Perfluorooctane Sulfonate Influences Feeding Behavior and Gut Motility via the Hypothalamus
Open accessAbstract
Perfluorinated compounds (PFCs) have been employed as surface treatment agents in a variety of products. Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are the two most commonly found PFCs in the environment and human blood. We investigated the effects of PFOS and PFOA on feeding behavior. PFOS or PFOA was administered intracerebroventricularly in mice or rats. Following administration, food intake, gastroduodenal motility, gastric emptying, gene expression of hypothalamic neuropeptides, and c-Fos expression along with immunoreaction for urocortin 2 in the paraventricular nucleus (PVN) were determined. Centrally administered PFOS and PFOA decreased food intake. Administration of PFOS decreased gastric emptying and disrupted the fasted motor activity in the antrum and duodenum. The gene expression of urocortin 2 in the hypothalamus and c-Fos expression and immunoreaction for urocortin 2 in the PVN were increased by the action of PFOS. A centrally administered corticotropin-releasing factor type 2 receptor (CRFR2) antagonist blocked PFOS-induced anorexia. These findings indicate that PFOS and PFOA influence feeding behavior. This effect is mediated via the activation of hypothalamic urocortin 2 and CRFR2, and the suppression of gastroduodenal motor activity. These observations indicate that PFCs may act centrally to influence behavior and physiological functions in humans.
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When administered through intracerebroventricular injection in mice, PFOS and PFOA caused a dose-dependent decrease in food intake, with effects lasting 24 h.
“when administered through intracerebroventricular (ICV) injection in mice, PFOS and PFOA caused a dose-dependent decrease (Asakawa et al., 2007; Camilleri, 2015) in food intake, with effects lasting 24 h.”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Asakawa et al., 2007
The Results report that ICV-administered PFOS reduced food intake in food-deprived mice in a dose-related manner, with the reduction remaining significant for 24 hours. They report an equally anorexic effect for PFOA at one dose (300 μg/kg), but do not establish a dose-dependent effect or a 24-hour duration for PFOA. (LLM, conf=0.90)
Experimental — accuracy not yet measuredPFOS decreased gastric emptying in mice and influenced gastroduodenal motility in rats.
“PFOS decreased gastric emptying in mice and influenced gastroduodenal motility in rats”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Asakawa et al., 2007
Feeding behavior was rescued through administration of a CRFR2 antagonist, validating the role of CRFR2 activity in the impaired behavior.
“Feeding behavior was rescued through administration of a CRFR2 antagonist, thus validating the role of CRFR2 activity in the impaired behavior (Asakawa et al., 2007).”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Asakawa et al., 2007
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- Authors
- Asakawa, A., Toyoshima, M., Fujimiya, M., Harada, K., Ataka, K., Inoue, K., & Koizumi, A.
- Affiliations
- Kyoto University (JP)
- Shiga University of Medical Science (JP)
- Corresponding author
- Koizumi, Akio
- Venue
- International Journal of Molecular Medicine
- Publisher
- Spandidos Publications
- Published
- 2007-05-01
- Volume
- 19
- Issue
- 5
- Pages
- 733-9
- ISSN
- 1107-3756 (ISSN-L)
- 1791-244X
- OpenAlex
- W2027642054
- Cited by
- 33
- References
- 31
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 4 · 2022: 3 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 4 · 2015: 1 · 2012: 2
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- PFOS, perfluorooctanoic acid, perfluorinated compounds, feeding behavior, anorexia, hypothalamus, urocortin 2, paraventricular nucleus, c-fos, gastric emptying, gastroduodenal motility, dietary intake
- MeSH terms
- Animals, Duodenum, Feeding Behavior, Fluorocarbons, Food Deprivation, Gastrointestinal Motility, Gene Expression Regulation, Hypothalamus, Male, Movement, Paraventricular Hypothalamic Nucleus, Peptide Fragments, Peptides, Proto-Oncogene Proteins c-fos, Rats, Wistar, Alkanesulfonic Acids, Mice, Rats
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