M., Suzuki, K., Kato, S., Fujita, K., Nozaki, Y., Hosono, K., Saito, S., & Nakajima, A. (2010) · Radiology · doi:10.1148/radiol.10091662 · Cited by 347 · see citing works
Liver Stiffness Measurement Using XL Probe in Patients With Nonalcoholic Fatty Liver Disease
Wong, V. W.-S., Vergniol, J., Wong, G. L.-H., Foucher, J., Chan, A. W.-H., Chermak, F., Choi, P. C.-L., Merrouche, W., Chu, S. H.-T., Pesque, S., et al. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.331 · Cited by 345 · see citing works
Self-citationPalmeri, M. L., Wang, M. H., Rouze, N. C., Abdelmalek, M. F., Guy, C. D., Moser, B. K., Diehl, A. M., & Nightingale, K. R. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2010.12.019 · Cited by 343 · see citing works
the LIDO Study Group and the CYTOL study group, Poynard, T., Ratziu, V., Charlotte, F., Messous, D., Munteanu, M., Imbert‐Bismut, F., Massard, J., Bonyhay, L., Tahiri, M., et al. (2006) · BMC Gastroenterology · doi:10.1186/1471-230x-6-34 · Cited by 297 · see citing works
Feldstein, A. E., López, R., Tamimi, T., Yerian, L. M., Chung, Y.-M., Berk, M. P., Zhang, R., McIntyre, T. M., & Hazen, S. L. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m007096 · Cited by 296 · see citing works
Nonalcoholic steatohepatitis and cryptogenic cirrhosis within kindreds
Struben, V. M. D., Hespenheide, E. E., & Caldwell, S. H. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00315-0 · Cited by 295 · see citing works
Yoneda, M., Mawatari, H., Fujita, K., Iida, H., Yonemitsu, K., Kato, S., Takahashi, H., Kirikoshi, H., Inamori, M., Nozaki, Y., et al. (2007) · Journal of Gastroenterology · doi:10.1007/s00535-007-2060-x · Cited by 294 · see citing works
Increased Hepatic Myeloperoxidase Activity in Obese Subjects with Nonalcoholic Steatohepatitis
Rensen, S. S., Slaats, Y., Nijhuis, J., Jans, A., Bieghs, V., Driessen, A., Malle, E., Greve, J. W., & Buurman, W. A. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080999 · Cited by 290 · see citing works
Hepatic MRI for Fat Quantitation
Fishbein, M. H., Castro, F., Cheruku, S. M., Jain, S., Webb, B., Gleason, T., & Stevens, W. R. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200508000-00012 · Cited by 277 · see citing works
A Novel Diagnostic Biomarker Panel for Obesity-related Nonalcoholic Steatohepatitis (NASH)
Younossi, Z. M., Jarrar, M. H., Nugent, C., Randhawa, M., Afendy, M., Stepanova, M., Rafiq, N., Goodman, Z. D., Chandhoke, V., & Baranova, A. V. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9506-y · Cited by 275 · see citing works
Exceeding the limits of liver histology markers
Mehta, S. H., Lau, B. M., Afdhal, N. H., & Thomas, D. L. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.07.039 · Cited by 273 · see citing works
Gaia, S., Carenzi, S., Barilli, A. L., Bugianesi, E., Smedile, A., Brunello, F., Marzano, A., & Rizzetto, M. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.06.022 · Cited by 264 · see citing works
Comparison of blood tests for liver fibrosis specific or not to NAFLD
Calès, P., Lainé, F., Boursier, J., Deugnier, Y., Moal, V., Oberti, F., Hunault, G., Rousselet, M. C., Hubert, I., Laafi, J., et al. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.07.035 · Cited by 252 · see citing works
Geroldi, D., Falcone, C., & Emanuele, E. (2006) · Current Medicinal Chemistry · doi:10.2174/092986706777585013 · Cited by 249 · see citing works
Non-invasive diagnosis of non-alcoholic steatohepatitis by combined serum biomarkers
Shen, J., Chan, H. L., Wong, G. L., Choi, P. C., Chan, A. W. H., Chan, H., Chim, A. M., Yeung, D. K., Chan, F. K. L., Woo, J., et al. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.12.025 · Cited by 247 · see citing works
Serum cytokine and soluble cytokine receptor levels in patients with non‐alcoholic steatohepatitis
Abiru, S., Migita, K., Maeda, Y., Daikoku, M., Ito, M., Ohata, K., Nagaoka, S., Matsumoto, T., Takii, Y., Kusumoto, K., et al. (2005) · Liver International · doi:10.1111/j.1478-3231.2005.01191.x · Cited by 209 · see citing works
Basta, G., Sironi, A. M., Lazzerini, G., Turco, S. D., Buzzigoli, E., Casolaro, A., Natali, A., Ferrannini, E., & Gastaldelli, A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2559 · Cited by 204 · see citing works
Metabolic and Adipokine Profile of Chinese Patients With Nonalcoholic Fatty Liver Disease
Wong, V. W., Hui, A., Tsang, S. W., Chan, J. L.-Y., Tse, A. M. L., Chan, K., So, W., Cheng, A. Y., Ng, W.-F., Wong, G. L., et al. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.06.011 · Cited by 199 · see citing works
