CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691 · see citing works

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

Szklarczyk, D., Gable, A. L., Lyon, D., Junge, A., Wyder, S., Huerta-Cepas, J., Simonovic, M., Doncheva, N. T., Morris, J. H., Bork, P., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gky1131 · Cited by 17,749 · see citing works

Regulation of Ferroptotic Cancer Cell Death by GPX4

Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713 · see citing works

UniProt: a worldwide hub of protein knowledge

The UniProt Consortium (2019) · Nucleic Acids Research · doi:10.1093/nar/gky1049 · Cited by 7,698 · see citing works

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.021 · Cited by 7,695 · see citing works

UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses

Chandrashekar, D. S., Bashel, B., Balasubramanya, S. A. H., Creighton, C. J., Ponce-Rodriguez, I., Chakravarthi, B. V. S. K., & Varambally, S. (2017) · Neoplasia · doi:10.1016/j.neo.2017.05.002 · Cited by 6,086 · see citing works

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2239 · Cited by 4,293 · see citing works

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732 · see citing works

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Bersuker, K., Hendricks, J. M., Li, Z., Magtanong, L., Ford, B., Tang, P. H., Roberts, M. A., Tong, B., Maimone, T. J., Zoncu, R., et al. (2019) · Nature · doi:10.1038/s41586-019-1705-2 · Cited by 3,703 · see citing works

Ferroptosis as a p53-mediated activity during tumour suppression

Jiang, L., Kon, N., Li, T., Wang, S.-J., Su, T., Hibshoosh, H., Baer, R., & Gu, W. (2015) · Nature · doi:10.1038/nature14344 · Cited by 3,398 · see citing works

Targeting Ferroptosis to Iron Out Cancer

Hassannia, B., Vandenabeele, P., & Berghe, T. V. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.04.002 · Cited by 2,483 · see citing works

Glutaminolysis and transferrin regulate ferroptosis

Gao, M., Monian, P., Quadri, N., Ramasamy, R., & Jiang, X. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.011 · Cited by 2,069 · see citing works

Activation of the p62–Keap1–NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

Sun, X., Ou, Z., Chen, R., Niu, X., Chen, D., Kang, R., & Tang, D. (2016) · Hepatology · doi:10.1002/hep.28251 · Cited by 2,012 · see citing works

JASPAR 2020: update of the open-access database of transcription factor binding profiles

Fornes, O., Castro-Mondragon, J. A., Khan, A., van der Lee, R., Zhang, X., Richmond, P. A., Modi, B. P., Correard, S., Gheorghe, M., Baranašić, D., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1001 · Cited by 1,763 · see citing works

Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion

Angeli, J. P. F., Krysko, D. V., & Conrad, M. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0149-1 · Cited by 1,262 · see citing works

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

Wu, J., Minikes, A. M., Gao, M., Bian, H., Li, Y., Stockwell, B. R., Chen, Z.-N., & Jiang, X. (2019) · Nature · doi:10.1038/s41586-019-1426-6 · Cited by 1,110 · see citing works

Histone core modifications regulating nucleosome structure and dynamics

Tessarz, P., & Kouzarides, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3890 · Cited by 1,018 · see citing works

Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses

Ou, Y., Wang, S.-J., Li, D., Chu, B., & Gu, W. J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607152113 · Cited by 775 · see citing works

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

Song, X., Zhu, S., Chen, P., Hou, W., Wen, Q., Liu, J., Xie, Y., Liu, J., Klionsky, D. J., Kroemer, G., et al. (2018) · Current Biology · doi:10.1016/j.cub.2018.05.094 · Cited by 753 · see citing works

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

Gaschler, M. M., Andia, A. A., Liu, H., Csuka, J. M., Hurlocker, B., Vaiana, C. A., Heindel, D. W., Zuckerman, D. S., Bos, P. H., Reznik, E., et al. (2018) · Nature Chemical Biology · doi:10.1038/s41589-018-0031-6 · Cited by 750 · see citing works

Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA

Hoeffler, J. P., Meyer, T. E., Yun, Y., Jameson, J. L., & Habener, J. F. (1988) · Science · doi:10.1126/science.2974179 · Cited by 731 · see citing works

HSPB1 as a novel regulator of ferroptotic cancer cell death

Sun, X., Ou, Z., Xie, M., Kang, R., Fan, Y., Niu, X., Wang, H., Cao, L., & Tang, D. (2015) · Oncogene · doi:10.1038/onc.2015.32 · Cited by 666 · see citing works

ROS in Cancer: The Burning Question

Chio, I. I. C., & Tuveson, D. A. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.03.004 · Cited by 532 · see citing works

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

Hayano, M., Yang, W., Corn, C. K., Pagano, N. C., & Stockwell, B. R. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.93 · Cited by 462 · see citing works

The structural basis of protein acetylation by the p300/CBP transcriptional coactivator

Liu, X., Wang, L., Zhao, K., Thompson, P. R., Hwang, Y., Marmorstein, R., & Cole, P. A. (2008) · Nature · doi:10.1038/nature06546 · Cited by 454 · see citing works

Metabolic control of epigenetics in cancer

Kinnaird, A. S., Zhao, S., Wellen, K. E., & Michelakis, E. D. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.82 · Cited by 419 · see citing works

LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in <i>KRAS</i> -Mutant Lung Adenocarcinoma

Galan-Cobo, A., Sitthideatphaiboon, P., Qu, X., Poteete, A., Pisegna, M. A., Tong, P., Chen, P.-H., Boroughs, L. K., Rodriguez, M. L. M., Zhang, W., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3527 · Cited by 292 · see citing works

circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma

Zhang, X. L., Xu, Y., Qian, Z., Zheng, W., Wu, Q., Chen, Y., Zhu, G., Liu, Y., Bian, Z., Xu, W., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1132-6 · Cited by 237 · see citing works

