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Cited by 154Magnesium in Health and DiseaseNutrition and Health in AgingNutrition and Health Studies

Effect of Oral Magnesium Supplementation on Physical Performance in Healthy Elderly Women Involved in a Weekly Exercise Program: A Randomized Controlled Trial

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Veronese, Nicola, Berton, Linda, Carraro, Sara, Bolzetta, Francesco, De Rui, Marina, Perissinotto, Egle, Toffanello, Elena Debora, Bano, Giulia +5 more·2014·The American Journal of Clinical Nutrition
DOI 10.3945/ajcn.113.080168
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Abstract

Background Magnesium deficiency is associated with poor physical performance, but no trials are available on how magnesium supplementation affects elderly people's physical performance.Objective The aim of our study was to investigate whether 12 wk of oral magnesium supplementation can improve physical performance in healthy elderly women.Design In a parallel-group, randomized controlled trial, 139 healthy women (mean ± SD age: 71.5 ± 5.2 y) attending a mild fitness program were randomly allocated to a treatment group (300 mg Mg/d; n = 62) or a control group (no placebo or intervention; n = 77) by using a computer-generated randomization sequence, and researchers were blinded to their grouping. After assessment at baseline and again after 12 wk, the primary outcome was a change in the Short Physical Performance Battery (SPPB); secondary outcomes were changes in peak torque isometric and isokinetic strength of the lower limbs and handgrip strength.Results A total of 124 participants allocated to the treatment (n = 53) or control (n = 71) group were considered in the final analysis. At baseline, the SPPB scores did not differ between the 2 groups. After 12 wk, the treated group had a significantly better total SPPB score (Δ = 0.41 ± 0.24 points; P = 0.03), chair stand times (Δ = -1.31 ± 0.33 s; P < 0.0001), and 4-m walking speeds (Δ = 0.14 ± 0.03 m/s; P = 0.006) than did the control group. These findings were more evident in participants with a magnesium dietary intake lower than the Recommended Dietary Allowance. No significant differences emerged for the secondary outcomes investigated, and no serious adverse effects were reported.Conclusions Daily magnesium oxide supplementation for 12 wk seems to improve physical performance in healthy elderly women. These findings suggest a role for magnesium supplementation in preventing or delaying the age-related decline in physical performance.

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  • Magnesium supplementation for 12 weeks in healthy elderly women may improve or delay age-related decline in muscle physical performance and strength.

    “A randomized controlled trial showed that magnesium supplementation for 12 weeks in healthy elderly women may improve or delay the age-related decline in muscle physical performance and strength [52].”

    From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [52]

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Authors
Veronese, N., Berton, L., Carraro, S., Bolzetta, F., De Rui, M., Perissinotto, E., Toffanello, E. D., Bano, G., Pizzato, S., Miotto, F., Coin, A., Manzato, E., & Sergi, G.
Affiliations
University of Padua (IT)
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2014-09
Volume
100
Issue
3
Pages
974-981
ISSN
0002-9165 (ISSN-L)
DOI
10.3945/ajcn.113.080168
OpenAlex
W2142647261
Cited by
154
References
40
Citations by year
2026: 5 · 2025: 18 · 2024: 13 · 2023: 10 · 2022: 15 · 2021: 14 · 2020: 15 · 2019: 17 · 2018: 8 · 2017: 16 · 2016: 10 · 2015: 9 · 2014: 3 · 2012: 1
FWCI
11.79
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
Keywords
magnesium supplementation, hypomagnesemia, physical performance, older women, exercise program, Short Physical Performance Battery, muscle strength, grip strength, walking speed, dietary magnesium, aging
MeSH terms
Aged, Aging, Double-Blind Method, Female, Follow-Up Studies, Gait, Humans, Italy, Magnesium, Magnesium Deficiency, Magnesium Oxide, Psychomotor Performance, Severity of Illness Index, Exercise, Geriatric Assessment, Hand Strength, Dietary Supplements, Lower Extremity, Muscle Strength, Performance-Enhancing Substances

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