Ballestri, S., Lonardo, A., Romagnoli, D., Carulli, L., Losi, L., Day, C. P., & Loria, P. (2012) · Liver International · doi:10.1111/j.1478-3231.2012.02804.x · Cited by 191 · see citing works
Geroldi, D., Falcone, C., Emanuele, E., D’Angelo, A., Calcagnino, M. M., Buzzi, M. P., Scioli, G. A., & Fogari, R. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000177535.45785.64 · Cited by 190 · see citing works
Friedrich‐Rust, M., Romen, D., Vermehren, J., Kriener, S., Sadet, D., Herrmann, E. M., Zeuzem, S., & Bojunga, J. (2011) · European Journal of Radiology · doi:10.1016/j.ejrad.2011.10.029 · Cited by 187 · see citing works
Festi, D., Schiumerini, R., Marzi, L., Biase, A. R. D., Mandolesi, D., Montrone, L., Scaioli, E., Bonato, G., Marchesini, G., & Colecchia, A. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12186 · Cited by 184 · see citing works
An apoptosis panel for nonalcoholic steatohepatitis diagnosis
Tamimi, T., Elgouhari, H. M., Alkhouri, N., Yerian, L. M., Berk, M. P., López, R., Schauer, P. R., Zein, N. N., & Feldstein, A. E. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.08.023 · Cited by 183 · see citing works
Predictors of Nonalcoholic Steatohepatitis (NASH) in Obese Patients Undergoing Gastric Bypass
Boza, C., Riquelme, A. J., Ibáñez, L., Duarte, I., Norero, E., Paola Viviani, G., Soza, A., Fernandez, J. I., Raddatz, A., Guzmán, S., et al. (2005) · Obesity Surgery · doi:10.1381/0960892055002347 · Cited by 183 · see citing works
Joka, D., Wahl, K., Moeller, S., Schlué, J., Vaske, B., Bahr, M. J., Manns, M. P., Schulze‐Osthoff, K., & Bantel, H. (2011) · Hepatology · doi:10.1002/hep.24734 · Cited by 182 · see citing works
Osawa, H., & Mori, Y. (1996) · Journal of Clinical Ultrasound · doi:10.1002/(sici)1097-0096(199601)24:1 · Cited by 176 · see citing works
McPherson, S., Jonsson, J. R., Cowin, G., O'Rourke, P. K., Clouston, A. D., Volp, A., Horsfall, L. U., Jothimani, D. K., Fawcett, J., Galloway, G. J., et al. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.04.012 · Cited by 174 · see citing works
Yilmaz, Y. N. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i6.837 · Cited by 168 · see citing works
Diab, D. L., Yerian, L. M., Schauer, P. R., Kashyap, S. R., López, R., Hazen, S. L., & Feldstein, A. E. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.07.016 · Cited by 168 · see citing works
A Biomarker Panel for Non-alcoholic Steatohepatitis (NASH) and NASH-Related Fibrosis
Younossi, Z. M., Page, S., Rafiq, N., Birerdinc, A., Stepanova, M., Hossain, N., Afendy, A., Younoszai, Z., Goodman, Z. D., & Baranova, A. V. (2010) · Obesity Surgery · doi:10.1007/s11695-010-0204-1 · Cited by 161 · see citing works
Petta, S., Marco, V. D., Cammà, C., Butera, G., Cabibi, D., & Craxı̀, A. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04668.x · Cited by 157 · see citing works
Nonalcoholic Fatty Liver Disease: Current Issues and Novel Treatment Approaches
Lomonaco, R., Sunny, N. E., Bril, F., & Cusi, K. J. (2013) · Drugs · doi:10.1007/s40265-012-0004-0 · Cited by 157 · see citing works
Anty, R., Iannelli, A., Patouraux, S., Bonnafous, S., Lavallard, V., Buratti, M. S., Amor, I. B., Staccini-Myx, A., Saint‐Paul, M., Berthier, F., et al. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04480.x · Cited by 152 · see citing works
Wong, G. L., Wong, V. W., Chim, A. M.-L., Yiu, K. K. L., Chu, S. H.-T., Li, M. K., & Chan, H. L. (2010) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06510.x · Cited by 141 · see citing works
Clarke, M. J. (2006) · Wiley Encyclopedia of Clinical Trials · doi:10.1002/9780471462422.eoct063 · Cited by 129 · see citing works
Wong, V. W., Wong, G. L., Tsang, S. W., Hui, A., Chan, A. W. H., Choi, P. C., Chim, A. M.-L., CHU, S., Chan, F. K. L., Sung, J. J. �., et al. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03896.x · Cited by 125 · see citing works
Cheung, O., Kapoor, A., Puri, P., Sistrun, S. N., Luketic, V. A., Sargeant, C., Contos, M. J., Shiffman, M. L., Stravitz, R. T., Sterling, R. K., et al. (2007) · Hepatology · doi:10.1002/hep.21803 · Cited by 124 · see citing works
Wong, V. W., Wong, G. L., Chim, A. M., Tse, A. M. L., Tsang, S. W., Hui, A., Choi, P. C., Chan, A. W. H., So, W., Chan, F. K. L., et al. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.01933.x · Cited by 123 · see citing works
Performance of unidimensional transient elastography in staging non-alcoholic steatohepatitis.