Epigenetic reprogramming of epithelial-mesenchymal transition promotes ferroptosis of head and neck cancer

Lee, J., You, J. H., Kim, M., & Roh, J. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101697 · Cited by 224 · see citing works

The m6A reader YTHDC2 inhibits lung adenocarcinoma tumorigenesis by suppressing SLC7A11-dependent antioxidant function

Ma, L., Chen, T., Zhang, X., Miao, Y., Tian, X., Yu, K., Xu, X., Niu, Y., Guo, S., Zhang, C., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101801 · Cited by 223 · see citing works

cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth

Chen, Z., Li, J., Lin, S., Cao, C., Gimbrone, N. T., Yang, R., Fu, D., Carper, M. B., Haura, E. B., Schabath, M. B., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85250 · Cited by 192 · see citing works

Physical and Functional Interactions among AP-2 Transcription Factors, p300/CREB-binding Protein, and CITED2

Bragança, J., Eloranta, J. J., Bamforth, S. D., Ibbitt, J. C., Hurst, H. C., & Bhattacharya, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208144200 · Cited by 155 · see citing works

Mutual Interaction Between Yap And Creb Promotes Tumorigenesis in Liver Cancer

Wang, J., Ma, L., Weng, W., Qiao, Y., Zhang, Y., He, J., Wang, H., Xiao, W., Li, L., Chu, Q., et al. (2013) · Hepatology · doi:10.1002/hep.26420 · Cited by 147 · see citing works

Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib

Houessinon, A., François, C., Sauzay, C., Louandre, C., Mongélard, G., Godin, C., Bodeau, S., Takahashi, S., Saidak, Z., Gutierrez, L., et al. (2016) · Molecular Cancer · doi:10.1186/s12943-016-0526-2 · Cited by 137 · see citing works

Histone methylation and acetylation in macrophages as a mechanism for regulation of inflammatory responses

Daskalaki, M., Tsatsanis, C., & Kampranis, S. C. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26497 · Cited by 137 · see citing works

Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis

Sehm, T., Rauh, M., Wiendieck, K., Buchfelder, M., Eyüpoglu, I. Y., & Savaskan, N. E. (2016) · Oncotarget · doi:10.18632/oncotarget.11858 · Cited by 129 · see citing works

Inhibition of Glutaredoxin 5 predisposes Cisplatin-resistant Head and Neck Cancer Cells to Ferroptosis

Lee, J., You, J. H., Shin, D., & Roh, J. (2020) · Theranostics · doi:10.7150/thno.46903 · Cited by 127 · see citing works

Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming

Ebrahımı, A., Sevinç, K., Sevinç, G. G., Cribbs, A. P., Philpott, M., Uyulur, F., Morova, T., Dunford, J. E., Göklemez, S., Arı, Ş., et al. (2019) · Nature Chemical Biology · doi:10.1038/s41589-019-0264-z · Cited by 98 · see citing works

Aldehyde dehydrogenase 1A1 confers erlotinib resistance via facilitating the reactive oxygen species-reactive carbonyl species metabolic pathway in lung adenocarcinomas

Lei, H.-M., Zhang, K., Wang, C. H., Wang, Y., Zhuang, G., Lu, L., Zhang, J., Shen, Y. H., Chen, H., & Zhu, L. (2019) · Theranostics · doi:10.7150/thno.35729 · Cited by 77 · see citing works

The membrane protein melanoma cell adhesion molecule (MCAM) is a novel tumor marker that stimulates tumorigenesis in hepatocellular carcinoma

Wang, J., Tang, X., Weng, W., Qiao, Y., Lin, J., Liu, W., Liu, R., Ma, L., Yu, W., Yu, Y., et al. (2015) · Oncogene · doi:10.1038/onc.2015.36 · Cited by 62 · see citing works

TFCP2 Is Required for YAP-Dependent Transcription to Stimulate Liver Malignancy

Zhang, X., Sun, F., Qiao, Y., Zheng, W., Liu, Y., Chen, Y., Wu, Q., Liu, X., Zhu, G., Chen, Y., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.017 · Cited by 58 · see citing works

RBM10 inhibits cell proliferation of lung adenocarcinoma via RAP1/AKT/CREB signalling pathway

Jin, X., Di, X., Wang, R., Ma, H., Tian, C., Zhao, M., Cong, S., Liu, J., Li, R., & Wang, K. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14263 · Cited by 52 · see citing works

Enterovirus 71 modulates a COX‐2/PGE2/cAMP‐dependent viral replication in human neuroblastoma cells: Role of the c‐Src/EGFR/p42/p44 MAPK/CREB signaling pathway

Tung, W., Hsieh, H., Lee, I., & Yang, C. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22946 · Cited by 51 · see citing works

The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non–small cell lung cancer

Rodón, L., Svensson, R. U., Wiater, E., Chun, M. G. H., Tsai, W., Eichner, L. J., Shaw, R. J., & Montminy, M. (2019) · Science Advances · doi:10.1126/sciadv.aaw6455 · Cited by 49 · see citing works

Small molecule inhibition of cAMP response element binding protein in human acute myeloid leukemia cells

Mitton, B. A., Chae, H., Hsu, K., Dutta, R., Aldana-Masangkay, G. I., Ferrari, R., Davis, K. L., Tiu, B. C., Kaul, A., Lacayo, N. J., et al. (2016) · Leukemia · doi:10.1038/leu.2016.139 · Cited by 43 · see citing works