Lupșor‐Platon, M., Badea, R., Ştefănescu, H., Grigorescu, M. D., Serban, A., Radu, C., Crișan, D., Sparchez, Z. A., Iancu, S., & Maniu, A. (2010) · PubMed · Cited by 120 · see citing works
Kumar, R. K., Rastogi, A., Sharma, M. K., Bhatia, V., Tyagi, P. K., Sharma, P., Garg, H., Kumar, K., Bihari, C., & Sarin, S. K. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2306-1 · Cited by 118 · see citing works
Friedrich‐Rust, M., Hadji-Hosseini, H., Kriener, S., Herrmann, E. M., Sircar, I., Kau, A., Zeuzem, S., & Bojunga, J. (2010) · European Radiology · doi:10.1007/s00330-010-1820-9 · Cited by 109 · see citing works
Lassailly, G., Caiazzo, R. J., Hollebecque, A., Buob, D., Leteurtre, E., Arnalsteen, L., Louvet, A., Pigeyre, M., Raverdy, V., Verkindt, H., et al. (2011) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e3283464111 · Cited by 103 · see citing works
CT and MRI of diffuse liver disease
Rofsky, N. M., & Fleishaker, H. (1995) · Seminars in Ultrasound CT and MRI · doi:10.1016/0887-2171(95)90012-8 · Cited by 94 · see citing works
Histological progression of non‐alcoholic fatty liver disease in Chinese patients
Hui, A., Wong, V. W., Chan, H. L., Liew, C. T., Chan, J. L.-Y., Chan, F. K. L., & Sung, J. J. �. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02334.x · Cited by 91 · see citing works
Plasma Pentraxin3 is a Novel Marker for Nonalcoholic Steatohepatitis (NASH)
Yoneda, M., Uchiyama, T., Kato, S., Endo, H., Fujita, K., Yoneda, K., Mawatari, H., Iida, H., Takahashi, H., Kirikoshi, H., et al. (2008) · BMC Gastroenterology · doi:10.1186/1471-230x-8-53 · Cited by 91 · see citing works
Detection of elevated caspase activation and early apoptosis in liver diseases
Bantel, H., Ruck, P., Gregor, M., & Schulze‐Osthoff, K. (2001) · European Journal of Cell Biology · doi:10.1078/0171-9335-00154 · Cited by 90 · see citing works
Myers, R. P., Elkashab, M., Ma, M. M., Crotty, P., & Pomier–Layrargues, G. (2010) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2010/153986 · Cited by 77 · see citing works
Shear wave velocity is a useful marker for managing nonalcoholic steatohepatitis
Osaki, A. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i23.2918 · Cited by 76 · see citing works
Blood oxidative stress markers are unreliable markers of hepatic steatosis
Bonnefont‐Rousselot, D., Ratziu, V., Giral, P., Charlotte, F., Beucler, I., Poynard, T., & FOR THE LIDO STUDY GROUP (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02719.x · Cited by 70 · see citing works
Yilmaz, Y. N., Ulukaya, E., Gül, Ö. Ö., Arabul, M., Gul, C. B., Atuğ, Ö., Oral, A. Y., Aker, S., & Dolar, E. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.02.003 · Cited by 65 · see citing works
Horoz, M., Bölükbaş, C., Bolukbas, F. F., Sabuncu, T., Aslan, M., Sarifakiogullari, S., Gunaydin, N., & Erel, Ö. (2005) · BMC Gastroenterology · doi:10.1186/1471-230x-5-35 · Cited by 62 · see citing works
Hui, J. M., Farrell, G. C., Kench, J. G., & George, J. (2004) · Hepatology · doi:10.1002/hep.20223 · Cited by 61 · see citing works
Uysal, S., Armutçu, F., Aydoğan, T., Akın, K., İkizek, M., & Yiǧitoǧlu, M. R. (2011) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2011.09.017 · Cited by 53 · see citing works
The role of cytokines in non-alcoholic steatohepatitis. A review.
Copaci, I., Micu, L., & Voiculescu, M. (2006) · PubMed · Cited by 53 · see citing works
Kayadibi, H., Gültepe, M., Yaşar, B., İnce, A. T., Özcan, Ö., İpçioğlu, O. M., Kurdaş, O. Ö., Bolat, B., Benek, Y. Z., Güveli, H., et al. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0535-0 · Cited by 52 · see citing works
Grigorescu, M., Crişan, D., Radu, C., Grigorescu, M., Sparchez, Z. A., & Serban, A. (2012) · PubMed · Cited by 48 · see citing works
Serum Apoptotic Caspase Activity in Chronic Hepatitis C and Nonalcoholic Fatty Liver Disease
Papatheodoridis, G., Hadziyannis, E. S., Tsochatzis, E. A., Georgiou, A. N., Kafiri, G., TINIAKOS, D. G., Margariti, K., Manolakopoulos, S., Manesis, E. K., & Archimandritis, A. J. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181c0945a · Cited by 43 · see citing works
Kirovski, G., Dorn, C., Huber, H., Moleda, L., Niessen, C., Wobser, H., Schacherer, D., Buechler, C., Wiest, R., & Hellerbrand, C. (2011) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2011.08.001 · Cited by 42 · see citing works
Nomura, K., Yano, E., Shinozaki, T., & Tagawa, K. (2004) · Journal of Occupational Health · doi:10.1539/joh.46.423 · Cited by 31 · see citing works
METANDI: Stata module to perform meta-analysis of diagnostic accuracy
Harbord, R. M. (2008) · RePEc: Research Papers in Economics · Cited by 30 · see citing works
Pîrvulescu, I., Gheorghe, L., Csiki, I. E., Becheanu, G., Dumbravă, M., Fica, S. V., Martin, S., Sarbu, A. E., Gheorghe, C., Diculescu, M. M., et al. (2012) · PubMed · Cited by 28 · see citing works
Musso, G., Cassader, M., Michieli, F. D., Saba, F., Bo, S., & Gambino, R. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.015610 · Cited by 24 · see citing works
Kikuchi, M., Tomita, K., Nakahara, T., Kitamura, N., Teratani, T., Irie, R., Yokoyama, H., Suzuki, T., Yokoyama, T., Taguchi, T., et al. (2008) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520802433249 · Cited by 20 · see citing works
Masuda, K., Ono, M., Fukumoto, M., Hirose, A., Munekage, K., Ochi, T., Okamoto, N., Akagi, N., Ogawa, Y., & Saibara, T. (2012) · Hepatology Research · doi:10.1111/j.1872-034x.2011.00923.x · Cited by 13 · see citing works
Tarçın, O., Gedik, N., Karakoyun, B., Tahan, V., Sood, G., Çelikel, Ç., & Tozun, N. A. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-0073-1 · Cited by 11 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Grigorescu M, Crisan D, Radu C, Grigorescu MD, Sparchez Z, Serban A. A novel pathophysiological-based panel of biomarkers for the diagnosis of nonalcoholic steatohepatitis. J Physiol Pharmacol 2012; 63: 347-53.
Cited by
Sorted by citations
EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease
(2016) · Journal of Hepatology · doi:10.1016/j.jhep.2015.11.004 · Cited by 4,836 · see citing works
Tacke, F., Horn, P., Wai-Sun Wong, V., Ratziu, V., Bugianesi, E., Francque, S., Zelber-Sagi, S., Valenti, L., Roden, M., Schick, F., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.04.031 · Cited by 2,210 · see citing works
Noninvasive assessment of liver disease in patients with nonalcoholic fatty liver disease
Castera, L., Friedrich-Rust, M., & Loomba, R. (2019) · Gastroenterology · doi:10.1053/j.gastro.2018.12.036 · Cited by 1,494 · see citing works
Dietrich, C., Bamber, J. C., Berzigotti, A., Bota, S. I., Cantisani, V., Castéra, L., Cosgrove, D. O., Ferraioli, G., Friedrich‐Rust, M., Gilja, O. H., et al. (2017) · Ultraschall in der Medizin - European Journal of Ultrasound · doi:10.1055/s-0043-103952 · Cited by 1,016 · see citing works
Cusi, K., Isaacs, S., Barb, D., Basu, R., Caprio, S., Garvey, W. T., Kashyap, S., Mechanick, J. I., Mouzaki, M., Nadolsky, K., et al. (2022) · Endocrine Practice · doi:10.1016/j.eprac.2022.03.010 · Cited by 1,021 · see citing works
WFUMB Guidelines and Recommendations for Clinical Use of Ultrasound Elastography: Part 3: Liver
Ferraioli, G., Fìlice, C., Castéra, L., Choi, B. I., Sporea, I., Wilson, S. R., Cosgrove, D. O., Dietrich, C. F., Amy, D., Bamber, J. C., et al. (2015) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2015.03.007 · Cited by 880 · see citing works
Nonalcoholic fatty liver disease
Brunt, E., Wong, V., Nobili, V., Day, C., Sookoian, S., Maher, J., Bugianesi, E., Sirlin, C., Neuschwander-Tetri, B., & Rinella, M. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.80 · Cited by 591 · see citing works
Eslam, M., Sarin, S. K., Wong, V. W., Fan, J.-G., Kawaguchi, T., Ahn, S. H., Zheng, M., Shiha, G. E.-S., Yilmaz, Y. N., Gani, R. A., et al. (2020) · Hepatology International · doi:10.1007/s12072-020-10094-2 · Cited by 837 · see citing works
Imajo, K., Kessoku, T., Honda, Y., Tomeno, W., Ogawa, Y., Mawatari, H., Fujita, K., Yoneda, M., Taguri, M., Hyogo, H., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.11.048 · Cited by 815 · see citing works
EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease
European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD), & European Association for the Study of Obesity (EASO) (2016) · Diabetologia · doi:10.1007/s00125-016-3902-y · Cited by 685 · see citing works
Noninvasive biomarkers in NAFLD and NASH — current progress and future promise
Wong, V. W., Adams, L. A., de Lédinghen, V., Wong, G. L., & Sookoian, S. C. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0014-9 · Cited by 617 · see citing works
Vilar‐Gómez, E., & Chalasani, N. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.11.013 · Cited by 608 · see citing works
Noureddin, M., Vipani, A., Bresee, C. J., Todo, T., Kim, I. K., Alkhouri, N., Setiawan, V. W., Tran, T. T., Ayoub, W. S., Lu, S. C.-L., et al. (2018) · The American Journal of Gastroenterology · doi:10.1038/s41395-018-0088-6 · Cited by 578 · see citing works
EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease
European Association for the Study of the Liver (EASL), E. A. F. T. S. O. D. (. (2016) · Obesity Facts · doi:10.1159/000443344 · Cited by 522 · see citing works
Wong, V. W., Chan, W., Chitturi, S., Chawla, Y. K., Dan, Y. Y., Duseja, A. K., Fan, J., Goh, K., Hamaguchi, M., Hashimoto, E., et al. (2017) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13857 · Cited by 506 · see citing works
(2024) · Obesity Facts · doi:10.1159/000539371 · Cited by 510 · see citing works
Non-alcoholic fatty liver disease, obesity and the metabolic syndrome
Dietrich, P., & Hellerbrand, C. (2014) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2014.07.008 · Cited by 458 · see citing works
Sarcopenia is an independent risk factor for non-alcoholic steatohepatitis and significant fibrosis
Koo, B. K., Kim, D., Joo, S. K., Kim, J. H., Chang, M. S., Kim, B. G., Lee, K. L., & Kim, W. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2016.08.019 · Cited by 440 · see citing works
NAFLD: Mechanisms, Treatments, and Biomarkers
Nassir, F. (2022) · Biomolecules · doi:10.3390/biom12060824 · Cited by 422 · see citing works
Non-alcoholic fatty liver disease
Maurice, J. B., & Manousou, P. (2018) · Clinical Medicine · doi:10.7861/clinmedicine.18-3-245 · Cited by 367 · see citing works
Mikolasevic, I., Orlic, L., Franjic, N., Hauser, G., Stimac, D., & Milic, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i32.7236 · Cited by 273 · see citing works