MnTE-2-PyP reduces prostate cancer growth and metastasis by suppressing p300 activity and p300/HIF-1/CREB binding to the promoter region of the PAI-1 gene

Tong, Q., Weaver, M. R., Kosmacek, E. A., O’Connor, B. P., Harmacek, L. D., Venkataraman, S., & Oberley‐Deegan, R. E. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.02.036 · Cited by 42 · see citing works

Enhancement by lithium of cAMP-induced CRE/CREB-directed gene transcription conferred by TORC on the CREB basic leucine zipper domain

Böer, U., Eglins, J., Krause, D., Schnell, S., Schöfl, C., & Knepel, W. (2007) · Biochemical Journal · doi:10.1042/bj20070796 · Cited by 39 · see citing works

KRAS-Driven Lung Adenocarcinoma and B Cell Infiltration: Novel Insights for Immunotherapy

Rosamaria, P., Petriella, D., Lacalamita, R., Montrone, M., Catino, A., Pizzutilo, P., Antonietta, B. M., Zito, A. F., Bene, G. D., Zonno, A., et al. (2019) · Cancers · doi:10.3390/cancers11081145 · Cited by 37 · see citing works

Replication factor C3 is a CREB target gene that regulates cell cycle progression through the modulation of chromatin loading of PCNA

Chae, H.-D., Mitton, B. A., Lacayo, N. J., & Sakamoto, K. M. (2014) · Leukemia · doi:10.1038/leu.2014.350 · Cited by 36 · see citing works

Immune checkpoint-inhibitors and chemoradiation in stage III unresectable non-small cell lung cancer

Melosky, B. L., Juergens, R. A., McLeod, D., Leighl, N. B., Brade, A. M., Card, P. B., & Chu, Q. S.-C. (2019) · Lung Cancer · doi:10.1016/j.lungcan.2019.05.027 · Cited by 34 · see citing works

β-Catenin Cooperates with CREB Binding Protein to Promote the Growth of Tumor Cells

Yu, W., Li, L., Zheng, F., Yang, W., Zhao, S., Tian, C., Yin, W., Chen, Y., Guo, W., Zou, L., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485013 · Cited by 25 · see citing works

PCDH17 functions as a common tumor suppressor gene in acute leukemia and its transcriptional downregulation is mediated primarily by aberrant histone acetylation, not DNA methylation

Uyen, L. T. N., Amano, Y., Al‐Kzayer, L. F. Y., Kubota, N., Kobayashi, J., Nakazawa, Y., Koike, K., & Sakashita, K. (2019) · International Journal of Hematology · doi:10.1007/s12185-019-02799-4 · Cited by 8 · see citing works

GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment

Liu, Y., Wan, Y., Jiang, Y., Zhang, L., & Cheng, W. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188890 · Cited by 536 · see citing works

System Xc−/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy

Li, F., Long, H., Zhou, Z.-W., Luo, H., Xu, S., & Gao, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.910292 · Cited by 460 · see citing works

GPX4, ferroptosis, and diseases

Zhang, W., Liu, Y., Yan, L., Zhu, C., & Zou, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116512 · Cited by 447 · see citing works

Ferroptosis: when metabolism meets cell death

Zheng, J., & Conrad, M. (2024) · Physiological Reviews · doi:10.1152/physrev.00031.2024 · Cited by 270 · see citing works

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

Wang, Y., Hu, J., Wu, S., Fleishman, J. S., Li, Y., Xu, Y.-S., Zou, W., Wang, J., Feng, Y., Chen, J., et al. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01720-0 · Cited by 220 · see citing works

METTL5 stabilizes c‐Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression

Xia, P., Zhang, H., Lu, H., Xu, K., Jiang, X. W., Jiang, Y., Gongye, X., Chen, Z., Liu, J., Chen, X., et al. (2023) · 癌症：英文版 · doi:10.1002/cac2.12403 · Cited by 200 · see citing works

Ginkgolide B alleviates oxidative stress and ferroptosis by inhibiting GPX4 ubiquitination to improve diabetic nephropathy

Chen, J., Ou, Z., Gao, T., Yang, Y., Shu, A., Xu, H., Chen, Y., & Lv, Z. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113953 · Cited by 184 · see citing works

Targeting GPX4 in human cancer: Implications of ferroptosis induction for tackling cancer resilience

Lee, J., & Roh, J. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216119 · Cited by 147 · see citing works

cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironment

Zhang, H., Liu, Y., Liu, J., Chen, J., Wang, J., Hua, H. M., & Jiang, Y. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01524-x · Cited by 149 · see citing works

The role of ferroptosis in lung cancer

Wu, S., Zhu, C., Tang, D., Dou, Q. P., Shen, J., & Chen, X. (2021) · Biomarker Research · doi:10.1186/s40364-021-00338-0 · Cited by 132 · see citing works

LPCAT3 Is Transcriptionally Regulated by YAP/ZEB/EP300 and Collaborates with ACSL4 and YAP to Determine Ferroptosis Sensitivity

Cui, J., Wang, Y., Tian, X., Miao, Y., Ma, L., Zhang, C., Xu, X., Wang, J., Fang, W., & Zhang, X. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0237 · Cited by 131 · see citing works

Regulation of Ferroptosis in Lung Adenocarcinoma

Wei, X., Li, X., Hu, S., Cheng, J., & Cai, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914614 · Cited by 122 · see citing works

Histone lactylation-driven B7-H3 expression promotes tumor immune evasion

Ma, Z., Yang, J., Jia, W., Li, L., Li, Y., Hu, J., Luo, W., Li, R., Ye, D., & Lan, P. (2025) · Theranostics · doi:10.7150/thno.105947 · Cited by 113 · see citing works

Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases

Talukdar, P. D., & Chatterji, U. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01651-w · Cited by 96 · see citing works

Ferroptosis in lung cancer: a novel pathway regulating cell death and a promising target for drug therapy

Xing, N., Du, Q., Guo, S., Xiang, G., Zhang, Y., Meng, X., Li, X., & Wang, S. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01407-z · Cited by 88 · see citing works

A white paper on Phospholipid Hydroperoxide Glutathione Peroxidase (GPx4) forty years later

Ursini, F., Bosello-Travain, V., Cozza, G., Miotto, G., Roveri, A., Toppo, S., & Maiorino, M. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.06.227 · Cited by 80 · see citing works

Exposure to low-dose cadmium induces testicular ferroptosis

Xiong, L., Zhou, B., Young, J. L., Wintergerst, K. A., & Cai, L. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113373 · Cited by 73 · see citing works

Old wine in new bottles: Kaempferol is a promising agent for treating the trilogy of liver diseases

Xiao, X., Hu, Q., Deng, X., Shi, K., Zhang, W., Jiang, Y., Ma, X., Zeng, J., & Wang, X. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.106005 · Cited by 63 · see citing works

Understanding the mechanistic regulation of ferroptosis in cancer: the gene matters

Gao, M., Fan, K., Chen, Y., Zhang, G., Chen, J., & Zhang, Y. (2022) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2022.06.002 · Cited by 57 · see citing works

Protectin conjugates in tissue regeneration 1 alleviates sepsis-induced acute lung injury by inhibiting ferroptosis

Lv, Y., Chen, D., Tian, X., Xiao, J., Xu, C., Du, L., Li, J., Zhou, S., Chen, Y., Zhuang, R., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04111-9 · Cited by 50 · see citing works

GPX4 suppresses ferroptosis to promote malignant progression of endometrial carcinoma via transcriptional activation by ELK1

Wei, S., Yu, Z., Shi, R., An, L., Zhang, Q., Zhang, Q., Zhang, T., Zhang, J., & Wang, H. (2022) · BMC Cancer · doi:10.1186/s12885-022-09986-3 · Cited by 48 · see citing works

Identification and Validation of the Pyroptosis-Related Molecular Subtypes of Lung Adenocarcinoma by Bioinformatics and Machine Learning

Liu, L., Lu, L., Zhao, Q., Kou, Q.-J., Jiang, Z.-Z., Gui, R., Luo, Y., & Zhao, Q. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.756340 · Cited by 46 · see citing works

COPZ1 regulates ferroptosis through NCOA4-mediated ferritinophagy in lung adenocarcinoma

Wu, A., Yang, H., Xiao, T., Gu, W., Li, H., & Chen, P. (2024) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2024.130706 · Cited by 46 · see citing works

PM2 .5 exposure‐induced ferroptosis in neuronal cells via inhibiting ERK / CREB pathway

Xiong, Q., Tian, X., Xu, C., Ma, B., Liu, W. D., Sun, B., Ru, Q., & Shu, X. (2022) · Environmental Toxicology · doi:10.1002/tox.23586 · Cited by 39 · see citing works

Self-engineered lipid peroxidation nano-amplifier for ferroptosis-driven antitumor therapy

Sun, X., Yang, X., Wang, J., Shang, Y., Wang, P., Sheng, X., Liu, X., Sun, J., He, Z., Zhang, S., et al. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.138991 · Cited by 38 · see citing works

Dexmedetomidine attenuates myocardial ischemia-reperfusion injury via inhibiting ferroptosis by the cAMP/PKA/CREB pathway

Ma, X., Xu, J., Gao, N., Tian, J., & Song, T. (2023) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2023.101899 · Cited by 37 · see citing works

Transcriptional activation of ENPP2 by FoxO4 protects cardiomyocytes from doxorubicin‑induced toxicity

He, L., Yang, Y., Chen, J., Zou, P., & Li, J. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12307 · Cited by 36 · see citing works

Inhibition of ferroptosis reverses heart failure with preserved ejection fraction in mice

Xiong, Y., Liu, X., Jiang, L., Hao, T., Wang, Y., & Li, T. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-023-04734-y · Cited by 35 · see citing works

Ferroptosis in Lung Cancer: From Molecular Mechanisms to Prognostic and Therapeutic Opportunities

Tabnak, P., HajiEsmailPoor, Z., & Soraneh, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.792827 · Cited by 35 · see citing works

Targeting ALDH1A1 to enhance the efficacy of KRAS-targeted therapy through ferroptosis

Bian, Y., Shan, G., Bi, G., Liang, J., Hu, Z., Sui, Q., Shi, H., Zheng, Z., Yao, G., Wang, Q., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103361 · Cited by 34 · see citing works

A review on the research progress of traditional Chinese medicine with anti-cancer effect targeting ferroptosis

Wang, L., Huang, H., Li, X., Ouyang, L., Wei, X., Xie, J., Liu, D., Tan, P., & Hu, Z. (2023) · Chinese Medicine · doi:10.1186/s13020-023-00838-1 · Cited by 32 · see citing works

Comprehensive analysis of the autophagy-dependent ferroptosis-related gene FANCD2 in lung adenocarcinoma

Miao, H., Ren, Q., Li, H., Zeng, M., Chen, D. S., Xu, C., Chen, Y., & Wen, Z. (2022) · BMC Cancer · doi:10.1186/s12885-022-09314-9 · Cited by 31 · see citing works

Ferroptosis and Its Potential Role in Lung Cancer: Updated Evidence from Pathogenesis to Therapy