Quantitative Elastography Methods in Liver Disease: Current Evidence and Future Directions
Kennedy, P., Wagner, M., Castéra, L., Hong, C. W., Johnson, C. L., Sirlin, C. B., & Taouli, B. A. (2018) · Radiology · doi:10.1148/radiol.2018170601 · Cited by 271 · see citing works
KASL clinical practice guidelines: Management of nonalcoholic fatty liver disease
Kang, S. H., Lee, H. W., Yoo, J., Cho, Y., Kim, S. U., Lee, T. H., Jang, B. K., Ahn, S. B., Ahn, S. B., Kim, H., et al. (2021) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2021.0178 · Cited by 269 · see citing works
Singh, S., Venkatesh, S. K., Loomba, R. S., Wang, Z., Sirlin, C. B., Chen, J., Yin, M., Miller, F. H., Low, R. N., Hassanein, T., et al. (2015) · European Radiology · doi:10.1007/s00330-015-3949-z · Cited by 252 · see citing works
Non‐invasive screening of diabetics in primary care for NAFLD and advanced fibrosis by MRI and MRE
Doycheva, I., Cui, J. Y., Nguyen, P., Costa, E. A., Hooker, J. C., Hofflich, H., Bettencourt, R., Brouha, S. S., Sirlin, C. B., & Loomba, R. S. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13405 · Cited by 209 · see citing works
Non-alcoholic fatty liver disease: What the clinician needs to know
Machado, M. V. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i36.12956 · Cited by 209 · see citing works
Pavlides, M., Banerjee, R., Tunnicliffe, E. M., Kelly, M., Collier, J. D., Wang, L. M., Fleming, K. A., Cobbold, J., Robson, M. D., Neubauer, S., et al. (2016) · Liver International · doi:10.1111/liv.13284 · Cited by 197 · see citing works
Abdelhameed, F., Kite, C., Lagojda, L., Dallaway, A., Chatha, K. K., Chaggar, S. S., Dalamaga, Μ., Kassi, E. N., Kyrou, I., & Randeva, H. S. (2024) · Current Obesity Reports · doi:10.1007/s13679-024-00574-z · Cited by 193 · see citing works
Nonalcoholic fatty liver disease: A comprehensive review of a growing epidemic
Hassan, K. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i34.12082 · Cited by 186 · see citing works
Yip, T. C., Ma, A. J., Wong, V. W., Tse, Y. K., Chan, H. L., Yuen, P. C., & Wong, G. L. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14172 · Cited by 189 · see citing works
Biomarkers of Hepatic Toxicity: An Overview
Thakur, S., Kumar, V., Das, R., Sharma, V., & Mehta, D. K. (2024) · Current Therapeutic Research · doi:10.1016/j.curtheres.2024.100737 · Cited by 184 · see citing works
Wong, V. W., Irlès, M., Wong, G. L., Shili, S., Chan, A. W. H., Merrouche, W., Shu, S. S., Foucher, J., Bail, B. L., Chan, W., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-317334 · Cited by 174 · see citing works
Wong, V. W., Wong, G. L., Yeung, D. K., Lau, T. K., Chan, C. K.-M., Chim, A. M., Abrigo, J., Chan, R., Woo, J., Tse, Y., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.08.041 · Cited by 173 · see citing works
Biomarkers in Nonalcoholic Fatty Liver Disease
Neuman, M. G., Cohen, L. B., & Nanau, R. M. (2014) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2014/757929 · Cited by 172 · see citing works
Siddiqui, M. S., Harrison, S. A., Abdelmalek, M. F., Anstee, Q. M., Bédossa, P., Castéra, L., Dimick‐Santos, L., Friedman, S. L., Greene, K., Kleiner, D. E., et al. (2017) · Hepatology · doi:10.1002/hep.29607 · Cited by 167 · see citing works
Tapper, E. B., Challies, T. L., Nasser, I. A., Afdhal, N. H., & Lai, M. (2016) · The American Journal of Gastroenterology · doi:10.1038/ajg.2016.49 · Cited by 163 · see citing works
Petta, S., Wong, V. W., Cammà, C., Hiriart, J., Wong, G. L., Vergniol, J., Chan, A. W. H., Marco, V. D., Merrouche, W., Chan, H. L., et al. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14219 · Cited by 159 · see citing works
Cao, Y.-T., Xiang, L.-L., Qi, F., Zhang, Y., Chen, Y., & Zhou, X. (2022) · EClinicalMedicine · doi:10.1016/j.eclinm.2022.101547 · Cited by 159 · see citing works
Distinctive features of hepatocellular carcinoma in non-alcoholic fatty liver disease
Degasperi, E., & Colombo, M. (2016) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(16)30018-8 · Cited by 155 · see citing works
Distinguishing between Hepatic Inflammation and Fibrosis with MR Elastography
Yin, M., Glaser, K. J., Manduca, A., Mounajjed, T., Malhi, H., Simonetto, D. A., Wang, R., Yang, L., Mao, S. A., Glorioso, J. M., et al. (2017) · Radiology · doi:10.1148/radiol.2017160622 · Cited by 155 · see citing works
Non-alcoholic Fatty Liver Disease: A Clinical Update