Chen, K., Zhang, S., Jiao, J., & Zhao, S. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s347955 · Cited by 29 · see citing works

ASCL1-mediated ferroptosis resistance enhances the progress of castration-resistant prostate cancer to neurosecretory prostate cancer

Nie, J., Zhang, P., Liang, C., Yu, Y., & Wang, X. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.06.006 · Cited by 28 · see citing works

GZMA suppressed GPX4-mediated ferroptosis to improve intestinal mucosal barrier function in inflammatory bowel disease

Niu, R., Lan, J., Liang, D., Xiang, L., Wu, J., Zhang, X., Li, Z., Chen, H., Geng, L., Xu, W., et al. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01836-y · Cited by 27 · see citing works

ASMTL‐AS1 impedes the malignant progression of lung adenocarcinoma by regulating SAT1 to promote ferroptosis

Sui, X., Hu, N., Zhang, Z., Wang, Y., Wang, P., & Xiu, G. (2021) · Pathology International · doi:10.1111/pin.13158 · Cited by 27 · see citing works

Vitronectin Destroyed Intestinal Epithelial Cell Differentiation through Activation of PDE4-Mediated Ferroptosis in Inflammatory Bowel Disease

Pan, W., Xiang, L., Liang, X., Du, W., Zhao, J., Zhang, S., Zhou, X., Geng, L., Gong, S., & Xu, W. (2023) · Mediators of Inflammation · doi:10.1155/2023/6623329 · Cited by 27 · see citing works

Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC

Xue, W., Jian, W., Meng, Y., Wang, T., Cai, L., Yu, Y., Yu, Y., Xia, Z., & Zhang, C. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06057-8 · Cited by 27 · see citing works

Secreted Apoe rewires melanoma cell state vulnerability to ferroptosis

More, S., Bonnereau, J., Wouters, D., Spotbeen, X., Karras, P., Rizzollo, F., Killian, T., Venken, T., Naulaerts, S., Vervoort, E., et al. (2024) · Science Advances · doi:10.1126/sciadv.adp6164 · Cited by 25 · see citing works

Decoding GPX4 regulation in ferroptosis: mechanisms and therapeutic implications

Chen, X. (2026) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2026.01.008 · Cited by 25 · see citing works

Pea (Pisum sativum) peel extract attenuates DOX-induced oxidative myocardial injury

Abdelghffar, E. A. R., Obaid, W. A., Elgamal, A. M., Daoud, R., Sobeh, M., & Raey, M. A. E. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112120 · Cited by 25 · see citing works

KLF14 directly downregulates the expression of GPX4 to exert antitumor effects by promoting ferroptosis in cervical cancer

Ye, H., Ding, X., Lv, X., Du, Y., Guo, R., Qiu, J., Li, R., & Cao, L. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05714-6 · Cited by 24 · see citing works

MMP9 drives ferroptosis by regulating GPX4 and iron signaling

Gawargi, F. I., & Mishra, P. K. (2024) · iScience · doi:10.1016/j.isci.2024.110622 · Cited by 23 · see citing works

Ferroptosis-based drug delivery system as a new therapeutic opportunity for brain tumors

Yao, Y., Ji, P., Chen, H., Ge, J., Xu, Y., Wang, P., Li, X., & Yan, Z. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1084289 · Cited by 21 · see citing works

PTGER3 knockdown inhibits the vulnerability of triple‐negative breast cancer to ferroptosis

Wang, S., Zhang, Y.-Y., Zhang, D., Meng, J., Che, N., Zhao, X.-L., & Liu, T. (2024) · Cancer Science · doi:10.1111/cas.16169 · Cited by 20 · see citing works

Selenium-containing compounds, selenium nanoparticles and selenoproteins in the prevention and treatment of lung cancer

Varlamova, E. G. (2025) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2025.127620 · Cited by 18 · see citing works

Construction of a Ferroptosis-Related Long Non-coding RNA Prognostic Signature and Competing Endogenous RNA Network in Lung Adenocarcinoma

Fei, X., Hu, C., Wang, X., Lu, C., Chen, H., Sun, B., & Li, C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.751490 · Cited by 18 · see citing works

Combination regimen of granulocyte colony-stimulating factor and recombinant human thrombopoietin improves the curative effect on elderly patients with leukemia through inducing pyroptosis and ferroptosis of leukemia cells

Wang, X., Liu, X., & Wang, H. (2022) · Cancer Gene Therapy · doi:10.1038/s41417-022-00497-8 · Cited by 17 · see citing works

Ferroptosis and its emerging role in esophageal cancer

Maimaitizunong, R., Wang, K., & Li, H. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1027912 · Cited by 17 · see citing works

The old second messenger cAMP teams up with novel cell death mechanisms: potential translational therapeutical benefit for Alzheimer’s disease and Parkinson’s disease

Zhang, T., Luu, M. D. A., Dolga, A. M., Eisel, U. L. M., & Schmidt, M. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1207280 · Cited by 16 · see citing works

Natural products and ferroptosis: A novel approach for heart failure management

Zhang, Z., Yang, Z., Wang, S., Wang, X., & Mao, J. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156783 · Cited by 17 · see citing works

Function and regulation of GPX4 in the development and progression of fibrotic disease

Li, Z., Zhu, Z., Liu, Y., Liu, Y., & Zhao, H. W. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30780 · Cited by 16 · see citing works

Unravelling the signaling power of pollutants

Manzano-Covarrubias, A. L., Yan, H., Luu, M. D. A., Gadjdjoe, P. S., Dolga, A. M., & Schmidt, M. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.09.002 · Cited by 17 · see citing works

The AMPK-related kinase NUAK2 suppresses glutathione peroxidase 4 expression and promotes ferroptotic cell death in breast cancer cells

Singh, T., Beatty, A., & Peterson, J. R. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01044-y · Cited by 16 · see citing works

FOXO: a key target in regulating aging and age-related diseases

Wang, W., Zhu, H., Jiang, Q., Shi, Y., & Wang, X. (2026) · Biogerontology · doi:10.1007/s10522-025-10380-2 · Cited by 15 · see citing works

Stratification of lung squamous cell carcinoma based on ferroptosis regulators: Potential for new therapeutic strategies involving ferroptosis induction

Asakawa, A., Kawade, G., Kurata, M., Fukuda, S., Onishi, I., Kinowaki, Y., Ishibashi, S., Ikeda, M., Watabe, S., Kobayashi, M., et al. (2022) · Lung Cancer · doi:10.1016/j.lungcan.2022.01.012 · Cited by 15 · see citing works

Inhibition of CREB promotes glucocorticoids action on airway inflammation in pediatric asthma by promoting ferroptosis of eosinophils

Yu, T., Yu, Y., Ma, Y., & Chen, G. (2023) · Allergologia et Immunopathologia · doi:10.15586/aei.v51i4.873 · Cited by 15 · see citing works

Emerging mechanisms of ferroptosis and its implications in lung cancer

Li, Q., Song, Q., Pei, H., & Chen, Y. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003048 · Cited by 15 · see citing works

Regulators of epigenetic change in ferroptosis‑associated cancer (Review)

Wu, J., Zhu, S., Wang, P., Wang, J., Huang, J., Wang, T., Guo, L., Liang, D., Meng, Q., & Pan, H. (2022) · Oncology Reports · doi:10.3892/or.2022.8430 · Cited by 15 · see citing works

SETD1A ‐mediated H3K4me3 methylation upregulates lncRNA HOXC‐AS3 and the binding of HOXC‐AS3 to EP300 and increases EP300 stability to suppress the ferroptosis of NSCLC cells

Shi, Z., Zhang, H., Shen, Y., Zhang, S., Zhang, X., Xu, Y., & Sun, D. (2023) · Thoracic Cancer · doi:10.1111/1759-7714.15037 · Cited by 14 · see citing works

Osteopontin promotes tumor growth and metastasis and GPX4-mediated anti-lipid peroxidation in triple-negative breast cancer by activating the PI3k/Akt/mTOR pathway

Guo, M., Liu, M., Li, W., Wang, C., Zhang, L., & Zhang, H. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-024-05658-w · Cited by 14 · see citing works

Downregulation of 4-HNE and FOXO4 collaboratively promotes NSCLC cell migration and tumor growth

Zhong, T., Li, Y., Jin, M., Liu, J., Wu, Z.-Y., Zhu, F., Zhao, L., Fan, Y., Xu, L., & Ji, J. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06948-4 · Cited by 14 · see citing works

A Supramolecular Deferoxamine–Crisaborole Nanoparticle Targets Ferroptosis, Inflammation, and Oxidative Stress in the Treatment of Retinal Ischemia/Reperfusion Injury

Lu, Y., Zhu, F., Zhou, X., Li, Y., Rong, G., Liu, N., Hong, J., & Cheng, Y. (2024) · Nano Letters · doi:10.1021/acs.nanolett.4c05012 · Cited by 13 · see citing works

Inhibition of ZDHHC16 promoted osteogenic differentiation and reduced ferroptosis of dental pulp stem cells by CREB

Liu, W., Yu, W., Zhou, L., Ling, D., Xu, Y., & He, F. (2024) · BMC Oral Health · doi:10.1186/s12903-024-04107-x · Cited by 12 · see citing works

Tetrandrine citrate suppresses lung adenocarcinoma growth via SLC7A11/GPX4-mediated ferroptosis

Mo, X., Hu, D., Yuan, K., Luo, J., Huang, C., & Xu, M. Q. (2023) · Discover Oncology · doi:10.1007/s12672-023-00691-6 · Cited by 12 · see citing works

Luciferase-Based Reporter System for Investigating GPx4-Mediated Ferroptosis and Its Therapeutic Implications in Diabetes

Ramkumar, K. M., Susindran, O. T., Ganesh, G. V., Harithpriya, K., & Paulmurugan, R. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.4c03065 · Cited by 11 · see citing works

ZIP8 modulates ferroptosis to drive esophageal carcinoma progression

Yang, Z., Zhao, K., Li, X., Yanzhang, R., Zhang, H., Yin, Y., Yan, M., Fang, S., Li, T., Li, H., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07692-z · Cited by 11 · see citing works

CREB1 Transcriptionally Activates LTBR to Promote the NF-κB Pathway and Apoptosis in Lung Epithelial Cells

Hu, Z., & Zhou, G. (2022) · Computational and Mathematical Methods in Medicine · doi:10.1155/2022/9588740 · Cited by 10 · see citing works

Unleashing T cell anti-tumor immunity: new potential for 5-Nonloxytryptamine as an agent mediating MHC-I upregulation in tumors

Stachura, P., Liu, W., Xu, H. C., Wlodarczyk, A., Stencel, O., Pandey, P., Vogt, M., Bhatia, S., Picard, D. J., Remke, M., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01833-8 · Cited by 9 · see citing works

Upregulation of Ferroptosis-Related Fanconi Anemia Group D2 is a Poor Prognostic Factor and an Indicator of Tumor Immune Cell Infiltration in Lung Adenocarcinoma