Pappachan, J. M., Babu, S. V., Krishnan, B., & Ravindran, N. (2017) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2017.00013 · Cited by 157 · see citing works
Diagnosis and Assessment of NAFLD: Definitions and Histopathological Classification
Lackner, C., TINIAKOS, D. G., & Burt, A. D. (2015) · Seminars in Liver Disease · doi:10.1055/s-0035-1562942 · Cited by 145 · see citing works
Bhati, C. S., Idowu, M. O., Sanyal, A. J., Rivera, M., Driscoll, C. J., Stravitz, R. T., Kohli, D. R., Matherly, S. C., Puri, P., Gilles, H., et al. (2017) · Transplantation · doi:10.1097/tp.0000000000001709 · Cited by 139 · see citing works
Nonalcoholic Fatty Liver Disease and Type 2 Diabetes: Common Pathophysiologic Mechanisms
Saponaro, C., Gaggini, M., & Gastaldelli, A. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0607-4 · Cited by 137 · see citing works
Application of transient elastography in nonalcoholic fatty liver disease
Zhang, X., Wong, G. L., & Wong, V. W. (2019) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2019.0001n · Cited by 138 · see citing works
Furlan, A., TUBLIN, M. E., Yu, L., Chopra, K. B., Lippello, A., & Behari, J. (2019) · American Journal of Roentgenology · doi:10.2214/ajr.19.21267 · Cited by 138 · see citing works
Perakakis, N., Polyzos, S. A., Yazdani, A., Sala-Vila, A., Kountouras, J., Anastasilakis, A. D., & Mantzoros, C. S. (2019) · Metabolism · doi:10.1016/j.metabol.2019.154005 · Cited by 137 · see citing works
Khoo, J., Hsiang, J. C., Taneja, R., Koo, S., Soon, G., Kam, C. J., Law, N., & Ang, T. (2019) · Liver International · doi:10.1111/liv.14065 · Cited by 136 · see citing works
Jiang, W., Huang, S., Teng, H., Wang, P., Wu, M., Zhou, X., & Ran, H. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-021787 · Cited by 135 · see citing works
Dietrich, C. F., Bamber, J. C., Berzigotti, A., Bota, S. I., Cantisani, V., Castéra, L., Cosgrove, D. O., Ferraioli, G., Friedrich‐Rust, M., Gilja, O. H., et al. (2017) · Ultraschall in der Medizin - European Journal of Ultrasound · doi:10.1055/s-0043-103955 · Cited by 135 · see citing works
Drescher, H. K., Weiskirchen, S., & Weiskirchen, R. (2019) · Cells · doi:10.3390/cells8080845 · Cited by 134 · see citing works
Koo, B. K., Um, S. H., Seo, D. S., Joo, S. K., Bae, J. M., Park, J. H., Chang, M. S., Kim, J. H., Lee, J., Jeong, W., et al. (2017) · Liver International · doi:10.1111/liv.13587 · Cited by 129 · see citing works
He, L., Deng, L.-F., Zhang, Q., Guo, J., Zhou, J., Wen-jian, S., & Yuan, F. (2017) · BioMed Research International · doi:10.1155/2017/9729107 · Cited by 126 · see citing works
Biopsy and Noninvasive Methods to Assess Progression of Nonalcoholic Fatty Liver Disease
Bédossa, P., & Patel, K. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.03.008 · Cited by 122 · see citing works
Vuppalanchi, R., Jain, A. K., Deppe, R., Yates, K., Comerford, M., Masuoka, H. C., Neuschwander-Tetri, B. A., Loomba, R., Brunt, E. M., Kleiner, D. E., et al. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.05.010 · Cited by 116 · see citing works
Zhang, P.-W., Chen, F.-X., Li, D., Ling, W.-H., & Guo, H.-H. (2015) · Medicine · doi:10.1097/md.0000000000000758 · Cited by 116 · see citing works
Kazankov, K., Francisco Barrera, M., Møller, H. J., Rosso, C., Bugianesi, E., David, E., Jouness, R. I. K., Esmaili, S., Eslam, M., McLeod, D. J., et al. (2016) · Liver International · doi:10.1111/liv.13150 · Cited by 113 · see citing works
Non-invasive testing and risk-stratification in patients with MASLD
Zoncapè, M., Liguori, A., & Tsochatzis, E. A. (2024) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2024.01.013 · Cited by 112 · see citing works
Nonalcoholic fatty liver disease – current status and future directions
Demir, M., Lang, S., & Steffen, H. (2015) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12291 · Cited by 105 · see citing works
Predictors of advanced fibrosis in non‐cirrhotic non‐alcoholic fatty liver disease in Germany
Labenz, C., Huber, Y., Kalliga, E., Nagel, M., Ruckes, C., Straub, B. K., Galle, P. R., Wörns, M., Anstee, Q. M., Schuppan, D., et al. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14976 · Cited by 106 · see citing works
Clinical and Molecular Biomarkers for Diagnosis and Staging of NAFLD
Mauro, S. D., Scamporrino, A., Filippello, A., Pino, A. D., Scicali, R., Malaguarnera, R., Purrello, F., & Piro, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111905 · Cited by 104 · see citing works
Roeb, E., Canbay, A. E., Tacke, F., Bantel, H., Bojunga, J., de Laffolie, J., Demir, M., Denzer, U. W., Geier, A., Hofmann, W. P., et al. (2022) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1880-2283 · Cited by 102 · see citing works