Zhang, J.-T., Wang, D., Chen, X.-X., Ji, L.-Y., Yu, M.-O., Guo, M.-H., Zhang, D.-J., Chen, W.-D., & Xu, F. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.825685 · Cited by 7 · see citing works

Silencing of CircTRIM25/miR-138-5p/CREB1 axis promotes chondrogenesis in osteoarthritis

He, C., Zeng, Z., Yang, Y., Ye, S., Wu, Q., Liu, X., Liu, C., Zeng, W., & Liu, S. (2024) · Autoimmunity · doi:10.1080/08916934.2024.2361749 · Cited by 9 · see citing works

Potentially functional genetic variants in ferroptosis‐related CREB3 and GALNT14 genes predict survival of hepatitis B virus‐related hepatocellular carcinoma

Zhan, S., Qiu, M., Wei, X., Wei, J., Qin, L., Jiang, B., Wen, Q., Chen, P., Lin, Q., Wei, X., et al. (2023) · Cancer Medicine · doi:10.1002/cam4.6848 · Cited by 9 · see citing works

Research on the function of GPX4 in tumor-targeted treatment based on its molecular structure and features

Geng, H., Ma, L., Wu, L., Yao, C., Wang, C., Gan, X., Li, Y., & Chen, F. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1594234 · Cited by 8 · see citing works

METTL3-mediated m6A modification enhances ZDHHC16 expression in nonsmall- cell lung cancer patients, attenuating ferroptosis by suppressing CREB ubiquitination

Liu, Z., Jing, C., & Zhang, W. (2024) · Cellular and Molecular Biology · doi:10.14715/cmb/2024.70.2.5 · Cited by 8 · see citing works

Classical prescription Daqinjiao decoction inhibit cerebral ischemia/reperfusion induced necroptosis and ferroptosis through multiple mechanisms

Liu, Y., Liu, J., Hu, N., Li, Z., Liu, A., Luo, R., Du, S., Guo, D., Li, J., & Duan, J. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.119300 · Cited by 8 · see citing works

Network Pharmacology and Molecular Docking Study on the Mechanism of the Therapeutic Effect of Strychni Semen in NSCLC

Geng, H., Xue, Y., Yan, B., Lu, Z., Yang, H., Li, P., & Zhou, J. (2024) · Biological Procedures Online · doi:10.1186/s12575-024-00259-w · Cited by 8 · see citing works

Long non‐coding RNA TPT1‐AS1 inhibits ferroptosis in ovarian cancer by regulating GPX4 via CREB1 regulation

Cao, L., Wang, Y., Liu, J., Bai, X., & Chi, X. (2024) · American Journal of Reproductive Immunology · doi:10.1111/aji.13864 · Cited by 7 · see citing works

CircSCUBE3 promoted ferroptosis to inhibit lung adenocarcinoma progression

Fu, H., & Zhao, Q. (2024) · Cellular and Molecular Biology · doi:10.14715/cmb/2024.70.2.23 · Cited by 7 · see citing works

Rabeprazole suppressed gastric intestinal metaplasia through activation of GPX4-mediated ferroptosis

Xie, J., Liang, X., Xie, F., Huang, C., Lin, Z., Xie, S., Yang, F., Zheng, F., Geng, L., Xu, W., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1409001 · Cited by 6 · see citing works

Inhibition of miR-9-3p facilitates ferroptosis by activating SAT1/p53 pathway in lung adenocarcinoma

Wu, A., Zhang, A., Wang, T., Chen, J., & Shi, J. (2024) · Translational Lung Cancer Research · doi:10.21037/tlcr-24-762 · Cited by 6 · see citing works

Emerging strategies for enhanced glutathione biosynthesis and its biomedical applications

Wang, Y., Ma, R., Zhou, J., Tan, Z., Hong-liang, L., Shi, H. S., & Zhang, Y. (2025) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2025.11.016 · Cited by 5 · see citing works

Prognostic markers of ferroptosis-related long non-coding RNA in lung adenocarcinomas

Mao, K., Tang, R. N., Wu, Y., Zhang, Z., Gao, Y., & Huang, H. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1118273 · Cited by 5 · see citing works

Construction and Characterization of Long Non-Coding RNA-Associated Networks to Reveal Potential Prognostic Biomarkers in Human Lung Adenocarcinoma

Zhou, W., Bai, C., Long, C., Hu, L., & Zheng, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.720400 · Cited by 5 · see citing works

GATA1 activates HSD17B6 to improve efficiency of cisplatin in lung adenocarcinoma via DNA damage

Shao, X., Hou, H. W., Chen, H., Xia, W., Geng, X., & Wang, J. (2024) · Genes and Environment · doi:10.1186/s41021-024-00321-9 · Cited by 4 · see citing works

EP300 attenuates ferroptosis and stimulates proliferation, migration, and fibrosis of keloid fibroblasts via YY1/GPX4 axis

Jin, J., Wang, K., Lu, C., Yao, C., & Xie, F. (2026) · Cell Cycle · doi:10.1080/15384101.2026.2627885 · Cited by 4 · see citing works

Norepinephrine Induces Sertoli Cell Ferroptosis via Receptors Desensitization Causing Stress‐Related Male Reproductive Dysfunction

Zhang, L., Gao, S., Xiong, X., Liu, X., Li, R., Wang, X., Han, L., Xiao, X., Wang, X., Li, W., et al. (2025) · Advanced Science · doi:10.1002/advs.202504817 · Cited by 3 · see citing works

A comprehensive and visualized analysis of relationship between ferroptosis and tumor using bibliometrics and bioinformatics.

Wang, X., Song, D., Zhou, Z., Jiang, Z., Zhang, N., Zhang, H., & Xia, D. (2023) · PubMed Central · Cited by 3 · see citing works

Comprehensive molecular analyses of cuproptosis-related genes with regard to prognosis, immune landscape, and response to immune checkpoint blockers in lung adenocarcinoma

Li, R., Tong, R., Zhang, J. L., Zhang, Z., Deng, M., & Hou, G. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-024-05774-7 · Cited by 3 · see citing works

GPX4 suppresses ferroptosis to promote malignant progression of endometrial carcinoma via transcriptional activation by ELK1Preprint

Wei, S., Yu, Z., Shi, R., An, L., Zhang, Q., Zhang, Q., Zhang, T., Zhang, J., & Wang, H. (2022) · Research Square · doi:10.21203/rs.3.rs-1550688/v1 · Cited by 3 · see citing works

CTB alleviated premature ovarian insufficiency induced by cigarette smoke exposure in mice through activating CREB1 by P300-mediated histone acetylation modifications

Hu, N., Xin, N., Wang, Y., Liu, D., Zhao, Y., Xu, M., Li, F., Miao, J., Ji, S., & Wang, L. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118625 · Cited by 2 · see citing works

Roflumilast mitigates idiopathic pulmonary fibrosis via inhibition of iron accumulation and ferroptosis

Feng, L., Han, S., Li, Y., Zhan, S., Li, L., Wang, Y., & Feng, J. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178385 · Cited by 2 · see citing works

A CREB5-NR4A1 checkpoint protects against disc degeneration by controlling ferroptosis

Huang, Y., Xiao, B., Liang, H., Zhu, Y., Yang, S., Li, S., Shi, Y., Wang, X., & Wang, X. (2026) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2026.03.115 · Cited by 2 · see citing works

Lactylation of β-catenin promotes non-small cell lung cancer by inhibiting ferroptosis through TCF4-mediated GPX4 transcription

Yang, X., Guo, C., Lu, Y., Zhou, R., Liu, Z., Yang, Z., Xu, S., & Li, W. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08247-2 · Cited by 2 · see citing works

Bibliometric analysis of ferroptosis: a comprehensive evaluation of its contribution to lung cancer

Yao, F., Guo, F., Sun, C., Wang, E., Wang, H., & Li, N. (2025) · Frontiers in Genetics · doi:10.3389/fgene.2024.1449491 · Cited by 1 · see citing works

Metabolomics analysis identifies hypoxia-induced ferroptosis in the liver of silver carp (Hypophthalmichthys molitrix)

Zhang, C., Li, X., Feng, C., Sha, H., Luo, X., Ai, S., Zou, G., Zhang, J., & Liang, H. (2025) · Water Biology and Security · doi:10.1016/j.watbs.2025.100422 · Cited by 1 · see citing works

Zinc oxide nanoparticles as emerging modulators of ferroptosis in cancer therapy

Kumari, N., Sivasubramanian, N., Prabhune, N. M., & Prabhu, S. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107697 · Cited by 1 · see citing works

AQP4-AS1 Can Regulate the Expression of Ferroptosis-Related Regulator ALOX15 through Competitive Binding with miR-4476 in Lung Adenocarcinoma

Du, L., Xu, G., Zhang, X., Zhang, Z., Yang, Y., Teng, H., & Yang, T. (2024) · Global Medical Genetics · doi:10.1055/s-0044-1789199 · Cited by 1 · see citing works

Identification of cross-talk between m6A/m5C regulators and ferroptosis associated with immune infiltration and prognosis in pan-cancerPreprint

Zhang, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-1058834/v1 · Cited by 1 · see citing works

Upregulation of Ferroptosis-Related Fanconi Anemia Group D2 is a Poor Prognostic Factor and Indicator of Tumor Immune Cell Infiltration in Lung AdenocarcinomaPreprint

Zhang, J., Wang, D., Chen, X., Yu, M., Guo, M., Zhang, D., Chen, W., & Xu, F. (2022) · Research Square · doi:10.21203/rs.3.rs-1311625/v1

Osteopontin promotes cell pelletizing and angiogenesis in triple negative breast cancer by activating the PI3k/Akt/mTOR pathway to regulate GPX4-mediated anti-lipid peroxidation levelsPreprint

Guo, M., Li, W., Liu, M., Wang, C., Zhang, L., & Zhang, H. (2022) · Research Square · doi:10.21203/rs.3.rs-1631687/v1

Ubiquitin‐Specific Protease 45 Inhibits Lung Adenocarcinoma Ferroptosis by Regulating Ubiquitination and Stability of Glutathione Peroxidase 4

Huang, M., Fang, M., Wang, Y., Liu, S., & Li, F. (2026) · Cancer Medicine · doi:10.1002/cam4.71901

CircSCUBE3 promoted ferroptosis to inhibit lung adenocarcinoma progression

Fu, H., & Zhao, Q. (2024) · Cellular and Molecular Biology · doi:10.14715/cmb/2024.70.2.23 · Cited by 7 · see citing works

TDP-43 drives ferroptosis evasion by modulating PCBP1/PCBP2 axis to promote lung adenocarcinoma growth

Liu, B., Chen, X., Chen, J., Feng, J., Wang, J., Jin, X., Cao, J., Zhao, B., Yin, H., Wang, J., et al. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104346

Transcription factor NFYA inhibits ferroptosis in lung adenocarcinoma cells by regulating PEBP1

Chen, F., Xu, T., Jin, N., Li, D., Ying, Y., & Wang, C. (2024) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2024.111873 · Cited by 4 · see citing works

Regulation of Ferroptosis in Lung Adenocarcinoma

Wei, X., Li, X., Hu, S., Cheng, J., & Cai, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914614 · Cited by 122 · see citing works