Sebastiani, G., Alshaalan, R., Wong, P. Y. N., Rubino, M., Salman, A., Metrakos, P. P., Deschênes, M., & Ghali, P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128774 · Cited by 99 · see citing works
Similarities and differences between pediatric and adult nonalcoholic fatty liver disease
Crespo, M., Lappe, S. C., Feldstein, A. E., & Alkhouri, N. (2016) · Metabolism · doi:10.1016/j.metabol.2016.01.008 · Cited by 96 · see citing works
Tapper, E. B., Sengupta, N., Hunink, M. G. M., Afdhal, N. H., & Lai, M. (2015) · The American Journal of Gastroenterology · doi:10.1038/ajg.2015.241 · Cited by 90 · see citing works
Staufer, K., Halilbasic, E., Spindelboeck, W., Eilenberg, M., Prager, G., Stadlbauer, V., Posch, A., Munda, P., Marculescu, R., Obermayer-Pietsch, B. M., et al. (2019) · United European Gastroenterology Journal · doi:10.1177/2050640619865133 · Cited by 89 · see citing works
Chang, P. E. (2016) · World Journal of Gastrointestinal Pharmacology and Therapeutics · doi:10.4292/wjgpt.v7.i1.91 · Cited by 88 · see citing works
Pang, J., Xu, W., Zhang, X., Wong, G. L., Chan, A. W. H., Chan, H., Tse, C., Shu, S. S., Choi, P. C., Chan, H. L., et al. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14119 · Cited by 88 · see citing works
Boursier, J., Anty, R., Vonghia, L., Moal, V., Vanwolleghem, T., Canivet, C. M., Michalak, S., Bonnafous, S., Michielsen, P. P., Oberti, F., et al. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14621 · Cited by 81 · see citing works
Current Modalities of Fibrosis Assessment in Non-alcoholic Fatty Liver Disease
Cheah, M. C. C., McCullough, A. J., & Goh, G. B. (2017) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2017.00009 · Cited by 81 · see citing works
Long, M. T., Gandhi, S., & Loomba, R. S. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154259 · Cited by 79 · see citing works
Lee, J., Vali, Y., Boursier, J., Duffin, K., Verheij, J., Brosnan, M. J., Zwinderman, K., Anstee, Q. M., Bossuyt, P. M., & Zafarmand, M. H. (2020) · PLOS ONE · doi:10.1371/journal.pone.0238717 · Cited by 74 · see citing works
FILOZOF, C. M., Goldstein, B. J., Williams, R. N., & Sanyal, A. J. (2015) · Drugs · doi:10.1007/s40265-015-0437-3 · Cited by 76 · see citing works
Martinou, E., Pericleous, M., Stefanova, I., Kaur, V., & Angelidi, A. M. (2022) · Diagnostics · doi:10.3390/diagnostics12020407 · Cited by 76 · see citing works
Fibrosis in Chronic Liver Disease: An Update on Diagnostic and Treatment Modalities
Manka, P. P., Zeller, A. C., & Syn, W. (2019) · Drugs · doi:10.1007/s40265-019-01126-9 · Cited by 77 · see citing works
Quantification of liver function using gadoxetic acid-enhanced MRI
Poetter‐Lang, S., Bastati, N., Messner, A., Kristic, A., Herold, A., Hodge, J. C., & Ba‐Ssalamah, A. (2020) · Abdominal Radiology · doi:10.1007/s00261-020-02779-x · Cited by 75 · see citing works
The intersection of nonalcoholic fatty liver disease and obesity
Baidal, J. W., & Lavine, J. E. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad8390 · Cited by 75 · see citing works
Cost-utility analysis of nonalcoholic steatohepatitis screening
Zhang, E. W., Wartelle‐Bladou, C., Lepanto, L., Lachaîne, J., Cloutier, G., & Tang, A. (2015) · European Radiology · doi:10.1007/s00330-015-3731-2 · Cited by 74 · see citing works
Wong, V. W., Wong, G. L., Chan, H., Yeung, D. K. ‐., Chan, R. S. ‐., Chim, A. M. ‐., Chan, C. K. ‐., Tse, Y. ‐., Woo, J., Chu, W. C. ‐., et al. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13327 · Cited by 73 · see citing works
Non-alcoholic fatty liver diseases: update on the challenge of diagnosis and treatment
Oh, H., Jun, D. W., Saeed, W. K., & Nguyen, M. H. (2016) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2016.0049 · Cited by 72 · see citing works
Hashemi, S.-A., Alavian, S. M., & Fesharaki, M. G. (2016) · PubMed Central · Cited by 72 · see citing works
Kumari, A., Pathak, D. P., & Asthana, S. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.44774 · Cited by 71 · see citing works
Hannah, W. N., & Harrison, S. A. (2016) · Hepatology · doi:10.1002/hep.28699 · Cited by 71 · see citing works
Noureddin, M., Wong, M. M., Todo, T., Lu, S. C.-L., Sanyal, A. J., & Mena, E. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i11.1269 · Cited by 71 · see citing works
Sumida, Y., Yoneda, M., Tokushige, K., Kawanaka, M., Fujii, H., Yoneda, M., Imajo, K., Takahashi, H., Eguchi, Y., Ono, M., et al. (2021) · Life · doi:10.3390/life11020143 · Cited by 70 · see citing works
Atkinson, S. R., Grove, J. I., Liebig, S., Astbury, S., Vergis, N., Goldin, R. D., Quaglia, A., Bantel, H., Guha, I. N., Thursz, M. R., et al. (2020) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000912 · Cited by 70 · see citing works
Yoneda, M., Imajo, K., Takahashi, H., Ogawa, Y., Eguchi, Y., Sumida, Y., Yoneda, M., Kawanaka, M., Saito, S., Tokushige, K., et al. (2017) · Journal of Gastroenterology · doi:10.1007/s00535-017-1414-2 · Cited by 69 · see citing works
Clinical assessment and management of liver fibrosis in non-alcoholic fatty liver disease
Campos-Murguía, A., Ruiz‐Margáin, A., González-Regueiro, J. A., & Macías‐Rodríguez, R. U. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i39.5919 · Cited by 69 · see citing works
Kim, T. H., Lee, Y., Lee, Y.-S., Yim, S. Y., Ko, E., Yim, S. Y., Jung, Y. K., Kang, S., Kim, B., Kim, J. H., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-94115-6 · Cited by 69 · see citing works
Chan, W., Treeprasertsuk, S., Imajo, K., Nakajima, A., Seki, Y., Kasama, K., Kakizaki, S., Fan, J., Song, M. J., Yoon, S. K., et al. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14506 · Cited by 69 · see citing works
Natural History of Simple Steatosis or Nonalcoholic Fatty Liver
De, A., & Duseja, A. K. (2019) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2019.09.005 · Cited by 69 · see citing works
Non‐alcoholic fatty liver diseases and risk of colorectal neoplasia
Ahn, J., Sinn, D. H., Min, Y. W., Hong, S. N., Kim, H. S., Jung, S., Gu, S., Rhee, P., Paik, S. W., Son, H. J., et al. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13866 · Cited by 68 · see citing works
Nonalcoholic steatohepatitis is associated with a state of betaine‐insufficiency
Sookoian, S., Puri, P., Castaño, G. O., Scian, R., Mirshahi, F., Sanyal, A. J., & Pirola, C. J. (2016) · Liver International · doi:10.1111/liv.13249 · Cited by 68 · see citing works
Tapper, E. B., Hunink, M. G. M., Afdhal, N. H., Lai, M., & Sengupta, N. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147237 · Cited by 68 · see citing works
Zhang, X., Zheng, M., Liu, D., Lin, Y., Song, S. J., Chu, E. S., Liu, D., Singh, S., Berman, M., Lau, H. C.-H., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.10.008 · Cited by 67 · see citing works
Elastography Techniques for the Assessment of Liver Fibrosis in Non-Alcoholic Fatty Liver Disease
Honda, Y., Yoneda, M., Imajo, K., & Nakajima, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114039 · Cited by 67 · see citing works
Burden of Disease due to Nonalcoholic Fatty Liver Disease
Muthiah, M. D., & Sanyal, A. J. (2020) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2019.09.007 · Cited by 65 · see citing works
Eren, F., Kaya, E., & Yilmaz, Y. (2020) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000001946 · Cited by 66 · see citing works
Controlled Attenuation Parameter for Quantification of Steatosis: Which Cut‐Offs to Use?
Șirli, R., & Sporea, I. (2021) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2021/6662760 · Cited by 65 · see citing works
Lee, M. S., Bae, J. M., Joo, S. K., Woo, H., Lee, D. H., Jung, Y. J., Kim, B. G., Lee, K. L., & Kim, W. K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188321 · Cited by 64 · see citing works
- Authors
- Kwok, R., Tse, Y. ‐., Wong, G. L. ‐., Ha, Y., Lee, A. U., Ngu, M. C., Chan, H. L. ‐., & Wong, V. W. ‐.
- Affiliations
- Chinese University of Hong Kong (HK)
- Asan Medical Center (KR)
- Concord Repatriation General Hospital (AU)
- Corresponding author
- Wong, G. L.‐H.
- Wong, V. W.‐S.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2013-12-05
- Volume
- 39
- Issue
- 3
- Pages
- 254-269
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2073137449
- Cited by
- 405
- References
- 116
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 33 · 2023: 20 · 2022: 40 · 2021: 33 · 2020: 52 · 2019: 40 · 2018: 31 · 2017: 42 · 2016: 38 · 2015: 34 · 2014: 17
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hong Kong Government
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Keywords
- non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, liver fibrosis, transient elastography, liver stiffness measurement, cytokeratin-18 fragments, NAFLD fibrosis score, non-invasive diagnosis, serum biomarkers, liver biopsy
- MeSH terms
- Biopsy, Fatty Liver, Humans, Liver Cirrhosis, Obesity, Sensitivity and Specificity, Biomarkers, Keratin-18, Elasticity Imaging Techniques, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
